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The map label for this gene is folK [H]

Identifier: 126454085

GI number: 126454085

Start: 3223182

End: 3223709

Strand: Direct

Name: folK [H]

Synonym: BURPS1106A_3305

Alternate gene names: 126454085

Gene position: 3223182-3223709 (Clockwise)

Preceding gene: 126452950

Following gene: 126455460

Centisome position: 80.81

GC content: 67.61

Gene sequence:

>528_bases
ATGACGGTTGCTTATCTCGGGTTGGGGGCCAATCTCGGCGACGCGCGCCAGGCCTTGAAGGACGCAGTGGTCTGCCTCGC
CCAGCAGCACGCCATCACGGTGCTCGGCAAGTCGAGCCTGTATCGCACCGCGCCCGTCGACGCGAGTGGCGGCGATTACT
ACAACTGCGTCGTGAAGATCGACACGGTGCTCGCCGCGCGCACGCTCCTCGCGCTGTGCCAGAAGATCGAGCACCACTTC
GGCCGCGAGCGGCCGTACCGAAACGCGCCGCGCACGCTCGACATCGACATCCTGCTCTACGGTGAACTGACGATAGACGA
ACCCGACCTCGTCGTTCCGCATCCGCGCCTGACCGAGCGCGCGTTCGCGCTCGTGCCGCTCGTCGAGATCGAGCCGGCGC
TCGCGATTCCCGCACGCGGCCGCGCCGACGGATTCCTCGCCGACGTCGCGCACCAGCGCATCGAGAAGGTCCAGACCTGC
CAGTGCCTCGCGATGCGGGCCGCCGCCGAAAAGAACCGTTGCCGATGA

Upstream 100 bases:

>100_bases
GACGGCCGACAGCGCCGAGGGCGCGGAAGGCGCCGCGCGCGGCGAGTCCGACGCGAACGACTGACGCTTGGCTCCGTCGA
ACGACGTAGGAAGGAAAGCC

Downstream 100 bases:

>100_bases
ACTCGACACCGCTTACCGTCACCGCCCCCGACTGGCGGCCGCCGTGCCGCTACCTCGCGATCGAAGGGCCGATCGGCGTC
GGCAAGACGACGCTCGCGAC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MTVAYLGLGANLGDARQALKDAVVCLAQQHAITVLGKSSLYRTAPVDASGGDYYNCVVKIDTVLAARTLLALCQKIEHHF
GRERPYRNAPRTLDIDILLYGELTIDEPDLVVPHPRLTERAFALVPLVEIEPALAIPARGRADGFLADVAHQRIEKVQTC
QCLAMRAAAEKNRCR

Sequences:

>Translated_175_residues
MTVAYLGLGANLGDARQALKDAVVCLAQQHAITVLGKSSLYRTAPVDASGGDYYNCVVKIDTVLAARTLLALCQKIEHHF
GRERPYRNAPRTLDIDILLYGELTIDEPDLVVPHPRLTERAFALVPLVEIEPALAIPARGRADGFLADVAHQRIEKVQTC
QCLAMRAAAEKNRCR
>Mature_174_residues
TVAYLGLGANLGDARQALKDAVVCLAQQHAITVLGKSSLYRTAPVDASGGDYYNCVVKIDTVLAARTLLALCQKIEHHFG
RERPYRNAPRTLDIDILLYGELTIDEPDLVVPHPRLTERAFALVPLVEIEPALAIPARGRADGFLADVAHQRIEKVQTCQ
CLAMRAAAEKNRCR

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=156, Percent_Identity=39.7435897435897, Blast_Score=96, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324073, Length=136, Percent_Identity=35.2941176470588, Blast_Score=92, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19187; Mature: 19056

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAYLGLGANLGDARQALKDAVVCLAQQHAITVLGKSSLYRTAPVDASGGDYYNCVVKI
CEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCEEECCCCCCCCCEEEEEEEH
DTVLAARTLLALCQKIEHHFGRERPYRNAPRTLDIDILLYGELTIDEPDLVVPHPRLTER
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEECCCCEECCCCCHHHH
AFALVPLVEIEPALAIPARGRADGFLADVAHQRIEKVQTCQCLAMRAAAEKNRCR
HHHHEEHEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TVAYLGLGANLGDARQALKDAVVCLAQQHAITVLGKSSLYRTAPVDASGGDYYNCVVKI
EEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCEEECCCCCCCCCEEEEEEEH
DTVLAARTLLALCQKIEHHFGRERPYRNAPRTLDIDILLYGELTIDEPDLVVPHPRLTER
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEECCCCEECCCCCHHHH
AFALVPLVEIEPALAIPARGRADGFLADVAHQRIEKVQTCQCLAMRAAAEKNRCR
HHHHEEHEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]