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The map label for this gene is hpt [H]

Identifier: 126453542

GI number: 126453542

Start: 3422992

End: 3423543

Strand: Direct

Name: hpt [H]

Synonym: BURPS1106A_3518

Alternate gene names: 126453542

Gene position: 3422992-3423543 (Clockwise)

Preceding gene: 126451954

Following gene: 126452879

Centisome position: 85.82

GC content: 63.95

Gene sequence:

>552_bases
ATGAATCGAGAAGAAGCCCTCCACATTTTCCAACACTCCGAGGAGATCGTCTCCGCCGGCGAAGTCAACGCGTCGATCGG
CCGGATGGCCGGGGAGATCCGCGGCCAGATCGGCGAGGAGTTTCCGCTCGTGCTGTCGGTGATGGGCGGTGCGGCGGTGT
TCACCGGCATGCTGCTGCCGCACCTCGATTTCCCGCTCGAATTCGACTACATCCATCTGACGCGCTACCGCAACACGACG
AAGGGCGGCCCCGAAATGCACTGGCGCGTCGCGCCGCGCGAATCGGTGAAGGACCGCATCGTGCTCGTGCTCGACGACAT
CCTCGACGAAGGCGAAACGATGGCCGCGATCCGCGATCGCATTCTCGAGATGGGCGCGAAGCGTTTCATGTCCGCCGTGC
TGTGCGAAAAGACGCTCGCGAAGGCAAAGCCGCTGCATCCGGACTTCTGCGGGTTCGCGGTGCCCGATCGCTATGTGTTC
GGCTGCGGGATGGACGCGAAGGGGTACTGGCGCAACCTGCCGACGATCCGCGCATTGACGGCCGACGTCTGA

Upstream 100 bases:

>100_bases
TGATTCGCCGCGGCGCCGCGCACGGGTATATGCTGTAGCGCGTGGCGTCGCATTGTTTCATTCTTATTGGTATCCCAGAC
GAGACCGCTCGCCAGACCTC

Downstream 100 bases:

>100_bases
CGACGCCCCCGTGCGGGCCGGCTCAGGCTTGCCCGCCGCCCGTCGGAAACAAAAAAGCGGCTCGCGCATCGTGCGCGAGC
CGCTTTTCTTTGCGCCGCTT

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MNREEALHIFQHSEEIVSAGEVNASIGRMAGEIRGQIGEEFPLVLSVMGGAAVFTGMLLPHLDFPLEFDYIHLTRYRNTT
KGGPEMHWRVAPRESVKDRIVLVLDDILDEGETMAAIRDRILEMGAKRFMSAVLCEKTLAKAKPLHPDFCGFAVPDRYVF
GCGMDAKGYWRNLPTIRALTADV

Sequences:

>Translated_183_residues
MNREEALHIFQHSEEIVSAGEVNASIGRMAGEIRGQIGEEFPLVLSVMGGAAVFTGMLLPHLDFPLEFDYIHLTRYRNTT
KGGPEMHWRVAPRESVKDRIVLVLDDILDEGETMAAIRDRILEMGAKRFMSAVLCEKTLAKAKPLHPDFCGFAVPDRYVF
GCGMDAKGYWRNLPTIRALTADV
>Mature_183_residues
MNREEALHIFQHSEEIVSAGEVNASIGRMAGEIRGQIGEEFPLVLSVMGGAAVFTGMLLPHLDFPLEFDYIHLTRYRNTT
KGGPEMHWRVAPRESVKDRIVLVLDDILDEGETMAAIRDRILEMGAKRFMSAVLCEKTLAKAKPLHPDFCGFAVPDRYVF
GCGMDAKGYWRNLPTIRALTADV

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI9910262, Length=170, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI4504483, Length=155, Percent_Identity=26.4516129032258, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510817, Length=165, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20464; Mature: 20464

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNREEALHIFQHSEEIVSAGEVNASIGRMAGEIRGQIGEEFPLVLSVMGGAAVFTGMLLP
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
HLDFPLEFDYIHLTRYRNTTKGGPEMHWRVAPRESVKDRIVLVLDDILDEGETMAAIRDR
CCCCCCCCCEEEEEECCCCCCCCCCEEEEECCHHHHHHHEEHHHHHHHCCCHHHHHHHHH
ILEMGAKRFMSAVLCEKTLAKAKPLHPDFCGFAVPDRYVFGCGMDAKGYWRNLPTIRALT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCHHHHCCCHHHHHC
ADV
CCC
>Mature Secondary Structure
MNREEALHIFQHSEEIVSAGEVNASIGRMAGEIRGQIGEEFPLVLSVMGGAAVFTGMLLP
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
HLDFPLEFDYIHLTRYRNTTKGGPEMHWRVAPRESVKDRIVLVLDDILDEGETMAAIRDR
CCCCCCCCCEEEEEECCCCCCCCCCEEEEECCHHHHHHHEEHHHHHHHCCCHHHHHHHHH
ILEMGAKRFMSAVLCEKTLAKAKPLHPDFCGFAVPDRYVFGCGMDAKGYWRNLPTIRALT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCHHHHCCCHHHHHC
ADV
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]