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The map label for this gene is ffh [H]

Identifier: 126451954

GI number: 126451954

Start: 3421527

End: 3422894

Strand: Direct

Name: ffh [H]

Synonym: BURPS1106A_3517

Alternate gene names: 126451954

Gene position: 3421527-3422894 (Clockwise)

Preceding gene: 126451831

Following gene: 126453542

Centisome position: 85.79

GC content: 66.74

Gene sequence:

>1368_bases
ATGCTCGACAATCTCACCCAACGGATGGCGCGCGTCGTCAAGACGCTGCGCGGCGAGGCCCGGCTCACCGAGGCGAACAC
CCAGGAGATGCTCCGCGAAGTGCGGCTCGCGCTCCTCGAAGCCGACGTCGCCCTGCCCGTCGTCCGCGACTTCATCGCGA
AGGTCAAGGAGAAGGCGCTCGGCGAGGACGTGATCGGCAGCCTGTCGCCCGGCCAGGCGCTCGTCGGCGTGGTCCAGAAG
GAGTTGACCGCCGTGATCGGCGGCGACTACGAAGGCAAGGCGGCCGAGCTGAACCTCGCCGTGGCGCCGCCCGCGATCAT
CCTGATGGCGGGCCTGCAGGGCGCCGGCAAAACCACCACCGTCGGCAAGCTCGCGAAGCTCCTGCGCGAGAAGTACAAGA
AGAAGGTGCTCACGGTGTCGTGCGACGTCTATCGTCCCGCCGCGATCGCGCAGTTGAAGACGGTGAGCGAGCAGGTCGGC
GCCGACTTCTTCCCGTCGACGCCCGACCAGAAGCCCGTCGATATCGCGAACGCGGCCGTCGACTGGGCGAAGCGCCACTA
TCACGACGTGCTGCTCGTCGACACCGCGGGCCGTCTCGGCATCGACGAAGCGATGATGCAGGAGATCGCCGCGCTGCACG
CGGCGCTCAAGCCGGTGGAGACACTCTTCGTCGTCGACGCGATGCTCGGCCAGGACGCCGTCAACACCGCGAAGGCGTTC
AACGACGCGCTGCCGCTCACGGGCGTCGTGCTGACGAAGCTCGACGGCGACTCGCGCGGCGGCGCCGCGCTGTCGGTGCG
GCACGTGACGGGCAAGCCGATCAAGTTCGTCGGCGTGGCCGAAAAGCTCGACGGCCTCGAAATCTTCCATCCGGACCGGA
TGGCCAACCGGATCCTCGGGATGGGCGACATCCTCGCGCTCGTCGAGGAGGCGCAGCGCGGCGTCGACATCCAGGCCGCG
GAGAAGCTCGCCAACAAGGTGAAGAAAGGCGGCGATTTCGACCTGAACGATTTCCGCGCGCAGATCTCGCAGATGAAGAA
CATGGGCGGGCTGTCGTCGCTGATGGACAAGCTGCCCGCGCAATTCCAGCAGGCCGCCGCCGGCGCCGACATGAGCCAGG
CCGAAAAGCAGATCCGCCGGATGGAAGGCATCATCAATTCGATGACGCCCGCCGAGCGCGCGAAGCCCGAGATCATCAAG
GCGACGCGCAAGCGCCGGATCGCGGCGGGCGCGGGCGTGCCGGTGCAGGAGGTCAACCGGATGCTCAATCAGTACGACCA
GATGCGCACGATGATGAAGAAGCTCAAGGGCGGCAACCTGCAGAAGATGATGCGCGGCATAAAGGGCATGATGCCCGGCA
TGCGTTGA

Upstream 100 bases:

>100_bases
GTACAATATCCATGTTCGAAGTTTACACTAGGCCCCTTACCCGCGACGGCCGGCTTTTTGTCCCACTCGCGCCTGCGGGC
TTCACTGTCCATCGCTCCCC

Downstream 100 bases:

>100_bases
TTCGCCGCGGCGCCGCGCACGGGTATATGCTGTAGCGCGTGGCGTCGCATTGTTTCATTCTTATTGGTATCCCAGACGAG
ACCGCTCGCCAGACCTCATG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MLDNLTQRMARVVKTLRGEARLTEANTQEMLREVRLALLEADVALPVVRDFIAKVKEKALGEDVIGSLSPGQALVGVVQK
ELTAVIGGDYEGKAAELNLAVAPPAIILMAGLQGAGKTTTVGKLAKLLREKYKKKVLTVSCDVYRPAAIAQLKTVSEQVG
ADFFPSTPDQKPVDIANAAVDWAKRHYHDVLLVDTAGRLGIDEAMMQEIAALHAALKPVETLFVVDAMLGQDAVNTAKAF
NDALPLTGVVLTKLDGDSRGGAALSVRHVTGKPIKFVGVAEKLDGLEIFHPDRMANRILGMGDILALVEEAQRGVDIQAA
EKLANKVKKGGDFDLNDFRAQISQMKNMGGLSSLMDKLPAQFQQAAAGADMSQAEKQIRRMEGIINSMTPAERAKPEIIK
ATRKRRIAAGAGVPVQEVNRMLNQYDQMRTMMKKLKGGNLQKMMRGIKGMMPGMR

Sequences:

>Translated_455_residues
MLDNLTQRMARVVKTLRGEARLTEANTQEMLREVRLALLEADVALPVVRDFIAKVKEKALGEDVIGSLSPGQALVGVVQK
ELTAVIGGDYEGKAAELNLAVAPPAIILMAGLQGAGKTTTVGKLAKLLREKYKKKVLTVSCDVYRPAAIAQLKTVSEQVG
ADFFPSTPDQKPVDIANAAVDWAKRHYHDVLLVDTAGRLGIDEAMMQEIAALHAALKPVETLFVVDAMLGQDAVNTAKAF
NDALPLTGVVLTKLDGDSRGGAALSVRHVTGKPIKFVGVAEKLDGLEIFHPDRMANRILGMGDILALVEEAQRGVDIQAA
EKLANKVKKGGDFDLNDFRAQISQMKNMGGLSSLMDKLPAQFQQAAAGADMSQAEKQIRRMEGIINSMTPAERAKPEIIK
ATRKRRIAAGAGVPVQEVNRMLNQYDQMRTMMKKLKGGNLQKMMRGIKGMMPGMR
>Mature_455_residues
MLDNLTQRMARVVKTLRGEARLTEANTQEMLREVRLALLEADVALPVVRDFIAKVKEKALGEDVIGSLSPGQALVGVVQK
ELTAVIGGDYEGKAAELNLAVAPPAIILMAGLQGAGKTTTVGKLAKLLREKYKKKVLTVSCDVYRPAAIAQLKTVSEQVG
ADFFPSTPDQKPVDIANAAVDWAKRHYHDVLLVDTAGRLGIDEAMMQEIAALHAALKPVETLFVVDAMLGQDAVNTAKAF
NDALPLTGVVLTKLDGDSRGGAALSVRHVTGKPIKFVGVAEKLDGLEIFHPDRMANRILGMGDILALVEEAQRGVDIQAA
EKLANKVKKGGDFDLNDFRAQISQMKNMGGLSSLMDKLPAQFQQAAAGADMSQAEKQIRRMEGIINSMTPAERAKPEIIK
ATRKRRIAAGAGVPVQEVNRMLNQYDQMRTMMKKLKGGNLQKMMRGIKGMMPGMR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=458, Percent_Identity=30.3493449781659, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI226371618, Length=353, Percent_Identity=31.728045325779, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI89061728, Length=165, Percent_Identity=34.5454545454545, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI23308697, Length=202, Percent_Identity=32.6732673267327, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI295424842, Length=202, Percent_Identity=32.6732673267327, Blast_Score=99, Evalue=9e-21,
Organism=Escherichia coli, GI1788963, Length=452, Percent_Identity=65.2654867256637, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI1789874, Length=279, Percent_Identity=33.6917562724014, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17539958, Length=454, Percent_Identity=28.6343612334802, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI193206261, Length=202, Percent_Identity=34.6534653465347, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=449, Percent_Identity=30.7349665924276, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17647949, Length=445, Percent_Identity=29.8876404494382, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24641198, Length=274, Percent_Identity=28.4671532846715, Blast_Score=102, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49195; Mature: 49195

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDNLTQRMARVVKTLRGEARLTEANTQEMLREVRLALLEADVALPVVRDFIAKVKEKAL
CCCHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEDVIGSLSPGQALVGVVQKELTAVIGGDYEGKAAELNLAVAPPAIILMAGLQGAGKTTT
CHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHCCCCCCCCHH
VGKLAKLLREKYKKKVLTVSCDVYRPAAIAQLKTVSEQVGADFFPSTPDQKPVDIANAAV
HHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
DWAKRHYHDVLLVDTAGRLGIDEAMMQEIAALHAALKPVETLFVVDAMLGQDAVNTAKAF
HHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
NDALPLTGVVLTKLDGDSRGGAALSVRHVTGKPIKFVGVAEKLDGLEIFHPDRMANRILG
HCCCCHHHEEEEEECCCCCCCCEEEEEECCCCCEEEEEHHHHCCCCEEECCHHHHHHHHC
MGDILALVEEAQRGVDIQAAEKLANKVKKGGDFDLNDFRAQISQMKNMGGLSSLMDKLPA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
QFQQAAAGADMSQAEKQIRRMEGIINSMTPAERAKPEIIKATRKRRIAAGAGVPVQEVNR
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHH
MLNQYDQMRTMMKKLKGGNLQKMMRGIKGMMPGMR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLDNLTQRMARVVKTLRGEARLTEANTQEMLREVRLALLEADVALPVVRDFIAKVKEKAL
CCCHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEDVIGSLSPGQALVGVVQKELTAVIGGDYEGKAAELNLAVAPPAIILMAGLQGAGKTTT
CHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHCCCCCCCCHH
VGKLAKLLREKYKKKVLTVSCDVYRPAAIAQLKTVSEQVGADFFPSTPDQKPVDIANAAV
HHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
DWAKRHYHDVLLVDTAGRLGIDEAMMQEIAALHAALKPVETLFVVDAMLGQDAVNTAKAF
HHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
NDALPLTGVVLTKLDGDSRGGAALSVRHVTGKPIKFVGVAEKLDGLEIFHPDRMANRILG
HCCCCHHHEEEEEECCCCCCCCEEEEEECCCCCEEEEEHHHHCCCCEEECCHHHHHHHHC
MGDILALVEEAQRGVDIQAAEKLANKVKKGGDFDLNDFRAQISQMKNMGGLSSLMDKLPA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
QFQQAAAGADMSQAEKQIRRMEGIINSMTPAERAKPEIIKATRKRRIAAGAGVPVQEVNR
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHH
MLNQYDQMRTMMKKLKGGNLQKMMRGIKGMMPGMR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]