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The map label for this gene is hmgA

Identifier: 126453053

GI number: 126453053

Start: 3130785

End: 3132137

Strand: Reverse

Name: hmgA

Synonym: BURPS1106A_3213

Alternate gene names: 126453053

Gene position: 3132137-3130785 (Counterclockwise)

Preceding gene: 126452161

Following gene: 126454358

Centisome position: 78.53

GC content: 67.33

Gene sequence:

>1353_bases
ATGGAGAGAACGACAATCATGACATTGGATTTTTCGAAACCGGGCGAAGCCGGCTATCAGAGCGGCTTCGCGAACGAATT
CGCGACCGAGGCGCTGCCGGGCGCGTTGCCGCACGCGCGCAACTCGCCGCAGCGCGCGCCGTACGGGCTCTACGCGGAGC
AGTTCTCCGGCACCGCGTTCACCGCGCCGCGCGGCCACAACCGCCGCTCGTGGCTGTACCGGATCCGGCCCGCCGCCGTG
CATCGGCCGTTCGAGCTCGTGTCGGGCGAGCGCCGGATCGTCGCCGAGTTCGGCGATTCGGACGACGTGCCGCCGACGCC
GCCGAACCAGTTGCGCTGGGATCCGCTGCCGATGCCCGCGCAGCCGACCGATTTCGTCGACGGCTGGGTGACGATGGCGG
GCAACGGCTCGGCCGCCGCGATGAGCGGCTGCGCGATCCACCTGTACGCGGCGAACCGCTCGATGCGCGAGCGCTTCTTC
TACAGCGCGGACGGCGAGCTGCTGATCGTGCCGCAGGAAGGGCGCCTCTTCATCATGACGGAGCTCGGCCGGCTCGACGT
CGAGCCGTTCGAGATCGCGGTGATCCCGCGCGGCGTGCGCTTCGCGGTCGCGCTGCCGGACGGGCGCGCGCGCGGCTATG
TATGCGAGAACTTCGGTGCGCTGCTCAGGCTGCCGGACCTCGGGCCGATCGGCTCGAACGGCCTCGCGAATCCGCGCGAC
TTCCTCACGCCGCACGCGTCGTACGAGGATCGCGAAGGCGCGTTCGAGCTCGTCGCGAAGCTGAATGGCCGGCTCTGGCG
CGCGGACATCGATCATTCGCCGTTCGACGTCGTCGCGTGGCACGGCAACTACGCGCCGTACAAGTACGACCTGCGTCACT
TCAACACGATCGGCTCGATCAGCTACGATCATCCGGACCCGTCGATCTTCCTCGTGCTGCAGTCGCAAAGCGATACGCCG
GGCGTCGACGCGATCGACTTCGTGATCTTCCCCCCGCGCTGGCTCGCGGCCGAGGATACGTTCCGCCCGCCTTGGTTCCA
CCGCAACGTCGCGAGCGAATTCATGGGGCTCGTGCACGGCGTCTACGACGCGAAGGCCGAAGGCTTCGTGCCGGGCGGCG
CGAGCCTGCACAACTGCATGTCCGGCCACGGGCCCGACGCGGACACGTTCGAGAAGGCTTCTTCGATCGACACGTCGAAG
CCGAACAAGGTCGGCGACACGATGGCGTTCATGTTCGAGACCCGCACGCTGATCCGGCCGACGCGTTTCGCGCTCGACAC
CGCGCAACTGCAGGCGAACTACTTCGAATGCTGGCAAGGCCTCAAGAAACACTTCAATCCGGAGCAACGATGA

Upstream 100 bases:

>100_bases
TCACGCGGCGGCCGTGCCGGTGCTGTGCTCGGCCGTCTTCGTGATCGGCCTCGCGAGCGTGACGCGGCGGCGCGGCACGG
CCGCGCCGAACGTCGCTTGA

Downstream 100 bases:

>100_bases
GCGCTATTCCCGACACGCTGCGCGCGAGCCTCGATCCGTCCCGCAAGAGCTGGCTCGATACGGCGAACGCGGCCGCGTGC
GACTTCCCGATCCAGAACCT

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MERTTIMTLDFSKPGEAGYQSGFANEFATEALPGALPHARNSPQRAPYGLYAEQFSGTAFTAPRGHNRRSWLYRIRPAAV
HRPFELVSGERRIVAEFGDSDDVPPTPPNQLRWDPLPMPAQPTDFVDGWVTMAGNGSAAAMSGCAIHLYAANRSMRERFF
YSADGELLIVPQEGRLFIMTELGRLDVEPFEIAVIPRGVRFAVALPDGRARGYVCENFGALLRLPDLGPIGSNGLANPRD
FLTPHASYEDREGAFELVAKLNGRLWRADIDHSPFDVVAWHGNYAPYKYDLRHFNTIGSISYDHPDPSIFLVLQSQSDTP
GVDAIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGVYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASSIDTSK
PNKVGDTMAFMFETRTLIRPTRFALDTAQLQANYFECWQGLKKHFNPEQR

Sequences:

>Translated_450_residues
MERTTIMTLDFSKPGEAGYQSGFANEFATEALPGALPHARNSPQRAPYGLYAEQFSGTAFTAPRGHNRRSWLYRIRPAAV
HRPFELVSGERRIVAEFGDSDDVPPTPPNQLRWDPLPMPAQPTDFVDGWVTMAGNGSAAAMSGCAIHLYAANRSMRERFF
YSADGELLIVPQEGRLFIMTELGRLDVEPFEIAVIPRGVRFAVALPDGRARGYVCENFGALLRLPDLGPIGSNGLANPRD
FLTPHASYEDREGAFELVAKLNGRLWRADIDHSPFDVVAWHGNYAPYKYDLRHFNTIGSISYDHPDPSIFLVLQSQSDTP
GVDAIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGVYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASSIDTSK
PNKVGDTMAFMFETRTLIRPTRFALDTAQLQANYFECWQGLKKHFNPEQR
>Mature_450_residues
MERTTIMTLDFSKPGEAGYQSGFANEFATEALPGALPHARNSPQRAPYGLYAEQFSGTAFTAPRGHNRRSWLYRIRPAAV
HRPFELVSGERRIVAEFGDSDDVPPTPPNQLRWDPLPMPAQPTDFVDGWVTMAGNGSAAAMSGCAIHLYAANRSMRERFF
YSADGELLIVPQEGRLFIMTELGRLDVEPFEIAVIPRGVRFAVALPDGRARGYVCENFGALLRLPDLGPIGSNGLANPRD
FLTPHASYEDREGAFELVAKLNGRLWRADIDHSPFDVVAWHGNYAPYKYDLRHFNTIGSISYDHPDPSIFLVLQSQSDTP
GVDAIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGVYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASSIDTSK
PNKVGDTMAFMFETRTLIRPTRFALDTAQLQANYFECWQGLKKHFNPEQR

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family

Homologues:

Organism=Homo sapiens, GI115527117, Length=444, Percent_Identity=52.027027027027, Blast_Score=458, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17507969, Length=435, Percent_Identity=51.9540229885057, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24583650, Length=437, Percent_Identity=50.5720823798627, Blast_Score=423, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HGD_BURM7 (A3MMH2)

Other databases:

- EMBL:   CP000548
- RefSeq:   YP_001081458.1
- ProteinModelPortal:   A3MMH2
- SMR:   A3MMH2
- GeneID:   4894448
- GenomeReviews:   CP000548_GR
- KEGG:   bmn:BMA10247_1921
- TIGR:   BMA10247_1921
- HOGENOM:   HBG293508
- OMA:   RNCMSEF
- ProtClustDB:   PRK05341
- BioCyc:   BMAL320389:BMA10247_1921-MONOMER
- HAMAP:   MF_00334
- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950
- PANTHER:   PTHR11056
- TIGRFAMs:   TIGR01015

Pfam domain/function: PF04209 HgmA; SSF51182 RmlC_like_cupin

EC number: =1.13.11.5

Molecular weight: Translated: 50131; Mature: 50131

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTTIMTLDFSKPGEAGYQSGFANEFATEALPGALPHARNSPQRAPYGLYAEQFSGTAF
CCCEEEEEEECCCCCCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCEE
TAPRGHNRRSWLYRIRPAAVHRPFELVSGERRIVAEFGDSDDVPPTPPNQLRWDPLPMPA
ECCCCCCCCCEEEEECHHHHCCCHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
QPTDFVDGWVTMAGNGSAAAMSGCAIHLYAANRSMRERFFYSADGELLIVPQEGRLFIMT
CCCCCCCCEEEEECCCCCCEECCCEEEEEECCCHHHHHEEECCCCCEEEEECCCCEEEEE
ELGRLDVEPFEIAVIPRGVRFAVALPDGRARGYVCENFGALLRLPDLGPIGSNGLANPRD
ECCCCCCCCEEEEEECCCEEEEEECCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCCHH
FLTPHASYEDREGAFELVAKLNGRLWRADIDHSPFDVVAWHGNYAPYKYDLRHFNTIGSI
HCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCEEEEECCCCCCEEECHHHHCCCCCC
SYDHPDPSIFLVLQSQSDTPGVDAIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHG
EECCCCCEEEEEEECCCCCCCCCEEEEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHH
VYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASSIDTSKPNKVGDTMAFMFETRTLIRP
HHHCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
TRFALDTAQLQANYFECWQGLKKHFNPEQR
HHHEEHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MERTTIMTLDFSKPGEAGYQSGFANEFATEALPGALPHARNSPQRAPYGLYAEQFSGTAF
CCCEEEEEEECCCCCCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCEE
TAPRGHNRRSWLYRIRPAAVHRPFELVSGERRIVAEFGDSDDVPPTPPNQLRWDPLPMPA
ECCCCCCCCCEEEEECHHHHCCCHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
QPTDFVDGWVTMAGNGSAAAMSGCAIHLYAANRSMRERFFYSADGELLIVPQEGRLFIMT
CCCCCCCCEEEEECCCCCCEECCCEEEEEECCCHHHHHEEECCCCCEEEEECCCCEEEEE
ELGRLDVEPFEIAVIPRGVRFAVALPDGRARGYVCENFGALLRLPDLGPIGSNGLANPRD
ECCCCCCCCEEEEEECCCEEEEEECCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCCHH
FLTPHASYEDREGAFELVAKLNGRLWRADIDHSPFDVVAWHGNYAPYKYDLRHFNTIGSI
HCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCEEEEECCCCCCEEECHHHHCCCCCC
SYDHPDPSIFLVLQSQSDTPGVDAIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHG
EECCCCCEEEEEEECCCCCCCCCEEEEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHH
VYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASSIDTSKPNKVGDTMAFMFETRTLIRP
HHHCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
TRFALDTAQLQANYFECWQGLKKHFNPEQR
HHHEEHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA