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The map label for this gene is cobT [H]

Identifier: 126451756

GI number: 126451756

Start: 1012753

End: 1014675

Strand: Direct

Name: cobT [H]

Synonym: BURPS1106A_1037

Alternate gene names: 126451756

Gene position: 1012753-1014675 (Clockwise)

Preceding gene: 126452870

Following gene: 126452810

Centisome position: 25.39

GC content: 73.95

Gene sequence:

>1923_bases
ATGACGATGCACGACGCGCCGACCTCGCGCCCGACCCGCTACGGCACGCGGCATCTCGTGCTGAAGGCGGGCGCGCGCAC
GCTGCTCGACGATTTCACGCACACGTTCGAGCCGGGCGAGCTGTGGTGCGTGGCCGGCCCGAACGGCGCGGGCAAGACGA
CGCTCATCACGACGCTCGCGGGGCTCGCGAAGCCCGCCGCCGGGCACGTCGAAGCGGACGGCGCGCCGCTCGCCGCGTGG
CGGCCCGAAGCGCTCGCGCGGCGGCGCGCGTGGATGGCGCAGACGCTGCACGACGCGTTCAGCGCGAGCGTGCTCGATAC
CGTGCTGCTTGCTCGCTTCCCGCATCTGCCGGGCTGGGGCTGGGAGCGGGCCGACGATCACGCGGCCGCGCGCGCGGCGC
TCGCGCGGCTCGGGCTCGAAGCGTTCGCCGCGCGCGACGTGCTGTCGCTGTCGGGCGGCGAGCGGCAGCGCGTCGCGCTC
GCGGCCGCGCTGTGCCAGGACGCGCCGCTGCTGTTGCTCGACGAGCCGCTCGCGCACCTCGACCTGCATCACCAGATCGA
CTGTCTCGCCGCGCTCGCCGATTGGCTGCGCGCGGGCGAGCGCACCGCGATCTTCTCGTGCCACGACCTGAATCTCGCGC
GCCGCTTCGCGACGCACGCGCTGTTGCTCGACGGCGAGGGCGGCGCGCACGCGGGCCCGGTGCGCGACGTGCTCACGCCC
GAGCGCGCGAGCCGCGCGTTCGGCTATCCGCTCGTGCTGATCGAGCGCGACGGCCACGAGGCGCTCGTGCCCGCGTGGCC
CGATGCGCGCGCCTGCCCTGATCGACGCGCATCACGCAACCCCTTTCATCCACGAGACGAACCGATGACGACCTCAACCT
TTTCCCTGCCGAGCGTCGATCCGCTCGACGACGCCGCACTGCGCGCGACGCTCGCACGCATCATCGATCACAAGACGAAG
CCGCCCGGCAGCCTCGGCCGTCTCGAAGCGCTCGCGCTGCAGCTCGGCATGATCCAGCGCACGAGCGCGCCGAGCGTCGC
GCGCCCGGCGATGATCGTGTTCGCCGGCGATCACGGGATCGCCGCCGAAGGCGTGAGCCCGTATCCGCAGGCGGTGACCG
CGCAGATGGTCGCGAACTTCGTCGCGGGCGGCGCGGCGATCAACGCGTTCTCCCGCGTCGCGGGCCTCGCGCTCGAGATC
GTCGATGCGGGCGTCGCGTCGCCGCTGCCGGCTTCGCCGCAGCTCGTCGACGCCGCGATCGCGCGCGGCACGCGCAACTT
CGCGCAAGAGCGCGCGATGTCGCGGGACGAAGCGCTCGCCGCGCTCGCCGCGGGCGCCGCGCGCGTGCGGCATCACGCGG
CGCTCGGCACCAACGTGATCGGCTTCGGCGAGATGGGGATCGCGAACACCTCGGCGGCCGCGTGCATGATGAGCCGCCTG
CTCGACGTGCCGATCGACGCGTGCGTCGGCCGCGGCACGGGCCTCGACGACGCGGGCCTCGCGCACAAGCGCGCGGTGCT
CGGGCGCGCGCTCGAGCGGCACGCGCACGCGCGCGAGCCGCTCGACGTGCTCGCCGCGTTCGGCGGCTTCGAGATCGCGA
TGATCGCGGGCGCGTTCATCGAAGCGGCGCACGCGCGCATGGCGATTCTCGTCGACGGCTTCATCGCGACGTCGGCGCTG
CTCGTCGCCGACGCGCTCGCGCCCGCGGTGCGCGAATACTGCGTGTTCTCGCACGTATCGAACGAAGCGGGGCATCGGCG
CATGCTCGAGCACCTCGGCGGCGAGCCGCTCCTCGCGCTCGACCTGCGTCTCGGCGAGGGCACGGGCGCCGCGCTCGCGC
TGCCGCTCGTGCGCGCGGCGGCGGCGTTCGTCAACGAGATGGCGAGCTTCGAATCGGCGGGCGTGGCGAACCGCGATGCG
TGA

Upstream 100 bases:

>100_bases
CGCGCACGGCGATCGCGCCCGCGCAGTTGCCGGTCGGCGTGATGACCGCGCTGATCGGCGTGCCGCTCTTCCTGTGGATG
CTGTTGCGCGGGGCCGCGCG

Downstream 100 bases:

>100_bases
CGCGCGATGAATCCGCTCGCCGAACTGCGCTACTTCGTCGTCGCGCTCGGGTACTTCACGCGCGTGCCGGTGCCGCGCGC
GATCAGCGGCCAGGCCGTCG

Product: cobalamin ABC transporter, ATP-binding protein

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase [H]

Number of amino acids: Translated: 640; Mature: 639

Protein sequence:

>640_residues
MTMHDAPTSRPTRYGTRHLVLKAGARTLLDDFTHTFEPGELWCVAGPNGAGKTTLITTLAGLAKPAAGHVEADGAPLAAW
RPEALARRRAWMAQTLHDAFSASVLDTVLLARFPHLPGWGWERADDHAAARAALARLGLEAFAARDVLSLSGGERQRVAL
AAALCQDAPLLLLDEPLAHLDLHHQIDCLAALADWLRAGERTAIFSCHDLNLARRFATHALLLDGEGGAHAGPVRDVLTP
ERASRAFGYPLVLIERDGHEALVPAWPDARACPDRRASRNPFHPRDEPMTTSTFSLPSVDPLDDAALRATLARIIDHKTK
PPGSLGRLEALALQLGMIQRTSAPSVARPAMIVFAGDHGIAAEGVSPYPQAVTAQMVANFVAGGAAINAFSRVAGLALEI
VDAGVASPLPASPQLVDAAIARGTRNFAQERAMSRDEALAALAAGAARVRHHAALGTNVIGFGEMGIANTSAAACMMSRL
LDVPIDACVGRGTGLDDAGLAHKRAVLGRALERHAHAREPLDVLAAFGGFEIAMIAGAFIEAAHARMAILVDGFIATSAL
LVADALAPAVREYCVFSHVSNEAGHRRMLEHLGGEPLLALDLRLGEGTGAALALPLVRAAAAFVNEMASFESAGVANRDA

Sequences:

>Translated_640_residues
MTMHDAPTSRPTRYGTRHLVLKAGARTLLDDFTHTFEPGELWCVAGPNGAGKTTLITTLAGLAKPAAGHVEADGAPLAAW
RPEALARRRAWMAQTLHDAFSASVLDTVLLARFPHLPGWGWERADDHAAARAALARLGLEAFAARDVLSLSGGERQRVAL
AAALCQDAPLLLLDEPLAHLDLHHQIDCLAALADWLRAGERTAIFSCHDLNLARRFATHALLLDGEGGAHAGPVRDVLTP
ERASRAFGYPLVLIERDGHEALVPAWPDARACPDRRASRNPFHPRDEPMTTSTFSLPSVDPLDDAALRATLARIIDHKTK
PPGSLGRLEALALQLGMIQRTSAPSVARPAMIVFAGDHGIAAEGVSPYPQAVTAQMVANFVAGGAAINAFSRVAGLALEI
VDAGVASPLPASPQLVDAAIARGTRNFAQERAMSRDEALAALAAGAARVRHHAALGTNVIGFGEMGIANTSAAACMMSRL
LDVPIDACVGRGTGLDDAGLAHKRAVLGRALERHAHAREPLDVLAAFGGFEIAMIAGAFIEAAHARMAILVDGFIATSAL
LVADALAPAVREYCVFSHVSNEAGHRRMLEHLGGEPLLALDLRLGEGTGAALALPLVRAAAAFVNEMASFESAGVANRDA
>Mature_639_residues
TMHDAPTSRPTRYGTRHLVLKAGARTLLDDFTHTFEPGELWCVAGPNGAGKTTLITTLAGLAKPAAGHVEADGAPLAAWR
PEALARRRAWMAQTLHDAFSASVLDTVLLARFPHLPGWGWERADDHAAARAALARLGLEAFAARDVLSLSGGERQRVALA
AALCQDAPLLLLDEPLAHLDLHHQIDCLAALADWLRAGERTAIFSCHDLNLARRFATHALLLDGEGGAHAGPVRDVLTPE
RASRAFGYPLVLIERDGHEALVPAWPDARACPDRRASRNPFHPRDEPMTTSTFSLPSVDPLDDAALRATLARIIDHKTKP
PGSLGRLEALALQLGMIQRTSAPSVARPAMIVFAGDHGIAAEGVSPYPQAVTAQMVANFVAGGAAINAFSRVAGLALEIV
DAGVASPLPASPQLVDAAIARGTRNFAQERAMSRDEALAALAAGAARVRHHAALGTNVIGFGEMGIANTSAAACMMSRLL
DVPIDACVGRGTGLDDAGLAHKRAVLGRALERHAHAREPLDVLAAFGGFEIAMIAGAFIEAAHARMAILVDGFIATSALL
VADALAPAVREYCVFSHVSNEAGHRRMLEHLGGEPLLALDLRLGEGTGAALALPLVRAAAAFVNEMASFESAGVANRDA

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) [H]

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family [H]

Homologues:

Organism=Homo sapiens, GI73747915, Length=212, Percent_Identity=29.7169811320755, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI9665248, Length=218, Percent_Identity=29.3577981651376, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI156105685, Length=242, Percent_Identity=29.3388429752066, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1788300, Length=343, Percent_Identity=37.6093294460641, Blast_Score=204, Evalue=2e-53,
Organism=Escherichia coli, GI1786803, Length=239, Percent_Identity=35.1464435146443, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1786345, Length=249, Percent_Identity=32.5301204819277, Blast_Score=132, Evalue=9e-32,
Organism=Escherichia coli, GI1790739, Length=226, Percent_Identity=32.7433628318584, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1788002, Length=237, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI87081709, Length=203, Percent_Identity=30.5418719211823, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1786253, Length=196, Percent_Identity=34.1836734693878, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1786563, Length=208, Percent_Identity=34.6153846153846, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1790544, Length=192, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788225, Length=221, Percent_Identity=28.9592760180996, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1789032, Length=220, Percent_Identity=30, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1788450, Length=219, Percent_Identity=30.1369863013699, Blast_Score=83, Evalue=7e-17,
Organism=Escherichia coli, GI1789873, Length=212, Percent_Identity=31.1320754716981, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1786872, Length=182, Percent_Identity=31.8681318681319, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87081791, Length=203, Percent_Identity=30.5418719211823, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1787112, Length=200, Percent_Identity=34, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI87081834, Length=202, Percent_Identity=30.6930693069307, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1789891, Length=257, Percent_Identity=28.0155642023346, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1787712, Length=181, Percent_Identity=32.0441988950276, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1786698, Length=191, Percent_Identity=27.7486910994764, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1787029, Length=203, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788165, Length=230, Percent_Identity=31.7391304347826, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1788761, Length=236, Percent_Identity=30.5084745762712, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1789672, Length=215, Percent_Identity=28.3720930232558, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1786703, Length=190, Percent_Identity=33.6842105263158, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787143, Length=197, Percent_Identity=27.9187817258883, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082267, Length=212, Percent_Identity=26.4150943396226, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789962, Length=198, Percent_Identity=25.7575757575758, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1787105, Length=194, Percent_Identity=31.4432989690722, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789864, Length=207, Percent_Identity=26.0869565217391, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787164, Length=204, Percent_Identity=36.2745098039216, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1789593, Length=229, Percent_Identity=29.6943231441048, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1787500, Length=204, Percent_Identity=25, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788540, Length=180, Percent_Identity=32.2222222222222, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1786653, Length=185, Percent_Identity=27.5675675675676, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082064, Length=167, Percent_Identity=34.7305389221557, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1788644, Length=213, Percent_Identity=26.7605633802817, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71992290, Length=163, Percent_Identity=31.2883435582822, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17511077, Length=221, Percent_Identity=28.0542986425339, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17541710, Length=216, Percent_Identity=30.0925925925926, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558664, Length=181, Percent_Identity=29.2817679558011, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533592, Length=240, Percent_Identity=27.0833333333333, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641565, Length=223, Percent_Identity=28.6995515695067, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650853, Length=214, Percent_Identity=27.5700934579439, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281362751, Length=218, Percent_Identity=27.9816513761468, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24650855, Length=214, Percent_Identity=27.5700934579439, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846 [H]

Pfam domain/function: PF02277 DBI_PRT [H]

EC number: =2.4.2.21 [H]

Molecular weight: Translated: 67259; Mature: 67127

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMHDAPTSRPTRYGTRHLVLKAGARTLLDDFTHTFEPGELWCVAGPNGAGKTTLITTLA
CCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHH
GLAKPAAGHVEADGAPLAAWRPEALARRRAWMAQTLHDAFSASVLDTVLLARFPHLPGWG
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
WERADDHAAARAALARLGLEAFAARDVLSLSGGERQRVALAAALCQDAPLLLLDEPLAHL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCHHHH
DLHHQIDCLAALADWLRAGERTAIFSCHDLNLARRFATHALLLDGEGGAHAGPVRDVLTP
HHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHEEEEEECCCCCCCCCHHHHCCH
ERASRAFGYPLVLIERDGHEALVPAWPDARACPDRRASRNPFHPRDEPMTTSTFSLPSVD
HHHHHHCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCC
PLDDAALRATLARIIDHKTKPPGSLGRLEALALQLGMIQRTSAPSVARPAMIVFAGDHGI
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCC
AAEGVSPYPQAVTAQMVANFVAGGAAINAFSRVAGLALEIVDAGVASPLPASPQLVDAAI
CCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
ARGTRNFAQERAMSRDEALAALAAGAARVRHHAALGTNVIGFGEMGIANTSAAACMMSRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHH
LDVPIDACVGRGTGLDDAGLAHKRAVLGRALERHAHAREPLDVLAAFGGFEIAMIAGAFI
HHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHH
EAAHARMAILVDGFIATSALLVADALAPAVREYCVFSHVSNEAGHRRMLEHLGGEPLLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEEE
DLRLGEGTGAALALPLVRAAAAFVNEMASFESAGVANRDA
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TMHDAPTSRPTRYGTRHLVLKAGARTLLDDFTHTFEPGELWCVAGPNGAGKTTLITTLA
CCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHH
GLAKPAAGHVEADGAPLAAWRPEALARRRAWMAQTLHDAFSASVLDTVLLARFPHLPGWG
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
WERADDHAAARAALARLGLEAFAARDVLSLSGGERQRVALAAALCQDAPLLLLDEPLAHL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCHHHH
DLHHQIDCLAALADWLRAGERTAIFSCHDLNLARRFATHALLLDGEGGAHAGPVRDVLTP
HHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHEEEEEECCCCCCCCCHHHHCCH
ERASRAFGYPLVLIERDGHEALVPAWPDARACPDRRASRNPFHPRDEPMTTSTFSLPSVD
HHHHHHCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCC
PLDDAALRATLARIIDHKTKPPGSLGRLEALALQLGMIQRTSAPSVARPAMIVFAGDHGI
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCC
AAEGVSPYPQAVTAQMVANFVAGGAAINAFSRVAGLALEIVDAGVASPLPASPQLVDAAI
CCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
ARGTRNFAQERAMSRDEALAALAAGAARVRHHAALGTNVIGFGEMGIANTSAAACMMSRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHH
LDVPIDACVGRGTGLDDAGLAHKRAVLGRALERHAHAREPLDVLAAFGGFEIAMIAGAFI
HHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHH
EAAHARMAILVDGFIATSALLVADALAPAVREYCVFSHVSNEAGHRRMLEHLGGEPLLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEEE
DLRLGEGTGAALALPLVRAAAAFVNEMASFESAGVANRDA
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA