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The map label for this gene is nuoM [H]

Identifier: 126451700

GI number: 126451700

Start: 1282886

End: 1284376

Strand: Direct

Name: nuoM [H]

Synonym: BURPS1106A_1311

Alternate gene names: 126451700

Gene position: 1282886-1284376 (Clockwise)

Preceding gene: 126451636

Following gene: 126455306

Centisome position: 32.16

GC content: 62.91

Gene sequence:

>1491_bases
ATGCACTCTTTTCCGATTCTCAGTACCGCGATCTGGTTGCCGATCGTTTTCGGCCTCGTCGTGCTCGCGGTCGGTTCCGA
CAAGCATCCGGGCGCGGCGCGCTGGATCGCGCTGATCGGCTCGCTGGCGGGCCTGGCCGTGACGATCCCGCTGATCACCG
GCTTCGATTCGAGCACCGCCGCGCTGCAGTTCGTCGAGCAATCGACGTGGATCGAGCGTTTCAACATCTCGTATCACCTG
GGCGTCGACGGCATCTCGATGTGGTTCGTCGTGCTGACCGCGCTCATCACGGTAATCGTCGTGATCGCCGGCTGGGAGGT
GATCACCGAGAACGTGTCGCAGTATCTCGCCGCGTTCCTGATCCTGTCGGGGATCATGATCGGCGTGTTCTCGGCGGCTG
ACGGCCTGCTGTTCTACGTGTTCTTCGAGGCGACGCTGATCCCGATGTACATCATCATCGGCGTGTGGGGCGGCCCGAAC
CGCGTGTACGCGGCGTTCAAGTTCTTCCTGTACACGCTCGCCGGCTCGCTGCTGATGCTGGTCGCGCTGATCTATCTGTA
CACGCAGACGCATTCGTTCGACCTCGCGACGTGGCAGAACGCGAAGATCGCGATGACGCCGCAGGTGCTGCTCTTCATCG
CGTTCTTCCTCGCGTTCGCGGTGAAGGTGCCGATGTGGCCGGTGCACACGTGGCTGCCGGACGCGCACGTCGAAGCGCCG
ACGGGCGGCTCGGTCGTGCTGGCCGCGATCATGCTGAAGCTCGGCGCGTACGGTTTCCTGCGCTTCTCGCTGCCGATCAC
GCCGGACGCGAGCCACTTCTTCGCGCCCGTCGTGATCTCGCTGTCGCTGATCGCGGTGATCTACATCGGCCTCGTCGCGA
TGGTGCAGGCGGACATGAAGAAACTCGTCGCGTATTCGTCGATCGCGCACATGGGCTTCGTCACGCTCGGCTTCTTCATC
TTCAACCAGTTGGGCGTCGAAGGCGCGATCGTTCAGATGATCTCGCACGGGTTCGTGTCGGGCGCGATGTTCCTGTGCAT
CGGCGTGCTGTACGACCGCCTGCACTCGCGCCAGATCGCCGATTACGGCGGCGTCGTCAACGTGATGCCGAAGTTCGCCG
CGTTCGCGATGCTGTTCTCGATGGCCAATTGCGGCCTGCCGGGCACGTCGGGTTTCGTCGGCGAGTTCATGGTGATCCTC
GCCGCCGTCCAGTTCAATTTCTGGATCGCGTTCGGTGCGGCATTCACGCTGATTCTCGGCGCCGCCTACACGCTGTGGAT
GTACAAGCGCGTGTATTTCGGCGCGGTGGCGAACGATCACGTCGCGAAGCTGAAGGACATCGGCCGCCGCGAATTCACGA
TGCTCGCCGTGCTCGCCGCGTTCACGCTGCTGATGGGCCTCTATCCGAAGCCGTTCACCGACGTGATGCACGTTTCCGTG
GAAAACCTCCTCTCCCACGTCGCGCAGTCGAAACTGCCGCTGGCCCAGTAA

Upstream 100 bases:

>100_bases
CGGTTACATCTATCACTACGCGTTCGCCATGATCATCGGCATGCTGGGGCTCCTGACCCTGTTTGTAACGCTCGGCGGCA
AATAAGGCGGGGGACGACTA

Downstream 100 bases:

>100_bases
GCGCGAGCGGAGGATACAAAGATCATGCAAAACGCACCTATGAATGTCCTGTTGCCTGATGCGCTGGTGATGGCCGCCAT
CATCGTCGCCTGGCTGAACG

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MHSFPILSTAIWLPIVFGLVVLAVGSDKHPGAARWIALIGSLAGLAVTIPLITGFDSSTAALQFVEQSTWIERFNISYHL
GVDGISMWFVVLTALITVIVVIAGWEVITENVSQYLAAFLILSGIMIGVFSAADGLLFYVFFEATLIPMYIIIGVWGGPN
RVYAAFKFFLYTLAGSLLMLVALIYLYTQTHSFDLATWQNAKIAMTPQVLLFIAFFLAFAVKVPMWPVHTWLPDAHVEAP
TGGSVVLAAIMLKLGAYGFLRFSLPITPDASHFFAPVVISLSLIAVIYIGLVAMVQADMKKLVAYSSIAHMGFVTLGFFI
FNQLGVEGAIVQMISHGFVSGAMFLCIGVLYDRLHSRQIADYGGVVNVMPKFAAFAMLFSMANCGLPGTSGFVGEFMVIL
AAVQFNFWIAFGAAFTLILGAAYTLWMYKRVYFGAVANDHVAKLKDIGRREFTMLAVLAAFTLLMGLYPKPFTDVMHVSV
ENLLSHVAQSKLPLAQ

Sequences:

>Translated_496_residues
MHSFPILSTAIWLPIVFGLVVLAVGSDKHPGAARWIALIGSLAGLAVTIPLITGFDSSTAALQFVEQSTWIERFNISYHL
GVDGISMWFVVLTALITVIVVIAGWEVITENVSQYLAAFLILSGIMIGVFSAADGLLFYVFFEATLIPMYIIIGVWGGPN
RVYAAFKFFLYTLAGSLLMLVALIYLYTQTHSFDLATWQNAKIAMTPQVLLFIAFFLAFAVKVPMWPVHTWLPDAHVEAP
TGGSVVLAAIMLKLGAYGFLRFSLPITPDASHFFAPVVISLSLIAVIYIGLVAMVQADMKKLVAYSSIAHMGFVTLGFFI
FNQLGVEGAIVQMISHGFVSGAMFLCIGVLYDRLHSRQIADYGGVVNVMPKFAAFAMLFSMANCGLPGTSGFVGEFMVIL
AAVQFNFWIAFGAAFTLILGAAYTLWMYKRVYFGAVANDHVAKLKDIGRREFTMLAVLAAFTLLMGLYPKPFTDVMHVSV
ENLLSHVAQSKLPLAQ
>Mature_496_residues
MHSFPILSTAIWLPIVFGLVVLAVGSDKHPGAARWIALIGSLAGLAVTIPLITGFDSSTAALQFVEQSTWIERFNISYHL
GVDGISMWFVVLTALITVIVVIAGWEVITENVSQYLAAFLILSGIMIGVFSAADGLLFYVFFEATLIPMYIIIGVWGGPN
RVYAAFKFFLYTLAGSLLMLVALIYLYTQTHSFDLATWQNAKIAMTPQVLLFIAFFLAFAVKVPMWPVHTWLPDAHVEAP
TGGSVVLAAIMLKLGAYGFLRFSLPITPDASHFFAPVVISLSLIAVIYIGLVAMVQADMKKLVAYSSIAHMGFVTLGFFI
FNQLGVEGAIVQMISHGFVSGAMFLCIGVLYDRLHSRQIADYGGVVNVMPKFAAFAMLFSMANCGLPGTSGFVGEFMVIL
AAVQFNFWIAFGAAFTLILGAAYTLWMYKRVYFGAVANDHVAKLKDIGRREFTMLAVLAAFTLLMGLYPKPFTDVMHVSV
ENLLSHVAQSKLPLAQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=363, Percent_Identity=35.5371900826446, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI251831117, Length=409, Percent_Identity=24.9388753056235, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1788613, Length=469, Percent_Identity=39.8720682302772, Blast_Score=321, Evalue=9e-89,
Organism=Escherichia coli, GI1788827, Length=379, Percent_Identity=23.4828496042216, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1788831, Length=316, Percent_Identity=25, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788829, Length=333, Percent_Identity=28.8288288288288, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788614, Length=383, Percent_Identity=26.6318537859008, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693160, Length=450, Percent_Identity=23.3333333333333, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54091; Mature: 54091

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSFPILSTAIWLPIVFGLVVLAVGSDKHPGAARWIALIGSLAGLAVTIPLITGFDSSTA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ALQFVEQSTWIERFNISYHLGVDGISMWFVVLTALITVIVVIAGWEVITENVSQYLAAFL
HHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSGIMIGVFSAADGLLFYVFFEATLIPMYIIIGVWGGPNRVYAAFKFFLYTLAGSLLML
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
VALIYLYTQTHSFDLATWQNAKIAMTPQVLLFIAFFLAFAVKVPMWPVHTWLPDAHVEAP
HHHHHHHHCCCCCCCEECCCCEEEECHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCC
TGGSVVLAAIMLKLGAYGFLRFSLPITPDASHFFAPVVISLSLIAVIYIGLVAMVQADMK
CCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLVAYSSIAHMGFVTLGFFIFNQLGVEGAIVQMISHGFVSGAMFLCIGVLYDRLHSRQIA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYGGVVNVMPKFAAFAMLFSMANCGLPGTSGFVGEFMVILAAVQFNFWIAFGAAFTLILG
HHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAYTLWMYKRVYFGAVANDHVAKLKDIGRREFTMLAVLAAFTLLMGLYPKPFTDVMHVSV
HHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ENLLSHVAQSKLPLAQ
HHHHHHHHHCCCCCCC
>Mature Secondary Structure
MHSFPILSTAIWLPIVFGLVVLAVGSDKHPGAARWIALIGSLAGLAVTIPLITGFDSSTA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ALQFVEQSTWIERFNISYHLGVDGISMWFVVLTALITVIVVIAGWEVITENVSQYLAAFL
HHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSGIMIGVFSAADGLLFYVFFEATLIPMYIIIGVWGGPNRVYAAFKFFLYTLAGSLLML
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
VALIYLYTQTHSFDLATWQNAKIAMTPQVLLFIAFFLAFAVKVPMWPVHTWLPDAHVEAP
HHHHHHHHCCCCCCCEECCCCEEEECHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCC
TGGSVVLAAIMLKLGAYGFLRFSLPITPDASHFFAPVVISLSLIAVIYIGLVAMVQADMK
CCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLVAYSSIAHMGFVTLGFFIFNQLGVEGAIVQMISHGFVSGAMFLCIGVLYDRLHSRQIA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYGGVVNVMPKFAAFAMLFSMANCGLPGTSGFVGEFMVILAAVQFNFWIAFGAAFTLILG
HHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAYTLWMYKRVYFGAVANDHVAKLKDIGRREFTMLAVLAAFTLLMGLYPKPFTDVMHVSV
HHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ENLLSHVAQSKLPLAQ
HHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]