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The map label for this gene is nuoL [H]

Identifier: 126451636

GI number: 126451636

Start: 1280831

End: 1282870

Strand: Direct

Name: nuoL [H]

Synonym: BURPS1106A_1310

Alternate gene names: 126451636

Gene position: 1280831-1282870 (Clockwise)

Preceding gene: 126452436

Following gene: 126451700

Centisome position: 32.11

GC content: 63.68

Gene sequence:

>2040_bases
ATGTCAACGACACTCAATGAAAACCTGCTGCTGGCGATTCCGCTCGCGCCGCTGGCCGGCTCGCTGATCGCGGGGCTGTT
CGGCAACGCGGTGGGGCGCAAGGGCGCGCATCGCGTGACGATTCTCGGCGTCGCGCTCGCCTTCGTTCTTTCCGCGCTGG
TGTTCTTCCAGGTGCTGGACGGCGCGAGCTTCAACGCGACCGTCTACGAATGGATGAACGTCGGCTCGCTGAAGCTCGAG
GTGGGCTTCCTCGTCGATACGCTGACCGCGATGATGATGGTCGTCGTCACGTTCGTGTCGCTGATGGTGCACATCTACAC
GATCGGCTACATGTCGGAGGAGGACGGCTACCAGCGCTTCTTCTCGTACATCTCGCTGTTCACGTTCTCGATGCTGATGC
TCGTGATGAGCAACAACTTCCTGCAGCTGTTCTTCGGCTGGGAAGCGGTGGGTCTCGTGTCGTACCTGCTGATCGGCTTC
TACTTCACGCGCGAGAGCGCGATCTACGCGAACATGAAGGCGTTCCTCGTGAACCGCGTCGGCGATTTCGGGTTCCTGCT
CGGCATCGGTCTCATCCTCGCGTACGCCGGCTCGATGAACTACGGCGAAGTGTTCGCCAAGCGCGCGGAGCTCGCGTCGC
TGCACTTCCCGGGCACCCAGTGGGGCCTGCTGACGGTCGCCTGCATCTGCCTGTTCATCGGCGCGATGGGCAAGTCCGCG
CAGTTCCCGCTGCACGTGTGGCTGCCCGATTCGATGGAAGGCCCGACGCCGATCTCCGCGCTGATTCACGCGGCGACGAT
GGTGACGGCGGGCATTTTCATGGTCACGCGCATGTCGCCGCTGTTCGAGCTGTCCGACGCCGCGCTGTCGTTCATCACGG
TGATCGGCGCGATCACGGCGCTCTTCATGGGCTTCCTCGGCATCGTCCAGAACGACATCAAGCGCGTCGTCGCGTATTCG
ACGCTGTCGCAGCTCGGCTACATGACGGTCGCGCTCGGCGTGTCCGCGTACCCGGTCGCGGTGTTCCACCTGATGACGCA
CGCGTTCTTCAAGGCGCTGCTGTTCCTCGGCGCGGGCTCGGTGATCATCGGCATGCACCACGATCAGGACATGCGCAACA
TGGGCGGCCTGCGCAAGTACATGCCGATCACGTGGATCACGTCGCTCGTCGGCTCGCTCGCGCTGATCGGCACGCCGTTC
TTCTCGGGCTTCTATTCGAAGGACTCGATCATCGACGCGGTGAAGCTGTCGCACCTGCCGGGCTCGGGCTTTGCATACTT
CGCGGTCGTCGCGAGCGTGTTCGTCACCGCGCTGTACTCGTTCCGGATGTATTTCCTCGTGTTCCACGGCGAGGAGCGCT
TCCGTCATCCGAAGACGTTCGGCAACAACCACGGCGCCGAATCGGCCGCGCATCACGGCCATGACGACCACGGCCACGCG
CACGAACCGCACGAAACGCCGTGGGTCGTGTGGGTGCCGCTCGTGCTGCTCGCGATTCCGTCGGTCATCATCGGCGCGAT
CGCGATCGGCCCGATGCTGTACGGCGACTTCTTCCAGCACGGCGTCGCGTTCGACAAGGTGATCTTCATCGGCCAGAACC
ACCCGGCGCTCGCCGAGATGGCGGAGGAGTTCCACGGCTGGACGGCGATGGGGCTGCACTCGGTGTCGGGCCTGCCGGTG
TGGCTCGCGCTCGCGGGCGTCGTCGTCGCATGGTTCCTGTACCTGAAGCGCCCGGATCTGCCGGCGGCGATCCGTCGCGC
GTTCGGCCCGGTCTATACGCTGCTCGACAACAAGTACTACATGGACAAGATCAACGAGGTCGTGTTCGCGAAGGGTTCGA
TCGCGATCGGCCGCGGTCTGTGGAAGGAGGGCGACGTCGTGGTGATCGACGGCCTCGTCAACGGCAGCGCGCGCTTCATC
GGCTGGTTCGCCGGCGTGATCCGCTTCCTCCAATCCGGTTACATCTATCACTACGCGTTCGCCATGATCATCGGCATGCT
GGGGCTCCTGACCCTGTTTGTAACGCTCGGCGGCAAATAA

Upstream 100 bases:

>100_bases
CAATCGGCCTCGCGATTCTGGTGACCCTGTTCCGTAAGCTCGACACGATCAATGTCGAGGATCTCGATCAGCTCAAAGGT
TAATTTCAGGCAACGCTGTT

Downstream 100 bases:

>100_bases
GGCGGGGGACGACTAATGCACTCTTTTCCGATTCTCAGTACCGCGATCTGGTTGCCGATCGTTTTCGGCCTCGTCGTGCT
CGCGGTCGGTTCCGACAAGC

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MSTTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRVTILGVALAFVLSALVFFQVLDGASFNATVYEWMNVGSLKLE
VGFLVDTLTAMMMVVVTFVSLMVHIYTIGYMSEEDGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGF
YFTRESAIYANMKAFLVNRVGDFGFLLGIGLILAYAGSMNYGEVFAKRAELASLHFPGTQWGLLTVACICLFIGAMGKSA
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVTRMSPLFELSDAALSFITVIGAITALFMGFLGIVQNDIKRVVAYS
TLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPF
FSGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRHPKTFGNNHGAESAAHHGHDDHGHA
HEPHETPWVVWVPLVLLAIPSVIIGAIAIGPMLYGDFFQHGVAFDKVIFIGQNHPALAEMAEEFHGWTAMGLHSVSGLPV
WLALAGVVVAWFLYLKRPDLPAAIRRAFGPVYTLLDNKYYMDKINEVVFAKGSIAIGRGLWKEGDVVVIDGLVNGSARFI
GWFAGVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK

Sequences:

>Translated_679_residues
MSTTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRVTILGVALAFVLSALVFFQVLDGASFNATVYEWMNVGSLKLE
VGFLVDTLTAMMMVVVTFVSLMVHIYTIGYMSEEDGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGF
YFTRESAIYANMKAFLVNRVGDFGFLLGIGLILAYAGSMNYGEVFAKRAELASLHFPGTQWGLLTVACICLFIGAMGKSA
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVTRMSPLFELSDAALSFITVIGAITALFMGFLGIVQNDIKRVVAYS
TLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPF
FSGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRHPKTFGNNHGAESAAHHGHDDHGHA
HEPHETPWVVWVPLVLLAIPSVIIGAIAIGPMLYGDFFQHGVAFDKVIFIGQNHPALAEMAEEFHGWTAMGLHSVSGLPV
WLALAGVVVAWFLYLKRPDLPAAIRRAFGPVYTLLDNKYYMDKINEVVFAKGSIAIGRGLWKEGDVVVIDGLVNGSARFI
GWFAGVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK
>Mature_678_residues
STTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRVTILGVALAFVLSALVFFQVLDGASFNATVYEWMNVGSLKLEV
GFLVDTLTAMMMVVVTFVSLMVHIYTIGYMSEEDGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFY
FTRESAIYANMKAFLVNRVGDFGFLLGIGLILAYAGSMNYGEVFAKRAELASLHFPGTQWGLLTVACICLFIGAMGKSAQ
FPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVTRMSPLFELSDAALSFITVIGAITALFMGFLGIVQNDIKRVVAYST
LSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPFF
SGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRHPKTFGNNHGAESAAHHGHDDHGHAH
EPHETPWVVWVPLVLLAIPSVIIGAIAIGPMLYGDFFQHGVAFDKVIFIGQNHPALAEMAEEFHGWTAMGLHSVSGLPVW
LALAGVVVAWFLYLKRPDLPAAIRRAFGPVYTLLDNKYYMDKINEVVFAKGSIAIGRGLWKEGDVVVIDGLVNGSARFIG
WFAGVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=423, Percent_Identity=38.7706855791962, Blast_Score=291, Evalue=1e-78,
Organism=Escherichia coli, GI1788614, Length=608, Percent_Identity=38.6513157894737, Blast_Score=357, Evalue=1e-99,
Organism=Escherichia coli, GI1788829, Length=416, Percent_Identity=28.6057692307692, Blast_Score=153, Evalue=4e-38,
Organism=Escherichia coli, GI1788831, Length=348, Percent_Identity=31.0344827586207, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1788827, Length=459, Percent_Identity=28.1045751633987, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI2367154, Length=125, Percent_Identity=36, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1788613, Length=391, Percent_Identity=24.5524296675192, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI145693160, Length=318, Percent_Identity=24.8427672955975, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 74261; Mature: 74130

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRVTILGVALAFVLSALVFFQVLD
CCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GASFNATVYEWMNVGSLKLEVGFLVDTLTAMMMVVVTFVSLMVHIYTIGYMSEEDGYQRF
CCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
FSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFYFTRESAIYANMKAFLVNRV
HHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHC
GDFGFLLGIGLILAYAGSMNYGEVFAKRAELASLHFPGTQWGLLTVACICLFIGAMGKSA
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCCCC
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVTRMSPLFELSDAALSFITVIGAITA
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LFMGFLGIVQNDIKRVVAYSTLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
VIIGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPFFSGFYSKDSIIDAVKLSHLP
EEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHCCC
GSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRHPKTFGNNHGAESAAHHGHDDHGHA
CCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHCCCCCCCCCCCCCHHHCCCCCCCCCC
HEPHETPWVVWVPLVLLAIPSVIIGAIAIGPMLYGDFFQHGVAFDKVIFIGQNHPALAEM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCCCHHHHH
AEEFHGWTAMGLHSVSGLPVWLALAGVVVAWFLYLKRPDLPAAIRRAFGPVYTLLDNKYY
HHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHCCCHH
MDKINEVVFAKGSIAIGRGLWKEGDVVVIDGLVNGSARFIGWFAGVIRFLQSGYIYHYAF
HHHHHHHHEECCCEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
AMIIGMLGLLTLFVTLGGK
HHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRVTILGVALAFVLSALVFFQVLD
CCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GASFNATVYEWMNVGSLKLEVGFLVDTLTAMMMVVVTFVSLMVHIYTIGYMSEEDGYQRF
CCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
FSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFYFTRESAIYANMKAFLVNRV
HHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHC
GDFGFLLGIGLILAYAGSMNYGEVFAKRAELASLHFPGTQWGLLTVACICLFIGAMGKSA
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCCCC
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVTRMSPLFELSDAALSFITVIGAITA
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LFMGFLGIVQNDIKRVVAYSTLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
VIIGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPFFSGFYSKDSIIDAVKLSHLP
EEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHCCC
GSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRHPKTFGNNHGAESAAHHGHDDHGHA
CCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHCCCCCCCCCCCCCHHHCCCCCCCCCC
HEPHETPWVVWVPLVLLAIPSVIIGAIAIGPMLYGDFFQHGVAFDKVIFIGQNHPALAEM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCCCHHHHH
AEEFHGWTAMGLHSVSGLPVWLALAGVVVAWFLYLKRPDLPAAIRRAFGPVYTLLDNKYY
HHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHCCCHH
MDKINEVVFAKGSIAIGRGLWKEGDVVVIDGLVNGSARFIGWFAGVIRFLQSGYIYHYAF
HHHHHHHHEECCCEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
AMIIGMLGLLTLFVTLGGK
HHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]