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The map label for this gene is nuoN [H]

Identifier: 126455306

GI number: 126455306

Start: 1284401

End: 1285873

Strand: Direct

Name: nuoN [H]

Synonym: BURPS1106A_1312

Alternate gene names: 126455306

Gene position: 1284401-1285873 (Clockwise)

Preceding gene: 126451700

Following gene: 126454747

Centisome position: 32.2

GC content: 65.78

Gene sequence:

>1473_bases
ATGCAAAACGCACCTATGAATGTCCTGTTGCCTGATGCGCTGGTGATGGCCGCCATCATCGTCGCCTGGCTGAACGACAC
CTTCGTCGGCGCGGCCGGCCGCCGCCTCACGTATCTGATCGCGGTCGTCGCGTCGGCGGCGGCGGGCGTGTGGTTCGCGC
TGCAAGCCCTCGATCCGCAGCAGTACTACTTCTTCTCGCGGATGGTGGTGGTCGATTCGTTCGCGAGCGCGATGAAGGCG
GTCGTGTCGATCGGCTTCGCGGTGACGCTCGTCTACTCGCGCAAATACCTCGAAGATCGCGACCTGTTCCGCGGCGACGT
GTTCCTGCTCGGCATGTTCTCGCTGCTCGGCCAGCTCGTGATGATCTCGGGCAACCACTTCCTCACGCTGTACCTCGGCC
TCGAGCTGATGTCGCTGTCGCTGTACGCGGTGATCGCGCTGCGCCGCGACGCGGCGCAGTCGAGCGAAGCGGCGATGAAG
TACTACGTGCTCGGCGCGCTCGCCTCGGGCTTCGTGCTGTACGGGATCTCGATGCTGTACGGCGCGACGGGCTCGCTCGA
GCTGAACGAAGTGCTCAAGGCGGTCGCCTCCGGCCGCATCAACGACGCGGTGCTGCTGTTCGGCGTGATCTTCATCGTCG
CGGGCGTTGCGTTCAAGCTCGGCGCCGTGCCGTTCCACATGTGGGTGCCGGACGTCTACCAGGGCGCGCCGACCGCGATG
ACGCTGTTCGTCGGCGGCGGCCCGAAGGTCGCGGCGTTCGCGTGGGGCCTGCGCTTCCTCGTGATGGGCCTGCTGCCGCT
CGCGGTCGACTGGCAGGAAATGCTGGTGATTCTCGCGGCGCTGTCGCTGATCGTCGGCAACCTCACCGGTATCGTCCAGC
GCAACATCAAGCGGATGCTCGCGTACTCGGCGATCTCGAACATGGGCTTCGTGCTGCTCGGCCTGCTCGCGGGCATCGTC
AACGGCAATCCGTCGGCGGCGGCGAGCGCGTACAGCTCGGCGATGTTCTACACGATCGTCTACCTCGTGACGACGCTCGG
CTCGTTCGGCGTCGTGATGCTGCTCGCGCGCCGCGATTTCGAGGCGGAAACGCTCGACGACTTCAAGGGCCTCAACAAGC
GCAGCCCGGTGTTCGCGTTCGTGATGATGGTGATGATGTTCTCGCTCGCCGGCATCCCGCCGACGGTCGGCTTCTACGCG
AAGCTCGCGGTGCTGGAGGCGACGGTCAACGCCGGCCTCACATGGCTCGCGGTGCTCGCCGTCGTCACGTCGCTGTTCGG
CGCGTTCTACTATCTGCGCATCGTCAAGCTGATGTATTTCGACGCGCCGCAGGACACGACGCCGATCGCGGGCGACGCAT
GCAAGCGCGCGATCCTCGTGCTCAACGGCCTCGCAGTCGTCGTGCTCGGCATCGTGCCGGGCCCGCTGATGACGATCTGC
CTGCAGGCGATCAGCCACACGCTGCCGCTGTAA

Upstream 100 bases:

>100_bases
CACCGACGTGATGCACGTTTCCGTGGAAAACCTCCTCTCCCACGTCGCGCAGTCGAAACTGCCGCTGGCCCAGTAAGCGC
GAGCGGAGGATACAAAGATC

Downstream 100 bases:

>100_bases
TGTCGGCCTCCGGCTGGTTCATCGTGCTGTTGGCGCTCACGGGCGCCAACCTGCCGTTCCTGAATCAGCGCCTGTTCGCC
GTCGTGCCGCTGAAAAGCGC

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MQNAPMNVLLPDALVMAAIIVAWLNDTFVGAAGRRLTYLIAVVASAAAGVWFALQALDPQQYYFFSRMVVVDSFASAMKA
VVSIGFAVTLVYSRKYLEDRDLFRGDVFLLGMFSLLGQLVMISGNHFLTLYLGLELMSLSLYAVIALRRDAAQSSEAAMK
YYVLGALASGFVLYGISMLYGATGSLELNEVLKAVASGRINDAVLLFGVIFIVAGVAFKLGAVPFHMWVPDVYQGAPTAM
TLFVGGGPKVAAFAWGLRFLVMGLLPLAVDWQEMLVILAALSLIVGNLTGIVQRNIKRMLAYSAISNMGFVLLGLLAGIV
NGNPSAAASAYSSAMFYTIVYLVTTLGSFGVVMLLARRDFEAETLDDFKGLNKRSPVFAFVMMVMMFSLAGIPPTVGFYA
KLAVLEATVNAGLTWLAVLAVVTSLFGAFYYLRIVKLMYFDAPQDTTPIAGDACKRAILVLNGLAVVVLGIVPGPLMTIC
LQAISHTLPL

Sequences:

>Translated_490_residues
MQNAPMNVLLPDALVMAAIIVAWLNDTFVGAAGRRLTYLIAVVASAAAGVWFALQALDPQQYYFFSRMVVVDSFASAMKA
VVSIGFAVTLVYSRKYLEDRDLFRGDVFLLGMFSLLGQLVMISGNHFLTLYLGLELMSLSLYAVIALRRDAAQSSEAAMK
YYVLGALASGFVLYGISMLYGATGSLELNEVLKAVASGRINDAVLLFGVIFIVAGVAFKLGAVPFHMWVPDVYQGAPTAM
TLFVGGGPKVAAFAWGLRFLVMGLLPLAVDWQEMLVILAALSLIVGNLTGIVQRNIKRMLAYSAISNMGFVLLGLLAGIV
NGNPSAAASAYSSAMFYTIVYLVTTLGSFGVVMLLARRDFEAETLDDFKGLNKRSPVFAFVMMVMMFSLAGIPPTVGFYA
KLAVLEATVNAGLTWLAVLAVVTSLFGAFYYLRIVKLMYFDAPQDTTPIAGDACKRAILVLNGLAVVVLGIVPGPLMTIC
LQAISHTLPL
>Mature_490_residues
MQNAPMNVLLPDALVMAAIIVAWLNDTFVGAAGRRLTYLIAVVASAAAGVWFALQALDPQQYYFFSRMVVVDSFASAMKA
VVSIGFAVTLVYSRKYLEDRDLFRGDVFLLGMFSLLGQLVMISGNHFLTLYLGLELMSLSLYAVIALRRDAAQSSEAAMK
YYVLGALASGFVLYGISMLYGATGSLELNEVLKAVASGRINDAVLLFGVIFIVAGVAFKLGAVPFHMWVPDVYQGAPTAM
TLFVGGGPKVAAFAWGLRFLVMGLLPLAVDWQEMLVILAALSLIVGNLTGIVQRNIKRMLAYSAISNMGFVLLGLLAGIV
NGNPSAAASAYSSAMFYTIVYLVTTLGSFGVVMLLARRDFEAETLDDFKGLNKRSPVFAFVMMVMMFSLAGIPPTVGFYA
KLAVLEATVNAGLTWLAVLAVVTSLFGAFYYLRIVKLMYFDAPQDTTPIAGDACKRAILVLNGLAVVVLGIVPGPLMTIC
LQAISHTLPL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=331, Percent_Identity=24.773413897281, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI145693160, Length=495, Percent_Identity=34.1414141414141, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1788614, Length=419, Percent_Identity=23.3890214797136, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788831, Length=385, Percent_Identity=25.4545454545455, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1788827, Length=328, Percent_Identity=26.219512195122, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI2367154, Length=263, Percent_Identity=25.8555133079848, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1788613, Length=376, Percent_Identity=25.531914893617, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 52569; Mature: 52569

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCC
>Mature Secondary Structure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HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA