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The map label for this gene is hipA [H]

Identifier: 126446852

GI number: 126446852

Start: 627719

End: 629071

Strand: Reverse

Name: hipA [H]

Synonym: BMA10247_A0680

Alternate gene names: 126446852

Gene position: 629071-627719 (Counterclockwise)

Preceding gene: 126447378

Following gene: 126446631

Centisome position: 26.74

GC content: 72.21

Gene sequence:

>1353_bases
GTGAGCGCCCGCCGCGCACGCGCGACGCGCCTGCACCTGTGGATGAACGGCCTGCCCGTCGGCTACTGGGAGCACGCGCG
CGACGGCGAGCGCCTCGTCTACTTCGACGAATGGATCGGCGATCCGCAAGGCCGGCCGCTGTCGCTGTCGCTGCCGTTCA
CGCCGGGCAACCAGCCGTATCGCGGTCGGCTCGTCAGCGATTATTTCGACAACCTGCTGCCCGACAGCGAGCCGATCCGC
CGGCGAATCGCGATGCGCTACCGCACGGGCGGCACGTCCGCGTTCGCGCTGCTCGCGACGCTCGGCCGCGATTGCGTCGG
CGCGCTGCAGATGCTGCCGCCCGACGAAGCGCCGGACGACATCGAACGCATCCGCGGCCACGCGCTCGCCGACGCGGACA
TCGCGCGCCTGCTGCGCGAAGTCACGTCCGCGCCGCAGGCCGGCCGGCACGCGCCGCTCGACGATCTGCGCCTGTCGATC
GCCGGCGCGCAGGAGAAGACCGCGCTGCTGCGCCACCGCGGCCGCTGGCTGCTGCCCGAAGGGAGCACGCCGACCACGCA
CATCCTGAAGCTGCCGCTCGGGCTCGTCGGCAACCGGCGCGCCGACATGCGCACGTCGGTCGAGAACGAATGGCTGTGCG
CGCGGATCGTCGCCGCGTACGGGTTGCCCGTCGCGCGCTGCGACATCGCGCAGTTCGACGATCAGAAAGCGCTCGTCGTC
GAGCGCTTCGACCGCCGGCCGTCGCGCGACGCGCGCTGGCTCCTGCGGCTGCCGCAGGAAGACATGTGCCAGGCAACCGG
CACGTCCGCGCTCGACAAATATCAGGCCGACGGCGGCCCCGGCATCGAGACGATCATGGAAGTGCTCGCCGGCTCCGAAC
ACGCGCGGGACGACCGCCGCGCGTTCTTCGCGGCGCAGATCGTGTTCTGGCTGCTCGCCGCGACCGACGGCCACGCGAAG
AACTTCAGCATCGCGCACCTGCCCGGCAACCGCTACCGTTCGACACCGCTTTACGACGTGCTGTCCGCGCATCCGGTCAT
CGGCCGGGGCGCGAACCAGTTGCCCGCGCAGCGCGCGCGGCTCGCGATGGGCGTGCGCGGCAAGCACATCCACTATCCGC
TGCACCAGATCCGGCGGCGGCACTGGATCGCGCAGGGCCAGCGCGTCGGCTTCGCGCCCGCCGACGTCGACGCGCTGATC
GACACGCTGACCGCGCGCACCGCGGACGTCGTCGACGCGGTGTCGGCGCGGCTGCCGCGCGATTTTCCGCGCGACGTCGC
CGATGCGATCTTCAGCGGAATGCTCGGCCTGAGCGCAAGGCTCGCCGGCGACGCGGCCGCGCGCGCGCCATGA

Upstream 100 bases:

>100_bases
GACGTGCCGTGCCGCCCGCGTCCGCGCCCGCTCCGAGCGCCGCCGGGCGCCCGCCCCGCCCCGCCCGCAAGCGCGCCGCC
CCGAAAAAGCGGGAGGACTG

Downstream 100 bases:

>100_bases
CGGGATGGCGCGGCCGCCGCCGCGCGCCGCGCCGTGCAATCGGCACGCAATCGCCGCTCAATCGGTGCTCAATCGGTGCT
CAATCGGTGCTCAATCGCCG

Product: putative regulatory protein HipA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSI
AGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAK
NFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALI
DTLTARTADVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP

Sequences:

>Translated_450_residues
MSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSI
AGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAK
NFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALI
DTLTARTADVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP
>Mature_449_residues
SARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIRR
RIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSIA
GAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVVE
RFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAKN
FSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALID
TLTARTADVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP

Specific function: Unbalanced or excessive expression of hipA is toxic to the cell [H]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae HI_0665 [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=443, Percent_Identity=39.5033860045147, Blast_Score=295, Evalue=3e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 49882; Mature: 49750

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPY
CCCCHHHHHEEEEEECCCCCCCHHCCCCCCEEEEEHHHCCCCCCCEEEEECCCCCCCCCC
RGRLVSDYFDNLLPDSEPIRRRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDD
CCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
IERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSIAGAQEKTALLRHRGRWLLPE
HHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHEEECCCHHHHHHHHHCCCEECCC
GSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
CCCCCHHHHCCCHHHCCCCCHHHHHCCCCHHHHHHHHHHHCCCHHEEHHHHCCCCHHHHH
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRR
HHHCCCCCCCCHHHHCCCHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHH
AFFAAQIVFWLLAATDGHAKNFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRAR
HHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHH
LAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALIDTLTARTADVVDAVSARLPR
HHHCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DFPRDVADAIFSGMLGLSARLAGDAAARAP
CCHHHHHHHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
SARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPY
CCCHHHHHEEEEEECCCCCCCHHCCCCCCEEEEEHHHCCCCCCCEEEEECCCCCCCCCC
RGRLVSDYFDNLLPDSEPIRRRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDD
CCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
IERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSIAGAQEKTALLRHRGRWLLPE
HHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHEEECCCHHHHHHHHHCCCEECCC
GSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
CCCCCHHHHCCCHHHCCCCCHHHHHCCCCHHHHHHHHHHHCCCHHEEHHHHCCCCHHHHH
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRR
HHHCCCCCCCCHHHHCCCHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHH
AFFAAQIVFWLLAATDGHAKNFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRAR
HHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHH
LAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALIDTLTARTADVVDAVSARLPR
HHHCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DFPRDVADAIFSGMLGLSARLAGDAAARAP
CCHHHHHHHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1715862; 9278503; 8021189 [H]