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The map label for this gene is yveA [H]

Identifier: 126443431

GI number: 126443431

Start: 533917

End: 535917

Strand: Reverse

Name: yveA [H]

Synonym: BURPS668_A0567

Alternate gene names: 126443431

Gene position: 535917-533917 (Counterclockwise)

Preceding gene: 126442723

Following gene: 126444577

Centisome position: 17.14

GC content: 70.81

Gene sequence:

>2001_bases
ATGCGCGATGCGCGACGCCGCCGATCGGGCGCCGGCCTTGCGTTTCGCGCGGAGACGATGCCGCGCGAAACCGCCGCGAC
GGCTCGCCCGCGCGCCGCCGCGTCGCCGCGTCGCGATCCGGCAGGCAGCGCCCACGCAGGCGGTCCGCGCGCGCCGCAGC
ACGATTCGGCTGAATCGGCCGGGCGCGCCGCCGCGGATCGGCGCGCGCCTCGCCGTCGCACGGGCCACCCCGCCCACCGC
CACGCAAGCGCGGCTGTAACGGCCGCGGCGGGCGCGCCGTCAGTTCCGCCCGCGGCGGCCCTCCCATGCGCCGCCGCGCC
CCGCCCGCCGCTCGAGACGATCGAAACCCGTCCATCAAATCAAGGAGACAAGCCCATGCCCGCCCAAGGCAATGCCCAGC
GAACCGCGCCGCTCGCGCGGCCCGCGCCCACCGACGCCGGCCACGGCAAGTTCAAGAAACAGCTGTCGCTCACCGATCTG
ACGTTCATCGGCCTCGGCGCGATCTTCGGCTCGGGGTGGCTGTTCGCCGCGAGCCACGTATCGATGATCGCGGGCCCGGC
CGGCATCCTCTCGTGGCTGCTCGGCGGCTTCGCGGTGCTGCTGCTCGGCATCGTCTACTGCGAACTCGGCGCGGCGCTGC
CGCGCGCGGGCGGCGTCGTCCGCTATCCGGTGTTCTCGCACGGCCCGCTGCTCGGCTACCTGATGGGCGCGATCACGCTG
ATCGCGTTCTCGAGCCTGATCGCGATCGAAGTCGTCGCCGCGCGCCAGTATGCGGCCGCGTGGTTTGCGGGCCTGACCGT
CGAGGGCTCGGGCAATCCGACGACGCTCGGCTGGCTCGTGCAGGCGGCGCTGCTCTGTTTCTTCTTCTACCTGAACTATT
CGAGCGTGAAGACGTTCGCGAAGGCGAACAACGTCATCAGCGTGTTCAAGTTCGTCGTGCCGCTCGCGGTGATCGTCGTG
CTGTTCGCGTTCTTCAAGCCCGCGAACCTCACCCTGCACGGCTTCGCGCCGTTCGGCATGCCCGGCGTCGAGATGGCCGT
GTCCGCGGGCGGCATCATCTTCGCGTATCTCGGCCTCACGCCGATCGTCTCGGTCGCGAGCGAGGTGCGCGACCCGCAGC
GCACGATTCCGATCGCGCTGATCCTGTCGATCGTGCTCTCGACGCTGATCTACGTGCTGCTGCAGCTCGCGTTCCTCGGC
GGCATCCCGAGCGCGATGCTCGCGGGCGGCTGGCACGACATCGGCAAGGCTTTCTCGCTGCCGTACCGCGACATCGCGCT
CGCGCTCGGCGTCGGCTGGCTCGCGTACATGGTCGTCGCCGACGCGATGATCTCGCCGTCCGGCTGCGGCAACATCTACA
TGAACGCGACGCCGCGCGTCGTCTACGGCTGGGCGAAGACGGGCACGTTCTTCAAGGTGTTCGCGCGCGTCGACGAGGCC
TCCGGCATTCCGCGCGCGGGGCTGTGGCTCACGTTCGCGCTGGCGCTCTTCTGGACGCTGCCGTTCCCGTCGTGGGAGGC
GCTCATCAACACCGTGTCGGCCGCGCTCGTGCTGAGCTACGCGGTCGCGCCGGTATCGGTCGCCGCGCTGCGCCGCACCG
CGCCCGGGCTGCCGCGGCCGTTTCGCGCGAGCGCGTTCGCGCTCACCGGCCCCGCTTCGTTCGTGATCGCCGCGCTGATC
GTCTACTGGTCCGGCTGGCGCACCGTGTCGTGGCTGCTCGGGCTGCAGATCGCGATGTTCGCCGTCTATCTCGCGTGCCG
CCGCCGGGTGCCCACCGCGCATCTGAGCCTCGCCGAGCAGGTGCGCTCGTGCGCGTGGCTGATCGCGTTCTACGCGCTGA
TGATCGTCGCGTCGTATTTCGGCGGCTTCGGCGGCACCGGGCAGCTCGCGCACCCGTACGATACGTTCGCCGTCGCGGCC
GTCGCGCTCGTCATCTACTACTGGGGCGCGCATACCGGCGTGCCGTCCGCGAAGCTGCAGCTCGACGACGACGAGAACTG
A

Upstream 100 bases:

>100_bases
GCCGGCTTGAGCCCCGGCCCGGCTCGGGCGACGTGCGCGGCGCGGAACGCGCCGGTATGCGCCCGCCGCCGATCGCCGCA
CGCGCCGCGTTGCGTGCGCG

Downstream 100 bases:

>100_bases
CGCGCGGCGCGAGCGCATCCGCTTTTTCAACGGCCGCGCGGCGACGCGCGGCCCGCACTTTCTGCGAGGAGAACCATGCG
ACTCACTGGCGAGCTTTTGA

Product: amino acid permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: L-aspartate transporter [H]

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MRDARRRRSGAGLAFRAETMPRETAATARPRAAASPRRDPAGSAHAGGPRAPQHDSAESAGRAAADRRAPRRRTGHPAHR
HASAAVTAAAGAPSVPPAAALPCAAAPRPPLETIETRPSNQGDKPMPAQGNAQRTAPLARPAPTDAGHGKFKKQLSLTDL
TFIGLGAIFGSGWLFAASHVSMIAGPAGILSWLLGGFAVLLLGIVYCELGAALPRAGGVVRYPVFSHGPLLGYLMGAITL
IAFSSLIAIEVVAARQYAAAWFAGLTVEGSGNPTTLGWLVQAALLCFFFYLNYSSVKTFAKANNVISVFKFVVPLAVIVV
LFAFFKPANLTLHGFAPFGMPGVEMAVSAGGIIFAYLGLTPIVSVASEVRDPQRTIPIALILSIVLSTLIYVLLQLAFLG
GIPSAMLAGGWHDIGKAFSLPYRDIALALGVGWLAYMVVADAMISPSGCGNIYMNATPRVVYGWAKTGTFFKVFARVDEA
SGIPRAGLWLTFALALFWTLPFPSWEALINTVSAALVLSYAVAPVSVAALRRTAPGLPRPFRASAFALTGPASFVIAALI
VYWSGWRTVSWLLGLQIAMFAVYLACRRRVPTAHLSLAEQVRSCAWLIAFYALMIVASYFGGFGGTGQLAHPYDTFAVAA
VALVIYYWGAHTGVPSAKLQLDDDEN

Sequences:

>Translated_666_residues
MRDARRRRSGAGLAFRAETMPRETAATARPRAAASPRRDPAGSAHAGGPRAPQHDSAESAGRAAADRRAPRRRTGHPAHR
HASAAVTAAAGAPSVPPAAALPCAAAPRPPLETIETRPSNQGDKPMPAQGNAQRTAPLARPAPTDAGHGKFKKQLSLTDL
TFIGLGAIFGSGWLFAASHVSMIAGPAGILSWLLGGFAVLLLGIVYCELGAALPRAGGVVRYPVFSHGPLLGYLMGAITL
IAFSSLIAIEVVAARQYAAAWFAGLTVEGSGNPTTLGWLVQAALLCFFFYLNYSSVKTFAKANNVISVFKFVVPLAVIVV
LFAFFKPANLTLHGFAPFGMPGVEMAVSAGGIIFAYLGLTPIVSVASEVRDPQRTIPIALILSIVLSTLIYVLLQLAFLG
GIPSAMLAGGWHDIGKAFSLPYRDIALALGVGWLAYMVVADAMISPSGCGNIYMNATPRVVYGWAKTGTFFKVFARVDEA
SGIPRAGLWLTFALALFWTLPFPSWEALINTVSAALVLSYAVAPVSVAALRRTAPGLPRPFRASAFALTGPASFVIAALI
VYWSGWRTVSWLLGLQIAMFAVYLACRRRVPTAHLSLAEQVRSCAWLIAFYALMIVASYFGGFGGTGQLAHPYDTFAVAA
VALVIYYWGAHTGVPSAKLQLDDDEN
>Mature_666_residues
MRDARRRRSGAGLAFRAETMPRETAATARPRAAASPRRDPAGSAHAGGPRAPQHDSAESAGRAAADRRAPRRRTGHPAHR
HASAAVTAAAGAPSVPPAAALPCAAAPRPPLETIETRPSNQGDKPMPAQGNAQRTAPLARPAPTDAGHGKFKKQLSLTDL
TFIGLGAIFGSGWLFAASHVSMIAGPAGILSWLLGGFAVLLLGIVYCELGAALPRAGGVVRYPVFSHGPLLGYLMGAITL
IAFSSLIAIEVVAARQYAAAWFAGLTVEGSGNPTTLGWLVQAALLCFFFYLNYSSVKTFAKANNVISVFKFVVPLAVIVV
LFAFFKPANLTLHGFAPFGMPGVEMAVSAGGIIFAYLGLTPIVSVASEVRDPQRTIPIALILSIVLSTLIYVLLQLAFLG
GIPSAMLAGGWHDIGKAFSLPYRDIALALGVGWLAYMVVADAMISPSGCGNIYMNATPRVVYGWAKTGTFFKVFARVDEA
SGIPRAGLWLTFALALFWTLPFPSWEALINTVSAALVLSYAVAPVSVAALRRTAPGLPRPFRASAFALTGPASFVIAALI
VYWSGWRTVSWLLGLQIAMFAVYLACRRRVPTAHLSLAEQVRSCAWLIAFYALMIVASYFGGFGGTGQLAHPYDTFAVAA
VALVIYYWGAHTGVPSAKLQLDDDEN

Specific function: Uptake of L-aspartate with the concomitant import of a proton. Can also transport aspartate hydroxamate and L-glutamate with lower affinity and efficiency [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. AGT (TC 2.A.3.11) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=411, Percent_Identity=26.0340632603406, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI258614003, Length=443, Percent_Identity=24.6049661399549, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI258614005, Length=443, Percent_Identity=24.6049661399549, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI258645169, Length=443, Percent_Identity=23.9277652370203, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI33286428, Length=446, Percent_Identity=24.4394618834081, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI187423910, Length=432, Percent_Identity=23.3796296296296, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI7657591, Length=432, Percent_Identity=23.3796296296296, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI115648063, Length=486, Percent_Identity=22.2222222222222, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI115648022, Length=486, Percent_Identity=22.2222222222222, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI181337167, Length=402, Percent_Identity=23.8805970149254, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1788480, Length=364, Percent_Identity=29.3956043956044, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786602, Length=433, Percent_Identity=24.0184757505774, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87081708, Length=360, Percent_Identity=23.0555555555556, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI87082250, Length=358, Percent_Identity=27.9329608938547, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=418, Percent_Identity=27.0334928229665, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17533459, Length=436, Percent_Identity=26.605504587156, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24667468, Length=408, Percent_Identity=25, Blast_Score=106, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21357367, Length=468, Percent_Identity=26.9230769230769, Blast_Score=97, Evalue=5e-20,
Organism=Drosophila melanogaster, GI221512776, Length=443, Percent_Identity=24.8306997742664, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24666159, Length=443, Percent_Identity=24.8306997742664, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI45550968, Length=481, Percent_Identity=25.7796257796258, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI19921172, Length=481, Percent_Identity=25.7796257796258, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24668806, Length=434, Percent_Identity=23.0414746543779, Blast_Score=76, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356285, Length=434, Percent_Identity=23.0414746543779, Blast_Score=76, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24668802, Length=434, Percent_Identity=23.0414746543779, Blast_Score=76, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221331183, Length=281, Percent_Identity=28.1138790035587, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17647653, Length=281, Percent_Identity=28.1138790035587, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664379, Length=281, Percent_Identity=28.1138790035587, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641993, Length=426, Percent_Identity=24.4131455399061, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641995, Length=426, Percent_Identity=24.4131455399061, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24651635, Length=458, Percent_Identity=22.4890829694323, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24651633, Length=458, Percent_Identity=22.4890829694323, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 70317; Mature: 70317

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDARRRRSGAGLAFRAETMPRETAATARPRAAASPRRDPAGSAHAGGPRAPQHDSAESA
CCCHHHHHCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
GRAAADRRAPRRRTGHPAHRHASAAVTAAAGAPSVPPAAALPCAAAPRPPLETIETRPSN
HHHHHHHCCCCCCCCCCHHHHHHHHHEECCCCCCCCCHHCCCCCCCCCCCHHHHHCCCCC
QGDKPMPAQGNAQRTAPLARPAPTDAGHGKFKKQLSLTDLTFIGLGAIFGSGWLFAASHV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SMIAGPAGILSWLLGGFAVLLLGIVYCELGAALPRAGGVVRYPVFSHGPLLGYLMGAITL
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHH
IAFSSLIAIEVVAARQYAAAWFAGLTVEGSGNPTTLGWLVQAALLCFFFYLNYSSVKTFA
HHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KANNVISVFKFVVPLAVIVVLFAFFKPANLTLHGFAPFGMPGVEMAVSAGGIIFAYLGLT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHH
PIVSVASEVRDPQRTIPIALILSIVLSTLIYVLLQLAFLGGIPSAMLAGGWHDIGKAFSL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHCC
PYRDIALALGVGWLAYMVVADAMISPSGCGNIYMNATPRVVYGWAKTGTFFKVFARVDEA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHH
SGIPRAGLWLTFALALFWTLPFPSWEALINTVSAALVLSYAVAPVSVAALRRTAPGLPRP
CCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
FRASAFALTGPASFVIAALIVYWSGWRTVSWLLGLQIAMFAVYLACRRRVPTAHLSLAEQ
CCCCCEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VRSCAWLIAFYALMIVASYFGGFGGTGQLAHPYDTFAVAAVALVIYYWGAHTGVPSAKLQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEE
LDDDEN
CCCCCC
>Mature Secondary Structure
MRDARRRRSGAGLAFRAETMPRETAATARPRAAASPRRDPAGSAHAGGPRAPQHDSAESA
CCCHHHHHCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
GRAAADRRAPRRRTGHPAHRHASAAVTAAAGAPSVPPAAALPCAAAPRPPLETIETRPSN
HHHHHHHCCCCCCCCCCHHHHHHHHHEECCCCCCCCCHHCCCCCCCCCCCHHHHHCCCCC
QGDKPMPAQGNAQRTAPLARPAPTDAGHGKFKKQLSLTDLTFIGLGAIFGSGWLFAASHV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SMIAGPAGILSWLLGGFAVLLLGIVYCELGAALPRAGGVVRYPVFSHGPLLGYLMGAITL
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHH
IAFSSLIAIEVVAARQYAAAWFAGLTVEGSGNPTTLGWLVQAALLCFFFYLNYSSVKTFA
HHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KANNVISVFKFVVPLAVIVVLFAFFKPANLTLHGFAPFGMPGVEMAVSAGGIIFAYLGLT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHH
PIVSVASEVRDPQRTIPIALILSIVLSTLIYVLLQLAFLGGIPSAMLAGGWHDIGKAFSL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHCC
PYRDIALALGVGWLAYMVVADAMISPSGCGNIYMNATPRVVYGWAKTGTFFKVFARVDEA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHH
SGIPRAGLWLTFALALFWTLPFPSWEALINTVSAALVLSYAVAPVSVAALRRTAPGLPRP
CCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
FRASAFALTGPASFVIAALIVYWSGWRTVSWLLGLQIAMFAVYLACRRRVPTAHLSLAEQ
CCCCCEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VRSCAWLIAFYALMIVASYFGGFGGTGQLAHPYDTFAVAAVALVIYYWGAHTGVPSAKLQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEE
LDDDEN
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 12730183 [H]