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The map label for this gene is purC [H]

Identifier: 126209472

GI number: 126209472

Start: 2244964

End: 2245821

Strand: Reverse

Name: purC [H]

Synonym: APL_2018

Alternate gene names: 126209472

Gene position: 2245821-2244964 (Counterclockwise)

Preceding gene: 126209485

Following gene: 126209466

Centisome position: 98.74

GC content: 43.47

Gene sequence:

>858_bases
ATGCAAATTAGCCTCAAAAAAATCTATTCGGGAAAAGTACGCGATCTTTATGAAATTGATGATAAACGTATGTTGATGGT
CGCCACCGACCGTTTATCCGCATTTGATGTGATCTTAGATGATCCGATTCCTCGTAAAGGCGAAATCCTTACCCAAATTT
CTAATTTCTGGTTCCAAAAATTAGCCCACATTATGCCGAATCATTTTACCGGCGATTCCGTTTTTGATGTTTTACCGAAA
GAAGAAGCGGAAGCGATTCAACACCGTGCCGTGGTTTGCAAACGTTTAACACCGGTAAAAATCGAATCTATCGTGCGCGG
CTATTTAACCGGTTCGGGCTTAAAAGATTACAAGCAAACCGGTACGATTTGCGGCTTAAAATTACCGGAAGGTTTAGTAG
AAGCAAGCAAATTGCCACAACCGATTTTCACCCCGTCAAGCAAAGCGGAAGTGGGTGATCACGATATCAATATTTCATAC
GAAGAATGTGAACACCAAATCGGTGCGGAATTAGCCGCGAAAGTTCGTGATGCGGCGATTGCACTTTATACCGAAGCGGC
GGAATATGCGCTCACAAAAGGCATTATTATTTGCGACACCAAATTTGAATTCGGTTTGGATGAGAACGGTACTCTTACCC
TAATGGATGAAGTGCTAACCCCTGACTCAAGTCGTTTCTGGTCGGTAGATACTTACCAAGAAGGCACAAACCCGCCGTCA
TTCGACAAGCAATTTGTGCGTGACTGGCTGGAAAACAGCGGTTGGAATAAACAAGCTCCGGCACCGAAAGTACCGGCGGA
CGTAATTGAAAAAACCGTGGCAAAATACCAAGAAGCGTTAGATTTATTAACCAAATAA

Upstream 100 bases:

>100_bases
GTTTTTTAAAAAATTTTTTTGCCCGTTAGAATAAATTCGCAATCGTTTGCGTAAACGAGTATAATTCGTTTAATTTTTTG
TTCTAAAGGAATTTTTAACC

Downstream 100 bases:

>100_bases
TTCTCGGCTTTCCCTAAAAGCAAGCGGTCGGATTCTGCAAATTTTCTGCAAATTCCGACCGCTTGTCGTTTATGAATTAC
TTCACGATGATCACTTTGCG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MQISLKKIYSGKVRDLYEIDDKRMLMVATDRLSAFDVILDDPIPRKGEILTQISNFWFQKLAHIMPNHFTGDSVFDVLPK
EEAEAIQHRAVVCKRLTPVKIESIVRGYLTGSGLKDYKQTGTICGLKLPEGLVEASKLPQPIFTPSSKAEVGDHDINISY
EECEHQIGAELAAKVRDAAIALYTEAAEYALTKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVDTYQEGTNPPS
FDKQFVRDWLENSGWNKQAPAPKVPADVIEKTVAKYQEALDLLTK

Sequences:

>Translated_285_residues
MQISLKKIYSGKVRDLYEIDDKRMLMVATDRLSAFDVILDDPIPRKGEILTQISNFWFQKLAHIMPNHFTGDSVFDVLPK
EEAEAIQHRAVVCKRLTPVKIESIVRGYLTGSGLKDYKQTGTICGLKLPEGLVEASKLPQPIFTPSSKAEVGDHDINISY
EECEHQIGAELAAKVRDAAIALYTEAAEYALTKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVDTYQEGTNPPS
FDKQFVRDWLENSGWNKQAPAPKVPADVIEKTVAKYQEALDLLTK
>Mature_285_residues
MQISLKKIYSGKVRDLYEIDDKRMLMVATDRLSAFDVILDDPIPRKGEILTQISNFWFQKLAHIMPNHFTGDSVFDVLPK
EEAEAIQHRAVVCKRLTPVKIESIVRGYLTGSGLKDYKQTGTICGLKLPEGLVEASKLPQPIFTPSSKAEVGDHDINISY
EECEHQIGAELAAKVRDAAIALYTEAAEYALTKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVDTYQEGTNPPS
FDKQFVRDWLENSGWNKQAPAPKVPADVIEKTVAKYQEALDLLTK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=287, Percent_Identity=46.6898954703833, Blast_Score=266, Evalue=2e-72,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 31945; Mature: 31945

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQISLKKIYSGKVRDLYEIDDKRMLMVATDRLSAFDVILDDPIPRKGEILTQISNFWFQK
CCCCHHHHHCCCHHHHHHCCCCEEEEEECCCHHHHHHEECCCCCCCHHHHHHHHHHHHHH
LAHIMPNHFTGDSVFDVLPKEEAEAIQHRAVVCKRLTPVKIESIVRGYLTGSGLKDYKQT
HHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHC
GTICGLKLPEGLVEASKLPQPIFTPSSKAEVGDHDINISYEECEHQIGAELAAKVRDAAI
CCEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALYTEAAEYALTKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVDTYQEGTNPPS
HHHHHHHHHHHHCCEEEEECCEECCCCCCCCEEEEHHHHCCCCCCEEEEECCCCCCCCCC
FDKQFVRDWLENSGWNKQAPAPKVPADVIEKTVAKYQEALDLLTK
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQISLKKIYSGKVRDLYEIDDKRMLMVATDRLSAFDVILDDPIPRKGEILTQISNFWFQK
CCCCHHHHHCCCHHHHHHCCCCEEEEEECCCHHHHHHEECCCCCCCHHHHHHHHHHHHHH
LAHIMPNHFTGDSVFDVLPKEEAEAIQHRAVVCKRLTPVKIESIVRGYLTGSGLKDYKQT
HHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHC
GTICGLKLPEGLVEASKLPQPIFTPSSKAEVGDHDINISYEECEHQIGAELAAKVRDAAI
CCEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALYTEAAEYALTKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVDTYQEGTNPPS
HHHHHHHHHHHHCCEEEEECCEECCCCCCCCEEEEHHHHCCCCCCEEEEECCCCCCCCCC
FDKQFVRDWLENSGWNKQAPAPKVPADVIEKTVAKYQEALDLLTK
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA