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The map label for this gene is mrdB [H]

Identifier: 126209062

GI number: 126209062

Start: 1824764

End: 1825888

Strand: Reverse

Name: mrdB [H]

Synonym: APL_1598

Alternate gene names: 126209062

Gene position: 1825888-1824764 (Counterclockwise)

Preceding gene: 126209063

Following gene: 126209061

Centisome position: 80.28

GC content: 44.0

Gene sequence:

>1125_bases
ATGAGTAGCGGAATCAGAAAATTTTTTTGGAAGATTTTTTCCCTTGACGTATGGCTGTTGCTCGGCTTGTTGGCGATTAC
CGGTTACGGTTTGATTGTGCTGTATAGTGCCAGCGGTGCGAGTGAAAAAATGTTTACCAACCGTATTATTCAAGTTTCGC
TCGGCTTGGGTTTAATGCTTCTTATGGCAATGATTCCGCCTCGTTTTTATGAACGAATTTCGCCTTATCTTTACCTCGTT
TGTATTGTCATGCTGATTTTGGTGGATTTAATCGGTGAAACCAGTAAAGGTGCGCAACGTTGGTTAAATTTGGGCTTTGT
TCGATTTCAGCCGTCGGAAATCGCCAAACTGTCCGTGCCGCTGATGGTAGCGACTTATTTGGCAAAACGAGCGTTACCGC
CAAGCTTGAAAGATACCTTTATTGCGTTGGGAATCATTATTGTGCCGACTTTATTAGTGGCGGCGCAACCGGACTTAGGT
ACGTCGATTTTAGTTTGTGCCGCCGGTATTTTCGTGCTGTTTTTAGCCGGATTAAGTTGGAAATTAATTAGTGCCGGTGT
GATTTTCTTAGCCGGTTTTATTCCGATTATGTGGTTTTTCTTAATGCACGACTATCAGAAAACCCGTGTAATGACCTTAA
TTGATCCGGAAAAAGACCCGTTGGGTGCCGGCTATCATATTATTCAATCGAAAATTGCCATCGGTTCCGGCGGAATTAAC
GGTAAAGGTTGGATGGAAGGCACGCAATCGCAGCTGGAATTTTTACCCGAGCCGCATACCGATTTTATTTTTGCCGTACT
GGGCGAAGAACACGGTATGATCGGGATTTTAATCCTATTGGCGATTTATTTGTTTATTATCGCCAGAGGATTGGTAATCG
GCGCTAAGAGCGATTCCGCCTTCGGACGTTTGATTTCAGGCGGTACTTCTCTACTTTTCTTTGTTTATGTTTTTGTAAAC
ATTGGTATGGTGAGTGGTATTTTACCCGTAGTTGGTGTACCCTTACCGCTGTTTAGCTATGGGGGGACCTCTTATGTGAC
CCTAATGGCGGCCTTCGGGTTGATGATGTCCGCTTATGTGCATCGTAAGCGTATCAGCGGTAACAACCCGTATAGTAAAC
TTTAA

Upstream 100 bases:

>100_bases
GATTTTGCGTTAAGAAAAACCTTAAAAGAACCGATGGGAACATCAGAACCGTTGCAAAATATCGAGCAAATTCAACCGCT
TGAAGAGGGACAGGCAAATA

Downstream 100 bases:

>100_bases
GTCAGGCTCTACAGGCTGAATATAGGGCTTGAACTTTTGCTTTTTTGCGGTATCAAAAAGCACATGCAAGAGCAGTTATC
TATCAAAAGAAAGATTAACA

Product: rod shape-determining protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSSGIRKFFWKIFSLDVWLLLGLLAITGYGLIVLYSASGASEKMFTNRIIQVSLGLGLMLLMAMIPPRFYERISPYLYLV
CIVMLILVDLIGETSKGAQRWLNLGFVRFQPSEIAKLSVPLMVATYLAKRALPPSLKDTFIALGIIIVPTLLVAAQPDLG
TSILVCAAGIFVLFLAGLSWKLISAGVIFLAGFIPIMWFFLMHDYQKTRVMTLIDPEKDPLGAGYHIIQSKIAIGSGGIN
GKGWMEGTQSQLEFLPEPHTDFIFAVLGEEHGMIGILILLAIYLFIIARGLVIGAKSDSAFGRLISGGTSLLFFVYVFVN
IGMVSGILPVVGVPLPLFSYGGTSYVTLMAAFGLMMSAYVHRKRISGNNPYSKL

Sequences:

>Translated_374_residues
MSSGIRKFFWKIFSLDVWLLLGLLAITGYGLIVLYSASGASEKMFTNRIIQVSLGLGLMLLMAMIPPRFYERISPYLYLV
CIVMLILVDLIGETSKGAQRWLNLGFVRFQPSEIAKLSVPLMVATYLAKRALPPSLKDTFIALGIIIVPTLLVAAQPDLG
TSILVCAAGIFVLFLAGLSWKLISAGVIFLAGFIPIMWFFLMHDYQKTRVMTLIDPEKDPLGAGYHIIQSKIAIGSGGIN
GKGWMEGTQSQLEFLPEPHTDFIFAVLGEEHGMIGILILLAIYLFIIARGLVIGAKSDSAFGRLISGGTSLLFFVYVFVN
IGMVSGILPVVGVPLPLFSYGGTSYVTLMAAFGLMMSAYVHRKRISGNNPYSKL
>Mature_373_residues
SSGIRKFFWKIFSLDVWLLLGLLAITGYGLIVLYSASGASEKMFTNRIIQVSLGLGLMLLMAMIPPRFYERISPYLYLVC
IVMLILVDLIGETSKGAQRWLNLGFVRFQPSEIAKLSVPLMVATYLAKRALPPSLKDTFIALGIIIVPTLLVAAQPDLGT
SILVCAAGIFVLFLAGLSWKLISAGVIFLAGFIPIMWFFLMHDYQKTRVMTLIDPEKDPLGAGYHIIQSKIAIGSGGING
KGWMEGTQSQLEFLPEPHTDFIFAVLGEEHGMIGILILLAIYLFIIARGLVIGAKSDSAFGRLISGGTSLLFFVYVFVNI
GMVSGILPVVGVPLPLFSYGGTSYVTLMAAFGLMMSAYVHRKRISGNNPYSKL

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=363, Percent_Identity=64.1873278236915, Blast_Score=443, Evalue=1e-126,
Organism=Escherichia coli, GI1786277, Length=371, Percent_Identity=33.9622641509434, Blast_Score=189, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 40851; Mature: 40720

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSGIRKFFWKIFSLDVWLLLGLLAITGYGLIVLYSASGASEKMFTNRIIQVSLGLGLML
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
LMAMIPPRFYERISPYLYLVCIVMLILVDLIGETSKGAQRWLNLGFVRFQPSEIAKLSVP
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCEEEECHHHHHHHHHH
LMVATYLAKRALPPSLKDTFIALGIIIVPTLLVAAQPDLGTSILVCAAGIFVLFLAGLSW
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHH
KLISAGVIFLAGFIPIMWFFLMHDYQKTRVMTLIDPEKDPLGAGYHIIQSKIAIGSGGIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCC
GKGWMEGTQSQLEFLPEPHTDFIFAVLGEEHGMIGILILLAIYLFIIARGLVIGAKSDSA
CCCCCCCCHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEECCCCHH
FGRLISGGTSLLFFVYVFVNIGMVSGILPVVGVPLPLFSYGGTSYVTLMAAFGLMMSAYV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHH
HRKRISGNNPYSKL
HHHHCCCCCCCCCC
>Mature Secondary Structure 
SSGIRKFFWKIFSLDVWLLLGLLAITGYGLIVLYSASGASEKMFTNRIIQVSLGLGLML
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
LMAMIPPRFYERISPYLYLVCIVMLILVDLIGETSKGAQRWLNLGFVRFQPSEIAKLSVP
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCEEEECHHHHHHHHHH
LMVATYLAKRALPPSLKDTFIALGIIIVPTLLVAAQPDLGTSILVCAAGIFVLFLAGLSW
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHH
KLISAGVIFLAGFIPIMWFFLMHDYQKTRVMTLIDPEKDPLGAGYHIIQSKIAIGSGGIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCC
GKGWMEGTQSQLEFLPEPHTDFIFAVLGEEHGMIGILILLAIYLFIIARGLVIGAKSDSA
CCCCCCCCHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEECCCCHH
FGRLISGGTSLLFFVYVFVNIGMVSGILPVVGVPLPLFSYGGTSYVTLMAAFGLMMSAYV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHH
HRKRISGNNPYSKL
HHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]