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The map label for this gene is ccmA [H]

Identifier: 126208836

GI number: 126208836

Start: 1568850

End: 1569485

Strand: Reverse

Name: ccmA [H]

Synonym: APL_1372

Alternate gene names: 126208836

Gene position: 1569485-1568850 (Counterclockwise)

Preceding gene: 126208837

Following gene: 126208835

Centisome position: 69.0

GC content: 39.31

Gene sequence:

>636_bases
ATGACACATACTAATCAATTAACCATTACTAATCTTGCTTGCGAGCGAGGTGAAAATCGTTTATTTGAAAATTGTAACTT
TTCTGTTACATCCGGTGAATGGGTACAAATTGAAGGTCATAACGGTATAGGCAAAACCAGCTTATTACGTATTCTTGCGG
GGCTTGCGATGCCTGCCGAAGGATATGTTTTATGGAATGATATTCCTATTCAAAAACAACGTGATGAATATTATTCGGAA
TTATTTTATTTGGCGCATCATGCAGGGGTTAAACCGGAGCTTTCTCCTTGGGAAAATTTACGTTTTTATCAAAAAATCCA
AGGGCTGGCGCTTGATGATGAAGCGTTATGGTATGCCTTAGATAAGGTCGGTTTAATCGGCAGAGAAGAACTTGCTTGTT
CGTACCTCTCCGCCGGTCAGCAACGCCGGGTCGCTTTAGCGAAATTATGGCTGATAAAGCAAAAGCTTTGGATTTTAGAC
GAGCCTTTTACCGCTATTGATAAGAAAGGAGTTTCCGATTTAATCGTCCATATTGAAAAGCATTGCGAAAATGGCGGAAT
GGTTATTTTTACCAGTCATCAAGCGGCGGAAAGTCATAAAGTTAAAATCTTATCTTTGGATCAGTTTAAACTATGA

Upstream 100 bases:

>100_bases
AATTTAACCGCTTATTACCTCTAAAGAGGTAATGATATGGCTACGTTAAATCTCCCTCTTATGTTAAACTTTGCCTATCT
GTTTCTTATTATTCATTGTT

Downstream 100 bases:

>100_bases
TTTTATTTACTATTATTCAACGCGAATTAACCATCGCTTTGCGTAAGCCGGCGGAAATATTGAACCCGCTTTGGTTCTTT
CTGATTGTGATTACTTTGTT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MTHTNQLTITNLACERGENRLFENCNFSVTSGEWVQIEGHNGIGKTSLLRILAGLAMPAEGYVLWNDIPIQKQRDEYYSE
LFYLAHHAGVKPELSPWENLRFYQKIQGLALDDEALWYALDKVGLIGREELACSYLSAGQQRRVALAKLWLIKQKLWILD
EPFTAIDKKGVSDLIVHIEKHCENGGMVIFTSHQAAESHKVKILSLDQFKL

Sequences:

>Translated_211_residues
MTHTNQLTITNLACERGENRLFENCNFSVTSGEWVQIEGHNGIGKTSLLRILAGLAMPAEGYVLWNDIPIQKQRDEYYSE
LFYLAHHAGVKPELSPWENLRFYQKIQGLALDDEALWYALDKVGLIGREELACSYLSAGQQRRVALAKLWLIKQKLWILD
EPFTAIDKKGVSDLIVHIEKHCENGGMVIFTSHQAAESHKVKILSLDQFKL
>Mature_210_residues
THTNQLTITNLACERGENRLFENCNFSVTSGEWVQIEGHNGIGKTSLLRILAGLAMPAEGYVLWNDIPIQKQRDEYYSEL
FYLAHHAGVKPELSPWENLRFYQKIQGLALDDEALWYALDKVGLIGREELACSYLSAGQQRRVALAKLWLIKQKLWILDE
PFTAIDKKGVSDLIVHIEKHCENGGMVIFTSHQAAESHKVKILSLDQFKL

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI153792144, Length=193, Percent_Identity=27.4611398963731, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI27881501, Length=177, Percent_Identity=27.683615819209, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI30795238, Length=177, Percent_Identity=27.683615819209, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI105990541, Length=199, Percent_Identity=26.6331658291457, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI150417984, Length=177, Percent_Identity=28.2485875706215, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI21536376, Length=183, Percent_Identity=30.6010928961749, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082064, Length=202, Percent_Identity=48.5148514851485, Blast_Score=171, Evalue=2e-44,
Organism=Escherichia coli, GI87081709, Length=206, Percent_Identity=27.6699029126214, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787029, Length=204, Percent_Identity=28.4313725490196, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1788225, Length=210, Percent_Identity=28.0952380952381, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI87081834, Length=164, Percent_Identity=31.0975609756098, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI87081782, Length=173, Percent_Identity=27.1676300578035, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1787164, Length=189, Percent_Identity=31.2169312169312, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI87081791, Length=169, Percent_Identity=29.585798816568, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789032, Length=191, Percent_Identity=27.2251308900524, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788761, Length=202, Percent_Identity=25.2475247524752, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788165, Length=193, Percent_Identity=27.4611398963731, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789891, Length=190, Percent_Identity=29.4736842105263, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1790525, Length=191, Percent_Identity=26.7015706806283, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789873, Length=203, Percent_Identity=24.1379310344828, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789593, Length=207, Percent_Identity=28.0193236714976, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786698, Length=206, Percent_Identity=26.2135922330097, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786563, Length=200, Percent_Identity=28.5, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1789586, Length=202, Percent_Identity=28.2178217821782, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1787041, Length=191, Percent_Identity=27.2251308900524, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789672, Length=211, Percent_Identity=22.2748815165877, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786872, Length=214, Percent_Identity=24.7663551401869, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17565586, Length=184, Percent_Identity=24.4565217391304, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI115533608, Length=177, Percent_Identity=28.2485875706215, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24666092, Length=209, Percent_Identity=28.2296650717703, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24648314, Length=195, Percent_Identity=25.1282051282051, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 24025; Mature: 23894

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHTNQLTITNLACERGENRLFENCNFSVTSGEWVQIEGHNGIGKTSLLRILAGLAMPAE
CCCCCEEEEEHHHHHCCCCHHHHCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCC
GYVLWNDIPIQKQRDEYYSELFYLAHHAGVKPELSPWENLRFYQKIQGLALDDEALWYAL
CEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHH
DKVGLIGREELACSYLSAGQQRRVALAKLWLIKQKLWILDEPFTAIDKKGVSDLIVHIEK
HHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCHHHHHHCCHHHHHHHHHH
HCENGGMVIFTSHQAAESHKVKILSLDQFKL
HCCCCCEEEEECCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
THTNQLTITNLACERGENRLFENCNFSVTSGEWVQIEGHNGIGKTSLLRILAGLAMPAE
CCCCEEEEEHHHHHCCCCHHHHCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCC
GYVLWNDIPIQKQRDEYYSELFYLAHHAGVKPELSPWENLRFYQKIQGLALDDEALWYAL
CEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHH
DKVGLIGREELACSYLSAGQQRRVALAKLWLIKQKLWILDEPFTAIDKKGVSDLIVHIEK
HHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCHHHHHHCCHHHHHHHHHH
HCENGGMVIFTSHQAAESHKVKILSLDQFKL
HCCCCCEEEEECCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA