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The map label for this gene is htpX

Identifier: 126208513

GI number: 126208513

Start: 1206907

End: 1207776

Strand: Reverse

Name: htpX

Synonym: APL_1039

Alternate gene names: 126208513

Gene position: 1207776-1206907 (Counterclockwise)

Preceding gene: 126208514

Following gene: 126208511

Centisome position: 53.1

GC content: 42.53

Gene sequence:

>870_bases
ATGGCAAAAAGAATTGTCTTATTTTTATTAACTAACTTAGCGATTACCTTCGTACTCGGTATTGTATTAAATATCATTTT
CCAAGTGACCGGTATTCAAGGCGGTAGTACCGGCGGTATTTTAGTGATGTCGCTCGTATTCGGTTTTGCCGGTTCTTTAA
TTTCTTTATTTATGTCAAAAAGTATGGCGTTACGTTCCGTCGGTGCGGAAGTGATTCAACAACCGCGTAATCATGCGGAA
CAATGGTTATTCGATACCGTACAACGTCAATCGCAACAAGCGAATATTCCGATGCCGGATATTGCGATTTATCATTCTGC
CGATGTCAATGCGTTTGCAACCGGTGCGACGAAAAATAATTCGTTAGTGGCGGTAAGTACCGGTTTATTGGATAACATGA
CCGAAGATGAAGCCGAAGCGGTGGTTGCGCATGAAATCGCACATATTGCGAACGGCGATATGGTGACAATGACTTTACTA
CAAGGCGTATTGAATACCTTTGTTATCTTCTTATCTCGTATTATTTCGACAGCGGCTTCAAGCGGTAAAGACGAAAACGG
TAACGCTACTCAAAACACCTTAGTTTTCTGGATCGTCGATATTGCGTTACAAATGATCTTCGGTGTCATCGCAACTATGA
TCGCAATGTGGTTCTCACGTTATCGTGAATACCGTGCGGATGCCGGTTCGGCACAATTAGTCGGTAAAGAGAAAATGATT
GCGGCGCTACAACGTTTACAGCACGTACACGAACCGCAAGAAATGCAAGGTTCTCTTGCGGCATTTATGATTAACGGCGC
ACGTTCTAAAGAATTATTTATGAGCCACCCGCCACTTGAAAAACGTATCGAAGCGTTAAGAAACTTATAA

Upstream 100 bases:

>100_bases
ATTTGTGGGAATAATTATTGTCAAACGCTTGAATTCTTATAGAATTACCCCTATTTAGTGACTAGTTTTTCCTCACTCTT
TTTTGGAGATTTATTTACCT

Downstream 100 bases:

>100_bases
TCGACAAGCGGTCTGATTTTGCAAAAAACTTGCAAGAACAGACCGCTTTTTTACTGGCCTTAAAACCAAGGCGAGAGAGC
AAAAAGTAAAATTAAATAAC

Product: heat shock protein HtpX

Products: NA

Alternate protein names: Heat shock protein HtpX

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MAKRIVLFLLTNLAITFVLGIVLNIIFQVTGIQGGSTGGILVMSLVFGFAGSLISLFMSKSMALRSVGAEVIQQPRNHAE
QWLFDTVQRQSQQANIPMPDIAIYHSADVNAFATGATKNNSLVAVSTGLLDNMTEDEAEAVVAHEIAHIANGDMVTMTLL
QGVLNTFVIFLSRIISTAASSGKDENGNATQNTLVFWIVDIALQMIFGVIATMIAMWFSRYREYRADAGSAQLVGKEKMI
AALQRLQHVHEPQEMQGSLAAFMINGARSKELFMSHPPLEKRIEALRNL

Sequences:

>Translated_289_residues
MAKRIVLFLLTNLAITFVLGIVLNIIFQVTGIQGGSTGGILVMSLVFGFAGSLISLFMSKSMALRSVGAEVIQQPRNHAE
QWLFDTVQRQSQQANIPMPDIAIYHSADVNAFATGATKNNSLVAVSTGLLDNMTEDEAEAVVAHEIAHIANGDMVTMTLL
QGVLNTFVIFLSRIISTAASSGKDENGNATQNTLVFWIVDIALQMIFGVIATMIAMWFSRYREYRADAGSAQLVGKEKMI
AALQRLQHVHEPQEMQGSLAAFMINGARSKELFMSHPPLEKRIEALRNL
>Mature_288_residues
AKRIVLFLLTNLAITFVLGIVLNIIFQVTGIQGGSTGGILVMSLVFGFAGSLISLFMSKSMALRSVGAEVIQQPRNHAEQ
WLFDTVQRQSQQANIPMPDIAIYHSADVNAFATGATKNNSLVAVSTGLLDNMTEDEAEAVVAHEIAHIANGDMVTMTLLQ
GVLNTFVIFLSRIISTAASSGKDENGNATQNTLVFWIVDIALQMIFGVIATMIAMWFSRYREYRADAGSAQLVGKEKMIA
ALQRLQHVHEPQEMQGSLAAFMINGARSKELFMSHPPLEKRIEALRNL

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=292, Percent_Identity=60.958904109589, Blast_Score=357, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_ACTP2 (A3N147)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053738.1
- ProteinModelPortal:   A3N147
- SMR:   A3N147
- STRING:   A3N147
- GeneID:   4850496
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1039
- eggNOG:   COG0501
- HOGENOM:   HBG739460
- OMA:   NRFLTAN
- PhylomeDB:   A3N147
- ProtClustDB:   PRK05457
- BioCyc:   APLE416269:APL_1039-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 31555; Mature: 31424

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 145-145

Signals:

None

Transmembrane regions:

HASH(0x1db54830)-; HASH(0x1d4c690c)-; HASH(0x1b81f320)-; HASH(0x1d518d7c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRIVLFLLTNLAITFVLGIVLNIIFQVTGIQGGSTGGILVMSLVFGFAGSLISLFMSK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SMALRSVGAEVIQQPRNHAEQWLFDTVQRQSQQANIPMPDIAIYHSADVNAFATGATKNN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEECCCCCCC
SLVAVSTGLLDNMTEDEAEAVVAHEIAHIANGDMVTMTLLQGVLNTFVIFLSRIISTAAS
CEEEEECCHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGKDENGNATQNTLVFWIVDIALQMIFGVIATMIAMWFSRYREYRADAGSAQLVGKEKMI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AALQRLQHVHEPQEMQGSLAAFMINGARSKELFMSHPPLEKRIEALRNL
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHCH
>Mature Secondary Structure 
AKRIVLFLLTNLAITFVLGIVLNIIFQVTGIQGGSTGGILVMSLVFGFAGSLISLFMSK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SMALRSVGAEVIQQPRNHAEQWLFDTVQRQSQQANIPMPDIAIYHSADVNAFATGATKNN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEECCCCCCC
SLVAVSTGLLDNMTEDEAEAVVAHEIAHIANGDMVTMTLLQGVLNTFVIFLSRIISTAAS
CEEEEECCHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGKDENGNATQNTLVFWIVDIALQMIFGVIATMIAMWFSRYREYRADAGSAQLVGKEKMI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AALQRLQHVHEPQEMQGSLAAFMINGARSKELFMSHPPLEKRIEALRNL
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA