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The map label for this gene is hpt [H]

Identifier: 126208162

GI number: 126208162

Start: 780335

End: 780874

Strand: Reverse

Name: hpt [H]

Synonym: APL_0682

Alternate gene names: 126208162

Gene position: 780874-780335 (Counterclockwise)

Preceding gene: 126208163

Following gene: 126208161

Centisome position: 34.33

GC content: 41.3

Gene sequence:

>540_bases
ATGAAAAAACATCACGTTGAAGCCCTTATTTCTCGCGAAGAAGTTCAATCTCGTATTATGGAACTTGCTAAAGAAATTAA
TCATCACTATGCACACGCACATTGCGAGAATTTGGTTGTTGTAGGGCTATTACGTGGTTCATTTATGTTTATGGCGGATT
TAGTGCGTTTAATTGATGTACCGGTTGAAGTTGATTTTATGACGGCTTCCAGCTATGGTTCCGGTACGGAGTCGAGCCGT
GACGTGAAGATCTTAAAAGATCTTGACGGTGAAATTCACGGTAAAGACGTGTTAATCGTCGAAGATATTATTGATACCGG
TTTTACTTTGAGCAAAGTGCGTGATATTTTGAATTTACGTGAGCCTCGTTCGGTAGCGATTTGTACCTTACTGGATAAAC
CTTCTCGTCGTGAAGTGGAAGTGCCGGTCGAATGGGTCGGTTTTGCGATTCCGGATGAATTTGTCGTAGGTTACGGTATC
GACTATGCACAGAAATATCGTAATCTTGATTTTATCGGTAAGGTTGTAATGGACGCATAG

Upstream 100 bases:

>100_bases
AATTGGCATAACATTTTGGTGTTATGCCAAATTTATTTTGATTTTAGTATTAATTGTCATTATCATTACCCTCTATTTTT
ATTAAGAGAGCTTAAACATT

Downstream 100 bases:

>100_bases
TTGCAATCTTTTACTAAGATTTGACCGCTTGTAAGGCTTAAGTGAACTTCAAGCGGTTTTCTTTTACTAAAATTTTACGC
ATTATCACATAGAATAGTAG

Product: yypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MKKHHVEALISREEVQSRIMELAKEINHHYAHAHCENLVVVGLLRGSFMFMADLVRLIDVPVEVDFMTASSYGSGTESSR
DVKILKDLDGEIHGKDVLIVEDIIDTGFTLSKVRDILNLREPRSVAICTLLDKPSRREVEVPVEWVGFAIPDEFVVGYGI
DYAQKYRNLDFIGKVVMDA

Sequences:

>Translated_179_residues
MKKHHVEALISREEVQSRIMELAKEINHHYAHAHCENLVVVGLLRGSFMFMADLVRLIDVPVEVDFMTASSYGSGTESSR
DVKILKDLDGEIHGKDVLIVEDIIDTGFTLSKVRDILNLREPRSVAICTLLDKPSRREVEVPVEWVGFAIPDEFVVGYGI
DYAQKYRNLDFIGKVVMDA
>Mature_179_residues
MKKHHVEALISREEVQSRIMELAKEINHHYAHAHCENLVVVGLLRGSFMFMADLVRLIDVPVEVDFMTASSYGSGTESSR
DVKILKDLDGEIHGKDVLIVEDIIDTGFTLSKVRDILNLREPRSVAICTLLDKPSRREVEVPVEWVGFAIPDEFVVGYGI
DYAQKYRNLDFIGKVVMDA

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=186, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=6e-21,
Organism=Homo sapiens, GI9910262, Length=174, Percent_Identity=31.6091954022989, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI87081689, Length=175, Percent_Identity=69.1428571428571, Blast_Score=248, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17510817, Length=168, Percent_Identity=37.5, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20243; Mature: 20243

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHHVEALISREEVQSRIMELAKEINHHYAHAHCENLVVVGLLRGSFMFMADLVRLIDV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHCC
PVEVDFMTASSYGSGTESSRDVKILKDLDGEIHGKDVLIVEDIIDTGFTLSKVRDILNLR
CCEEEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEEHHHHCCCCHHHHHHHHHCC
EPRSVAICTLLDKPSRREVEVPVEWVGFAIPDEFVVGYGIDYAQKYRNLDFIGKVVMDA
CCCCEEEEEEECCCCCCCEECCHHHEEECCCCHHEEECCCHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MKKHHVEALISREEVQSRIMELAKEINHHYAHAHCENLVVVGLLRGSFMFMADLVRLIDV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHCC
PVEVDFMTASSYGSGTESSRDVKILKDLDGEIHGKDVLIVEDIIDTGFTLSKVRDILNLR
CCEEEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEEHHHHCCCCHHHHHHHHHCC
EPRSVAICTLLDKPSRREVEVPVEWVGFAIPDEFVVGYGIDYAQKYRNLDFIGKVVMDA
CCCCEEEEEEECCCCCCCEECCHHHEEECCCCHHEEECCCHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]