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The map label for this gene is slt [H]

Identifier: 126208161

GI number: 126208161

Start: 778118

End: 780226

Strand: Reverse

Name: slt [H]

Synonym: APL_0681

Alternate gene names: 126208161

Gene position: 780226-778118 (Counterclockwise)

Preceding gene: 126208162

Following gene: 126208160

Centisome position: 34.3

GC content: 42.58

Gene sequence:

>2109_bases
ATGATTTGGAAAAAAACGTTATTGACGCTACTTGTCTTAAGTTCTTCAGTATGGGCGGCAGAGAAAAAATCTCATGCGCA
AAAGACATTTAGCGAAAGCGAGGTAACCGCATTAAAAGCGGAATGGCTTGCCGAACAGAAAACGCAATGGTTACAACAAG
CGGGACAAAGAGAGAAACAACGGGAAGCCTTTTTAATTGCCGATAATTTGCTTAAAACGGCGATCTCAAGCAAACAATTT
TCGGCGGAAACGCAGCGATTGGTAAATGCCCTTATTCGTTCATTAGATACGTATCCGCTTAAACGTGATATTGATTGGGC
GGTATTAAAAGCCAAAATTGAGAGTAAACAAGTTACGGCGGACGATATTCGCGCATTTTCGGCATTATATCCGAATTCAC
CTTATCAAAAGCAATTCGAGCAATTGCCTTTTGCGCAATTATATGAGCGGAAAAAATGGGCTGACTTATTAAAATACAGC
GAAAAAGTTACGCCGGTCGGAATGGATAATCAGTGTCGAGTATTGGCGTCACAATTCCAACTCTTATCGGAAAAGTTGCA
ATCGGAATCGCCGCAAGCGCAAACGGAAAGCAATAGGTTTCTTATCGCCGATTTATTGGCGCAGTTTGAAAAATTATGGC
TAAAAACGACCGCTTTGCCGTCTGAATGCACGGAATTGGAAAGTTATTGGAAAGCGAAGTCAGGTATTACTGCGGAGAAA
ATTCGTTTAAGAGCGGTGCATTTATTTGATAAAAATGCAAAATCCGAATTGAGTAATCTGTTGCCGATAGCAGAGAATCA
AACGCCGGAACTTAAAAATTGGCTGGTTACGGTGGAGCAATTAGCTAAACAACCGACAACATTGCCGGCTTTTATCGAAC
AAGCCACGGCGGATGAACAGAGCCGTATGATTGCCAATAAGGCGTTTCCGCAGTTTATGAGAACAATCGCCGAGAATACG
GGAAATCCGGATTTTACTCCTTATCAAACGTGGGCGGATAAATTGGGCTTATCCGCTGAGGAACAAAAAGCTTGGAAAGT
GACTTTCTTAAATCGTTTGTTTGATAATGAGAACGGCAATTTCCAAATATGGCGAGATCAGCAGATCCAACAATTACAAG
CGGATAATCTGACCGAACGTCGGATTCGTTTAGCCATTTTGCAGCAAGCGCCGTTAGCCGACTGGCTGTCGTTGTTATCG
AATGAGGCTAAGAGTAAGCCGGAATGGCGTTATTGGGCGGCAAAAAACGAAAAAGAAGCGAAAAAACGGGAAGCATCGCT
TATCGCTCTGTCTAAAGAGCGCGGTTTTTATCCGATGTTAGCCGCACAGTTACTCGGAAAACAGTATGTGCCGACGCAAG
GATTATTGTTGAAATCGGATGTACAAAGCCGTTTACAGCCGCAATTTGATCGCATTAAAGAATTACGTGATTTACAGCGT
TTTGCACAAGCTAAAACGGCTTGGATTGAATTACTGGATGAACTTTCCGTCGATGATAAATTAGCGGTTACCGATTATGC
CAAACAACAAAATTGGTATGATTTGGCGGTGGAAGGTACGATTCAGGCAAAAGCATTCGATTATTTATCGCTGCGTTTGC
CGAATGCCTATTCCGATTGGTTTGATCTGAATTTGGAAGGTAAGCCGATAAGCAAAACCTTTGCGATGGCGATTGCCCGT
CAAGAAAGTGCATGGAACTTCCAAGCCAGATCGCACGCTAATGCCTTGGGATTAATGCAAATGCTACCGAGTACCGCACA
AAAAACGGCGCAAGATAATCAACTGCCTTATCGTAATGAGCAGGATTTATTACAGCCGTTTAACAATATTATGCTGGGTA
CGACACATCTTACGGAACTTAATGCAAAATATCCGAATAATCGTTTTCTGATTGCCGCCGCTTATAACGCCGGAGCAAGC
AGGGTGGAGCGTTGGCTTGTCAGAGCAAACGGAAAACTTGCTTTAGACGAATTTGTTGCCTCTATTCCGTTTTATGAAAC
GCGCGGTTATGTACAAAATGTCGTCGCTTATGATTATTATCAACAGCTGCTACAAAAAGTAGAGAAGCCGATAATGTTTT
ATAAAGACGAATGGCAGAGAAAATACTAA

Upstream 100 bases:

>100_bases
TTTTACTAAGATTTGACCGCTTGTAAGGCTTAAGTGAACTTCAAGCGGTTTTCTTTTACTAAAATTTTACGCATTATCAC
ATAGAATAGTAGGGAATATT

Downstream 100 bases:

>100_bases
GTTTGAAAAGCAAGTGGATTAACCTACTTGCTTTTTTTAGCGATAGATAAAAAGTGGTTATCACGAATATACGAAAATAG
TGATGAAGCGTATAATACAA

Product: putative soluble lytic murein transglycosylase precursor

Products: 1,6-Anhydrobond [C]

Alternate protein names: Peptidoglycan lytic exotransglycosylase [H]

Number of amino acids: Translated: 702; Mature: 702

Protein sequence:

>702_residues
MIWKKTLLTLLVLSSSVWAAEKKSHAQKTFSESEVTALKAEWLAEQKTQWLQQAGQREKQREAFLIADNLLKTAISSKQF
SAETQRLVNALIRSLDTYPLKRDIDWAVLKAKIESKQVTADDIRAFSALYPNSPYQKQFEQLPFAQLYERKKWADLLKYS
EKVTPVGMDNQCRVLASQFQLLSEKLQSESPQAQTESNRFLIADLLAQFEKLWLKTTALPSECTELESYWKAKSGITAEK
IRLRAVHLFDKNAKSELSNLLPIAENQTPELKNWLVTVEQLAKQPTTLPAFIEQATADEQSRMIANKAFPQFMRTIAENT
GNPDFTPYQTWADKLGLSAEEQKAWKVTFLNRLFDNENGNFQIWRDQQIQQLQADNLTERRIRLAILQQAPLADWLSLLS
NEAKSKPEWRYWAAKNEKEAKKREASLIALSKERGFYPMLAAQLLGKQYVPTQGLLLKSDVQSRLQPQFDRIKELRDLQR
FAQAKTAWIELLDELSVDDKLAVTDYAKQQNWYDLAVEGTIQAKAFDYLSLRLPNAYSDWFDLNLEGKPISKTFAMAIAR
QESAWNFQARSHANALGLMQMLPSTAQKTAQDNQLPYRNEQDLLQPFNNIMLGTTHLTELNAKYPNNRFLIAAAYNAGAS
RVERWLVRANGKLALDEFVASIPFYETRGYVQNVVAYDYYQQLLQKVEKPIMFYKDEWQRKY

Sequences:

>Translated_702_residues
MIWKKTLLTLLVLSSSVWAAEKKSHAQKTFSESEVTALKAEWLAEQKTQWLQQAGQREKQREAFLIADNLLKTAISSKQF
SAETQRLVNALIRSLDTYPLKRDIDWAVLKAKIESKQVTADDIRAFSALYPNSPYQKQFEQLPFAQLYERKKWADLLKYS
EKVTPVGMDNQCRVLASQFQLLSEKLQSESPQAQTESNRFLIADLLAQFEKLWLKTTALPSECTELESYWKAKSGITAEK
IRLRAVHLFDKNAKSELSNLLPIAENQTPELKNWLVTVEQLAKQPTTLPAFIEQATADEQSRMIANKAFPQFMRTIAENT
GNPDFTPYQTWADKLGLSAEEQKAWKVTFLNRLFDNENGNFQIWRDQQIQQLQADNLTERRIRLAILQQAPLADWLSLLS
NEAKSKPEWRYWAAKNEKEAKKREASLIALSKERGFYPMLAAQLLGKQYVPTQGLLLKSDVQSRLQPQFDRIKELRDLQR
FAQAKTAWIELLDELSVDDKLAVTDYAKQQNWYDLAVEGTIQAKAFDYLSLRLPNAYSDWFDLNLEGKPISKTFAMAIAR
QESAWNFQARSHANALGLMQMLPSTAQKTAQDNQLPYRNEQDLLQPFNNIMLGTTHLTELNAKYPNNRFLIAAAYNAGAS
RVERWLVRANGKLALDEFVASIPFYETRGYVQNVVAYDYYQQLLQKVEKPIMFYKDEWQRKY
>Mature_702_residues
MIWKKTLLTLLVLSSSVWAAEKKSHAQKTFSESEVTALKAEWLAEQKTQWLQQAGQREKQREAFLIADNLLKTAISSKQF
SAETQRLVNALIRSLDTYPLKRDIDWAVLKAKIESKQVTADDIRAFSALYPNSPYQKQFEQLPFAQLYERKKWADLLKYS
EKVTPVGMDNQCRVLASQFQLLSEKLQSESPQAQTESNRFLIADLLAQFEKLWLKTTALPSECTELESYWKAKSGITAEK
IRLRAVHLFDKNAKSELSNLLPIAENQTPELKNWLVTVEQLAKQPTTLPAFIEQATADEQSRMIANKAFPQFMRTIAENT
GNPDFTPYQTWADKLGLSAEEQKAWKVTFLNRLFDNENGNFQIWRDQQIQQLQADNLTERRIRLAILQQAPLADWLSLLS
NEAKSKPEWRYWAAKNEKEAKKREASLIALSKERGFYPMLAAQLLGKQYVPTQGLLLKSDVQSRLQPQFDRIKELRDLQR
FAQAKTAWIELLDELSVDDKLAVTDYAKQQNWYDLAVEGTIQAKAFDYLSLRLPNAYSDWFDLNLEGKPISKTFAMAIAR
QESAWNFQARSHANALGLMQMLPSTAQKTAQDNQLPYRNEQDLLQPFNNIMLGTTHLTELNAKYPNNRFLIAAAYNAGAS
RVERWLVRANGKLALDEFVASIPFYETRGYVQNVVAYDYYQQLLQKVEKPIMFYKDEWQRKY

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082441, Length=635, Percent_Identity=32.9133858267717, Blast_Score=263, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011989
- InterPro:   IPR016026
- InterPro:   IPR008258
- InterPro:   IPR012289
- InterPro:   IPR008939
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 81040; Mature: 81040

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIWKKTLLTLLVLSSSVWAAEKKSHAQKTFSESEVTALKAEWLAEQKTQWLQQAGQREKQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REAFLIADNLLKTAISSKQFSAETQRLVNALIRSLDTYPLKRDIDWAVLKAKIESKQVTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCH
DDIRAFSALYPNSPYQKQFEQLPFAQLYERKKWADLLKYSEKVTPVGMDNQCRVLASQFQ
HHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LLSEKLQSESPQAQTESNRFLIADLLAQFEKLWLKTTALPSECTELESYWKAKSGITAEK
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHH
IRLRAVHLFDKNAKSELSNLLPIAENQTPELKNWLVTVEQLAKQPTTLPAFIEQATADEQ
HHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHH
SRMIANKAFPQFMRTIAENTGNPDFTPYQTWADKLGLSAEEQKAWKVTFLNRLFDNENGN
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
FQIWRDQQIQQLQADNLTERRIRLAILQQAPLADWLSLLSNEAKSKPEWRYWAAKNEKEA
EEEECHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHH
KKREASLIALSKERGFYPMLAAQLLGKQYVPTQGLLLKSDVQSRLQPQFDRIKELRDLQR
HHHHHHHEEEECCCCCHHHHHHHHHCCCCCCCCCCEEHHHHHHHHCCHHHHHHHHHHHHH
FAQAKTAWIELLDELSVDDKLAVTDYAKQQNWYDLAVEGTIQAKAFDYLSLRLPNAYSDW
HHHHHHHHHHHHHHCCCCCCEEHHHHHHCCCCEEEEEECEEEHHHHHHHEEECCCCCCCC
FDLNLEGKPISKTFAMAIARQESAWNFQARSHANALGLMQMLPSTAQKTAQDNQLPYRNE
EEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
QDLLQPFNNIMLGTTHLTELNAKYPNNRFLIAAAYNAGASRVERWLVRANGKLALDEFVA
HHHHHHHHHHEECCHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEHHHHHH
SIPFYETRGYVQNVVAYDYYQQLLQKVEKPIMFYKDEWQRKY
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHCCCC
>Mature Secondary Structure
MIWKKTLLTLLVLSSSVWAAEKKSHAQKTFSESEVTALKAEWLAEQKTQWLQQAGQREKQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REAFLIADNLLKTAISSKQFSAETQRLVNALIRSLDTYPLKRDIDWAVLKAKIESKQVTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCH
DDIRAFSALYPNSPYQKQFEQLPFAQLYERKKWADLLKYSEKVTPVGMDNQCRVLASQFQ
HHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LLSEKLQSESPQAQTESNRFLIADLLAQFEKLWLKTTALPSECTELESYWKAKSGITAEK
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHH
IRLRAVHLFDKNAKSELSNLLPIAENQTPELKNWLVTVEQLAKQPTTLPAFIEQATADEQ
HHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHH
SRMIANKAFPQFMRTIAENTGNPDFTPYQTWADKLGLSAEEQKAWKVTFLNRLFDNENGN
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
FQIWRDQQIQQLQADNLTERRIRLAILQQAPLADWLSLLSNEAKSKPEWRYWAAKNEKEA
EEEECHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHH
KKREASLIALSKERGFYPMLAAQLLGKQYVPTQGLLLKSDVQSRLQPQFDRIKELRDLQR
HHHHHHHEEEECCCCCHHHHHHHHHCCCCCCCCCCEEHHHHHHHHCCHHHHHHHHHHHHH
FAQAKTAWIELLDELSVDDKLAVTDYAKQQNWYDLAVEGTIQAKAFDYLSLRLPNAYSDW
HHHHHHHHHHHHHHCCCCCCEEHHHHHHCCCCEEEEEECEEEHHHHHHHEEECCCCCCCC
FDLNLEGKPISKTFAMAIARQESAWNFQARSHANALGLMQMLPSTAQKTAQDNQLPYRNE
EEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
QDLLQPFNNIMLGTTHLTELNAKYPNNRFLIAAAYNAGASRVERWLVRANGKLALDEFVA
HHHHHHHHHHEECCHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEHHHHHH
SIPFYETRGYVQNVVAYDYYQQLLQKVEKPIMFYKDEWQRKY
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]