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The map label for this gene is hsrA [H]

Identifier: 126208160

GI number: 126208160

Start: 776545

End: 777936

Strand: Reverse

Name: hsrA [H]

Synonym: APL_0680

Alternate gene names: 126208160

Gene position: 777936-776545 (Counterclockwise)

Preceding gene: 126208161

Following gene: 126208157

Centisome position: 34.2

GC content: 42.82

Gene sequence:

>1392_bases
ATGGGAGACGTTTCAAATAAAGGCTTGGCATGGATTGCCGCACTAGCGTTATTTATGCAAGCATTGGACGCAACCATTCT
TAATACCGCCTTACCGGCGATTTCCGACAGTCTAAAAGAATCGCCGTTAGATATGCAAATGGCAATTATCAGCTATGCTT
TGACCGTTGCCGCTTTAATTCCGTTAAGCGGCTGGTTAGCGGATAAATTTGGTACATTGCGAGTATTTCGCAGTGCGATT
TTGTTATTTGTATTAGGATCCGTCGCTTGTGCGTTGTCTTGGTCGTTAAACAGCTTAGTAGTGGCTCGTATCGTACAAGG
TGTCGGCGGAGCATTAATGATGCCGGTTGCTCGTTTGACGATTATTCGTAGCGTACCGAAAACGCAACTGGTCGCTACTT
GGAATTTAATGGCGATGGCAGGTTTAACCGGACCGATCCTCGGGCCGATTTTAGGCGGCTGGTTGGTTACTTATACCTCG
TGGCATTGGATTTTCTTAATTAATATTCCGATCGGATTGCTAGGCATCGCTATTGCCGGCAGATATATGCCGAATCTCAC
ACAACCGCCGCGTAAATTGGATTGGATCGGTTTTTTGCTATTTGCAAGCGGTTTAGTCGGATTAACGCTAGGTTTAGAAT
TTGCGGCGGAAGATACGGATAATGTTATGAGAGCCGTACCGATTTTAACAGTCGGTTTTATTCTTATCTGTGCCTATTGT
CTTTATGCTTACCGAGTAGCGGAGCCGTTATTGCCTTTGGCGATGTTTAAGATTCGCACTTTCCGAATCGGTATTTTATC
CAATATGTTGATTCGGTTAAGCGGTTCCGGTATCCCGTTTTTATTACCGTTAATGCTACAAGTCGCTTTTGGTTATAGTG
CGGATATCGCCGGTTGGCTTATGGCACCTTTAGCATTAAGTTCGGTTTTGGCAAAGTCGTTTATCGGTTCGGTATTAGAA
AAGCTGGGTTATCGAAACACCTTATTGATTAATGTGTTATTGATGACGTGCGCCATTATCGGAATGTCGTTCTTAGACGC
TCAATCACCGCTTTGGCTATTTATTTTATTGGTGATGTGGTTCGTGACTTGTATGTCGTTTATGTTTACCGCAGTAAATA
CCCTAACGGTGTGCGATTTAAGCGATCAATACGCCAGTGCCGGTTCAACCATGATGAGTGTGGTTCAGCAAGTCGGTATC
GGAATAGGAATTGCGGTATCTGCCGTGATTCTTGGTATTTATCGTGCAAATATCGGTGAAACGGATGTGTTATTAACTCA
AGCGTTTAGTTATACATTTCTAACTTCCGCTATATTCGGATTAATATTAGCACTTAATATTTCTCGTTTAGCTAGACAGG
ATGGTAATCATCTACATAATAAAAAAGCATAA

Upstream 100 bases:

>100_bases
GATGAAGCGTATAATACAAGCAGGTTAAATTCTGCAGAAATTTTACAAAATAATTCAAAAATTCAACCGCTTATCTTATC
CCTATCTTATGAGGTTTATA

Downstream 100 bases:

>100_bases
AAAAACGGTCGTAATGACCGTTTTTGTTTAAATCTAGTTTAATGAAAACTCTTTGCTGGTTGATTCGTATTTGATACCTG
AGTTTGAGCCTTCAGCACCG

Product: transport protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MGDVSNKGLAWIAALALFMQALDATILNTALPAISDSLKESPLDMQMAIISYALTVAALIPLSGWLADKFGTLRVFRSAI
LLFVLGSVACALSWSLNSLVVARIVQGVGGALMMPVARLTIIRSVPKTQLVATWNLMAMAGLTGPILGPILGGWLVTYTS
WHWIFLINIPIGLLGIAIAGRYMPNLTQPPRKLDWIGFLLFASGLVGLTLGLEFAAEDTDNVMRAVPILTVGFILICAYC
LYAYRVAEPLLPLAMFKIRTFRIGILSNMLIRLSGSGIPFLLPLMLQVAFGYSADIAGWLMAPLALSSVLAKSFIGSVLE
KLGYRNTLLINVLLMTCAIIGMSFLDAQSPLWLFILLVMWFVTCMSFMFTAVNTLTVCDLSDQYASAGSTMMSVVQQVGI
GIGIAVSAVILGIYRANIGETDVLLTQAFSYTFLTSAIFGLILALNISRLARQDGNHLHNKKA

Sequences:

>Translated_463_residues
MGDVSNKGLAWIAALALFMQALDATILNTALPAISDSLKESPLDMQMAIISYALTVAALIPLSGWLADKFGTLRVFRSAI
LLFVLGSVACALSWSLNSLVVARIVQGVGGALMMPVARLTIIRSVPKTQLVATWNLMAMAGLTGPILGPILGGWLVTYTS
WHWIFLINIPIGLLGIAIAGRYMPNLTQPPRKLDWIGFLLFASGLVGLTLGLEFAAEDTDNVMRAVPILTVGFILICAYC
LYAYRVAEPLLPLAMFKIRTFRIGILSNMLIRLSGSGIPFLLPLMLQVAFGYSADIAGWLMAPLALSSVLAKSFIGSVLE
KLGYRNTLLINVLLMTCAIIGMSFLDAQSPLWLFILLVMWFVTCMSFMFTAVNTLTVCDLSDQYASAGSTMMSVVQQVGI
GIGIAVSAVILGIYRANIGETDVLLTQAFSYTFLTSAIFGLILALNISRLARQDGNHLHNKKA
>Mature_462_residues
GDVSNKGLAWIAALALFMQALDATILNTALPAISDSLKESPLDMQMAIISYALTVAALIPLSGWLADKFGTLRVFRSAIL
LFVLGSVACALSWSLNSLVVARIVQGVGGALMMPVARLTIIRSVPKTQLVATWNLMAMAGLTGPILGPILGGWLVTYTSW
HWIFLINIPIGLLGIAIAGRYMPNLTQPPRKLDWIGFLLFASGLVGLTLGLEFAAEDTDNVMRAVPILTVGFILICAYCL
YAYRVAEPLLPLAMFKIRTFRIGILSNMLIRLSGSGIPFLLPLMLQVAFGYSADIAGWLMAPLALSSVLAKSFIGSVLEK
LGYRNTLLINVLLMTCAIIGMSFLDAQSPLWLFILLVMWFVTCMSFMFTAVNTLTVCDLSDQYASAGSTMMSVVQQVGIG
IGIAVSAVILGIYRANIGETDVLLTQAFSYTFLTSAIFGLILALNISRLARQDGNHLHNKKA

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=465, Percent_Identity=50.1075268817204, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1788392, Length=461, Percent_Identity=40.7809110629067, Blast_Score=298, Evalue=3e-82,
Organism=Escherichia coli, GI1789042, Length=408, Percent_Identity=28.1862745098039, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1788710, Length=410, Percent_Identity=30, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87081983, Length=407, Percent_Identity=25.0614250614251, Blast_Score=108, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6322958, Length=362, Percent_Identity=27.0718232044199, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6325455, Length=234, Percent_Identity=26.4957264957265, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49926; Mature: 49794

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDVSNKGLAWIAALALFMQALDATILNTALPAISDSLKESPLDMQMAIISYALTVAALI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
PLSGWLADKFGTLRVFRSAILLFVLGSVACALSWSLNSLVVARIVQGVGGALMMPVARLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IIRSVPKTQLVATWNLMAMAGLTGPILGPILGGWLVTYTSWHWIFLINIPIGLLGIAIAG
HHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHH
RYMPNLTQPPRKLDWIGFLLFASGLVGLTLGLEFAAEDTDNVMRAVPILTVGFILICAYC
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LYAYRVAEPLLPLAMFKIRTFRIGILSNMLIRLSGSGIPFLLPLMLQVAFGYSADIAGWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHH
MAPLALSSVLAKSFIGSVLEKLGYRNTLLINVLLMTCAIIGMSFLDAQSPLWLFILLVMW
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
FVTCMSFMFTAVNTLTVCDLSDQYASAGSTMMSVVQQVGIGIGIAVSAVILGIYRANIGE
HHHHHHHHHHHHHHHEEECCCHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
TDVLLTQAFSYTFLTSAIFGLILALNISRLARQDGNHLHNKKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
GDVSNKGLAWIAALALFMQALDATILNTALPAISDSLKESPLDMQMAIISYALTVAALI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]