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The map label for this gene is pgm [C]

Identifier: 126208073

GI number: 126208073

Start: 673326

End: 674984

Strand: Direct

Name: pgm [C]

Synonym: APL_0591

Alternate gene names: 126208073

Gene position: 673326-674984 (Clockwise)

Preceding gene: 126208070

Following gene: 126208076

Centisome position: 29.6

GC content: 42.19

Gene sequence:

>1659_bases
ATGAGTACAATTTTTACTATCGCCCAAAATTGGTTGGCACAAGATACGGATCAGGAAACTCGAGCTGAATTAGCGCAACT
TATTGAAATGGCGCACGCAGGCGATGAAAAAGCCTTAGCGGAATTGACCGCTCGTTTTGACGGTCGTTTACAATTCGGCA
CGGCAGGTTTACGTGGTCGTTTACAAGCAGGTTCTATGGGGATGAACCGAGTATTAGTGGCTCAAGCTGCTGGCGGTTTA
GCGGATTATTTAAAAGGCTACGATAAAGAACCTTCAATCGTTATCGGTTATGACGGTCGTAAAAACTCGGACGTGTTTGC
ACGTGATACCGCAGAAATTATGGCGGGTGCAGGGATTAAGGCTTATTTATTACCCCGTAAATTACCAACGCCTGTACTTG
CGTATGCAATTAAATATTTTGATACTACAGCGGGCGTTATGGTGACAGCAAGTCACAACCCACCGGAAGATAACGGTTAT
AAAGTGTATTTAGGTAAAGCAAACGGCGGTGGTCAAATCGTTTCGCCGGCGGATAAAGATATTGCGGCATTAATTGATAA
AGTGGCGGCAGGTAATATTGCGGATCTACCACGTAGCCAAGACTTTACGGTATTAGATGATGAAATCGTAGAAGCATATA
TCGAAAAAACAGCTGCATTAGCGAAAGAGCAGGCAGCAGAGATTAACTATGTTTATACCGCAATGCATGGTGTCGGTTAT
GAAGTGTTAAGCAAAACGTTAGAAAAAGCCGGCTTACCGCAACCGCATTTAGTGGCGGAACAAATTCAACCGGACGGTTC
TTTCCCAACCGTGAATTTCCCAAATCCGGAAGAAAAAGGTGCATTAGACTTAGCAATTAAATTAGCGAAAGAGAAGAATG
CGGAATTTATCATTGCCAATGATCCTGACGCAGACCGTTTAGCGGTAGCTATGCCGGATGCACAAGGTAACTGGAAAGGT
TTACACGGTAACGTTGTTGGCTGTTTATTAGGTTGGTATTTAGCTAAACAGTATCACGCACAAGGTAAACAAGGCGTATT
AGCTTGTTCATTAGTGTCTTCGCCGGCATTGGCTGAAATTGCGAAAAAATACGGTTTACAATCGGAAGAAACTTTAACCG
GCTTTAAATATATCGGTAAAGTAAACGGCTTATTATTCGGTTTTGAAGAAGCGTTAGGCTATTTGGTTGACCCTGATAAA
GTACGTGATAAAGACGGTATTTCAGCGGCTATTGTGTTCTTAGATTTTATCCGTAACTTAAAAGCACAAGGTAAAACGTT
GCAAGACGCAATCACCGATTTCAATAATGAATTCGGTGCTTATGTAAGCGGTCAAATTTCAATTCGTGTCAGCGATTTAT
CTGAAATCGGTAAATTAATGACGGCATTACGCAACAACCCACCAAGTGCAATCGGTAGTTTCAACGTGGTGCAATTAATT
GACCATACGAAAACGGATCGTCAAAGCGATATTTTGGTATTCGTATTAGAAAACGGTAGCCGTTTAATCACTCGTCCGTC
CGGTACGGAACCGAAAATTAAGTTCTACTTAGATGCGAAAGGTAAAGATGCAGCGGATGCAGACAAAGTATTAAGCCAAT
TTGACGAAAGCGTACGTGAATTATTACGCCAAGAGCAATACGGCAAACAAGATTGCTAA

Upstream 100 bases:

>100_bases
ACAAACTTACTAAAAAGATGAAAGAAATCATTTTTATTTATGTTATTTTCCGCTAGGCTATATATGTTTTATCATTTATT
TTTTAGTATAAGGAATTGCT

Downstream 100 bases:

>100_bases
TTAGCATAAAGAAAAGCCCTGTGTTTACAGGGCTTTGAGCTATTTTTGAAATGAATTGAAATTAACTGAAAAGCGGATTT
TTTATTCCCACTCAATCGTT

Product: phosphoglucomutase/phosphomannomutase

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MSTIFTIAQNWLAQDTDQETRAELAQLIEMAHAGDEKALAELTARFDGRLQFGTAGLRGRLQAGSMGMNRVLVAQAAGGL
ADYLKGYDKEPSIVIGYDGRKNSDVFARDTAEIMAGAGIKAYLLPRKLPTPVLAYAIKYFDTTAGVMVTASHNPPEDNGY
KVYLGKANGGGQIVSPADKDIAALIDKVAAGNIADLPRSQDFTVLDDEIVEAYIEKTAALAKEQAAEINYVYTAMHGVGY
EVLSKTLEKAGLPQPHLVAEQIQPDGSFPTVNFPNPEEKGALDLAIKLAKEKNAEFIIANDPDADRLAVAMPDAQGNWKG
LHGNVVGCLLGWYLAKQYHAQGKQGVLACSLVSSPALAEIAKKYGLQSEETLTGFKYIGKVNGLLFGFEEALGYLVDPDK
VRDKDGISAAIVFLDFIRNLKAQGKTLQDAITDFNNEFGAYVSGQISIRVSDLSEIGKLMTALRNNPPSAIGSFNVVQLI
DHTKTDRQSDILVFVLENGSRLITRPSGTEPKIKFYLDAKGKDAADADKVLSQFDESVRELLRQEQYGKQDC

Sequences:

>Translated_552_residues
MSTIFTIAQNWLAQDTDQETRAELAQLIEMAHAGDEKALAELTARFDGRLQFGTAGLRGRLQAGSMGMNRVLVAQAAGGL
ADYLKGYDKEPSIVIGYDGRKNSDVFARDTAEIMAGAGIKAYLLPRKLPTPVLAYAIKYFDTTAGVMVTASHNPPEDNGY
KVYLGKANGGGQIVSPADKDIAALIDKVAAGNIADLPRSQDFTVLDDEIVEAYIEKTAALAKEQAAEINYVYTAMHGVGY
EVLSKTLEKAGLPQPHLVAEQIQPDGSFPTVNFPNPEEKGALDLAIKLAKEKNAEFIIANDPDADRLAVAMPDAQGNWKG
LHGNVVGCLLGWYLAKQYHAQGKQGVLACSLVSSPALAEIAKKYGLQSEETLTGFKYIGKVNGLLFGFEEALGYLVDPDK
VRDKDGISAAIVFLDFIRNLKAQGKTLQDAITDFNNEFGAYVSGQISIRVSDLSEIGKLMTALRNNPPSAIGSFNVVQLI
DHTKTDRQSDILVFVLENGSRLITRPSGTEPKIKFYLDAKGKDAADADKVLSQFDESVRELLRQEQYGKQDC
>Mature_551_residues
STIFTIAQNWLAQDTDQETRAELAQLIEMAHAGDEKALAELTARFDGRLQFGTAGLRGRLQAGSMGMNRVLVAQAAGGLA
DYLKGYDKEPSIVIGYDGRKNSDVFARDTAEIMAGAGIKAYLLPRKLPTPVLAYAIKYFDTTAGVMVTASHNPPEDNGYK
VYLGKANGGGQIVSPADKDIAALIDKVAAGNIADLPRSQDFTVLDDEIVEAYIEKTAALAKEQAAEINYVYTAMHGVGYE
VLSKTLEKAGLPQPHLVAEQIQPDGSFPTVNFPNPEEKGALDLAIKLAKEKNAEFIIANDPDADRLAVAMPDAQGNWKGL
HGNVVGCLLGWYLAKQYHAQGKQGVLACSLVSSPALAEIAKKYGLQSEETLTGFKYIGKVNGLLFGFEEALGYLVDPDKV
RDKDGISAAIVFLDFIRNLKAQGKTLQDAITDFNNEFGAYVSGQISIRVSDLSEIGKLMTALRNNPPSAIGSFNVVQLID
HTKTDRQSDILVFVLENGSRLITRPSGTEPKIKFYLDAKGKDAADADKVLSQFDESVRELLRQEQYGKQDC

Specific function: Unknown

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=596, Percent_Identity=34.0604026845638, Blast_Score=298, Evalue=1e-80,
Organism=Homo sapiens, GI31377548, Length=561, Percent_Identity=34.4028520499109, Blast_Score=276, Evalue=2e-74,
Organism=Escherichia coli, GI1789566, Length=504, Percent_Identity=25.9920634920635, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786904, Length=531, Percent_Identity=23.728813559322, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71993870, Length=589, Percent_Identity=33.955857385399, Blast_Score=298, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI71993878, Length=368, Percent_Identity=33.9673913043478, Blast_Score=190, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6323934, Length=612, Percent_Identity=35.4575163398693, Blast_Score=283, Evalue=4e-77,
Organism=Drosophila melanogaster, GI20129809, Length=594, Percent_Identity=34.3434343434343, Blast_Score=285, Evalue=7e-77,
Organism=Drosophila melanogaster, GI24651977, Length=548, Percent_Identity=34.6715328467153, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24653722, Length=608, Percent_Identity=31.7434210526316, Blast_Score=238, Evalue=7e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 59776; Mature: 59645

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIFTIAQNWLAQDTDQETRAELAQLIEMAHAGDEKALAELTARFDGRLQFGTAGLRGR
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCCCCCC
LQAGSMGMNRVLVAQAAGGLADYLKGYDKEPSIVIGYDGRKNSDVFARDTAEIMAGAGIK
CCCCCCCCCEEEEEHHCCCHHHHHCCCCCCCCEEEEECCCCCCCEEHHHHHHHHHCCCCE
AYLLPRKLPTPVLAYAIKYFDTTAGVMVTASHNPPEDNGYKVYLGKANGGGQIVSPADKD
EEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCHH
IAALIDKVAAGNIADLPRSQDFTVLDDEIVEAYIEKTAALAKEQAAEINYVYTAMHGVGY
HHHHHHHHHCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHCCH
EVLSKTLEKAGLPQPHLVAEQIQPDGSFPTVNFPNPEEKGALDLAIKLAKEKNAEFIIAN
HHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHEEEHHCCCCCEEEEC
DPDADRLAVAMPDAQGNWKGLHGNVVGCLLGWYLAKQYHAQGKQGVLACSLVSSPALAEI
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHH
AKKYGLQSEETLTGFKYIGKVNGLLFGFEEALGYLVDPDKVRDKDGISAAIVFLDFIRNL
HHHHCCCCCHHHHHHHHHHHHHHHEEEHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHH
KAQGKTLQDAITDFNNEFGAYVSGQISIRVSDLSEIGKLMTALRNNPPSAIGSFNVVQLI
HHCCCHHHHHHHHHCCCCCCEEEEEEEEEEHHHHHHHHHHHHHHCCCCCHHCCCHHHHHH
DHTKTDRQSDILVFVLENGSRLITRPSGTEPKIKFYLDAKGKDAADADKVLSQFDESVRE
HCCCCCCCCCEEEEEEECCCEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHH
LLRQEQYGKQDC
HHHHHHCCCCCC
>Mature Secondary Structure 
STIFTIAQNWLAQDTDQETRAELAQLIEMAHAGDEKALAELTARFDGRLQFGTAGLRGR
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCCCCCC
LQAGSMGMNRVLVAQAAGGLADYLKGYDKEPSIVIGYDGRKNSDVFARDTAEIMAGAGIK
CCCCCCCCCEEEEEHHCCCHHHHHCCCCCCCCEEEEECCCCCCCEEHHHHHHHHHCCCCE
AYLLPRKLPTPVLAYAIKYFDTTAGVMVTASHNPPEDNGYKVYLGKANGGGQIVSPADKD
EEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCHH
IAALIDKVAAGNIADLPRSQDFTVLDDEIVEAYIEKTAALAKEQAAEINYVYTAMHGVGY
HHHHHHHHHCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHCCH
EVLSKTLEKAGLPQPHLVAEQIQPDGSFPTVNFPNPEEKGALDLAIKLAKEKNAEFIIAN
HHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHEEEHHCCCCCEEEEC
DPDADRLAVAMPDAQGNWKGLHGNVVGCLLGWYLAKQYHAQGKQGVLACSLVSSPALAEI
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHH
AKKYGLQSEETLTGFKYIGKVNGLLFGFEEALGYLVDPDKVRDKDGISAAIVFLDFIRNL
HHHHCCCCCHHHHHHHHHHHHHHHEEEHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHH
KAQGKTLQDAITDFNNEFGAYVSGQISIRVSDLSEIGKLMTALRNNPPSAIGSFNVVQLI
HHCCCHHHHHHHHHCCCCCCEEEEEEEEEEHHHHHHHHHHHHHHCCCCCHHCCCHHHHHH
DHTKTDRQSDILVFVLENGSRLITRPSGTEPKIKFYLDAKGKDAADADKVLSQFDESVRE
HCCCCCCCCCEEEEEEECCCEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHH
LLRQEQYGKQDC
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]