Click here to switch to the map view.

The map label for this gene is glmU

Identifier: 126208070

GI number: 126208070

Start: 670619

End: 671992

Strand: Direct

Name: glmU

Synonym: APL_0588

Alternate gene names: 126208070

Gene position: 670619-671992 (Clockwise)

Preceding gene: 126208069

Following gene: 126208073

Centisome position: 29.48

GC content: 43.67

Gene sequence:

>1374_bases
ATGACTCAACTAAGCGTAGTAATTTTAGCGGCGGGTAAAGGTACTCGTATGTATTCTGATTTACCCAAAGTGCTTCACAC
CGTTGCAGGTAAGCCGATGGTTCAACATGTTATCGATACGGCAAAGCAGATCGATGCCAAACAAATCCATTTAATTTATG
GCCACGGTGGCGAATTATTACAACAACGCTTAAGTTCTGAGCCGGTAAACTGGGTATTACAAGCAGAGCAATTAGGTACA
GGCCATGCAATGCAACAAGCGGCACCATTCTTTGCTGATGATGAAAATATCTTAATGCTTTATGGTGATGCGCCGTTAAT
TACTAAAGAAACCCTGGAGCGTTTAATCGCAGCAAAACCGGCAAACGGTATCGCATTATTAACCGTAGAATTGGAAAACC
CGACCGGTTACGGACGCATTATTCGTGAAAACGGCTCGGTGGTTGCAATTGTAGAACAAAAAGATGCGAATGCAGAACAA
TTGAAAATTCGTGAAGTGAATACCGGCGTAATGGTAGCGAGCGGTGCCAGTTTCAAAAAATGGCTGGCTAATTTGAATAA
CAATAATGCACAGGGCGAATACTATATTACCGATGTAATCGCTATGGCAAATCAAGACGGCTATAAAGTTCAAGCGGTAC
AAGCGAGTGAGTTTATGGAAGTTGAAGGGGCGAATAACCGTTTACAACTTGCCGCATTAGAGCGTTTCTACCAAAAAACG
CAAGCGGAAAAATTACTGTTAGCCGGCGTGCGTTTAATTGATCCGGCTCGTTTTGATATTCGTGGTAGCTTAACTCACGG
TAAAGATGTTGAAATTGATGTAAACGTCATTATCGAAGGTGAAGTAAAACTGGGTAATCGTGTTCGTATCGGTGCAGGTT
GTGTACTTAAAAACTGCGAAATCGGCGATGATGTAGAAATTAAACCGTATTCTGTGATTGAAGATGCGGTAGTGGGTAAA
GCGGCACAAATCGGTCCGTTCTCTCGTTTACGTCCGGGGGCAAATCTTGCGGAAGAAACTCATGTCGGTAACTTCGTTGA
GATTAAAAACGCACAAGTCGGTAAAGGATCAAAAGTAAACCACTTAACTTATGTCGGTGATGCGGAAGTGGGGAGCAATT
GTAATATCGGTGCGGGTGTAATTACTTGCAACTATGACGGTGCAAACAAATTCAAAACGATTATCGGTAACAATGTGTTT
GTCGGCTCGGACAGCCAATTAGTCGCACCGGTGACTATCGCAGACGGTGCAACAATCGGTGCGGGTGCAACCGTAACTAA
AGATGTGGCGGAAAACGAGTTGGTGATTAGCCGTGTACCACAACGTCATATTCAAGGCTGGCAGCGTCCGACAAAGAAAA
AAATAGCGGATTAA

Upstream 100 bases:

>100_bases
ATGAAGAAAATGTATTTTAGCAATATGTAGTTCATTCTGTTTATGGCGTTTTTCTATTACAATATTATAGTATTTATTTA
ATTCATTAAGGGATTACACA

Downstream 100 bases:

>100_bases
CCTCAAAATATAAAAATTAACAAGCGGTCGTTTTCGCAGATTTTTTTGCAAAAACGACCGCTTGCTTTTTTGATATTTAT
ATGGATTTCAATCTATTTTT

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTQLSVVILAAGKGTRMYSDLPKVLHTVAGKPMVQHVIDTAKQIDAKQIHLIYGHGGELLQQRLSSEPVNWVLQAEQLGT
GHAMQQAAPFFADDENILMLYGDAPLITKETLERLIAAKPANGIALLTVELENPTGYGRIIRENGSVVAIVEQKDANAEQ
LKIREVNTGVMVASGASFKKWLANLNNNNAQGEYYITDVIAMANQDGYKVQAVQASEFMEVEGANNRLQLAALERFYQKT
QAEKLLLAGVRLIDPARFDIRGSLTHGKDVEIDVNVIIEGEVKLGNRVRIGAGCVLKNCEIGDDVEIKPYSVIEDAVVGK
AAQIGPFSRLRPGANLAEETHVGNFVEIKNAQVGKGSKVNHLTYVGDAEVGSNCNIGAGVITCNYDGANKFKTIIGNNVF
VGSDSQLVAPVTIADGATIGAGATVTKDVAENELVISRVPQRHIQGWQRPTKKKIAD

Sequences:

>Translated_457_residues
MTQLSVVILAAGKGTRMYSDLPKVLHTVAGKPMVQHVIDTAKQIDAKQIHLIYGHGGELLQQRLSSEPVNWVLQAEQLGT
GHAMQQAAPFFADDENILMLYGDAPLITKETLERLIAAKPANGIALLTVELENPTGYGRIIRENGSVVAIVEQKDANAEQ
LKIREVNTGVMVASGASFKKWLANLNNNNAQGEYYITDVIAMANQDGYKVQAVQASEFMEVEGANNRLQLAALERFYQKT
QAEKLLLAGVRLIDPARFDIRGSLTHGKDVEIDVNVIIEGEVKLGNRVRIGAGCVLKNCEIGDDVEIKPYSVIEDAVVGK
AAQIGPFSRLRPGANLAEETHVGNFVEIKNAQVGKGSKVNHLTYVGDAEVGSNCNIGAGVITCNYDGANKFKTIIGNNVF
VGSDSQLVAPVTIADGATIGAGATVTKDVAENELVISRVPQRHIQGWQRPTKKKIAD
>Mature_456_residues
TQLSVVILAAGKGTRMYSDLPKVLHTVAGKPMVQHVIDTAKQIDAKQIHLIYGHGGELLQQRLSSEPVNWVLQAEQLGTG
HAMQQAAPFFADDENILMLYGDAPLITKETLERLIAAKPANGIALLTVELENPTGYGRIIRENGSVVAIVEQKDANAEQL
KIREVNTGVMVASGASFKKWLANLNNNNAQGEYYITDVIAMANQDGYKVQAVQASEFMEVEGANNRLQLAALERFYQKTQ
AEKLLLAGVRLIDPARFDIRGSLTHGKDVEIDVNVIIEGEVKLGNRVRIGAGCVLKNCEIGDDVEIKPYSVIEDAVVGKA
AQIGPFSRLRPGANLAEETHVGNFVEIKNAQVGKGSKVNHLTYVGDAEVGSNCNIGAGVITCNYDGANKFKTIIGNNVFV
GSDSQLVAPVTIADGATIGAGATVTKDVAENELVISRVPQRHIQGWQRPTKKKIAD

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=451, Percent_Identity=70.7317073170732, Blast_Score=674, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_ACTP2 (A3MZV4)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053295.1
- ProteinModelPortal:   A3MZV4
- SMR:   A3MZV4
- STRING:   A3MZV4
- GeneID:   4848525
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0588
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   A3MZV4
- ProtClustDB:   PRK09451
- BioCyc:   APLE416269:APL_0588-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 49267; Mature: 49136

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 361-361 BINDING 74-74 BINDING 138-138 BINDING 152-152 BINDING 167-167 BINDING 385-385 BINDING 403-403 BINDING 421-421 BINDING 438-438

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLSVVILAAGKGTRMYSDLPKVLHTVAGKPMVQHVIDTAKQIDAKQIHLIYGHGGELL
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHH
QQRLSSEPVNWVLQAEQLGTGHAMQQAAPFFADDENILMLYGDAPLITKETLERLIAAKP
HHHHCCCCCEEEEEECCCCCCHHHHHCCCCEECCCCEEEEECCCCCCCHHHHHHHHHCCC
ANGIALLTVELENPTGYGRIIRENGSVVAIVEQKDANAEQLKIREVNTGVMVASGASFKK
CCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCHHEEEEEECCCEEEECCCHHHH
WLANLNNNNAQGEYYITDVIAMANQDGYKVQAVQASEFMEVEGANNRLQLAALERFYQKT
HHHHCCCCCCCCCEEEEEEEEECCCCCCEEEEEECCCEEEECCCCCEEEHHHHHHHHHHH
QAEKLLLAGVRLIDPARFDIRGSLTHGKDVEIDVNVIIEGEVKLGNRVRIGAGCVLKNCE
HHHHHHHHCCEEECCCCEEEEECCCCCCCEEEEEEEEEEEEEEECCEEEECCCEEEECCC
IGDDVEIKPYSVIEDAVVGKAAQIGPFSRLRPGANLAEETHVGNFVEIKNAQVGKGSKVN
CCCCCCCCCHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHCCCCEEEECCCCCCCCCCCE
HLTYVGDAEVGSNCNIGAGVITCNYDGANKFKTIIGNNVFVGSDSQLVAPVTIADGATIG
EEEEECCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCEEEECCCCCEEEEEEEECCCEEC
AGATVTKDVAENELVISRVPQRHIQGWQRPTKKKIAD
CCCEEEHHHCCCCCHHHCCCHHHHHHHCCCCHHHCCC
>Mature Secondary Structure 
TQLSVVILAAGKGTRMYSDLPKVLHTVAGKPMVQHVIDTAKQIDAKQIHLIYGHGGELL
CCEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHH
QQRLSSEPVNWVLQAEQLGTGHAMQQAAPFFADDENILMLYGDAPLITKETLERLIAAKP
HHHHCCCCCEEEEEECCCCCCHHHHHCCCCEECCCCEEEEECCCCCCCHHHHHHHHHCCC
ANGIALLTVELENPTGYGRIIRENGSVVAIVEQKDANAEQLKIREVNTGVMVASGASFKK
CCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCHHEEEEEECCCEEEECCCHHHH
WLANLNNNNAQGEYYITDVIAMANQDGYKVQAVQASEFMEVEGANNRLQLAALERFYQKT
HHHHCCCCCCCCCEEEEEEEEECCCCCCEEEEEECCCEEEECCCCCEEEHHHHHHHHHHH
QAEKLLLAGVRLIDPARFDIRGSLTHGKDVEIDVNVIIEGEVKLGNRVRIGAGCVLKNCE
HHHHHHHHCCEEECCCCEEEEECCCCCCCEEEEEEEEEEEEEEECCEEEECCCEEEECCC
IGDDVEIKPYSVIEDAVVGKAAQIGPFSRLRPGANLAEETHVGNFVEIKNAQVGKGSKVN
CCCCCCCCCHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHCCCCEEEECCCCCCCCCCCE
HLTYVGDAEVGSNCNIGAGVITCNYDGANKFKTIIGNNVFVGSDSQLVAPVTIADGATIG
EEEEECCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCEEEECCCCCEEEEEEEECCCEEC
AGATVTKDVAENELVISRVPQRHIQGWQRPTKKKIAD
CCCEEEHHHCCCCCHHHCCCHHHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA