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The map label for this gene is era

Identifier: 126208026

GI number: 126208026

Start: 614750

End: 615664

Strand: Direct

Name: era

Synonym: APL_0544

Alternate gene names: 126208026

Gene position: 614750-615664 (Clockwise)

Preceding gene: 126208025

Following gene: 126208027

Centisome position: 27.03

GC content: 41.64

Gene sequence:

>915_bases
ATGACAGAACAAAATCAACAACCTAAAACCTACTGCGGCTTTATCGCCATTGTCGGTCGCCCGAATGTCGGCAAATCGAC
CTTATTAAATAAAATTTTAGGTCAAAAAATTTCAATTACTTCTCGTAAAGCGCAGACAACTCGTCACCGTATTGTCGGTA
TTCATACCGAAGATCAATATCAAGCGATTTACGTGGATACGCCGGGGTTACATATCGAAGAAAAACGAGCAATTAACCGT
TTAATGAACCGCGCGGCAAGCTCGGCAATCGGCGATGTGGATTTAATTATTTTCGTGGTGGAAGGCACAAAGTGGACCGA
CGATGACGAAATGGTATTAAATAAATTGCGTTCAGCAAAAGCGCCGGTGGTATTAGCGATTAATAAAGTTGATAACATTA
AAGAAAAAGACGAACTTTTACCGCATATTACCGAGCTTTCACAAAAATTCGATTTCGCAGAAATTTTACCGATCTCGGCA
CAACGTGGTAAAAACGTACATATCCTGCAAAAAATCGTGCGTAAATCCTTACGTGAAGGGGTGCACCATTTCCCTGAAGA
ATATGTTACCGACCGTAGCCAACGTTTTATGGCATCGGAAATCATTCGTGAAAAATTAATGCGTTTCACCGGTGAAGAAT
TGCCGTATTCGGTTACGGTAGAAATCGAACAATTTAAACTGAACGAGCGCGGTACTTATGAAATCAACGGTTTGATTTTG
GTTGAGCGTGAAGGTCAGAAAAAAATGGTGATTGGTGCGAAAGGGCAAAAAATCAAAACGATTGGAATGGAAGCGCGTGC
CGATATGGAACGCTTGTTTGATAACAAAGTTCACTTGGAATTATGGGTGAAAGTGAAAGCCGGCTGGGCGGATGACGAAC
GTGCATTACGCAGTTTAGGTTATATGGACGAGTAA

Upstream 100 bases:

>100_bases
ACAAGTATTGGCTAAACTAACGACGAAATAGAAGAAACCACAGAAATATACACTGATACCGTATTTTGTTGGTATCTCTG
TGGAAAATAAAGGATAAAAA

Downstream 100 bases:

>100_bases
ACCTCAATAATGATCGAAAACTGGCATCGAGGTTTTGTTCTTCACCGTCGCGAATATAGCGAAACAAGTCTATTAGTCGA
TTTCTTTACCGAAGAACACG

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MTEQNQQPKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIHTEDQYQAIYVDTPGLHIEEKRAINR
LMNRAASSAIGDVDLIIFVVEGTKWTDDDEMVLNKLRSAKAPVVLAINKVDNIKEKDELLPHITELSQKFDFAEILPISA
QRGKNVHILQKIVRKSLREGVHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIEQFKLNERGTYEINGLIL
VEREGQKKMVIGAKGQKIKTIGMEARADMERLFDNKVHLELWVKVKAGWADDERALRSLGYMDE

Sequences:

>Translated_304_residues
MTEQNQQPKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIHTEDQYQAIYVDTPGLHIEEKRAINR
LMNRAASSAIGDVDLIIFVVEGTKWTDDDEMVLNKLRSAKAPVVLAINKVDNIKEKDELLPHITELSQKFDFAEILPISA
QRGKNVHILQKIVRKSLREGVHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIEQFKLNERGTYEINGLIL
VEREGQKKMVIGAKGQKIKTIGMEARADMERLFDNKVHLELWVKVKAGWADDERALRSLGYMDE
>Mature_303_residues
TEQNQQPKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIHTEDQYQAIYVDTPGLHIEEKRAINRL
MNRAASSAIGDVDLIIFVVEGTKWTDDDEMVLNKLRSAKAPVVLAINKVDNIKEKDELLPHITELSQKFDFAEILPISAQ
RGKNVHILQKIVRKSLREGVHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIEQFKLNERGTYEINGLILV
EREGQKKMVIGAKGQKIKTIGMEARADMERLFDNKVHLELWVKVKAGWADDERALRSLGYMDE

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=320, Percent_Identity=27.5, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1788919, Length=296, Percent_Identity=78.3783783783784, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI87082120, Length=153, Percent_Identity=31.3725490196078, Blast_Score=66, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24646434, Length=302, Percent_Identity=25.1655629139073, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_ACTP2 (A3MZR0)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053251.1
- ProteinModelPortal:   A3MZR0
- SMR:   A3MZR0
- STRING:   A3MZR0
- GeneID:   4850396
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0544
- eggNOG:   COG1159
- HOGENOM:   HBG561652
- OMA:   AKDWQRD
- PhylomeDB:   A3MZR0
- ProtClustDB:   PRK00089
- BioCyc:   APLE416269:APL_0544-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PRINTS:   PR00326
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 34797; Mature: 34666

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQNQQPKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIHTEDQY
CCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHCCEEEECCHHHHHCCEEEEEEEECCCE
QAIYVDTPGLHIEEKRAINRLMNRAASSAIGDVDLIIFVVEGTKWTDDDEMVLNKLRSAK
EEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHCCC
APVVLAINKVDNIKEKDELLPHITELSQKFDFAEILPISAQRGKNVHILQKIVRKSLREG
CCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHEEECHHCCCCCHHHHHHHHHHHHHHH
VHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIEQFKLNERGTYEINGLIL
HHHCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCEEEEEEEE
VEREGQKKMVIGAKGQKIKTIGMEARADMERLFDNKVHLELWVKVKAGWADDERALRSLG
EEECCCCEEEEECCCCEEEEECCHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHHCC
YMDE
CCCC
>Mature Secondary Structure 
TEQNQQPKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIHTEDQY
CCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHCCEEEECCHHHHHCCEEEEEEEECCCE
QAIYVDTPGLHIEEKRAINRLMNRAASSAIGDVDLIIFVVEGTKWTDDDEMVLNKLRSAK
EEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHCCC
APVVLAINKVDNIKEKDELLPHITELSQKFDFAEILPISAQRGKNVHILQKIVRKSLREG
CCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHEEECHHCCCCCHHHHHHHHHHHHHHH
VHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIEQFKLNERGTYEINGLIL
HHHCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCEEEEEEEE
VEREGQKKMVIGAKGQKIKTIGMEARADMERLFDNKVHLELWVKVKAGWADDERALRSLG
EEECCCCEEEEECCCCEEEEECCHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHHCC
YMDE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA