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The map label for this gene is rnc

Identifier: 126208025

GI number: 126208025

Start: 614009

End: 614680

Strand: Direct

Name: rnc

Synonym: APL_0543

Alternate gene names: 126208025

Gene position: 614009-614680 (Clockwise)

Preceding gene: 126208024

Following gene: 126208026

Centisome position: 27.0

GC content: 41.07

Gene sequence:

>672_bases
ATGCAACTCGAAAGATTACAGAAAAAATTAAGTTATCAATTTACTAACTTGGATTATCTATTACAGGCTTTAACTCACCG
AAGCGCAGGGGCAAAAAATAATGAACGCTTAGAATTTTTGGGCGATTCGATTTTAAATTTTGCGATCGGTAAAGCGTTAT
TTGAGAAGTTTCCTAAGGCAAATGAAGGCGAATTAAGCCGTATGCGCGCAACATTAGTACGCGAACAAACGTTAGCGATT
TTAGCGCGTCAATTCGGCTTAGGCGAATATATGAGATTAGGTGCGGGCGAATTAAAAAGCGGCGGTTATCGCCGTGAATC
GATTCTTTCCGACTGTGTCGAAGCGATTATTGCCGCTATTTACTTAGATGCGGGCATGGATAAGGCGATTGAACAAGTTC
ATCTGTGGTATCAGGATTTACTAGCCGAGATGAAACCGGGCGATGCGCAAAAAGATCCGAAAACACGCTTACAAGAATTT
TTACAAGGCCGTAAATTACCGTTACCAACTTACGAAGTGTTGGATATTAAAGGTGAAGCGCATAATCAAACCTTTAAAGT
GACTTGCAAAATTGAAATGTTGGAAGAAATCTTTATCGGCATCGGTACCAGCCGCCGTAAAGCGGAACAAAATGCAGCCG
AACAAGTATTGGCTAAACTAACGACGAAATAG

Upstream 100 bases:

>100_bases
TTAATATTTGAGCGAAGTACATCATACAAGCGGGTCTTTTTTGTCAAAAATCGGCAAAATACGACCGCTTGTATTTTTGC
TTTGTTTTAGAATGAATAAT

Downstream 100 bases:

>100_bases
AAGAAACCACAGAAATATACACTGATACCGTATTTTGTTGGTATCTCTGTGGAAAATAAAGGATAAAAAATGACAGAACA
AAATCAACAACCTAAAACCT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MQLERLQKKLSYQFTNLDYLLQALTHRSAGAKNNERLEFLGDSILNFAIGKALFEKFPKANEGELSRMRATLVREQTLAI
LARQFGLGEYMRLGAGELKSGGYRRESILSDCVEAIIAAIYLDAGMDKAIEQVHLWYQDLLAEMKPGDAQKDPKTRLQEF
LQGRKLPLPTYEVLDIKGEAHNQTFKVTCKIEMLEEIFIGIGTSRRKAEQNAAEQVLAKLTTK

Sequences:

>Translated_223_residues
MQLERLQKKLSYQFTNLDYLLQALTHRSAGAKNNERLEFLGDSILNFAIGKALFEKFPKANEGELSRMRATLVREQTLAI
LARQFGLGEYMRLGAGELKSGGYRRESILSDCVEAIIAAIYLDAGMDKAIEQVHLWYQDLLAEMKPGDAQKDPKTRLQEF
LQGRKLPLPTYEVLDIKGEAHNQTFKVTCKIEMLEEIFIGIGTSRRKAEQNAAEQVLAKLTTK
>Mature_223_residues
MQLERLQKKLSYQFTNLDYLLQALTHRSAGAKNNERLEFLGDSILNFAIGKALFEKFPKANEGELSRMRATLVREQTLAI
LARQFGLGEYMRLGAGELKSGGYRRESILSDCVEAIIAAIYLDAGMDKAIEQVHLWYQDLLAEMKPGDAQKDPKTRLQEF
LQGRKLPLPTYEVLDIKGEAHNQTFKVTCKIEMLEEIFIGIGTSRRKAEQNAAEQVLAKLTTK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=228, Percent_Identity=30.2631578947368, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI155030236, Length=228, Percent_Identity=30.2631578947368, Blast_Score=99, Evalue=3e-21,
Organism=Escherichia coli, GI1788920, Length=218, Percent_Identity=60.5504587155963, Blast_Score=263, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI17506883, Length=231, Percent_Identity=29.004329004329, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI193202651, Length=231, Percent_Identity=29.004329004329, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17137682, Length=229, Percent_Identity=27.5109170305677, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_ACTP2 (A3MZQ9)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053250.1
- ProteinModelPortal:   A3MZQ9
- SMR:   A3MZQ9
- STRING:   A3MZQ9
- GeneID:   4849615
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0543
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   A3MZQ9
- ProtClustDB:   PRK00102
- BioCyc:   APLE416269:APL_0543-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25255; Mature: 25255

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLERLQKKLSYQFTNLDYLLQALTHRSAGAKNNERLEFLGDSILNFAIGKALFEKFPKA
CCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
NEGELSRMRATLVREQTLAILARQFGLGEYMRLGAGELKSGGYRRESILSDCVEAIIAAI
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHH
YLDAGMDKAIEQVHLWYQDLLAEMKPGDAQKDPKTRLQEFLQGRKLPLPTYEVLDIKGEA
HHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCHHEEECCCCC
HNQTFKVTCKIEMLEEIFIGIGTSRRKAEQNAAEQVLAKLTTK
CCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQLERLQKKLSYQFTNLDYLLQALTHRSAGAKNNERLEFLGDSILNFAIGKALFEKFPKA
CCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
NEGELSRMRATLVREQTLAILARQFGLGEYMRLGAGELKSGGYRRESILSDCVEAIIAAI
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHH
YLDAGMDKAIEQVHLWYQDLLAEMKPGDAQKDPKTRLQEFLQGRKLPLPTYEVLDIKGEA
HHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCHHEEECCCCC
HNQTFKVTCKIEMLEEIFIGIGTSRRKAEQNAAEQVLAKLTTK
CCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA