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The map label for this gene is lepB [H]

Identifier: 126208024

GI number: 126208024

Start: 612953

End: 613912

Strand: Direct

Name: lepB [H]

Synonym: APL_0542

Alternate gene names: 126208024

Gene position: 612953-613912 (Clockwise)

Preceding gene: 126208023

Following gene: 126208025

Centisome position: 26.95

GC content: 41.15

Gene sequence:

>960_bases
ATGGCGCAAATTATGCCGATTATTTTTATCGCAATTTTATATGGTGTTTGGAACACATTGGATTCAATGCAGTTACCGAA
CACCATTTCTATATTATTGGTTGCATTAGTCGTTATTTGCGGCGGTTTTTGGGCATTCTATAAATTTAGTGCGGATCCTC
GTCGTAATGCGGCAATTGCCAGAGAAGAAAAACGTTTAAACCGTCCTTTAACCGAAGAAGAAAAAGCGGAAATTCAACCT
CGTTCCTCTATCGGTGATTTCTTCGCTTCGCTTTTCGGCGTATTGTTTTTTGTCACGGTGCTACGCTCGTTTATTTTTGA
ACCGTTTCAAATCCCGAGCGGTTCGATGGAACCGACCCTACGTGTAGGGGATTTCTTAGTCGTGAATAAATTCAGCTATG
GCATTAAAGATCCGATTTGGCAAAATACTTTAATTGAAACCGGTCATCCGGAACGTGGCGATGTGATTGTATTTAAAGCA
CCGAAACAAGCGCATGTCGATTATATTAAACGTGTAGTAGGCGTTGGCGGTGATCGAGTGAAATACGATTCGCATACACA
GCAATTAACCGTTACTCACGCAGATGGTAAACAAACGGTATTTGAATACGGCGAAGGTAAGCCGAATGCGGATTTCTTCT
ATCACGGCGAAATGCAAATCGAACGTACTGAAAAAGGCGATGTAACGCATCAAATCCTAAATAACCCGTTTGCATTTAAT
TATGAACCGTATTTATTTGCACAAGAAGGTATGCCTTCGGGCGAATGGATTGTACCGGAAGGACATTACTTTGTAATGGG
CGATAACCGTGATAACAGTGAAGACAGCCGCTTCTGGGGATTCGTGCCGGAAAAAAACGTAGTCGGTAAAGCGACATTTA
TTTGGTTAAGTTTAGATAAAAAACCGAATGAATACCCAAGCGGTTTACGTTTTGACAGAATGTTTACCTCAATCAATTAA

Upstream 100 bases:

>100_bases
TACGCATACACGGAATATAAGCGGTCAAATTTTGTGAAAATGTTACAAAATCGACCGCATATTCCGTGTTTTCCGTAATC
AATAAACTAAGGAGAAAACA

Downstream 100 bases:

>100_bases
TATTTGAGCGAAGTACATCATACAAGCGGGTCTTTTTTGTCAAAAATCGGCAAAATACGACCGCTTGTATTTTTGCTTTG
TTTTAGAATGAATAATATGC

Product: Signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MAQIMPIIFIAILYGVWNTLDSMQLPNTISILLVALVVICGGFWAFYKFSADPRRNAAIAREEKRLNRPLTEEEKAEIQP
RSSIGDFFASLFGVLFFVTVLRSFIFEPFQIPSGSMEPTLRVGDFLVVNKFSYGIKDPIWQNTLIETGHPERGDVIVFKA
PKQAHVDYIKRVVGVGGDRVKYDSHTQQLTVTHADGKQTVFEYGEGKPNADFFYHGEMQIERTEKGDVTHQILNNPFAFN
YEPYLFAQEGMPSGEWIVPEGHYFVMGDNRDNSEDSRFWGFVPEKNVVGKATFIWLSLDKKPNEYPSGLRFDRMFTSIN

Sequences:

>Translated_319_residues
MAQIMPIIFIAILYGVWNTLDSMQLPNTISILLVALVVICGGFWAFYKFSADPRRNAAIAREEKRLNRPLTEEEKAEIQP
RSSIGDFFASLFGVLFFVTVLRSFIFEPFQIPSGSMEPTLRVGDFLVVNKFSYGIKDPIWQNTLIETGHPERGDVIVFKA
PKQAHVDYIKRVVGVGGDRVKYDSHTQQLTVTHADGKQTVFEYGEGKPNADFFYHGEMQIERTEKGDVTHQILNNPFAFN
YEPYLFAQEGMPSGEWIVPEGHYFVMGDNRDNSEDSRFWGFVPEKNVVGKATFIWLSLDKKPNEYPSGLRFDRMFTSIN
>Mature_318_residues
AQIMPIIFIAILYGVWNTLDSMQLPNTISILLVALVVICGGFWAFYKFSADPRRNAAIAREEKRLNRPLTEEEKAEIQPR
SSIGDFFASLFGVLFFVTVLRSFIFEPFQIPSGSMEPTLRVGDFLVVNKFSYGIKDPIWQNTLIETGHPERGDVIVFKAP
KQAHVDYIKRVVGVGGDRVKYDSHTQQLTVTHADGKQTVFEYGEGKPNADFFYHGEMQIERTEKGDVTHQILNNPFAFNY
EPYLFAQEGMPSGEWIVPEGHYFVMGDNRDNSEDSRFWGFVPEKNVVGKATFIWLSLDKKPNEYPSGLRFDRMFTSIN

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=320, Percent_Identity=43.75, Blast_Score=257, Evalue=9e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 36434; Mature: 36303

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQIMPIIFIAILYGVWNTLDSMQLPNTISILLVALVVICGGFWAFYKFSADPRRNAAIA
CCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHEEEECCCCCCCHHHH
REEKRLNRPLTEEEKAEIQPRSSIGDFFASLFGVLFFVTVLRSFIFEPFQIPSGSMEPTL
HHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
RVGDFLVVNKFSYGIKDPIWQNTLIETGHPERGDVIVFKAPKQAHVDYIKRVVGVGGDRV
EECCEEEEECCCCCCCCCCCCCCEECCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEE
KYDSHTQQLTVTHADGKQTVFEYGEGKPNADFFYHGEMQIERTEKGDVTHQILNNPFAFN
EECCCCEEEEEEECCCCHHHHHCCCCCCCCCEEEECCEEEEECCCCCHHHHHHCCCEEEC
YEPYLFAQEGMPSGEWIVPEGHYFVMGDNRDNSEDSRFWGFVPEKNVVGKATFIWLSLDK
CCCEEEECCCCCCCCEEECCCCEEEEECCCCCCCCCEEECCCCCCCCCCCEEEEEEEECC
KPNEYPSGLRFDRMFTSIN
CCCCCCCCCCHHHHHHCCC
>Mature Secondary Structure 
AQIMPIIFIAILYGVWNTLDSMQLPNTISILLVALVVICGGFWAFYKFSADPRRNAAIA
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHEEEECCCCCCCHHHH
REEKRLNRPLTEEEKAEIQPRSSIGDFFASLFGVLFFVTVLRSFIFEPFQIPSGSMEPTL
HHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
RVGDFLVVNKFSYGIKDPIWQNTLIETGHPERGDVIVFKAPKQAHVDYIKRVVGVGGDRV
EECCEEEEECCCCCCCCCCCCCCEECCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEE
KYDSHTQQLTVTHADGKQTVFEYGEGKPNADFFYHGEMQIERTEKGDVTHQILNNPFAFN
EECCCCEEEEEEECCCCHHHHHCCCCCCCCCEEEECCEEEEECCCCCHHHHHHCCCEEEC
YEPYLFAQEGMPSGEWIVPEGHYFVMGDNRDNSEDSRFWGFVPEKNVVGKATFIWLSLDK
CCCEEEECCCCCCCCEEECCCCEEEEECCCCCCCCCEEECCCCCCCCCCCEEEEEEEECC
KPNEYPSGLRFDRMFTSIN
CCCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]