| Definition | Actinobacillus pleuropneumoniae serovar 5b str. L20 chromosome, complete genome. |
|---|---|
| Accession | NC_009053 |
| Length | 2,274,482 |
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The map label for this gene is lepA [H]
Identifier: 126208023
GI number: 126208023
Start: 611049
End: 612848
Strand: Direct
Name: lepA [H]
Synonym: APL_0541
Alternate gene names: 126208023
Gene position: 611049-612848 (Clockwise)
Preceding gene: 126208022
Following gene: 126208024
Centisome position: 26.87
GC content: 44.83
Gene sequence:
>1800_bases ATGAAAATGCAAAATATTCGTAACTTTTCAATTATTGCTCATATTGACCACGGTAAATCTACGTTATCCGACCGTTTAAT CCAAACTTGCGGCGGTTTATCCGATCGTGAAATGGAAGCGCAAGTTTTAGACTCGATGGACTTAGAGCGTGAACGCGGTA TCACAATCAAAGCACAAAGTGTGACGCTCAATTATAAAGCGAAAGACGGTGAAACTTATCAATTAAACTTTATCGATACT CCGGGACACGTGGACTTCTCTTATGAAGTTTCTCGTTCGCTTGCCGCTTGTGAAGGGGCGTTATTAGTGGTGGATGCCGG TCAGGGTGTGGAAGCGCAAACATTGGCAAACTGCTATACCGCAATTGAAATGGATCTCGAAGTTGTGCCGATTCTGAATA AAATCGACTTACCGGCGGCAGAACCGGAACGAGTGGCAGAAGAGATTGAAGACATCGTCGGGATTGATGCGATGGATGCG GTGCGCTGTTCGGCAAAAACCGGTTTAGGTATCGAAGACGTGTTGGAAGACATCGTGAAAAAAATTCCGGCACCGGAAGG CGATCCCGATGCGCCGTTACAAGCGCTGATTATCGACTCGTGGTTTGATAACTATTTAGGTGTCGTGTCTTTAGTGCGTG TGAAGAACGGTACAATCAAAAAAGGCGATAAAATTAAAGTGATGAGTACCGGCCAATCGTATAACGTTGATCGTTTAGGT ATTTTCACACCGAAACAAGTGGATACCGCAGAACTTAAAACCGGCGAAGTGGGCTGGGTGGTCTGTGCGATTAAAGATAT TTTAGGCGCACCGGTAGGCGATACCTTAACCCATCATCATAATTCGGCGACGGAAGTGTTACCGGGCTTTAAAAAAGTTA AACCGCAGGTCTATGCCGGTTTATTCCCGATTAGCTCGGACGATTATGAAGCGTTCCGCGACGCATTAGGTAAATTAAGT CTGAATGACGCCTCGCTTTTCTATGAACCGGAAAATTCGACCGCATTGGGTTTCGGTTTCCGTTGCGGCTTCTTAGGCTT ATTACACATGGAGATCATTCAAGAGCGTTTAGAACGCGAATATGATCTCGACTTAATTACCACCGCACCGACGGTAGTTT ACGAAGTGGTACAAACCAACGGCGAAACCATTTATGTGGACAGCCCGTCAAAATTACCGCCGATCAGTAATATTGCGGAA ATTCGCGAACCGATTGCCGAATGTAATATGTTAGTGCCGCAAGAGTATTTAGGTAACGTAATTACCCTTTGTGTGGAAAA ACGCGGCGTACAAACCAATATGGTTTACCACGGCAACCAAATCGCACTTACGTACGAGATCCCGATGGGCGAAGTAGTGT TAGATTTCTTTGACCGCTTAAAATCGACTTCTCGCGGTTATGCGTCTTTGGATTACGGTTTCAAACGATTCCAAACGGCG GATATGGTGCGTGTCGATATTATGATCAACGGTGATCGTGTCGATGCGTTGGCACTCATCGTACATAAAGATAATGCCCC TTACCGTGGTCGTGAGTTAGTTGAAAAAATGAAAGAATTGATTCCGCGCCAACAATTCGATATTGCGATTCAAGCGGCAA TCGGCAACCATATTATTGCTCGTTCGACCGTAAAACAATTACGCAAAAACGTATTGGCGAAATGTTACGGCGGTGACGTG AGTCGTAAGAAAAAATTGCTACAAAAACAAAAAGAGGGTAAAAAACGAATGAAATCCCTCGGTAACGTAGATGTACCGCA AGAAGCGTTCTTAGCGATTCTTCATGTGGGTAAAGACTAG
Upstream 100 bases:
>100_bases TTTTGTGCTTTTCCTTTCCAAAATAGCGGATTTAAAGTAAAATTGGTCGGTTAATTTTCCCTTTAATAAATTTATTACAA CACAGGACATTTATTGCCCG
Downstream 100 bases:
>100_bases TTGTTACGCATACACGGAATATAAGCGGTCAAATTTTGTGAAAATGTTACAAAATCGACCGCATATTCCGTGTTTTCCGT AATCAATAAACTAAGGAGAA
Product: GTP-binding protein LepA
Products: NA
Alternate protein names: EF-4; Ribosomal back-translocase LepA [H]
Number of amino acids: Translated: 599; Mature: 599
Protein sequence:
>599_residues MKMQNIRNFSIIAHIDHGKSTLSDRLIQTCGGLSDREMEAQVLDSMDLERERGITIKAQSVTLNYKAKDGETYQLNFIDT PGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIEMDLEVVPILNKIDLPAAEPERVAEEIEDIVGIDAMDA VRCSAKTGLGIEDVLEDIVKKIPAPEGDPDAPLQALIIDSWFDNYLGVVSLVRVKNGTIKKGDKIKVMSTGQSYNVDRLG IFTPKQVDTAELKTGEVGWVVCAIKDILGAPVGDTLTHHHNSATEVLPGFKKVKPQVYAGLFPISSDDYEAFRDALGKLS LNDASLFYEPENSTALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVVQTNGETIYVDSPSKLPPISNIAE IREPIAECNMLVPQEYLGNVITLCVEKRGVQTNMVYHGNQIALTYEIPMGEVVLDFFDRLKSTSRGYASLDYGFKRFQTA DMVRVDIMINGDRVDALALIVHKDNAPYRGRELVEKMKELIPRQQFDIAIQAAIGNHIIARSTVKQLRKNVLAKCYGGDV SRKKKLLQKQKEGKKRMKSLGNVDVPQEAFLAILHVGKD
Sequences:
>Translated_599_residues MKMQNIRNFSIIAHIDHGKSTLSDRLIQTCGGLSDREMEAQVLDSMDLERERGITIKAQSVTLNYKAKDGETYQLNFIDT PGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIEMDLEVVPILNKIDLPAAEPERVAEEIEDIVGIDAMDA VRCSAKTGLGIEDVLEDIVKKIPAPEGDPDAPLQALIIDSWFDNYLGVVSLVRVKNGTIKKGDKIKVMSTGQSYNVDRLG IFTPKQVDTAELKTGEVGWVVCAIKDILGAPVGDTLTHHHNSATEVLPGFKKVKPQVYAGLFPISSDDYEAFRDALGKLS LNDASLFYEPENSTALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVVQTNGETIYVDSPSKLPPISNIAE IREPIAECNMLVPQEYLGNVITLCVEKRGVQTNMVYHGNQIALTYEIPMGEVVLDFFDRLKSTSRGYASLDYGFKRFQTA DMVRVDIMINGDRVDALALIVHKDNAPYRGRELVEKMKELIPRQQFDIAIQAAIGNHIIARSTVKQLRKNVLAKCYGGDV SRKKKLLQKQKEGKKRMKSLGNVDVPQEAFLAILHVGKD >Mature_599_residues MKMQNIRNFSIIAHIDHGKSTLSDRLIQTCGGLSDREMEAQVLDSMDLERERGITIKAQSVTLNYKAKDGETYQLNFIDT PGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIEMDLEVVPILNKIDLPAAEPERVAEEIEDIVGIDAMDA VRCSAKTGLGIEDVLEDIVKKIPAPEGDPDAPLQALIIDSWFDNYLGVVSLVRVKNGTIKKGDKIKVMSTGQSYNVDRLG IFTPKQVDTAELKTGEVGWVVCAIKDILGAPVGDTLTHHHNSATEVLPGFKKVKPQVYAGLFPISSDDYEAFRDALGKLS LNDASLFYEPENSTALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVVQTNGETIYVDSPSKLPPISNIAE IREPIAECNMLVPQEYLGNVITLCVEKRGVQTNMVYHGNQIALTYEIPMGEVVLDFFDRLKSTSRGYASLDYGFKRFQTA DMVRVDIMINGDRVDALALIVHKDNAPYRGRELVEKMKELIPRQQFDIAIQAAIGNHIIARSTVKQLRKNVLAKCYGGDV SRKKKLLQKQKEGKKRMKSLGNVDVPQEAFLAILHVGKD
Specific function: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- transloc
COG id: COG0481
COG function: function code M; Membrane GTPase LepA
Gene ontology:
Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the GTP-binding elongation factor family. LepA subfamily [H]
Homologues:
Organism=Homo sapiens, GI157426893, Length=601, Percent_Identity=47.9201331114809, Blast_Score=603, Evalue=1e-172, Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=45.8646616541353, Blast_Score=114, Evalue=3e-25, Organism=Homo sapiens, GI4503483, Length=147, Percent_Identity=43.5374149659864, Blast_Score=110, Evalue=3e-24, Organism=Homo sapiens, GI25306283, Length=149, Percent_Identity=42.9530201342282, Blast_Score=105, Evalue=2e-22, Organism=Homo sapiens, GI19923640, Length=149, Percent_Identity=42.9530201342282, Blast_Score=104, Evalue=3e-22, Organism=Homo sapiens, GI25306287, Length=149, Percent_Identity=42.9530201342282, Blast_Score=104, Evalue=3e-22, Organism=Homo sapiens, GI18390331, Length=160, Percent_Identity=35, Blast_Score=100, Evalue=6e-21, Organism=Homo sapiens, GI310132016, Length=110, Percent_Identity=44.5454545454545, Blast_Score=95, Evalue=2e-19, Organism=Homo sapiens, GI310110807, Length=110, Percent_Identity=44.5454545454545, Blast_Score=95, Evalue=2e-19, Organism=Homo sapiens, GI310123363, Length=110, Percent_Identity=44.5454545454545, Blast_Score=95, Evalue=2e-19, Organism=Homo sapiens, GI217272894, Length=133, Percent_Identity=37.593984962406, Blast_Score=84, Evalue=5e-16, Organism=Homo sapiens, GI217272892, Length=133, Percent_Identity=37.593984962406, Blast_Score=84, Evalue=5e-16, Organism=Homo sapiens, GI53729339, Length=263, Percent_Identity=30.4182509505703, Blast_Score=82, Evalue=1e-15, Organism=Homo sapiens, GI53729337, Length=263, Percent_Identity=30.4182509505703, Blast_Score=82, Evalue=1e-15, Organism=Homo sapiens, GI4503471, Length=170, Percent_Identity=30.5882352941176, Blast_Score=69, Evalue=1e-11, Organism=Homo sapiens, GI4503475, Length=332, Percent_Identity=25.3012048192771, Blast_Score=67, Evalue=3e-11, Organism=Escherichia coli, GI1788922, Length=597, Percent_Identity=87.6046901172529, Blast_Score=1059, Evalue=0.0, Organism=Escherichia coli, GI48994988, Length=477, Percent_Identity=29.3501048218029, Blast_Score=178, Evalue=8e-46, Organism=Escherichia coli, GI1789738, Length=155, Percent_Identity=35.4838709677419, Blast_Score=90, Evalue=4e-19, Organism=Escherichia coli, GI1790835, Length=156, Percent_Identity=32.0512820512821, Blast_Score=84, Evalue=3e-17, Organism=Escherichia coli, GI1789559, Length=229, Percent_Identity=30.1310043668122, Blast_Score=76, Evalue=7e-15, Organism=Escherichia coli, GI1789737, Length=333, Percent_Identity=27.027027027027, Blast_Score=66, Evalue=7e-12, Organism=Escherichia coli, GI1790412, Length=333, Percent_Identity=27.027027027027, Blast_Score=66, Evalue=7e-12, Organism=Caenorhabditis elegans, GI17557151, Length=612, Percent_Identity=41.5032679738562, Blast_Score=491, Evalue=1e-139, Organism=Caenorhabditis elegans, GI17556745, Length=159, Percent_Identity=35.8490566037736, Blast_Score=105, Evalue=7e-23, Organism=Caenorhabditis elegans, GI17506493, Length=227, Percent_Identity=32.15859030837, Blast_Score=100, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17533571, Length=146, Percent_Identity=36.3013698630137, Blast_Score=95, Evalue=9e-20, Organism=Caenorhabditis elegans, GI71988811, Length=134, Percent_Identity=36.5671641791045, Blast_Score=88, Evalue=1e-17, Organism=Caenorhabditis elegans, GI71988819, Length=134, Percent_Identity=36.5671641791045, Blast_Score=88, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17552882, Length=133, Percent_Identity=36.0902255639098, Blast_Score=84, Evalue=1e-16, Organism=Caenorhabditis elegans, GI32566303, Length=312, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=4e-12, Organism=Caenorhabditis elegans, GI25141371, Length=240, Percent_Identity=27.0833333333333, Blast_Score=67, Evalue=3e-11, Organism=Caenorhabditis elegans, GI71994658, Length=238, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=5e-11, Organism=Saccharomyces cerevisiae, GI6323320, Length=601, Percent_Identity=46.7554076539101, Blast_Score=553, Evalue=1e-158, Organism=Saccharomyces cerevisiae, GI6324707, Length=147, Percent_Identity=42.1768707482993, Blast_Score=113, Evalue=7e-26, Organism=Saccharomyces cerevisiae, GI6320593, Length=147, Percent_Identity=42.1768707482993, Blast_Score=113, Evalue=7e-26, Organism=Saccharomyces cerevisiae, GI6323098, Length=205, Percent_Identity=34.1463414634146, Blast_Score=109, Evalue=1e-24, Organism=Saccharomyces cerevisiae, GI6322359, Length=115, Percent_Identity=38.2608695652174, Blast_Score=94, Evalue=8e-20, Organism=Saccharomyces cerevisiae, GI6324166, Length=152, Percent_Identity=38.1578947368421, Blast_Score=85, Evalue=3e-17, Organism=Saccharomyces cerevisiae, GI6324761, Length=266, Percent_Identity=26.6917293233083, Blast_Score=73, Evalue=1e-13, Organism=Saccharomyces cerevisiae, GI6325337, Length=321, Percent_Identity=23.98753894081, Blast_Score=71, Evalue=5e-13, Organism=Saccharomyces cerevisiae, GI6319594, Length=321, Percent_Identity=23.98753894081, Blast_Score=71, Evalue=5e-13, Organism=Drosophila melanogaster, GI78706572, Length=603, Percent_Identity=43.4494195688226, Blast_Score=533, Evalue=1e-151, Organism=Drosophila melanogaster, GI24585711, Length=164, Percent_Identity=37.1951219512195, Blast_Score=103, Evalue=3e-22, Organism=Drosophila melanogaster, GI24585713, Length=164, Percent_Identity=37.1951219512195, Blast_Score=103, Evalue=3e-22, Organism=Drosophila melanogaster, GI24585709, Length=164, Percent_Identity=37.1951219512195, Blast_Score=103, Evalue=4e-22, Organism=Drosophila melanogaster, GI28574573, Length=140, Percent_Identity=43.5714285714286, Blast_Score=102, Evalue=6e-22, Organism=Drosophila melanogaster, GI24582462, Length=161, Percent_Identity=35.4037267080745, Blast_Score=101, Evalue=2e-21, Organism=Drosophila melanogaster, GI221458488, Length=149, Percent_Identity=38.255033557047, Blast_Score=92, Evalue=1e-18, Organism=Drosophila melanogaster, GI21357743, Length=133, Percent_Identity=36.0902255639098, Blast_Score=84, Evalue=2e-16, Organism=Drosophila melanogaster, GI28572034, Length=247, Percent_Identity=28.7449392712551, Blast_Score=72, Evalue=1e-12, Organism=Drosophila melanogaster, GI19921738, Length=233, Percent_Identity=29.6137339055794, Blast_Score=68, Evalue=2e-11, Organism=Drosophila melanogaster, GI281363316, Length=238, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=3e-11, Organism=Drosophila melanogaster, GI17864358, Length=238, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=3e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR009022 - InterPro: IPR006297 - InterPro: IPR013842 - InterPro: IPR000795 - InterPro: IPR005225 - InterPro: IPR000640 - InterPro: IPR004161 - InterPro: IPR009000 [H]
Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF06421 LepA_C [H]
EC number: NA
Molecular weight: Translated: 66327; Mature: 66327
Theoretical pI: Translated: 5.04; Mature: 5.04
Prosite motif: PS00301 EFACTOR_GTP
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKMQNIRNFSIIAHIDHGKSTLSDRLIQTCGGLSDREMEAQVLDSMDLERERGITIKAQS CCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHCCCEEEEEE VTLNYKAKDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYT EEEEEEECCCCEEEEEEECCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHH AIEMDLEVVPILNKIDLPAAEPERVAEEIEDIVGIDAMDAVRCSAKTGLGIEDVLEDIVK HHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHH KIPAPEGDPDAPLQALIIDSWFDNYLGVVSLVRVKNGTIKKGDKIKVMSTGQSYNVDRLG HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCEEE IFTPKQVDTAELKTGEVGWVVCAIKDILGAPVGDTLTHHHNSATEVLPGFKKVKPQVYAG CCCCCCCCCCCCCCCCCCCHHEEHHHHHCCCCCCHHHHCCCCHHHHCCCHHHCCCHHHEE LFPISSDDYEAFRDALGKLSLNDASLFYEPENSTALGFGFRCGFLGLLHMEIIQERLERE EECCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHH YDLDLITTAPTVVYEVVQTNGETIYVDSPSKLPPISNIAEIREPIAECNMLVPQEYLGNV CCCEEEECCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH ITLCVEKRGVQTNMVYHGNQIALTYEIPMGEVVLDFFDRLKSTSRGYASLDYGFKRFQTA HHHHHHHCCCEEEEEEECCEEEEEEECCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCC DMVRVDIMINGDRVDALALIVHKDNAPYRGRELVEKMKELIPRQQFDIAIQAAIGNHIIA CEEEEEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCHHCEEEEEHHCCHHHH RSTVKQLRKNVLAKCYGGDVSRKKKLLQKQKEGKKRMKSLGNVDVPQEAFLAILHVGKD HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCC >Mature Secondary Structure MKMQNIRNFSIIAHIDHGKSTLSDRLIQTCGGLSDREMEAQVLDSMDLERERGITIKAQS CCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHCCCEEEEEE VTLNYKAKDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYT EEEEEEECCCCEEEEEEECCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHH AIEMDLEVVPILNKIDLPAAEPERVAEEIEDIVGIDAMDAVRCSAKTGLGIEDVLEDIVK HHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHH KIPAPEGDPDAPLQALIIDSWFDNYLGVVSLVRVKNGTIKKGDKIKVMSTGQSYNVDRLG HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCEEE IFTPKQVDTAELKTGEVGWVVCAIKDILGAPVGDTLTHHHNSATEVLPGFKKVKPQVYAG CCCCCCCCCCCCCCCCCCCHHEEHHHHHCCCCCCHHHHCCCCHHHHCCCHHHCCCHHHEE LFPISSDDYEAFRDALGKLSLNDASLFYEPENSTALGFGFRCGFLGLLHMEIIQERLERE EECCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHH YDLDLITTAPTVVYEVVQTNGETIYVDSPSKLPPISNIAEIREPIAECNMLVPQEYLGNV CCCEEEECCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH ITLCVEKRGVQTNMVYHGNQIALTYEIPMGEVVLDFFDRLKSTSRGYASLDYGFKRFQTA HHHHHHHCCCEEEEEEECCEEEEEEECCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCC DMVRVDIMINGDRVDALALIVHKDNAPYRGRELVEKMKELIPRQQFDIAIQAAIGNHIIA CEEEEEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCHHCEEEEEHHCCHHHH RSTVKQLRKNVLAKCYGGDVSRKKKLLQKQKEGKKRMKSLGNVDVPQEAFLAILHVGKD HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA