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The map label for this gene is modE [H]

Identifier: 126175734

GI number: 126175734

Start: 4160627

End: 4161406

Strand: Reverse

Name: modE [H]

Synonym: Sbal_3537

Alternate gene names: 126175734

Gene position: 4161406-4160627 (Counterclockwise)

Preceding gene: 126175739

Following gene: 126175733

Centisome position: 81.16

GC content: 51.15

Gene sequence:

>780_bases
ATGGATTTACATGCATTACTTACGCTTTCCCTTGGGGATAAGCCCTTCGCTAATCCTAGGCGGATAAGCCTGCTCGAGCA
GGTCGCCAGCACAGGCTCGATAAGCCAAGGCGCCAAGCTTGCGGGGATCAGTTATAAAGCGGCGTGGGACGCGATCAATG
AGATGAACACCGCCATGCCCGAACCCGTAGTGTGTAGCGAAAAGGGCGGCAAAGGCGGTGGCGGCGCTAAACTCACCGAA
TTTGGCGAACGGTTGCTTAAGGTGTATTCCATCACCTCTCAAGTACAAGAAATGGCTTTGGCTGCCTTGCTCGATGAGTC
CGTCGACATGCACAGTTTATTGGATGTGATGGCGCATTTCTCCCTCAACACCAGCGCCCGCAATCAGTTAACGGGTCGTA
TCAATGGCATTGATTCATTTGGATTAAATGACAACATCAGCGTGACCTTAACGGGCGGACAACAGATTCAGATTTCAGTG
ACCCATTCGAGCCGCGAACGCTTGCAGTTAGCCCTGGATAAATCGGTGTTGTTACTGTTTAAAGCCCCCGCGGTACTGGC
GACGACTCATGCCTGTGAACTGGATGGGCAAAATTGCCTAAGCGGTCGTTTGCTGAGCGTGACTGAACTTGGCGATAAGG
CCGAATTAGCCATAGATATTGATGGCAAAGACATCATCTATTCAGTGATACCACTCACCCAAATGCAGAGTTTGGCTGTC
GGCGAATCATGTTTCGCCTGTTTTGATGCCACGCAGGTGATCCTCGCCAGCATGAATTAG

Upstream 100 bases:

>100_bases
ATTGGTATTGATCCGCTGAAATATCTCGGCAATCTTATTGGTATCCTCAAGGTGATGAAGGACAATAGGGCTCAAGTCAG
AGTTGGGTGCGGGATAAACG

Downstream 100 bases:

>100_bases
TCGAATTGAATGATTAATTCGATTAATCATTGGGTTATTCACTGGGGATGGCCTGTGACTTGGTGTTATTGTTTTCGCAA
TGGGTTGGTGGGGAATCTAA

Product: ModE family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MDLHALLTLSLGDKPFANPRRISLLEQVASTGSISQGAKLAGISYKAAWDAINEMNTAMPEPVVCSEKGGKGGGGAKLTE
FGERLLKVYSITSQVQEMALAALLDESVDMHSLLDVMAHFSLNTSARNQLTGRINGIDSFGLNDNISVTLTGGQQIQISV
THSSRERLQLALDKSVLLLFKAPAVLATTHACELDGQNCLSGRLLSVTELGDKAELAIDIDGKDIIYSVIPLTQMQSLAV
GESCFACFDATQVILASMN

Sequences:

>Translated_259_residues
MDLHALLTLSLGDKPFANPRRISLLEQVASTGSISQGAKLAGISYKAAWDAINEMNTAMPEPVVCSEKGGKGGGGAKLTE
FGERLLKVYSITSQVQEMALAALLDESVDMHSLLDVMAHFSLNTSARNQLTGRINGIDSFGLNDNISVTLTGGQQIQISV
THSSRERLQLALDKSVLLLFKAPAVLATTHACELDGQNCLSGRLLSVTELGDKAELAIDIDGKDIIYSVIPLTQMQSLAV
GESCFACFDATQVILASMN
>Mature_259_residues
MDLHALLTLSLGDKPFANPRRISLLEQVASTGSISQGAKLAGISYKAAWDAINEMNTAMPEPVVCSEKGGKGGGGAKLTE
FGERLLKVYSITSQVQEMALAALLDESVDMHSLLDVMAHFSLNTSARNQLTGRINGIDSFGLNDNISVTLTGGQQIQISV
THSSRERLQLALDKSVLLLFKAPAVLATTHACELDGQNCLSGRLLSVTELGDKAELAIDIDGKDIIYSVIPLTQMQSLAV
GESCFACFDATQVILASMN

Specific function: The modE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA reg

COG id: COG2005

COG function: function code R; N-terminal domain of molybdenum-binding protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the modE family [H]

Homologues:

Organism=Escherichia coli, GI1786976, Length=246, Percent_Identity=40.2439024390244, Blast_Score=152, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR004606
- InterPro:   IPR008995
- InterPro:   IPR003725
- InterPro:   IPR016462
- InterPro:   IPR005116
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03459 TOBE [H]

EC number: NA

Molecular weight: Translated: 27540; Mature: 27540

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLHALLTLSLGDKPFANPRRISLLEQVASTGSISQGAKLAGISYKAAWDAINEMNTAMP
CCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHCCC
EPVVCSEKGGKGGGGAKLTEFGERLLKVYSITSQVQEMALAALLDESVDMHSLLDVMAHF
CCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
SLNTSARNQLTGRINGIDSFGLNDNISVTLTGGQQIQISVTHSSRERLQLALDKSVLLLF
CCCCCHHHHHEEEECCEECCCCCCCEEEEEECCCEEEEEEECCCHHHHHHHHCCEEEEEE
KAPAVLATTHACELDGQNCLSGRLLSVTELGDKAELAIDIDGKDIIYSVIPLTQMQSLAV
ECCHHHHEEEEEECCCCCCCCCCEEEEEECCCCEEEEEEECCCEEEEEHHCHHHHHHHHH
GESCFACFDATQVILASMN
CHHHHHHHHHHHHHEECCC
>Mature Secondary Structure
MDLHALLTLSLGDKPFANPRRISLLEQVASTGSISQGAKLAGISYKAAWDAINEMNTAMP
CCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHCCC
EPVVCSEKGGKGGGGAKLTEFGERLLKVYSITSQVQEMALAALLDESVDMHSLLDVMAHF
CCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
SLNTSARNQLTGRINGIDSFGLNDNISVTLTGGQQIQISVTHSSRERLQLALDKSVLLLF
CCCCCHHHHHEEEECCEECCCCCCCEEEEEECCCEEEEEEECCCHHHHHHHHCCEEEEEE
KAPAVLATTHACELDGQNCLSGRLLSVTELGDKAELAIDIDGKDIIYSVIPLTQMQSLAV
ECCHHHHEEEEEECCCCCCCCCCEEEEEECCCCEEEEEEECCCEEEEEHHCHHHHHHHHH
GESCFACFDATQVILASMN
CHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]