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The map label for this gene is (rmlA1 [H]

Identifier: 126175092

GI number: 126175092

Start: 3400739

End: 3401599

Strand: Reverse

Name: (rmlA1 [H]

Synonym: Sbal_2889

Alternate gene names: 126175092

Gene position: 3401599-3400739 (Counterclockwise)

Preceding gene: 126175093

Following gene: 126175091

Centisome position: 66.34

GC content: 42.16

Gene sequence:

>861_bases
ATGAAGGGAATTATTCTAGCCGGCGGTTCAGGTACGCGTTTATATCCATTAACTCGCGGCGTATCTAAACAGTTATTGCC
AATTTACGACAAACCAATGATTTATTATCCGCTATCAACACTTATGTTAGCGGGCATTCGAGATATTTTAATCATTACAA
CTCCTGAAGATAATGAAGCATTTCGACGTTTACTTGGCAATGGGTCAGATTTTGGCATCAACTTGAATTATGCAGTACAA
CCATCACCAGATGGTTTGGCGCAAGCCTTTATTATTGGTGAAGAGTTTATTGGCGATGCGAATGTATGTTTAGTGCTTGG
TGATAACATCTTCTATGGCCAGTCTTTTTCCAAAACACTTAAAAATGCGGCTTCGCGTAAATCAGGTGCTACTGTTTTTG
GATATCAAGTGAAAGATCCCGAGCGTTTTGGTGTGGTGGAATTTGATGCAGATATGAAAGCCATTTCAATTGAAGAAAAG
CCCGCGAAGCCAAAATCTAATTACGCGGTCACTGGCTTGTATTTTTACGACAACAAAGTGGTTGAACTGGCGAAACTGGT
TAAACCATCGCACCGTGGTGAGCTTGAGATTACCACTCTTAATGAGATGTATCTCAAAGCTGGTGAGTTAAATGTCGAGC
TGCTCGGTCGTGGTTTTGCTTGGCTAGATACTGGCACCCACGAGAGTCTGCATGAGGCTTCATCTTTTGTTCAGACCATT
GAGCATGTTCAAGGGTTAAAGGTAGCGTGTTTAGAAGAAATAGCCTATCGCAATGGTTGGCTAACACGCGAACAATTGCA
CGAACTCGCCAAGCCGATGCTTAAAAATGACTATGGCCAGTATTTGGCCAAACTAGTGTAA

Upstream 100 bases:

>100_bases
CAGCGAGAGCGTTTAGGCATTTAATCTCTTTTATTATTTTGTTTTATGTCCTAGTTTTTCTTTAAACCTAGGATCTATTT
ATCTAGGAACTGATTTTACT

Downstream 100 bases:

>100_bases
GTGGTTAATAGTTAATGGTAAGTGAAACACAAATAACGAATAATTATGAAAATATTAGTCACCGGTAGTAATGGCCAAGT
GGGTAGTTGCCTCGTTAAAC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MKGIILAGGSGTRLYPLTRGVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIITTPEDNEAFRRLLGNGSDFGINLNYAVQ
PSPDGLAQAFIIGEEFIGDANVCLVLGDNIFYGQSFSKTLKNAASRKSGATVFGYQVKDPERFGVVEFDADMKAISIEEK
PAKPKSNYAVTGLYFYDNKVVELAKLVKPSHRGELEITTLNEMYLKAGELNVELLGRGFAWLDTGTHESLHEASSFVQTI
EHVQGLKVACLEEIAYRNGWLTREQLHELAKPMLKNDYGQYLAKLV

Sequences:

>Translated_286_residues
MKGIILAGGSGTRLYPLTRGVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIITTPEDNEAFRRLLGNGSDFGINLNYAVQ
PSPDGLAQAFIIGEEFIGDANVCLVLGDNIFYGQSFSKTLKNAASRKSGATVFGYQVKDPERFGVVEFDADMKAISIEEK
PAKPKSNYAVTGLYFYDNKVVELAKLVKPSHRGELEITTLNEMYLKAGELNVELLGRGFAWLDTGTHESLHEASSFVQTI
EHVQGLKVACLEEIAYRNGWLTREQLHELAKPMLKNDYGQYLAKLV
>Mature_286_residues
MKGIILAGGSGTRLYPLTRGVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIITTPEDNEAFRRLLGNGSDFGINLNYAVQ
PSPDGLAQAFIIGEEFIGDANVCLVLGDNIFYGQSFSKTLKNAASRKSGATVFGYQVKDPERFGVVEFDADMKAISIEEK
PAKPKSNYAVTGLYFYDNKVVELAKLVKPSHRGELEITTLNEMYLKAGELNVELLGRGFAWLDTGTHESLHEASSFVQTI
EHVQGLKVACLEEIAYRNGWLTREQLHELAKPMLKNDYGQYLAKLV

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=247, Percent_Identity=25.1012145748988, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI11761619, Length=247, Percent_Identity=25.1012145748988, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1790224, Length=286, Percent_Identity=74.1258741258741, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1788351, Length=285, Percent_Identity=69.4736842105263, Blast_Score=417, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI133931050, Length=227, Percent_Identity=27.7533039647577, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=228, Percent_Identity=27.1929824561404, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355443, Length=227, Percent_Identity=25.1101321585903, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24644084, Length=227, Percent_Identity=25.1101321585903, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 31735; Mature: 31735

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPLTRGVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIITTPEDNEA
CCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCHHH
FRRLLGNGSDFGINLNYAVQPSPDGLAQAFIIGEEFIGDANVCLVLGDNIFYGQSFSKTL
HHHHHCCCCCCEEEEEEEECCCCCHHHHEEEEHHHHCCCCCEEEEECCCEEECCHHHHHH
KNAASRKSGATVFGYQVKDPERFGVVEFDADMKAISIEEKPAKPKSNYAVTGLYFYDNKV
HHHHCCCCCCEEEEEEECCCCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEEEEECCHH
VELAKLVKPSHRGELEITTLNEMYLKAGELNVELLGRGFAWLDTGTHESLHEASSFVQTI
HHHHHHHCCCCCCEEEEEEHHHHHHCCCCCEEEEEECCEEEEECCCHHHHHHHHHHHHHH
EHVQGLKVACLEEIAYRNGWLTREQLHELAKPMLKNDYGQYLAKLV
HHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHCC
>Mature Secondary Structure
MKGIILAGGSGTRLYPLTRGVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIITTPEDNEA
CCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCHHH
FRRLLGNGSDFGINLNYAVQPSPDGLAQAFIIGEEFIGDANVCLVLGDNIFYGQSFSKTL
HHHHHCCCCCCEEEEEEEECCCCCHHHHEEEEHHHHCCCCCEEEEECCCEEECCHHHHHH
KNAASRKSGATVFGYQVKDPERFGVVEFDADMKAISIEEKPAKPKSNYAVTGLYFYDNKV
HHHHCCCCCCEEEEEEECCCCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEEEEECCHH
VELAKLVKPSHRGELEITTLNEMYLKAGELNVELLGRGFAWLDTGTHESLHEASSFVQTI
HHHHHHHCCCCCCEEEEEEHHHHHHCCCCCEEEEEECCEEEEECCCHHHHHHHHHHHHHH
EHVQGLKVACLEEIAYRNGWLTREQLHELAKPMLKNDYGQYLAKLV
HHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]