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The map label for this gene is metB1 [H]

Identifier: 125624948

GI number: 125624948

Start: 2148432

End: 2149520

Strand: Reverse

Name: metB1 [H]

Synonym: llmg_2181

Alternate gene names: 125624948

Gene position: 2149520-2148432 (Counterclockwise)

Preceding gene: 125624949

Following gene: 125624947

Centisome position: 84.98

GC content: 36.64

Gene sequence:

>1089_bases
ATGGATAAAAGATTAGATACTTTATTGGCACAAGTCGGAATTCATCAAGATGAAGCTACTGGGGCTTTAGTCGGTCCTTT
GCATTTTTCAACGACCTATCAACATCCAGAATATGGGAAATCGACTGGATTTGATTATACTCGAACGAAAAATCCCACAC
GAGCGACTTTAGAAGAAGCACTTGCTTCAATTGAATCAGGGCAATTCGCTTTGGCAACTTCGTCAGGAATGGCTGCAATT
GTTTTAGCATTTGAAGTTTTTCCTGTTGGAGCTAAAATCGTGGCCTCTAGAGATTTATATGGTGGCTCTTTTCGCTGGTT
TGACGAACAAGAAAAAGAAGGACGTTTTTCATTTGCTTATGCCAATAATGAAAAAGAAATGCTTGATTTAATTGATGAAT
CGACCGATATTGTTTATATTGAAAGTCCAACAAATCCAATGATGATTAAGTATAACATTGAAAAGATTGCTAACAAGGCG
CAAGCAAATCATGCGAAAGTGATTGTTGATAATACTTTTTATACTCCAATCTATCAGAGACCATTGGAGCTGGGGGCTGA
CATTGTCATTCATTCGGCGACAAAATATCTGTCAGGGCATAACGATGTTTTAGCTGGAGCGGTCATTGTTCATAATGAAA
AGCTTTATGAAAAATTAGTCTATAAACTTAATACTACCGGAGCAGTTCTTTCTCCTTTTGATAGTTATCTCGTCATGCGA
GGTTTAAAGACCTTAAGCCTGAGAATGGAAAGAGCAACTAAAAATGCGCTTAAAATTGTGGCTTTTCTAAAAAAGCTTCC
GTCAGTAAAAGAAGTGCTCTATCCGGGATTGGGAGGAATGATTTCTTTAAAGGTGACTGACAAAAATAAAATTCCAGACA
TTTTAAATCACTTACAAGTTTTTACTTTCGCTGAAAGTTTAGGAGGTGTTGAGTCTTTAATTACCTATCCTGCAGAACAA
ACCCACCATGATATTCCACTTGAAATTAGAGAAAGTTATGGTCTAACTGATGACTTGCTTCGCCTTTCTATTGGTATAGA
AGATGTACGTGATTTAATAGAAGACCTTAAAGAAGCACTAGAAAATTAA

Upstream 100 bases:

>100_bases
GCCCTATTTGGGAGAACGTCTTGGTCATCATTGCGGTGAAGAGAATTATGATTTTAATCAAAAAGAGTAGAACAAAGGTG
TTTTCTATAGGAGAAAATTT

Downstream 100 bases:

>100_bases
ATATTTACTGATGAAAGAACTAACATATCTGTAAATAGCTATCCATGGGCTCTGAGTTTCGCTGTGCCTTTTCTCTATCC
ACTAATCTTCGCTACGCTCG

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CGS; O-acetylhomoserine (thiol)-lyase; O-acetylhomoserine sulfhydrylase; OAH sulfhydrylase [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MDKRLDTLLAQVGIHQDEATGALVGPLHFSTTYQHPEYGKSTGFDYTRTKNPTRATLEEALASIESGQFALATSSGMAAI
VLAFEVFPVGAKIVASRDLYGGSFRWFDEQEKEGRFSFAYANNEKEMLDLIDESTDIVYIESPTNPMMIKYNIEKIANKA
QANHAKVIVDNTFYTPIYQRPLELGADIVIHSATKYLSGHNDVLAGAVIVHNEKLYEKLVYKLNTTGAVLSPFDSYLVMR
GLKTLSLRMERATKNALKIVAFLKKLPSVKEVLYPGLGGMISLKVTDKNKIPDILNHLQVFTFAESLGGVESLITYPAEQ
THHDIPLEIRESYGLTDDLLRLSIGIEDVRDLIEDLKEALEN

Sequences:

>Translated_362_residues
MDKRLDTLLAQVGIHQDEATGALVGPLHFSTTYQHPEYGKSTGFDYTRTKNPTRATLEEALASIESGQFALATSSGMAAI
VLAFEVFPVGAKIVASRDLYGGSFRWFDEQEKEGRFSFAYANNEKEMLDLIDESTDIVYIESPTNPMMIKYNIEKIANKA
QANHAKVIVDNTFYTPIYQRPLELGADIVIHSATKYLSGHNDVLAGAVIVHNEKLYEKLVYKLNTTGAVLSPFDSYLVMR
GLKTLSLRMERATKNALKIVAFLKKLPSVKEVLYPGLGGMISLKVTDKNKIPDILNHLQVFTFAESLGGVESLITYPAEQ
THHDIPLEIRESYGLTDDLLRLSIGIEDVRDLIEDLKEALEN
>Mature_362_residues
MDKRLDTLLAQVGIHQDEATGALVGPLHFSTTYQHPEYGKSTGFDYTRTKNPTRATLEEALASIESGQFALATSSGMAAI
VLAFEVFPVGAKIVASRDLYGGSFRWFDEQEKEGRFSFAYANNEKEMLDLIDESTDIVYIESPTNPMMIKYNIEKIANKA
QANHAKVIVDNTFYTPIYQRPLELGADIVIHSATKYLSGHNDVLAGAVIVHNEKLYEKLVYKLNTTGAVLSPFDSYLVMR
GLKTLSLRMERATKNALKIVAFLKKLPSVKEVLYPGLGGMISLKVTDKNKIPDILNHLQVFTFAESLGGVESLITYPAEQ
THHDIPLEIRESYGLTDDLLRLSIGIEDVRDLIEDLKEALEN

Specific function: Catalyzes the transformation of O-succinylhomoserine into cystathionine, as well as O-acetylhomoserine and sulfide into homocysteine [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=345, Percent_Identity=40.2898550724638, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI299473759, Length=345, Percent_Identity=37.3913043478261, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI25453487, Length=341, Percent_Identity=34.8973607038123, Blast_Score=202, Evalue=3e-52,
Organism=Escherichia coli, GI1790375, Length=381, Percent_Identity=40.4199475065617, Blast_Score=277, Evalue=7e-76,
Organism=Escherichia coli, GI1789383, Length=400, Percent_Identity=26.25, Blast_Score=126, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17560056, Length=367, Percent_Identity=38.9645776566758, Blast_Score=238, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI17538055, Length=353, Percent_Identity=38.2436260623229, Blast_Score=237, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI71980708, Length=390, Percent_Identity=34.3589743589744, Blast_Score=195, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6319307, Length=367, Percent_Identity=40.0544959128065, Blast_Score=267, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6321254, Length=403, Percent_Identity=31.2655086848635, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6323333, Length=442, Percent_Identity=31.447963800905, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6321904, Length=380, Percent_Identity=28.6842105263158, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321170, Length=277, Percent_Identity=26.7148014440433, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19922554, Length=365, Percent_Identity=41.0958904109589, Blast_Score=266, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =2.5.1.48; =2.5.1.49 [H]

Molecular weight: Translated: 40309; Mature: 40309

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRLDTLLAQVGIHQDEATGALVGPLHFSTTYQHPEYGKSTGFDYTRTKNPTRATLEEA
CCHHHHHHHHHHCCCCCCCCCEEEECEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
LASIESGQFALATSSGMAAIVLAFEVFPVGAKIVASRDLYGGSFRWFDEQEKEGRFSFAY
HHHHCCCCEEEEECCCCEEEEEEHHHHCCCCEEEEECCCCCCCEECCCCCCCCCCEEEEE
ANNEKEMLDLIDESTDIVYIESPTNPMMIKYNIEKIANKAQANHAKVIVDNTFYTPIYQR
ECCHHHHHHHHCCCCCEEEEECCCCCEEEEEEHHHHHHHHCCCCCEEEECCCCCCHHHHC
PLELGADIVIHSATKYLSGHNDVLAGAVIVHNEKLYEKLVYKLNTTGAVLSPFDSYLVMR
HHHCCCCEEEECHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHH
GLKTLSLRMERATKNALKIVAFLKKLPSVKEVLYPGLGGMISLKVTDKNKIPDILNHLQV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHH
FTFAESLGGVESLITYPAEQTHHDIPLEIRESYGLTDDLLRLSIGIEDVRDLIEDLKEAL
HHHHHHHCCHHHHHHCCCHHCCCCCCEEEHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHH
EN
CC
>Mature Secondary Structure
MDKRLDTLLAQVGIHQDEATGALVGPLHFSTTYQHPEYGKSTGFDYTRTKNPTRATLEEA
CCHHHHHHHHHHCCCCCCCCCEEEECEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
LASIESGQFALATSSGMAAIVLAFEVFPVGAKIVASRDLYGGSFRWFDEQEKEGRFSFAY
HHHHCCCCEEEEECCCCEEEEEEHHHHCCCCEEEEECCCCCCCEECCCCCCCCCCEEEEE
ANNEKEMLDLIDESTDIVYIESPTNPMMIKYNIEKIANKAQANHAKVIVDNTFYTPIYQR
ECCHHHHHHHHCCCCCEEEEECCCCCEEEEEEHHHHHHHHCCCCCEEEECCCCCCHHHHC
PLELGADIVIHSATKYLSGHNDVLAGAVIVHNEKLYEKLVYKLNTTGAVLSPFDSYLVMR
HHHCCCCEEEECHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHH
GLKTLSLRMERATKNALKIVAFLKKLPSVKEVLYPGLGGMISLKVTDKNKIPDILNHLQV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHH
FTFAESLGGVESLITYPAEQTHHDIPLEIRESYGLTDDLLRLSIGIEDVRDLIEDLKEAL
HHHHHHHCCHHHHHHCCCHHCCCCCCEEEHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHH
EN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]