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The map label for this gene is metA

Identifier: 125624949

GI number: 125624949

Start: 2149551

End: 2150510

Strand: Reverse

Name: metA

Synonym: llmg_2182

Alternate gene names: 125624949

Gene position: 2150510-2149551 (Counterclockwise)

Preceding gene: 125624950

Following gene: 125624948

Centisome position: 85.02

GC content: 34.69

Gene sequence:

>960_bases
ATGCCAGTAAAAGTGATTGAAGGTCTGCCTGCCATTGATGAGCTGAGAGCAGATAATATCTTTGTTATGGATAATGAACG
AGCGAAAAATCAAAATATTCGCCCTTTGAATTTGCTGGTGGTCAATCTCATGCCACGTAAATTGATTACTGATCGGCAAA
TTTTACGCTTATTATCAAACACTCCACTTCAAATTAATGTTGATTTTTTGTTTATGGCTAGTCATGAATTCAAAAATACT
AAGCAATCGCATTTGGACTCCTTCTATAAATCTTTTTCTGAAATTAAAGATGACTACTATGATGGTTTGATTATAACGGG
TGCGCCTGTTGAGCAACTTGAATTTGAGGAAGTCGATTATTGGTCTGAGTTTTTAGAAATTGTGAAGTGGTCAAAAAGCC
ATGTTTATTCTAGTTTACATATTTGTTGGGGAGCACAAGCAGCACTTTATGCCCGTTATGAGGTAACAAAAGAAAATCTT
CCACAAAAATTGTGTGGTATTTATAAAAGCTCAGTAGAGCAACCTAAAAATCCATTATTTAGAGGATTTGATGATTTTTT
TAATTATCCACAATCGCGATATACCCAATCAAATCCATCAGAAATAAAAAAAGTACCTGATTTGGAAGTCTTGTCAACAT
CCAAAGAAACTGGTTTTTCTATTTTAGCAAAAAAAAATTTACGTGAAGTTTATCTTTTTGGTCATTTAGAATATGACCGA
GAAACTCTGGCTTGGGAATATGAAAGAGATAGGGAAGAAGGCTTAAAGCCTGCTCTACCTAAAAATTATTTTCCAAAAGA
TAATGATAAAGAGAAACCACAAATGAGCTGGGCTTCAGCTGCCTCACTCTTTTTTTCAAATTGGCTGAATTATGCCGTTT
ATCAAGGAACGCCCTATTTGGGAGAACGTCTTGGTCATCATTGCGGTGAAGAGAATTATGATTTTAATCAAAAAGAGTAG

Upstream 100 bases:

>100_bases
TTTTAAATTATCCCATTACGGAATTATAATACGAGGCTATTGCAAATAAATCATGAAGGGCTATAATTGAGTCTAATTCT
ATGTGAAAGTTGAGTGAGAG

Downstream 100 bases:

>100_bases
AACAAAGGTGTTTTCTATAGGAGAAAATTTATGGATAAAAGATTAGATACTTTATTGGCACAAGTCGGAATTCATCAAGA
TGAAGCTACTGGGGCTTTAG

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MPVKVIEGLPAIDELRADNIFVMDNERAKNQNIRPLNLLVVNLMPRKLITDRQILRLLSNTPLQINVDFLFMASHEFKNT
KQSHLDSFYKSFSEIKDDYYDGLIITGAPVEQLEFEEVDYWSEFLEIVKWSKSHVYSSLHICWGAQAALYARYEVTKENL
PQKLCGIYKSSVEQPKNPLFRGFDDFFNYPQSRYTQSNPSEIKKVPDLEVLSTSKETGFSILAKKNLREVYLFGHLEYDR
ETLAWEYERDREEGLKPALPKNYFPKDNDKEKPQMSWASAASLFFSNWLNYAVYQGTPYLGERLGHHCGEENYDFNQKE

Sequences:

>Translated_319_residues
MPVKVIEGLPAIDELRADNIFVMDNERAKNQNIRPLNLLVVNLMPRKLITDRQILRLLSNTPLQINVDFLFMASHEFKNT
KQSHLDSFYKSFSEIKDDYYDGLIITGAPVEQLEFEEVDYWSEFLEIVKWSKSHVYSSLHICWGAQAALYARYEVTKENL
PQKLCGIYKSSVEQPKNPLFRGFDDFFNYPQSRYTQSNPSEIKKVPDLEVLSTSKETGFSILAKKNLREVYLFGHLEYDR
ETLAWEYERDREEGLKPALPKNYFPKDNDKEKPQMSWASAASLFFSNWLNYAVYQGTPYLGERLGHHCGEENYDFNQKE
>Mature_318_residues
PVKVIEGLPAIDELRADNIFVMDNERAKNQNIRPLNLLVVNLMPRKLITDRQILRLLSNTPLQINVDFLFMASHEFKNTK
QSHLDSFYKSFSEIKDDYYDGLIITGAPVEQLEFEEVDYWSEFLEIVKWSKSHVYSSLHICWGAQAALYARYEVTKENLP
QKLCGIYKSSVEQPKNPLFRGFDDFFNYPQSRYTQSNPSEIKKVPDLEVLSTSKETGFSILAKKNLREVYLFGHLEYDRE
TLAWEYERDREEGLKPALPKNYFPKDNDKEKPQMSWASAASLFFSNWLNYAVYQGTPYLGERLGHHCGEENYDFNQKE

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=299, Percent_Identity=46.1538461538462, Blast_Score=292, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_LACLM (A2RN61)

Other databases:

- EMBL:   AM406671
- RefSeq:   YP_001033432.1
- ProteinModelPortal:   A2RN61
- SMR:   A2RN61
- STRING:   A2RN61
- GeneID:   4796856
- GenomeReviews:   AM406671_GR
- KEGG:   llm:llmg_2182
- eggNOG:   COG1897
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- ProtClustDB:   PRK05368
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 37349; Mature: 37217

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKVIEGLPAIDELRADNIFVMDNERAKNQNIRPLNLLVVNLMPRKLITDRQILRLLSN
CCCCHHCCCCCHHHHCCCCEEEEECCCCCCCCCCHHHHHEEHHHHHHHHHHHHHHHHHCC
TPLQINVDFLFMASHEFKNTKQSHLDSFYKSFSEIKDDYYDGLIITGAPVEQLEFEEVDY
CCEEEEEEEEEEECCHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHH
WSEFLEIVKWSKSHVYSSLHICWGAQAALYARYEVTKENLPQKLCGIYKSSVEQPKNPLF
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCHHH
RGFDDFFNYPQSRYTQSNPSEIKKVPDLEVLSTSKETGFSILAKKNLREVYLFGHLEYDR
CCHHHHHCCCHHHCCCCCHHHHHHCCCHHHHHCCCCCCHHHHHHCCCEEEEEEEEEEECC
ETLAWEYERDREEGLKPALPKNYFPKDNDKEKPQMSWASAASLFFSNWLNYAVYQGTPYL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCHH
GERLGHHCGEENYDFNQKE
HHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PVKVIEGLPAIDELRADNIFVMDNERAKNQNIRPLNLLVVNLMPRKLITDRQILRLLSN
CCCHHCCCCCHHHHCCCCEEEEECCCCCCCCCCHHHHHEEHHHHHHHHHHHHHHHHHCC
TPLQINVDFLFMASHEFKNTKQSHLDSFYKSFSEIKDDYYDGLIITGAPVEQLEFEEVDY
CCEEEEEEEEEEECCHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHH
WSEFLEIVKWSKSHVYSSLHICWGAQAALYARYEVTKENLPQKLCGIYKSSVEQPKNPLF
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCHHH
RGFDDFFNYPQSRYTQSNPSEIKKVPDLEVLSTSKETGFSILAKKNLREVYLFGHLEYDR
CCHHHHHCCCHHHCCCCCHHHHHHCCCHHHHHCCCCCCHHHHHHCCCEEEEEEEEEEECC
ETLAWEYERDREEGLKPALPKNYFPKDNDKEKPQMSWASAASLFFSNWLNYAVYQGTPYL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCHH
GERLGHHCGEENYDFNQKE
HHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA