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The map label for this gene is hisD [H]

Identifier: 125624117

GI number: 125624117

Start: 1264356

End: 1265663

Strand: Reverse

Name: hisD [H]

Synonym: llmg_1295

Alternate gene names: 125624117

Gene position: 1265663-1264356 (Counterclockwise)

Preceding gene: 125624118

Following gene: 125624116

Centisome position: 50.04

GC content: 37.84

Gene sequence:

>1308_bases
ATGCTCAAACAAATTGATTATCAAGGAAGTCTTGAAGAAGTTGCAAATAAATTTCAAGGACGAAAAGCCGAAGTTTCAGA
AGAAGTAAATAAAAGTGTTCAAGAAATTGTCAATGCTATTCGTAAAGAAGGTGATTCTGCCTTATTTAGCTATGCAAAAA
AGTTTGATGGATATAATGCTGACAAAAATAATTTACTTGTCACGCGCAAGGAGCGCGAAGAAGGCTTAGAAAAAATTGAT
GAAAATTACTTTAGAATTCTGCGTCGTACCAAATCACAAATTGAAGAATTTCATAAGCATCAATTAGGAAATTCATGGAG
CATTTATAAAGAAAATGGGGTTATCATGGGTCAAATTGCACGTCCTTTAGAACGTGTCGCCCTTTACGTTCCAGGTGGCA
CAGCAGCCTATCCTTCAACAGTTATTATGAACGCAGTGCCCGCACTTTTAGCAGGGGTTAAAGAAATTATTATGATTACA
CCAGTTAAGTCTGACGGGCAAGTGAATGCAAATATTTTAGCCGCCGCTGAAGTTTGTGGAATTGAAACAATCTATAAAGT
CGGTGGCGCTCAAGCTGTGGCCGCCGTTGCTTACGGGACAGACTCTATTCCTAAAGTTGATAAGATTGTCGGACCCGGAA
ATATTTTTGTAGCCACGGCCAAGAAAATTTGTTACGGTATGGTTGATATTGATATGATTGCAGGACCGTCAGAAGTTTTG
GTCATTGCTGACGAAAAGGCAAATCCAAAATATATAGCCGCCGATTTAATGGCGCAAGCAGAACATGATAAACTTGCGTC
AGCGATTTTAGTGACAACTTCTGAAAGTCTTGTTCAAAAAGTAGATGAAGAATTAGAAAAACAAGTTCAAAGTTTAGAAC
GTCGTGAAATTATTGAAAGTTCTGTCAGTAATTATGGCGGTGCCATTGTTGTCAAATCTATTGACGAAGCCTTTGAAGTT
TCTAATCAATTGGCTCCGGAACATTTAGAAGTTTTGACTAGTGCCCCTTTAGCCCAACTTCCAAAAATCAAAAATGCTGG
TTCAATCTTTCTTGGAGAATACACGCCAGAACCATTGGGCGACTACATGTCAGGAAGTAATCATGTCTTACCTACTGGTG
GAACGGCCAAGTTTTATTCTGGCTTAGGCGTCTACAATTTTGTCAAATATTCAACTTATAGTTATTATCCTAAAGAAATT
TTGGCGGATTTCCAAGAAGATGTTGTAACTTTTGCTAAATCAGAAGGATTGAGTGCTCATGCCAATTCAATTTCTGTGAG
ATTTGATGATGAAAAAAAGGAGAAATAA

Upstream 100 bases:

>100_bases
ATTGAAAAAATCAGTCAAATTTCAACCCGAATGATTGTTAATAAAGTAAGTTTCAAATTCAAAAAAGATAAAATCATAGA
AATAGTGGAGAGATTAGAAA

Downstream 100 bases:

>100_bases
ATGCGTACAGCAACAATAACTCGTGAGACAAAAGAAACACAAATCTATCTAACGCTTGATTTAGATGGCTCAGGAAGAAG
CGAAATCGATACCAATATTG

Product: HisD protein

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLKQIDYQGSLEEVANKFQGRKAEVSEEVNKSVQEIVNAIRKEGDSALFSYAKKFDGYNADKNNLLVTRKEREEGLEKID
ENYFRILRRTKSQIEEFHKHQLGNSWSIYKENGVIMGQIARPLERVALYVPGGTAAYPSTVIMNAVPALLAGVKEIIMIT
PVKSDGQVNANILAAAEVCGIETIYKVGGAQAVAAVAYGTDSIPKVDKIVGPGNIFVATAKKICYGMVDIDMIAGPSEVL
VIADEKANPKYIAADLMAQAEHDKLASAILVTTSESLVQKVDEELEKQVQSLERREIIESSVSNYGGAIVVKSIDEAFEV
SNQLAPEHLEVLTSAPLAQLPKIKNAGSIFLGEYTPEPLGDYMSGSNHVLPTGGTAKFYSGLGVYNFVKYSTYSYYPKEI
LADFQEDVVTFAKSEGLSAHANSISVRFDDEKKEK

Sequences:

>Translated_435_residues
MLKQIDYQGSLEEVANKFQGRKAEVSEEVNKSVQEIVNAIRKEGDSALFSYAKKFDGYNADKNNLLVTRKEREEGLEKID
ENYFRILRRTKSQIEEFHKHQLGNSWSIYKENGVIMGQIARPLERVALYVPGGTAAYPSTVIMNAVPALLAGVKEIIMIT
PVKSDGQVNANILAAAEVCGIETIYKVGGAQAVAAVAYGTDSIPKVDKIVGPGNIFVATAKKICYGMVDIDMIAGPSEVL
VIADEKANPKYIAADLMAQAEHDKLASAILVTTSESLVQKVDEELEKQVQSLERREIIESSVSNYGGAIVVKSIDEAFEV
SNQLAPEHLEVLTSAPLAQLPKIKNAGSIFLGEYTPEPLGDYMSGSNHVLPTGGTAKFYSGLGVYNFVKYSTYSYYPKEI
LADFQEDVVTFAKSEGLSAHANSISVRFDDEKKEK
>Mature_435_residues
MLKQIDYQGSLEEVANKFQGRKAEVSEEVNKSVQEIVNAIRKEGDSALFSYAKKFDGYNADKNNLLVTRKEREEGLEKID
ENYFRILRRTKSQIEEFHKHQLGNSWSIYKENGVIMGQIARPLERVALYVPGGTAAYPSTVIMNAVPALLAGVKEIIMIT
PVKSDGQVNANILAAAEVCGIETIYKVGGAQAVAAVAYGTDSIPKVDKIVGPGNIFVATAKKICYGMVDIDMIAGPSEVL
VIADEKANPKYIAADLMAQAEHDKLASAILVTTSESLVQKVDEELEKQVQSLERREIIESSVSNYGGAIVVKSIDEAFEV
SNQLAPEHLEVLTSAPLAQLPKIKNAGSIFLGEYTPEPLGDYMSGSNHVLPTGGTAKFYSGLGVYNFVKYSTYSYYPKEI
LADFQEDVVTFAKSEGLSAHANSISVRFDDEKKEK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=434, Percent_Identity=38.2488479262673, Blast_Score=300, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6319819, Length=416, Percent_Identity=40.3846153846154, Blast_Score=290, Evalue=4e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47582; Mature: 47582

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKQIDYQGSLEEVANKFQGRKAEVSEEVNKSVQEIVNAIRKEGDSALFSYAKKFDGYNA
CCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
DKNNLLVTRKEREEGLEKIDENYFRILRRTKSQIEEFHKHQLGNSWSIYKENGVIMGQIA
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEHHHH
RPLERVALYVPGGTAAYPSTVIMNAVPALLAGVKEIIMITPVKSDGQVNANILAAAEVCG
HHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCEEHHHHHHH
IETIYKVGGAQAVAAVAYGTDSIPKVDKIVGPGNIFVATAKKICYGMVDIDMIAGPSEVL
HHHHHHCCCHHHHHHEEECCCCCCCHHHHCCCCCEEEEEHHHHHHHHHHHHEECCCCEEE
VIADEKANPKYIAADLMAQAEHDKLASAILVTTSESLVQKVDEELEKQVQSLERREIIES
EEECCCCCCCHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
SVSNYGGAIVVKSIDEAFEVSNQLAPEHLEVLTSAPLAQLPKIKNAGSIFLGEYTPEPLG
HHHCCCCEEEEECHHHHHHHHHCCCHHHHHHHHCCCHHHCCCCCCCCCEEEECCCCCCHH
DYMSGSNHVLPTGGTAKFYSGLGVYNFVKYSTYSYYPKEILADFQEDVVTFAKSEGLSAH
HHHCCCCEEECCCCCHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
ANSISVRFDDEKKEK
CCEEEEEECCCCCCC
>Mature Secondary Structure
MLKQIDYQGSLEEVANKFQGRKAEVSEEVNKSVQEIVNAIRKEGDSALFSYAKKFDGYNA
CCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
DKNNLLVTRKEREEGLEKIDENYFRILRRTKSQIEEFHKHQLGNSWSIYKENGVIMGQIA
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEHHHH
RPLERVALYVPGGTAAYPSTVIMNAVPALLAGVKEIIMITPVKSDGQVNANILAAAEVCG
HHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCEEHHHHHHH
IETIYKVGGAQAVAAVAYGTDSIPKVDKIVGPGNIFVATAKKICYGMVDIDMIAGPSEVL
HHHHHHCCCHHHHHHEEECCCCCCCHHHHCCCCCEEEEEHHHHHHHHHHHHEECCCCEEE
VIADEKANPKYIAADLMAQAEHDKLASAILVTTSESLVQKVDEELEKQVQSLERREIIES
EEECCCCCCCHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
SVSNYGGAIVVKSIDEAFEVSNQLAPEHLEVLTSAPLAQLPKIKNAGSIFLGEYTPEPLG
HHHCCCCEEEEECHHHHHHHHHCCCHHHHHHHHCCCHHHCCCCCCCCCEEEECCCCCCHH
DYMSGSNHVLPTGGTAKFYSGLGVYNFVKYSTYSYYPKEILADFQEDVVTFAKSEGLSAH
HHHCCCCEEECCCCCHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
ANSISVRFDDEKKEK
CCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1400209; 11337471 [H]