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The map label for this gene is hisB [H]

Identifier: 125624116

GI number: 125624116

Start: 1263756

End: 1264355

Strand: Reverse

Name: hisB [H]

Synonym: llmg_1294

Alternate gene names: 125624116

Gene position: 1264355-1263756 (Counterclockwise)

Preceding gene: 125624117

Following gene: 125624115

Centisome position: 49.98

GC content: 37.83

Gene sequence:

>600_bases
ATGCGTACAGCAACAATAACTCGTGAGACAAAAGAAACACAAATCTATCTAACGCTTGATTTAGATGGCTCAGGAAGAAG
CGAAATCGATACCAATATTGGTTTCTTAGACCACATGTTGACACTCCTTGCTTTTCATAGCGATTTTGATATTAAACTCA
CTGCTCATGGCGACCATGAAAATTCAGGCATGGACCCACATCATCTAATTGAAGATGTGGCAATTTCTCTTGGAAAATGT
ATCAATGAAGCTTTAGGAGATAAACTTGGAATTCGTCGCTATGGCAGTTTTACCATTCCAATGGATGAAGCACTGGTTAC
CTGTGATTTAGATATTAGTGGACGCCCTTATTTGGTATTTAATGCCGATTTATCAGGAAATAAAAAACTTGGGGGCTATG
ATACCGAAATGACTGAAGAATTTTTCCGAGCCCTTGCTTTTAATGCTGGGATTACTTTACATCTGAACGAACATTACGGG
AAAAATACGCATCATATCATTGAAGGAATCTTTAAATCTATGGCACGTGCCCTTAAACAAGCGATAAGTATTGATGAGAC
TAAAGTTGGAAAAATACCAAGCAGTAAAGGAGTTTTGTGA

Upstream 100 bases:

>100_bases
TTTCCAAGAAGATGTTGTAACTTTTGCTAAATCAGAAGGATTGAGTGCTCATGCCAATTCAATTTCTGTGAGATTTGATG
ATGAAAAAAAGGAGAAATAA

Downstream 100 bases:

>100_bases
GCGAGTTAAAAGAGTTATACATTAACATTGAGGAATTCCCTGAAAAACTTCAGAATACGTTAAAAGATGCAAAAGTTTAT
GATAGCAGTTCATCTCCTGA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MRTATITRETKETQIYLTLDLDGSGRSEIDTNIGFLDHMLTLLAFHSDFDIKLTAHGDHENSGMDPHHLIEDVAISLGKC
INEALGDKLGIRRYGSFTIPMDEALVTCDLDISGRPYLVFNADLSGNKKLGGYDTEMTEEFFRALAFNAGITLHLNEHYG
KNTHHIIEGIFKSMARALKQAISIDETKVGKIPSSKGVL

Sequences:

>Translated_199_residues
MRTATITRETKETQIYLTLDLDGSGRSEIDTNIGFLDHMLTLLAFHSDFDIKLTAHGDHENSGMDPHHLIEDVAISLGKC
INEALGDKLGIRRYGSFTIPMDEALVTCDLDISGRPYLVFNADLSGNKKLGGYDTEMTEEFFRALAFNAGITLHLNEHYG
KNTHHIIEGIFKSMARALKQAISIDETKVGKIPSSKGVL
>Mature_199_residues
MRTATITRETKETQIYLTLDLDGSGRSEIDTNIGFLDHMLTLLAFHSDFDIKLTAHGDHENSGMDPHHLIEDVAISLGKC
INEALGDKLGIRRYGSFTIPMDEALVTCDLDISGRPYLVFNADLSGNKKLGGYDTEMTEEFFRALAFNAGITLHLNEHYG
KNTHHIIEGIFKSMARALKQAISIDETKVGKIPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=198, Percent_Identity=46.4646464646465, Blast_Score=171, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6324776, Length=222, Percent_Identity=36.036036036036, Blast_Score=122, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 22024; Mature: 22024

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTATITRETKETQIYLTLDLDGSGRSEIDTNIGFLDHMLTLLAFHSDFDIKLTAHGDHE
CCCCEEECCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCC
NSGMDPHHLIEDVAISLGKCINEALGDKLGIRRYGSFTIPMDEALVTCDLDISGRPYLVF
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCEECCCCCEEEEEEECCCCCEEEEE
NADLSGNKKLGGYDTEMTEEFFRALAFNAGITLHLNEHYGKNTHHIIEGIFKSMARALKQ
ECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
AISIDETKVGKIPSSKGVL
HHCCCCHHCCCCCCCCCCC
>Mature Secondary Structure
MRTATITRETKETQIYLTLDLDGSGRSEIDTNIGFLDHMLTLLAFHSDFDIKLTAHGDHE
CCCCEEECCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCC
NSGMDPHHLIEDVAISLGKCINEALGDKLGIRRYGSFTIPMDEALVTCDLDISGRPYLVF
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCEECCCCCEEEEEEECCCCCEEEEE
NADLSGNKKLGGYDTEMTEEFFRALAFNAGITLHLNEHYGKNTHHIIEGIFKSMARALKQ
ECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
AISIDETKVGKIPSSKGVL
HHCCCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA