Click here to switch to the map view.

The map label for this gene is hisG

Identifier: 125624118

GI number: 125624118

Start: 1265647

End: 1266273

Strand: Reverse

Name: hisG

Synonym: llmg_1296

Alternate gene names: 125624118

Gene position: 1266273-1265647 (Counterclockwise)

Preceding gene: 125624119

Following gene: 125624117

Centisome position: 50.06

GC content: 34.77

Gene sequence:

>627_bases
ATGATTAGAGTAGCAATGACCAAAGGGCGCATTCAAAAGCAGGTCACGATTTTGCTAGAACAGGCAGGATTTGATATGAC
GGCGGTGCGCGAAATGGGGCGTGAGTTGGTGGTAACCATACCAGATGATTTGGAAATTATTTTTGGAAAAGCCAATGATG
TCATAACTTTTTTGGAGCATGGAATTGTTGATATTGGATTTGTCGGTAAAGATACGCTTGATGAAAATGATTTTGATGAT
TATTATGAGTTATTAGATTTAAAAGTTGGTCAGTGCATCTTTGCCCTTGCTTCCTATCCAGATTTTTTAAATAAAAAATT
TCACAGGCGTAAGCGAATTGCTTCTAAATATCCAAGAATCACTAAAAATTATTTTGCTCAAAAGCAAGAGGATATTGAGA
TTATCAAATTAGAAGGGTCTGTTGAGCTTGGTCCAGTAGTTGGTTTAGCAGATGCTATTGTTGATATTGTCGAAACTGGA
AATACACTGTCAGCAAATGGCTTAGTCGTGATTGAAAAAATCAGTCAAATTTCAACCCGAATGATTGTTAATAAAGTAAG
TTTCAAATTCAAAAAAGATAAAATCATAGAAATAGTGGAGAGATTAGAAAATGCTCAAACAAATTGA

Upstream 100 bases:

>100_bases
GCAAGCTGTCAAAGGCGACCAAGGGGGAGCTTTCAGGTTGCGGATAGAAGCTTGCGTAAGCAAGCTATCTGCTCGCCCTT
TGGGCAGATAGGAGACAGAT

Downstream 100 bases:

>100_bases
TTATCAAGGAAGTCTTGAAGAAGTTGCAAATAAATTTCAAGGACGAAAAGCCGAAGTTTCAGAAGAAGTAAATAAAAGTG
TTCAAGAAATTGTCAATGCT

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MIRVAMTKGRIQKQVTILLEQAGFDMTAVREMGRELVVTIPDDLEIIFGKANDVITFLEHGIVDIGFVGKDTLDENDFDD
YYELLDLKVGQCIFALASYPDFLNKKFHRRKRIASKYPRITKNYFAQKQEDIEIIKLEGSVELGPVVGLADAIVDIVETG
NTLSANGLVVIEKISQISTRMIVNKVSFKFKKDKIIEIVERLENAQTN

Sequences:

>Translated_208_residues
MIRVAMTKGRIQKQVTILLEQAGFDMTAVREMGRELVVTIPDDLEIIFGKANDVITFLEHGIVDIGFVGKDTLDENDFDD
YYELLDLKVGQCIFALASYPDFLNKKFHRRKRIASKYPRITKNYFAQKQEDIEIIKLEGSVELGPVVGLADAIVDIVETG
NTLSANGLVVIEKISQISTRMIVNKVSFKFKKDKIIEIVERLENAQTN
>Mature_208_residues
MIRVAMTKGRIQKQVTILLEQAGFDMTAVREMGRELVVTIPDDLEIIFGKANDVITFLEHGIVDIGFVGKDTLDENDFDD
YYELLDLKVGQCIFALASYPDFLNKKFHRRKRIASKYPRITKNYFAQKQEDIEIIKLEGSVELGPVVGLADAIVDIVETG
NTLSANGLVVIEKISQISTRMIVNKVSFKFKKDKIIEIVERLENAQTN

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=212, Percent_Identity=31.1320754716981, Blast_Score=88, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=209, Percent_Identity=30.622009569378, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_LACLM (A2RKS3)

Other databases:

- EMBL:   AM406671
- RefSeq:   YP_001032601.1
- ProteinModelPortal:   A2RKS3
- SMR:   A2RKS3
- STRING:   A2RKS3
- GeneID:   4798549
- GenomeReviews:   AM406671_GR
- KEGG:   llm:llmg_1296
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23543; Mature: 23543

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVAMTKGRIQKQVTILLEQAGFDMTAVREMGRELVVTIPDDLEIIFGKANDVITFLEH
CEEEEECHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEECCCCCEEEEECCCHHHHHHHC
GIVDIGFVGKDTLDENDFDDYYELLDLKVGQCIFALASYPDFLNKKFHRRKRIASKYPRI
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHH
TKNYFAQKQEDIEIIKLEGSVELGPVVGLADAIVDIVETGNTLSANGLVVIEKISQISTR
HHHHHHCCCCCEEEEEEECCEEECHHHHHHHHHHHHHHCCCEECCCCEEEEHHHHHHHHH
MIVNKVSFKFKKDKIIEIVERLENAQTN
HHHHHHHHHCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIRVAMTKGRIQKQVTILLEQAGFDMTAVREMGRELVVTIPDDLEIIFGKANDVITFLEH
CEEEEECHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEECCCCCEEEEECCCHHHHHHHC
GIVDIGFVGKDTLDENDFDDYYELLDLKVGQCIFALASYPDFLNKKFHRRKRIASKYPRI
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHH
TKNYFAQKQEDIEIIKLEGSVELGPVVGLADAIVDIVETGNTLSANGLVVIEKISQISTR
HHHHHHCCCCCEEEEEEECCEEECHHHHHHHHHHHHHHCCCEECCCCEEEEHHHHHHHHH
MIVNKVSFKFKKDKIIEIVERLENAQTN
HHHHHHHHHCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA