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The map label for this gene is purM

Identifier: 125623825

GI number: 125623825

Start: 951380

End: 952402

Strand: Direct

Name: purM

Synonym: llmg_0987

Alternate gene names: 125623825

Gene position: 951380-952402 (Clockwise)

Preceding gene: 125623824

Following gene: 125623826

Centisome position: 37.61

GC content: 40.66

Gene sequence:

>1023_bases
ATGACAGTGTCTGAGAATGCGTATGCAAAATCTGGGGTAGATGTAGAAGCAGGATATGAGGTGGTTTCTCGTATTAAGAA
GCACGTTGCTAAAACCGAACGTTTAGGGGTGCTTGGGGCACTGGGTGGTTTTGGTGGAAGTTTTGACTTATCTGTGCTTG
ATGTCAAAGAACCTGTATTGATTTCAGGGACAGATGGTGTAGGGACCAAGTTGATGCTGGCCATTCGAGCAGACAAGCAT
GATACGATTGGGATTGATTGCGTAGCCATGTGTGTCAATGACATTATTGCTGCTGGGGCTGAGCCGTTGTATTTTTTGGA
TTATATTGCGACAGGGAAAAATATTCCTGAAAAATTGGAGCAAGTTGTGGCTGGAGTGGCCGAAGGTTGCTTGCAAGCAG
GAGCAGCTCTGATTGGTGGAGAAACAGCTGAAATGCCCGGAATGTATGATGAAGATGATTATGATTTAGCTGGTTTTGCT
GTGGGTGTGGCTGAAAAATCACAATTAATTGATGGCGAAAAAGATGTGGAAGCAGGCGATGTTTTGCTTGGTCTTGCATC
ATCTGGGATTCATTCTAATGGATACTCTTTGGTTCGGAAAGTTTTTGCTGACTTTGATTTGAATGAATCATTGCCTGAAC
TTGACCAATCTTTGATTGATACTCTTTTAACTCCGACTAAAATCTATGTCAAAGAGCTCTTGCCTTTGATTAAGCAAAAT
AAAATAAAAGGAATTGCTCATATTACGGGTGGAGGATTCCATGAAAATTTGCCAAGAATGTTCGGAAATAGCTTGTCAGC
TGAAATTGTCGAAGGTTCTTGGGATGTTTTACCAATTTTCAAGGCTCTTGAAAAATATGGAAGTATCAAGCACGAAGAAA
TGTATGAAATTTTCAATATGGGGATTGGAATGGTTATCGCTGTTGCTCCTGAAAATGCTGCTGCTCTCAAAAAAGAGTTG
AATGCTTTCGAGATTGGTCAAATGGTTAATCGACAAGAGGCACCAGTAGTTATTAAAAAATAA

Upstream 100 bases:

>100_bases
CAATCCAATCAAAAAGTTTCAGTTCTACCTGCTGGAACTTTTTTTATGTTTGAAAATCATTTAACATGGAAGTAGAATAA
AATAAATCAGAAAATGGAGA

Downstream 100 bases:

>100_bases
TCTTTTTTCATTAAGAATAGGGGATAGAATGAAAATTGCAGTATTTGCATCAGGAAATGGCTCTAACTTTCAAAGACTAG
CTGAACAATTTCCTAAGGTA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MTVSENAYAKSGVDVEAGYEVVSRIKKHVAKTERLGVLGALGGFGGSFDLSVLDVKEPVLISGTDGVGTKLMLAIRADKH
DTIGIDCVAMCVNDIIAAGAEPLYFLDYIATGKNIPEKLEQVVAGVAEGCLQAGAALIGGETAEMPGMYDEDDYDLAGFA
VGVAEKSQLIDGEKDVEAGDVLLGLASSGIHSNGYSLVRKVFADFDLNESLPELDQSLIDTLLTPTKIYVKELLPLIKQN
KIKGIAHITGGGFHENLPRMFGNSLSAEIVEGSWDVLPIFKALEKYGSIKHEEMYEIFNMGIGMVIAVAPENAAALKKEL
NAFEIGQMVNRQEAPVVIKK

Sequences:

>Translated_340_residues
MTVSENAYAKSGVDVEAGYEVVSRIKKHVAKTERLGVLGALGGFGGSFDLSVLDVKEPVLISGTDGVGTKLMLAIRADKH
DTIGIDCVAMCVNDIIAAGAEPLYFLDYIATGKNIPEKLEQVVAGVAEGCLQAGAALIGGETAEMPGMYDEDDYDLAGFA
VGVAEKSQLIDGEKDVEAGDVLLGLASSGIHSNGYSLVRKVFADFDLNESLPELDQSLIDTLLTPTKIYVKELLPLIKQN
KIKGIAHITGGGFHENLPRMFGNSLSAEIVEGSWDVLPIFKALEKYGSIKHEEMYEIFNMGIGMVIAVAPENAAALKKEL
NAFEIGQMVNRQEAPVVIKK
>Mature_339_residues
TVSENAYAKSGVDVEAGYEVVSRIKKHVAKTERLGVLGALGGFGGSFDLSVLDVKEPVLISGTDGVGTKLMLAIRADKHD
TIGIDCVAMCVNDIIAAGAEPLYFLDYIATGKNIPEKLEQVVAGVAEGCLQAGAALIGGETAEMPGMYDEDDYDLAGFAV
GVAEKSQLIDGEKDVEAGDVLLGLASSGIHSNGYSLVRKVFADFDLNESLPELDQSLIDTLLTPTKIYVKELLPLIKQNK
IKGIAHITGGGFHENLPRMFGNSLSAEIVEGSWDVLPIFKALEKYGSIKHEEMYEIFNMGIGMVIAVAPENAAALKKELN
AFEIGQMVNRQEAPVVIKK

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=341, Percent_Identity=47.5073313782991, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI209869995, Length=341, Percent_Identity=47.5073313782991, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI209869993, Length=341, Percent_Identity=47.5073313782991, Blast_Score=307, Evalue=1e-83,
Organism=Escherichia coli, GI1788845, Length=326, Percent_Identity=54.2944785276074, Blast_Score=331, Evalue=5e-92,
Organism=Caenorhabditis elegans, GI17567511, Length=338, Percent_Identity=40.8284023668639, Blast_Score=235, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6321203, Length=341, Percent_Identity=45.4545454545455, Blast_Score=287, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24582400, Length=286, Percent_Identity=42.6573426573427, Blast_Score=228, Evalue=5e-60,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_LACLM (O68186)

Other databases:

- EMBL:   AF016634
- EMBL:   AM406671
- RefSeq:   YP_001032308.1
- ProteinModelPortal:   O68186
- SMR:   O68186
- STRING:   O68186
- GeneID:   4797128
- GenomeReviews:   AM406671_GR
- KEGG:   llm:llmg_0987
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- ProtClustDB:   PRK05385
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36292; Mature: 36161

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSENAYAKSGVDVEAGYEVVSRIKKHVAKTERLGVLGALGGFGGSFDLSVLDVKEPVL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEE
ISGTDGVGTKLMLAIRADKHDTIGIDCVAMCVNDIIAAGAEPLYFLDYIATGKNIPEKLE
EECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHH
QVVAGVAEGCLQAGAALIGGETAEMPGMYDEDDYDLAGFAVGVAEKSQLIDGEKDVEAGD
HHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCCCHHHHEEEHHHHHHHCCCCCCCCCCH
VLLGLASSGIHSNGYSLVRKVFADFDLNESLPELDQSLIDTLLTPTKIYVKELLPLIKQN
HEEEHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
KIKGIAHITGGGFHENLPRMFGNSLSAEIVEGSWDVLPIFKALEKYGSIKHEEMYEIFNM
CCCEEEEECCCCHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHC
GIGMVIAVAPENAAALKKELNAFEIGQMVNRQEAPVVIKK
CCCEEEEECCCCHHHHHHHCCHHHHHHHHCCCCCCEEEEC
>Mature Secondary Structure 
TVSENAYAKSGVDVEAGYEVVSRIKKHVAKTERLGVLGALGGFGGSFDLSVLDVKEPVL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEE
ISGTDGVGTKLMLAIRADKHDTIGIDCVAMCVNDIIAAGAEPLYFLDYIATGKNIPEKLE
EECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHH
QVVAGVAEGCLQAGAALIGGETAEMPGMYDEDDYDLAGFAVGVAEKSQLIDGEKDVEAGD
HHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCCCHHHHEEEHHHHHHHCCCCCCCCCCH
VLLGLASSGIHSNGYSLVRKVFADFDLNESLPELDQSLIDTLLTPTKIYVKELLPLIKQN
HEEEHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
KIKGIAHITGGGFHENLPRMFGNSLSAEIVEGSWDVLPIFKALEKYGSIKHEEMYEIFNM
CCCEEEEECCCCHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHC
GIGMVIAVAPENAAALKKELNAFEIGQMVNRQEAPVVIKK
CCCEEEEECCCCHHHHHHHCCHHHHHHHHCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA