Click here to switch to the map view.

The map label for this gene is ytpA [H]

Identifier: 125623776

GI number: 125623776

Start: 904223

End: 905068

Strand: Direct

Name: ytpA [H]

Synonym: llmg_0935

Alternate gene names: 125623776

Gene position: 904223-905068 (Clockwise)

Preceding gene: 125623775

Following gene: 125623777

Centisome position: 35.75

GC content: 36.17

Gene sequence:

>846_bases
ATGAAGAAACAGTATGAAATTATTTCAATGAAAGATCACTATCGGATTCGTCTTGGAATTTTTGAACCACAAGAAAAAGC
AAAAGGCGTGGTGCAATTAGTTCATGGTTTTGGCGAATATACGGGTCATTATTTATATTTAATCAATGAATTAGTTAATG
CTGGTTTTGTTTGCTTTATGCACGACCAAAGAGGACATGGGGTTCTAGCAGCAGCTAAACCTAAACTTCAAGGACGAGCA
AGAAATTATGAAAACTTTATTAGTGATGCTTTAGAAGTCCGAAAAATAATTGGCAAAAGATATCCCAAATTACCAGTTTA
TCTCTTCGGACACAGTATGGGAGGAAATATTTCACTGAATGTTCTGCTGAGAAATGTTGAAAATCAAAAACTTTATCAAA
AAGCAGTTATTGAATCTCCTTGGCTTGCCTTGACAAATCCACCGGCTATTCCCCTACAAAAGTTGGCTCAAGTTTTAGGG
AAATTTAATTCAAAAATTAGAGTTCGTACGGGACTTAAAGTTGATGCAATCTCTCATCGGAGTGACTTAGTTGATTTAGT
GACTAAAGATGGAATATATCATGAACTATTATCTTTACGTTTGTTTTCACAAATTATGGAAGCAGGACGTTTTGCCCAAA
GTCAGGCCGAGCAGTTAAAGATACCGACCTTATTATTTTGTGGAGAAGAAGACCAAATTTGTTCACCGTTAGCGATTCGT
TCCTTTGCTGAAAATGCTGGTGCTAATTTGGAATTAGTTGAAGTTGCTGAGGGCTATCATGCCCTTCATTTAGATACTAA
AGCAGATGCTTTCATTGACAAAATGAAGGCTTTCCTGCTTGAATAA

Upstream 100 bases:

>100_bases
TTTAACGATTCTTTAGAATTTACTAAAGTACTAAGTGAAGTAATCGAGAAAAATAAAGTTGAAGTTGAAGTTTAAAATTT
AGAGTAAAAGGAAATGCTTA

Downstream 100 bases:

>100_bases
GACTGAGTAAAATAAAAGGCTATTTAATTTTGAATAGCTTTTTTATTTTATGATTTTATATTTGCTGCTGAAAATTGAGC
CCTTTATATTTCAAAAATTT

Product: putative lysophospholipase

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MKKQYEIISMKDHYRIRLGIFEPQEKAKGVVQLVHGFGEYTGHYLYLINELVNAGFVCFMHDQRGHGVLAAAKPKLQGRA
RNYENFISDALEVRKIIGKRYPKLPVYLFGHSMGGNISLNVLLRNVENQKLYQKAVIESPWLALTNPPAIPLQKLAQVLG
KFNSKIRVRTGLKVDAISHRSDLVDLVTKDGIYHELLSLRLFSQIMEAGRFAQSQAEQLKIPTLLFCGEEDQICSPLAIR
SFAENAGANLELVEVAEGYHALHLDTKADAFIDKMKAFLLE

Sequences:

>Translated_281_residues
MKKQYEIISMKDHYRIRLGIFEPQEKAKGVVQLVHGFGEYTGHYLYLINELVNAGFVCFMHDQRGHGVLAAAKPKLQGRA
RNYENFISDALEVRKIIGKRYPKLPVYLFGHSMGGNISLNVLLRNVENQKLYQKAVIESPWLALTNPPAIPLQKLAQVLG
KFNSKIRVRTGLKVDAISHRSDLVDLVTKDGIYHELLSLRLFSQIMEAGRFAQSQAEQLKIPTLLFCGEEDQICSPLAIR
SFAENAGANLELVEVAEGYHALHLDTKADAFIDKMKAFLLE
>Mature_281_residues
MKKQYEIISMKDHYRIRLGIFEPQEKAKGVVQLVHGFGEYTGHYLYLINELVNAGFVCFMHDQRGHGVLAAAKPKLQGRA
RNYENFISDALEVRKIIGKRYPKLPVYLFGHSMGGNISLNVLLRNVENQKLYQKAVIESPWLALTNPPAIPLQKLAQVLG
KFNSKIRVRTGLKVDAISHRSDLVDLVTKDGIYHELLSLRLFSQIMEAGRFAQSQAEQLKIPTLLFCGEEDQICSPLAIR
SFAENAGANLELVEVAEGYHALHLDTKADAFIDKMKAFLLE

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=255, Percent_Identity=28.6274509803922, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI6005786, Length=255, Percent_Identity=28.6274509803922, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6322756, Length=276, Percent_Identity=27.536231884058, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 31706; Mature: 31706

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQYEIISMKDHYRIRLGIFEPQEKAKGVVQLVHGFGEYTGHYLYLINELVNAGFVCFM
CCCCEEEEEECCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
HDQRGHGVLAAAKPKLQGRARNYENFISDALEVRKIIGKRYPKLPVYLFGHSMGGNISLN
ECCCCCEEEEECCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEE
VLLRNVENQKLYQKAVIESPWLALTNPPAIPLQKLAQVLGKFNSKIRVRTGLKVDAISHR
EEEECCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCEEEEEECCEEEECCCH
SDLVDLVTKDGIYHELLSLRLFSQIMEAGRFAQSQAEQLKIPTLLFCGEEDQICSPLAIR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHH
SFAENAGANLELVEVAEGYHALHLDTKADAFIDKMKAFLLE
HHHHHCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKQYEIISMKDHYRIRLGIFEPQEKAKGVVQLVHGFGEYTGHYLYLINELVNAGFVCFM
CCCCEEEEEECCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
HDQRGHGVLAAAKPKLQGRARNYENFISDALEVRKIIGKRYPKLPVYLFGHSMGGNISLN
ECCCCCEEEEECCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEE
VLLRNVENQKLYQKAVIESPWLALTNPPAIPLQKLAQVLGKFNSKIRVRTGLKVDAISHR
EEEECCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCEEEEEECCEEEECCCH
SDLVDLVTKDGIYHELLSLRLFSQIMEAGRFAQSQAEQLKIPTLLFCGEEDQICSPLAIR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHH
SFAENAGANLELVEVAEGYHALHLDTKADAFIDKMKAFLLE
HHHHHCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]