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The map label for this gene is hemH

Identifier: 125623775

GI number: 125623775

Start: 903241

End: 904197

Strand: Direct

Name: hemH

Synonym: llmg_0934

Alternate gene names: 125623775

Gene position: 903241-904197 (Clockwise)

Preceding gene: 125623774

Following gene: 125623776

Centisome position: 35.71

GC content: 35.53

Gene sequence:

>957_bases
ATGGATAAGAAAAAAGGAATCTTATTAGTAGCTTTAGGGACGCCTCGTTCTTGTGAGACAGAGGATGTAAGGGAATATTT
AAAAGAATTTTTGGGTGATCCACTCGTCATTCAAAAACCAAGATGGCTTTGGCTTCCAATTTTGAATGGTATTATTTTAA
AAGTAAGACCGCAAAAATCAGCAGAGATGTATAAACAAATCTGGACTGACGAGGGTTCACCTTTGATGAGTTACACAATA
GCCCAAACAGAACAATTACAAGGACTTCGTGAAGACTTTGATGTTCGCTTTGCCATGACCTACGGAGAGCCCCGCATTGA
TAAGGTCATTAGAGAGATGAAAGAATCAGGAGTTGAGGATATTACTGTACTCCCACTCTATCCTCAATACTCATTAACAA
CCGTTGAGCCAATTATTCAACAAGTTAAGAAAATTGATGACAAAATTAATGTTATTCGAGATTTTCATCAGATTGAATCT
TATACAGACTTACTGGCAGAGTCTATCAGAGAAAAATGGCAAGCCAATCATTATGATAAGCTTATTCTTAGCTACCATGG
CATTCCACTATCGTATGTAACGAAGAAGAAAGATGCTTATGAGGCACAATGTATCGAAACTACGCGGCTATTTGTTGAAA
AATTAGGCTTAAAGGAAGAAGAATACGAGCATACTTACCAATCAAAATTTGGTCCTGAGAAATGGTTAGAGCCTGCAACA
ATAGATAGAATTGCTGAGCTTCCTAAAGAAGATACAAAGAAAGTATTAATTTGTTCTCCAGCTTTTGTGGCGGATTGTTT
GGAAACTTTATTTGAATTAGAAATTGAAAATAAAGAAGTTTTTGTGGAAAATGGGGGCGAGACTTTTGATTTTGTCCATC
CATTTAACGATTCTTTAGAATTTACTAAAGTACTAAGTGAAGTAATCGAGAAAAATAAAGTTGAAGTTGAAGTTTAA

Upstream 100 bases:

>100_bases
ATTGTCCCCAAAAATATGCTAGAATGAAAAAATATTGATTAATAATTGTAGAAATAATCAGTGATAAATATAAATTAACT
GATTTTTATATAGGTGGATA

Downstream 100 bases:

>100_bases
AATTTAGAGTAAAAGGAAATGCTTAATGAAGAAACAGTATGAAATTATTTCAATGAAAGATCACTATCGGATTCGTCTTG
GAATTTTTGAACCACAAGAA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MDKKKGILLVALGTPRSCETEDVREYLKEFLGDPLVIQKPRWLWLPILNGIILKVRPQKSAEMYKQIWTDEGSPLMSYTI
AQTEQLQGLREDFDVRFAMTYGEPRIDKVIREMKESGVEDITVLPLYPQYSLTTVEPIIQQVKKIDDKINVIRDFHQIES
YTDLLAESIREKWQANHYDKLILSYHGIPLSYVTKKKDAYEAQCIETTRLFVEKLGLKEEEYEHTYQSKFGPEKWLEPAT
IDRIAELPKEDTKKVLICSPAFVADCLETLFELEIENKEVFVENGGETFDFVHPFNDSLEFTKVLSEVIEKNKVEVEV

Sequences:

>Translated_318_residues
MDKKKGILLVALGTPRSCETEDVREYLKEFLGDPLVIQKPRWLWLPILNGIILKVRPQKSAEMYKQIWTDEGSPLMSYTI
AQTEQLQGLREDFDVRFAMTYGEPRIDKVIREMKESGVEDITVLPLYPQYSLTTVEPIIQQVKKIDDKINVIRDFHQIES
YTDLLAESIREKWQANHYDKLILSYHGIPLSYVTKKKDAYEAQCIETTRLFVEKLGLKEEEYEHTYQSKFGPEKWLEPAT
IDRIAELPKEDTKKVLICSPAFVADCLETLFELEIENKEVFVENGGETFDFVHPFNDSLEFTKVLSEVIEKNKVEVEV
>Mature_318_residues
MDKKKGILLVALGTPRSCETEDVREYLKEFLGDPLVIQKPRWLWLPILNGIILKVRPQKSAEMYKQIWTDEGSPLMSYTI
AQTEQLQGLREDFDVRFAMTYGEPRIDKVIREMKESGVEDITVLPLYPQYSLTTVEPIIQQVKKIDDKINVIRDFHQIES
YTDLLAESIREKWQANHYDKLILSYHGIPLSYVTKKKDAYEAQCIETTRLFVEKLGLKEEEYEHTYQSKFGPEKWLEPAT
IDRIAELPKEDTKKVLICSPAFVADCLETLFELEIENKEVFVENGGETFDFVHPFNDSLEFTKVLSEVIEKNKVEVEV

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=348, Percent_Identity=25.8620689655172, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI60499021, Length=348, Percent_Identity=25.8620689655172, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1786681, Length=318, Percent_Identity=36.4779874213836, Blast_Score=216, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6324750, Length=314, Percent_Identity=25.4777070063694, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17864156, Length=330, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_LACLM (A2RJS3)

Other databases:

- EMBL:   AM406671
- RefSeq:   YP_001032258.1
- ProteinModelPortal:   A2RJS3
- SMR:   A2RJS3
- STRING:   A2RJS3
- GeneID:   4797693
- GenomeReviews:   AM406671_GR
- KEGG:   llm:llmg_0934
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   TIEEIGM
- ProtClustDB:   CLSK697807
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 37035; Mature: 37035

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKKGILLVALGTPRSCETEDVREYLKEFLGDPLVIQKPRWLWLPILNGIILKVRPQKS
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCEEEHHHHCCEEEEECCCHH
AEMYKQIWTDEGSPLMSYTIAQTEQLQGLREDFDVRFAMTYGEPRIDKVIREMKESGVED
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHCCCCC
ITVLPLYPQYSLTTVEPIIQQVKKIDDKINVIRDFHQIESYTDLLAESIREKWQANHYDK
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LILSYHGIPLSYVTKKKDAYEAQCIETTRLFVEKLGLKEEEYEHTYQSKFGPEKWLEPAT
HHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHCCCCHH
IDRIAELPKEDTKKVLICSPAFVADCLETLFELEIENKEVFVENGGETFDFVHPFNDSLE
HHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHEECCCCEEEEECCCCEEEEECCCCCCHH
FTKVLSEVIEKNKVEVEV
HHHHHHHHHHCCCCEEEC
>Mature Secondary Structure
MDKKKGILLVALGTPRSCETEDVREYLKEFLGDPLVIQKPRWLWLPILNGIILKVRPQKS
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCEEEHHHHCCEEEEECCCHH
AEMYKQIWTDEGSPLMSYTIAQTEQLQGLREDFDVRFAMTYGEPRIDKVIREMKESGVED
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHCCCCC
ITVLPLYPQYSLTTVEPIIQQVKKIDDKINVIRDFHQIESYTDLLAESIREKWQANHYDK
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LILSYHGIPLSYVTKKKDAYEAQCIETTRLFVEKLGLKEEEYEHTYQSKFGPEKWLEPAT
HHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHCCCCHH
IDRIAELPKEDTKKVLICSPAFVADCLETLFELEIENKEVFVENGGETFDFVHPFNDSLE
HHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHEECCCCEEEEECCCCEEEEECCCCCCHH
FTKVLSEVIEKNKVEVEV
HHHHHHHHHHCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA