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The map label for this gene is lysS [H]

Identifier: 125623258

GI number: 125623258

Start: 380881

End: 382365

Strand: Reverse

Name: lysS [H]

Synonym: llmg_0389

Alternate gene names: 125623258

Gene position: 382365-380881 (Counterclockwise)

Preceding gene: 125623259

Following gene: 125623254

Centisome position: 15.12

GC content: 39.8

Gene sequence:

>1485_bases
TTGGCTGAAATCGAAGAACTTAATGACCAAATGAAAGTCCGCCGTGAAAAAATGGAAAACCTGCGCGATGCAGGAATTGA
CCCATTTGGACATAAATTTACACGTACGCACAACTCGCAAGAACTACACGAAGCTTATGACGAAAAGACGAAAGAAGAGT
TGCATGAACTTGCACTTTCAGGAATTGTCGCTGGTCGTTTGATGACTAAACGTGGTAAAGGTAAAGTCGGTTTCGCCCAT
CTTCAAGACCGCGAAGGCCAAATTCAACTTTACGTTCGTAAAGACGAAGTTGGTGAAGAAAATTATGAAATTTTCAAAAA
AGCTGACCTCGGAGACTTCCTCGGAGTTGAAGGCGAAATCATGAAAACTGATATGGGTGAATTGTCAATCAAAGCAAAAA
AATTGACTTTCCTCTCAAAAGCGCTTCGTCCTTTGCCTGAAAAATTCCATGGTTTGACTGATACTGAAACACGTTATCGC
AAACGTTATTTGGATTTGATTTCAAATAAAGAAAGCTTTAATCGCTTTGTGACTCGCTCAAAAATTATCAGTGAAATCCG
TCGTTATATGGATGGTCGTGGATATCTTGAAGTTGAAACTCCAGTTCTTAACAACGAAGCTGGTGGTGCTTCTGCTCGCC
CATTCTACACTCACCATAACAGCCTTGATATTGACATGGCACTTCGTATTGCAACTGAATTGCACTTGAAACGTTTGATT
GTTGGTGGAATGGAAAAAGTTTATGAACTTGGCCGTGTCTTCCGTAATGAAGGAATGGATATGACTCATAATCCTGAATT
CACAACAATGGAATCTTATGAAGCTTATGCTGATTTTGAAGATATCATGGATTTGACAGAAGGAATCTTCCAACACGTTG
CTAAAACTGTAGTTGGTCAAGATGTTCTTGAGTACGATGGTAAAGAAATCAATGTTGGTGGAAAATTCAAACGTGTTCAC
ATGGTTGATGCCATCAAGGAAGTTGCTGGAGTTGATTTCTGGCCTGAGATGACTTTTGAAGAAGCAACTGCTCTTGCAAA
AGAACATGACATTCATGTTGAAAAACATTTCACTTCTGTTGGTCACATCATTAACGAATTCTTTGAAAAATATGTTGAAG
AAACTTTGATTCAACCTACTTTCGTTTTTGGTCATCCAAAAGAAATTTCACCACTTGCTAAAATGAATGAAAAAGACCCA
CGTTTTACTGACCGTTTTGAACTTTTCATCAACGGTAAAGAATACGCCAATGCTTTCAGCGAATTGAATGACCCAATTGA
CCAATTGGAACGTTTTGAAGCTCAAGCCAAAGCTAAAGAACTTGGGGATGATGAAGCGACTGGTGTCGATTACGATTACG
TTGAAGCACTCGAACACGGTATGCCACCAACAGGTGGACTCGGTATCGGGATTGACCGCTTAGTGATGCTCTTTACTGGC
ACAACTTCAATCCGTGACGTTTTGCTTTTCCCAACGATGAAATAA

Upstream 100 bases:

>100_bases
TTTAAGCCTATTCTTAAAGCGTTTACTGACAAAAAAATTCTGTTAATTTTTTGAAAATATGTTAAAATAGAGAGAATAAA
AAATTACAAGGAGTACTATT

Downstream 100 bases:

>100_bases
AAAATAAAAACCGCTTTTGGCGGTTTTTTTATTTCTGTCAGTAAATTTATATCTTCAAAATTACTGACAGGCTCTTGTTT
TCTTATTCAAATTCAAAACT

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MAEIEELNDQMKVRREKMENLRDAGIDPFGHKFTRTHNSQELHEAYDEKTKEELHELALSGIVAGRLMTKRGKGKVGFAH
LQDREGQIQLYVRKDEVGEENYEIFKKADLGDFLGVEGEIMKTDMGELSIKAKKLTFLSKALRPLPEKFHGLTDTETRYR
KRYLDLISNKESFNRFVTRSKIISEIRRYMDGRGYLEVETPVLNNEAGGASARPFYTHHNSLDIDMALRIATELHLKRLI
VGGMEKVYELGRVFRNEGMDMTHNPEFTTMESYEAYADFEDIMDLTEGIFQHVAKTVVGQDVLEYDGKEINVGGKFKRVH
MVDAIKEVAGVDFWPEMTFEEATALAKEHDIHVEKHFTSVGHIINEFFEKYVEETLIQPTFVFGHPKEISPLAKMNEKDP
RFTDRFELFINGKEYANAFSELNDPIDQLERFEAQAKAKELGDDEATGVDYDYVEALEHGMPPTGGLGIGIDRLVMLFTG
TTSIRDVLLFPTMK

Sequences:

>Translated_494_residues
MAEIEELNDQMKVRREKMENLRDAGIDPFGHKFTRTHNSQELHEAYDEKTKEELHELALSGIVAGRLMTKRGKGKVGFAH
LQDREGQIQLYVRKDEVGEENYEIFKKADLGDFLGVEGEIMKTDMGELSIKAKKLTFLSKALRPLPEKFHGLTDTETRYR
KRYLDLISNKESFNRFVTRSKIISEIRRYMDGRGYLEVETPVLNNEAGGASARPFYTHHNSLDIDMALRIATELHLKRLI
VGGMEKVYELGRVFRNEGMDMTHNPEFTTMESYEAYADFEDIMDLTEGIFQHVAKTVVGQDVLEYDGKEINVGGKFKRVH
MVDAIKEVAGVDFWPEMTFEEATALAKEHDIHVEKHFTSVGHIINEFFEKYVEETLIQPTFVFGHPKEISPLAKMNEKDP
RFTDRFELFINGKEYANAFSELNDPIDQLERFEAQAKAKELGDDEATGVDYDYVEALEHGMPPTGGLGIGIDRLVMLFTG
TTSIRDVLLFPTMK
>Mature_493_residues
AEIEELNDQMKVRREKMENLRDAGIDPFGHKFTRTHNSQELHEAYDEKTKEELHELALSGIVAGRLMTKRGKGKVGFAHL
QDREGQIQLYVRKDEVGEENYEIFKKADLGDFLGVEGEIMKTDMGELSIKAKKLTFLSKALRPLPEKFHGLTDTETRYRK
RYLDLISNKESFNRFVTRSKIISEIRRYMDGRGYLEVETPVLNNEAGGASARPFYTHHNSLDIDMALRIATELHLKRLIV
GGMEKVYELGRVFRNEGMDMTHNPEFTTMESYEAYADFEDIMDLTEGIFQHVAKTVVGQDVLEYDGKEINVGGKFKRVHM
VDAIKEVAGVDFWPEMTFEEATALAKEHDIHVEKHFTSVGHIINEFFEKYVEETLIQPTFVFGHPKEISPLAKMNEKDPR
FTDRFELFINGKEYANAFSELNDPIDQLERFEAQAKAKELGDDEATGVDYDYVEALEHGMPPTGGLGIGIDRLVMLFTGT
TSIRDVLLFPTMK

Specific function: Unknown

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=503, Percent_Identity=41.7495029821074, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI194272210, Length=503, Percent_Identity=41.7495029821074, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI40789249, Length=279, Percent_Identity=25.8064516129032, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI45439306, Length=458, Percent_Identity=21.8340611353712, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1789256, Length=498, Percent_Identity=53.4136546184739, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI1790571, Length=496, Percent_Identity=52.2177419354839, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI87082379, Length=331, Percent_Identity=30.8157099697885, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1788173, Length=254, Percent_Identity=27.5590551181102, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17535925, Length=502, Percent_Identity=43.6254980079681, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17535927, Length=502, Percent_Identity=43.6254980079681, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71994340, Length=501, Percent_Identity=43.7125748502994, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI32566633, Length=173, Percent_Identity=27.7456647398844, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320242, Length=506, Percent_Identity=44.4664031620553, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6324256, Length=473, Percent_Identity=34.0380549682875, Blast_Score=230, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6323011, Length=462, Percent_Identity=23.8095238095238, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640851, Length=514, Percent_Identity=42.6070038910506, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24640849, Length=514, Percent_Identity=42.6070038910506, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI17136276, Length=465, Percent_Identity=23.6559139784946, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24584738, Length=280, Percent_Identity=26.7857142857143, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 56618; Mature: 56487

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIEELNDQMKVRREKMENLRDAGIDPFGHKFTRTHNSQELHEAYDEKTKEELHELALS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GIVAGRLMTKRGKGKVGFAHLQDREGQIQLYVRKDEVGEENYEIFKKADLGDFLGVEGEI
HHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHCCCHHHCCCCCEE
MKTDMGELSIKAKKLTFLSKALRPLPEKFHGLTDTETRYRKRYLDLISNKESFNRFVTRS
EECCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
KIISEIRRYMDGRGYLEVETPVLNNEAGGASARPFYTHHNSLDIDMALRIATELHLKRLI
HHHHHHHHHHCCCCEEEEECCEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
VGGMEKVYELGRVFRNEGMDMTHNPEFTTMESYEAYADFEDIMDLTEGIFQHVAKTVVGQ
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
DVLEYDGKEINVGGKFKRVHMVDAIKEVAGVDFWPEMTFEEATALAKEHDIHVEKHFTSV
HHHHCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
GHIINEFFEKYVEETLIQPTFVFGHPKEISPLAKMNEKDPRFTDRFELFINGKEYANAFS
HHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCCCCCCCCEEEEEECCHHHHHHHH
ELNDPIDQLERFEAQAKAKELGDDEATGVDYDYVEALEHGMPPTGGLGIGIDRLVMLFTG
HHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCC
TTSIRDVLLFPTMK
CHHHHHHHCCCCCC
>Mature Secondary Structure 
AEIEELNDQMKVRREKMENLRDAGIDPFGHKFTRTHNSQELHEAYDEKTKEELHELALS
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GIVAGRLMTKRGKGKVGFAHLQDREGQIQLYVRKDEVGEENYEIFKKADLGDFLGVEGEI
HHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHCCCHHHCCCCCEE
MKTDMGELSIKAKKLTFLSKALRPLPEKFHGLTDTETRYRKRYLDLISNKESFNRFVTRS
EECCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
KIISEIRRYMDGRGYLEVETPVLNNEAGGASARPFYTHHNSLDIDMALRIATELHLKRLI
HHHHHHHHHHCCCCEEEEECCEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
VGGMEKVYELGRVFRNEGMDMTHNPEFTTMESYEAYADFEDIMDLTEGIFQHVAKTVVGQ
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
DVLEYDGKEINVGGKFKRVHMVDAIKEVAGVDFWPEMTFEEATALAKEHDIHVEKHFTSV
HHHHCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
GHIINEFFEKYVEETLIQPTFVFGHPKEISPLAKMNEKDPRFTDRFELFINGKEYANAFS
HHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCCCCCCCCEEEEEECCHHHHHHHH
ELNDPIDQLERFEAQAKAKELGDDEATGVDYDYVEALEHGMPPTGGLGIGIDRLVMLFTG
HHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCC
TTSIRDVLLFPTMK
CHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]