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The map label for this gene is ppiA [C]

Identifier: 125623254

GI number: 125623254

Start: 376287

End: 377120

Strand: Reverse

Name: ppiA [C]

Synonym: llmg_0385

Alternate gene names: 125623254

Gene position: 377120-376287 (Counterclockwise)

Preceding gene: 125623258

Following gene: 125623249

Centisome position: 14.91

GC content: 33.81

Gene sequence:

>834_bases
ATGAATACGAATAAAAAAAATAACACAATTCTTTTTACAATCTTTGGGATTGTCCTAATTGTTGTCGTTGGGCTCTTAGT
TTTCTTTGCAAATCGCCCAAAAACAGATGATAGTTCAGCAAGTAGTACAAATACGTCTTCTTCAAGTCAAAAAGTTAACT
ATCCAACAAATTATACCTTAAATGCTGCAGTAAAAAATTCAAGTACTGCCCTTAATGATTTAACTTTACCACAACTTTCA
ACAACTGTTGGTGAAGACGAAGCTGAAGTTCAAATCAAAACAAGTGCTGGAAATATCAACATTAAACTTTTCCCTAAATT
AGCTCCTAATGCCGTTCAAAATTTCCTTGTTCTTGCAAAACATGGATATTATAAAAATAATGAATTTTTCCGTGTGATTA
AAGATTTCATGATTCAATCTGGAGACCCTTCAAATAAAGGAACTGGAACAGCTTCAATCTTCGGTGGGAAAACATTTGAT
ACAGAGATTTCAAATCAACTCTATAATATCCGTGGAGCCCTTGCTTTAGCAAATACAGGGCAAGCAAGCTCTAGCAGTTC
ACAATTTTTCATTGTTCAAAACCCTCAGGATATGACTAGTCAAATCCAAGATAAGAGCAAATATCCTCAAAAAATTATTG
ATGCTTATAAAAAGGGAGGATATCCTAGTTTAGATGGAAGTCACACTGTCTTTGGCCAATTCATTTCAGGAATGGATGTT
GTTGATAAAATTGCTAAAGCGGATGTAAAAACAAATTCTTCTGGGGAATCCTCAGCACCGATTGACCCTGTAAAAATTAA
ATCCGTTAAAATCCTTAAAGACTGGAAATTTTAA

Upstream 100 bases:

>100_bases
TTTCGTGATTTTTTTTATATTCTATACCTTTTTTTTTGAAATTGCAAGAATTAATTTAATATAAATTTATAATTACTCGT
TTTTATGATAAAATATTCCT

Downstream 100 bases:

>100_bases
TAAATAAAAAGTTACTGACAATTTTTCTGTCAGTAACTTTTTTTATTTCAATAAGTTTTTCATATCATCTGGCATGTCTA
ATTCCACATGAACCATTTCG

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MNTNKKNNTILFTIFGIVLIVVVGLLVFFANRPKTDDSSASSTNTSSSSQKVNYPTNYTLNAAVKNSSTALNDLTLPQLS
TTVGEDEAEVQIKTSAGNINIKLFPKLAPNAVQNFLVLAKHGYYKNNEFFRVIKDFMIQSGDPSNKGTGTASIFGGKTFD
TEISNQLYNIRGALALANTGQASSSSSQFFIVQNPQDMTSQIQDKSKYPQKIIDAYKKGGYPSLDGSHTVFGQFISGMDV
VDKIAKADVKTNSSGESSAPIDPVKIKSVKILKDWKF

Sequences:

>Translated_277_residues
MNTNKKNNTILFTIFGIVLIVVVGLLVFFANRPKTDDSSASSTNTSSSSQKVNYPTNYTLNAAVKNSSTALNDLTLPQLS
TTVGEDEAEVQIKTSAGNINIKLFPKLAPNAVQNFLVLAKHGYYKNNEFFRVIKDFMIQSGDPSNKGTGTASIFGGKTFD
TEISNQLYNIRGALALANTGQASSSSSQFFIVQNPQDMTSQIQDKSKYPQKIIDAYKKGGYPSLDGSHTVFGQFISGMDV
VDKIAKADVKTNSSGESSAPIDPVKIKSVKILKDWKF
>Mature_277_residues
MNTNKKNNTILFTIFGIVLIVVVGLLVFFANRPKTDDSSASSTNTSSSSQKVNYPTNYTLNAAVKNSSTALNDLTLPQLS
TTVGEDEAEVQIKTSAGNINIKLFPKLAPNAVQNFLVLAKHGYYKNNEFFRVIKDFMIQSGDPSNKGTGTASIFGGKTFD
TEISNQLYNIRGALALANTGQASSSSSQFFIVQNPQDMTSQIQDKSKYPQKIIDAYKKGGYPSLDGSHTVFGQFISGMDV
VDKIAKADVKTNSSGESSAPIDPVKIKSVKILKDWKF

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=181, Percent_Identity=37.0165745856354, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI7706339, Length=178, Percent_Identity=37.6404494382022, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI19557636, Length=183, Percent_Identity=33.879781420765, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI64276486, Length=184, Percent_Identity=32.6086956521739, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI4505991, Length=190, Percent_Identity=37.3684210526316, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI42560244, Length=189, Percent_Identity=33.8624338624339, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4826932, Length=166, Percent_Identity=33.7349397590361, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI20911035, Length=162, Percent_Identity=32.0987654320988, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI22547215, Length=196, Percent_Identity=31.1224489795918, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI22547212, Length=196, Percent_Identity=31.1224489795918, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI7657473, Length=196, Percent_Identity=31.1224489795918, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI45439316, Length=157, Percent_Identity=33.1210191082803, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI5454154, Length=176, Percent_Identity=32.3863636363636, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI303305009, Length=156, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI5174637, Length=153, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI6631100, Length=196, Percent_Identity=30.6122448979592, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1789763, Length=187, Percent_Identity=34.2245989304813, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1786736, Length=185, Percent_Identity=36.2162162162162, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17506311, Length=211, Percent_Identity=34.5971563981043, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71997782, Length=183, Percent_Identity=34.9726775956284, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17532641, Length=215, Percent_Identity=32.093023255814, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17539496, Length=187, Percent_Identity=34.7593582887701, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71980594, Length=155, Percent_Identity=36.1290322580645, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71980590, Length=155, Percent_Identity=35.4838709677419, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17506307, Length=156, Percent_Identity=37.8205128205128, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17552780, Length=174, Percent_Identity=34.4827586206897, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI32563659, Length=192, Percent_Identity=27.6041666666667, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532643, Length=175, Percent_Identity=34.2857142857143, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17539498, Length=154, Percent_Identity=31.8181818181818, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320359, Length=152, Percent_Identity=34.2105263157895, Blast_Score=75, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320510, Length=163, Percent_Identity=36.8098159509202, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323562, Length=176, Percent_Identity=31.25, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321848, Length=177, Percent_Identity=32.2033898305085, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17986117, Length=184, Percent_Identity=35.3260869565217, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI19922376, Length=183, Percent_Identity=31.1475409836066, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357249, Length=119, Percent_Identity=41.1764705882353, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24652460, Length=161, Percent_Identity=34.1614906832298, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19922912, Length=184, Percent_Identity=35.8695652173913, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17647301, Length=182, Percent_Identity=35.7142857142857, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI20130249, Length=153, Percent_Identity=39.2156862745098, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24650807, Length=177, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21355677, Length=192, Percent_Identity=29.1666666666667, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 30064; Mature: 30064

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNKKNNTILFTIFGIVLIVVVGLLVFFANRPKTDDSSASSTNTSSSSQKVNYPTNYTL
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCEEE
NAAVKNSSTALNDLTLPQLSTTVGEDEAEVQIKTSAGNINIKLFPKLAPNAVQNFLVLAK
EEEECCCCCCCCCCCCCHHHHHCCCCCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHH
HGYYKNNEFFRVIKDFMIQSGDPSNKGTGTASIFGGKTFDTEISNQLYNIRGALALANTG
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHEEEEEECCC
QASSSSSQFFIVQNPQDMTSQIQDKSKYPQKIIDAYKKGGYPSLDGSHTVFGQFISGMDV
CCCCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHH
VDKIAKADVKTNSSGESSAPIDPVKIKSVKILKDWKF
HHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEECCCC
>Mature Secondary Structure
MNTNKKNNTILFTIFGIVLIVVVGLLVFFANRPKTDDSSASSTNTSSSSQKVNYPTNYTL
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCEEE
NAAVKNSSTALNDLTLPQLSTTVGEDEAEVQIKTSAGNINIKLFPKLAPNAVQNFLVLAK
EEEECCCCCCCCCCCCCHHHHHCCCCCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHH
HGYYKNNEFFRVIKDFMIQSGDPSNKGTGTASIFGGKTFDTEISNQLYNIRGALALANTG
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHEEEEEECCC
QASSSSSQFFIVQNPQDMTSQIQDKSKYPQKIIDAYKKGGYPSLDGSHTVFGQFISGMDV
CCCCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHH
VDKIAKADVKTNSSGESSAPIDPVKIKSVKILKDWKF
HHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA