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The map label for this gene is pbp2B [H]

Identifier: 125623228

GI number: 125623228

Start: 344604

End: 346769

Strand: Direct

Name: pbp2B [H]

Synonym: llmg_0358

Alternate gene names: 125623228

Gene position: 344604-346769 (Clockwise)

Preceding gene: 125623227

Following gene: 125623229

Centisome position: 13.62

GC content: 38.09

Gene sequence:

>2166_bases
ATGTCAGTTAATAAAAGAAAAAACGATAAGCGCAATAAAGTCGGTCAGTCTAAAAAAACAAATAAAGAAACAAAAGTATT
AAAAGATCCAACAAAATTAATCCCAAAACGCATTAATCTTCTATTTTTCGTTATTTTTGTTCTGTTTATGATTTTAATCG
GAAAACTTTTTCACATGCAAGTTTTGAATTCTCATTTCTATGCCGAAAAATCAATTAGCGCCGGTGGCGATGTTCAGATT
ATCGAAGGAGCTCCGAGGGGAAATATTTACGATGCAAGTGGTAAAGCTTTAGCAACAACAATCCCTGTCCAAGCCGTTGA
ATTCACACGTAGTCAAAATGCGACAGCAGATGAAATGTATCAGGTAGCGAATAAGCTAGCAACTATTTTATCTAATGATA
TTGATGTTGCTGATTTGACAACTCGTGACAAAAAAGATTATTTCTTGGCTAATGCTAAAAATTTGGAAAAAATCGCAAAC
AAGCTAACTGATAAAGAAAAGAAAGATAAACAAGGCAATGATTTAACTGGCTCACAAATTTATGAAGTTGAGCTAAGTAA
AGTTAAAGATAGTGACTTGAACTTTACGGCGGAACAAACTTTTGCCGCAAAATTATTCAAAGAAATGAATAGTACAAGTA
CTTTTAATACTACTAAAATTGCAACTGGAAGTATTACGGCAGAGCAACAAGCGACAATTGCGGAGCAAGAAGGAGATTTG
CCAGGAATTACGGTTGGAACTTCTTGGGATCGCTCTTATGCTCAAAATTCGCTAACTCCATTAATGGGGACTATTACTTC
ACAGAAATCGGGGATTCCGGCGGAAGATTTAGATGCCTATCTTAAAAAAGGTTATCAACGTAATGACCGTGTGGGAACTG
GACTTCTTGAGAAAGGCTACGAAAGTGAACTTCAAGGAACGCACAGTATTAGCAAAGTCAAATTTGATAAAAATGGTGAT
GTTTCTGGAACGAAAACAATTCAAAAAGGAAAACGTGGGGATGATTTAAAATTAACCATTAACCTAGATTTCCAAAATGC
TGTCAACGATTTGGTTAAAACACAATTGGACCAATTAATTGCCCAAGGTTATGGTCAGTATAACAGAGGGGCTTATGCTG
TTGTTCTCAATGTTAAAACAGGTGCAGTACTAGCCCTATCTGGATATAACCGTGACCCTAATACAGGGGTAATTACGGAT
AATACACTTGGAACTTTCCAAAGTGTCTTTACGCCAGGGTCTGTTGTGAAAATGGGAACATTGACTGCTGCTTGGAATGC
TGGAGTGATTTCGGGAAATGACACTTTAACTGCGCAGTCTATTCAATTTAAAGGTTCACCTCCTATCAATGACTGGTGGG
GAGATGCTTCACCAATGGCTTTAACGGCTGTTGAAGCCCTGCAATATTCATCAAATACTTATATGATGCAGTTAGCGATG
AGAATGTTAGGGGCTCCTTATACTGCTGCTGGACAATATCTCAATGATAGTAACCGGGTTAAAGTCTATGAGCAGCTACG
AAGCGCATTTGCTTCTTACGGTTTAGGGACTTCAACAGGATTCGATATTCCGGGAGAGTCCACAGGATTTATTCCTTCAG
CAAAATCTAAAGATGCTTCTGGGGTTAATGTATTGTATGAATCATTTGGTCAGTATGATAACTATACTCCACTTCAATTG
GCAGTTTATGCTGCAACTTTAGGAAATAATGGAACACGCTTAGCGCCACACATCGTCCAAGGGATTTATGAGGGCGGAAA
TGATGGACAACCAGGAACCTTAATTAAAAATATTACGCCTAAAATTATGGATAAGGTTAATATTACTCCAGACAATATGG
ATGTTCTTCATCAAGGGATGTATGCTGTTGTTCATGGTGCAGGTGGTTTGACCACTGGTAAACCAATGAGCGCTGCAACG
GTTTCTATTTCTGGTAAAACGGGTACTTCCGAAAGTACGAAAATATTAGGAGATGGTAGTCAAGTTATCGTAACAGCAAA
TAATGCAGTTGCTTTTGCTCCGTCAGACAATCCAGAGATTGCGATTGGAGTTGTGTTGCCAGATAATACTGAAAGTAATG
CTTCTAGTGGTACGAAGGCAAACCAAAGCATTGTCACTGGAATTACCGATTTATACTACTCAAACGAAGCTTTTCGAACA
AATTAA

Upstream 100 bases:

>100_bases
AATCAAAATTGTAAGGAAAACTTTTCATAAATGTGGTAAAATGTTTAAGTACAAATTTTGAATTAAAAAATTATTTATAA
AACTCATTCTTGGAGTCCAA

Downstream 100 bases:

>100_bases
AATAAAAAAGCCCTCTTGAATGAGGGTTTTTCTTTTAAAAATCTTGTCGCATTTCCTTTTCATTTTAAGCCTTTTATAGT
AAAATTAATAAATTGAATAA

Product: penicillin-binding protein 2B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 721; Mature: 720

Protein sequence:

>721_residues
MSVNKRKNDKRNKVGQSKKTNKETKVLKDPTKLIPKRINLLFFVIFVLFMILIGKLFHMQVLNSHFYAEKSISAGGDVQI
IEGAPRGNIYDASGKALATTIPVQAVEFTRSQNATADEMYQVANKLATILSNDIDVADLTTRDKKDYFLANAKNLEKIAN
KLTDKEKKDKQGNDLTGSQIYEVELSKVKDSDLNFTAEQTFAAKLFKEMNSTSTFNTTKIATGSITAEQQATIAEQEGDL
PGITVGTSWDRSYAQNSLTPLMGTITSQKSGIPAEDLDAYLKKGYQRNDRVGTGLLEKGYESELQGTHSISKVKFDKNGD
VSGTKTIQKGKRGDDLKLTINLDFQNAVNDLVKTQLDQLIAQGYGQYNRGAYAVVLNVKTGAVLALSGYNRDPNTGVITD
NTLGTFQSVFTPGSVVKMGTLTAAWNAGVISGNDTLTAQSIQFKGSPPINDWWGDASPMALTAVEALQYSSNTYMMQLAM
RMLGAPYTAAGQYLNDSNRVKVYEQLRSAFASYGLGTSTGFDIPGESTGFIPSAKSKDASGVNVLYESFGQYDNYTPLQL
AVYAATLGNNGTRLAPHIVQGIYEGGNDGQPGTLIKNITPKIMDKVNITPDNMDVLHQGMYAVVHGAGGLTTGKPMSAAT
VSISGKTGTSESTKILGDGSQVIVTANNAVAFAPSDNPEIAIGVVLPDNTESNASSGTKANQSIVTGITDLYYSNEAFRT
N

Sequences:

>Translated_721_residues
MSVNKRKNDKRNKVGQSKKTNKETKVLKDPTKLIPKRINLLFFVIFVLFMILIGKLFHMQVLNSHFYAEKSISAGGDVQI
IEGAPRGNIYDASGKALATTIPVQAVEFTRSQNATADEMYQVANKLATILSNDIDVADLTTRDKKDYFLANAKNLEKIAN
KLTDKEKKDKQGNDLTGSQIYEVELSKVKDSDLNFTAEQTFAAKLFKEMNSTSTFNTTKIATGSITAEQQATIAEQEGDL
PGITVGTSWDRSYAQNSLTPLMGTITSQKSGIPAEDLDAYLKKGYQRNDRVGTGLLEKGYESELQGTHSISKVKFDKNGD
VSGTKTIQKGKRGDDLKLTINLDFQNAVNDLVKTQLDQLIAQGYGQYNRGAYAVVLNVKTGAVLALSGYNRDPNTGVITD
NTLGTFQSVFTPGSVVKMGTLTAAWNAGVISGNDTLTAQSIQFKGSPPINDWWGDASPMALTAVEALQYSSNTYMMQLAM
RMLGAPYTAAGQYLNDSNRVKVYEQLRSAFASYGLGTSTGFDIPGESTGFIPSAKSKDASGVNVLYESFGQYDNYTPLQL
AVYAATLGNNGTRLAPHIVQGIYEGGNDGQPGTLIKNITPKIMDKVNITPDNMDVLHQGMYAVVHGAGGLTTGKPMSAAT
VSISGKTGTSESTKILGDGSQVIVTANNAVAFAPSDNPEIAIGVVLPDNTESNASSGTKANQSIVTGITDLYYSNEAFRT
N
>Mature_720_residues
SVNKRKNDKRNKVGQSKKTNKETKVLKDPTKLIPKRINLLFFVIFVLFMILIGKLFHMQVLNSHFYAEKSISAGGDVQII
EGAPRGNIYDASGKALATTIPVQAVEFTRSQNATADEMYQVANKLATILSNDIDVADLTTRDKKDYFLANAKNLEKIANK
LTDKEKKDKQGNDLTGSQIYEVELSKVKDSDLNFTAEQTFAAKLFKEMNSTSTFNTTKIATGSITAEQQATIAEQEGDLP
GITVGTSWDRSYAQNSLTPLMGTITSQKSGIPAEDLDAYLKKGYQRNDRVGTGLLEKGYESELQGTHSISKVKFDKNGDV
SGTKTIQKGKRGDDLKLTINLDFQNAVNDLVKTQLDQLIAQGYGQYNRGAYAVVLNVKTGAVLALSGYNRDPNTGVITDN
TLGTFQSVFTPGSVVKMGTLTAAWNAGVISGNDTLTAQSIQFKGSPPINDWWGDASPMALTAVEALQYSSNTYMMQLAMR
MLGAPYTAAGQYLNDSNRVKVYEQLRSAFASYGLGTSTGFDIPGESTGFIPSAKSKDASGVNVLYESFGQYDNYTPLQLA
VYAATLGNNGTRLAPHIVQGIYEGGNDGQPGTLIKNITPKIMDKVNITPDNMDVLHQGMYAVVHGAGGLTTGKPMSAATV
SISGKTGTSESTKILGDGSQVIVTANNAVAFAPSDNPEIAIGVVLPDNTESNASSGTKANQSIVTGITDLYYSNEAFRTN

Specific function: Cell Wall Formation; Pbp-2 Is Responsible For The Determination Of The Rod Shape Of The Cell. Its Synthesize Cross- Linked Peptidoglycan From The Lipid Intermediates. [C]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=546, Percent_Identity=25.0915750915751, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1786272, Length=424, Percent_Identity=27.122641509434, Blast_Score=73, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 77602; Mature: 77471

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVNKRKNDKRNKVGQSKKTNKETKVLKDPTKLIPKRINLLFFVIFVLFMILIGKLFHMQ
CCCCCCCCCHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLNSHFYAEKSISAGGDVQIIEGAPRGNIYDASGKALATTIPVQAVEFTRSQNATADEMY
HHHHHHHHHCCCCCCCCEEEEECCCCCCEECCCCCEEEEECCHHHHHHHCCCCCCHHHHH
QVANKLATILSNDIDVADLTTRDKKDYFLANAKNLEKIANKLTDKEKKDKQGNDLTGSQI
HHHHHHHHHHCCCCCEEECCCCCCCCEEEECHHHHHHHHHHHCCHHHHCCCCCCCCCCEE
YEVELSKVKDSDLNFTAEQTFAAKLFKEMNSTSTFNTTKIATGSITAEQQATIAEQEGDL
EEEEEECCCCCCCCEEHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCCC
PGITVGTSWDRSYAQNSLTPLMGTITSQKSGIPAEDLDAYLKKGYQRNDRVGTGLLEKGY
CCEEECCCCCHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCC
ESELQGTHSISKVKFDKNGDVSGTKTIQKGKRGDDLKLTINLDFQNAVNDLVKTQLDQLI
HHHHCCCCCCEEEEECCCCCCCCHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHH
AQGYGQYNRGAYAVVLNVKTGAVLALSGYNRDPNTGVITDNTLGTFQSVFTPGSVVKMGT
HHCCCCCCCCEEEEEEEECCCEEEEEECCCCCCCCCEEECCCHHHHHHHCCCCCEEEEEE
LTAAWNAGVISGNDTLTAQSIQFKGSPPINDWWGDASPMALTAVEALQYSSNTYMMQLAM
EEEECCCCEECCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
RMLGAPYTAAGQYLNDSNRVKVYEQLRSAFASYGLGTSTGFDIPGESTGFIPSAKSKDAS
HHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GVNVLYESFGQYDNYTPLQLAVYAATLGNNGTRLAPHIVQGIYEGGNDGQPGTLIKNITP
CHHHHHHHHCCCCCCCHHEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCHHCCCH
KIMDKVNITPDNMDVLHQGMYAVVHGAGGLTTGKPMSAATVSISGKTGTSESTKILGDGS
HHHHCCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCEEECCCC
QVIVTANNAVAFAPSDNPEIAIGVVLPDNTESNASSGTKANQSIVTGITDLYYSNEAFRT
EEEEEECCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
N
C
>Mature Secondary Structure 
SVNKRKNDKRNKVGQSKKTNKETKVLKDPTKLIPKRINLLFFVIFVLFMILIGKLFHMQ
CCCCCCCCHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLNSHFYAEKSISAGGDVQIIEGAPRGNIYDASGKALATTIPVQAVEFTRSQNATADEMY
HHHHHHHHHCCCCCCCCEEEEECCCCCCEECCCCCEEEEECCHHHHHHHCCCCCCHHHHH
QVANKLATILSNDIDVADLTTRDKKDYFLANAKNLEKIANKLTDKEKKDKQGNDLTGSQI
HHHHHHHHHHCCCCCEEECCCCCCCCEEEECHHHHHHHHHHHCCHHHHCCCCCCCCCCEE
YEVELSKVKDSDLNFTAEQTFAAKLFKEMNSTSTFNTTKIATGSITAEQQATIAEQEGDL
EEEEEECCCCCCCCEEHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCCC
PGITVGTSWDRSYAQNSLTPLMGTITSQKSGIPAEDLDAYLKKGYQRNDRVGTGLLEKGY
CCEEECCCCCHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCC
ESELQGTHSISKVKFDKNGDVSGTKTIQKGKRGDDLKLTINLDFQNAVNDLVKTQLDQLI
HHHHCCCCCCEEEEECCCCCCCCHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHH
AQGYGQYNRGAYAVVLNVKTGAVLALSGYNRDPNTGVITDNTLGTFQSVFTPGSVVKMGT
HHCCCCCCCCEEEEEEEECCCEEEEEECCCCCCCCCEEECCCHHHHHHHCCCCCEEEEEE
LTAAWNAGVISGNDTLTAQSIQFKGSPPINDWWGDASPMALTAVEALQYSSNTYMMQLAM
EEEECCCCEECCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
RMLGAPYTAAGQYLNDSNRVKVYEQLRSAFASYGLGTSTGFDIPGESTGFIPSAKSKDAS
HHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GVNVLYESFGQYDNYTPLQLAVYAATLGNNGTRLAPHIVQGIYEGGNDGQPGTLIKNITP
CHHHHHHHHCCCCCCCHHEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCHHCCCH
KIMDKVNITPDNMDVLHQGMYAVVHGAGGLTTGKPMSAATVSISGKTGTSESTKILGDGS
HHHHCCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCEEECCCC
QVIVTANNAVAFAPSDNPEIAIGVVLPDNTESNASSGTKANQSIVTGITDLYYSNEAFRT
EEEEEECCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916; 2654541 [H]