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The map label for this gene is argD [H]

Identifier: 124485949

GI number: 124485949

Start: 1142513

End: 1143640

Strand: Reverse

Name: argD [H]

Synonym: Mlab_1129

Alternate gene names: 124485949

Gene position: 1143640-1142513 (Counterclockwise)

Preceding gene: 124485950

Following gene: 124485948

Centisome position: 63.36

GC content: 54.79

Gene sequence:

>1128_bases
ATGTCCACCTACAAAGAACTTGATGCAAAATACTACATGCCCTGCTTTGGACGGTCGATGGAGATCGTCAAAGGCGAGGG
ATGTAATGTTTGGGACGATAATGGGAAGAAATACCTCGACTTAGTCGCAGGTATCGCGGTCTGCAGTACGGGACACTGCC
ACCCGCAGGTAGTGGACGCAATATGCCGCCAGGCACACGAACTTATTCACTGTTCCAATCTTTACTACATACCGGGTCAG
GCCGAACTCGCAGAAAAACTGAGCAAAGCAAGCGGCATGGGAAAGGTCTTCTTCGGAAATAGCGGGGCCGAAGCAATAGA
TGCGGCTCTCAAACTCGCCAAAGTCCGCTCAGGACGCAAGAACTTTGTTTCATTCAATCATGATTTCCACGGCAGGACCA
TCGGGTCTCTAGCCGTCACCCACAAACCCCAGATCAGGGAACCCTTCGAGCCGCTCGGCATTCACTGTGATTTCCCCGAC
TACGGCGACCTTGAGGGACTCAAAGCTGCCGTCAATAAAGATACCGCCGCTGTTGTCTTCGAACCCATTCAGGGAGAGAC
CGGCATCATCATCCCGCCCGAGGACTTCCTGCCTGGAATCAGGGATATCTGCGACGACGCCAGAGCTCTTATGATCTGCG
ATGAAGTCCAGTCCGGTATGGGACGGACCGGCAAATGGTTCGCATTCCAGCACTCGAAGGTGCAGCCCGATATCATCAGC
ATTGCAAAAGGAATCGCTTCCGGTGTCCCGATGGGTGCGATCATCGCCCGGGAAGGACTCGAGTTCACGAAAGGCGAACA
CGGCAGCACCTTTGCCGGCGGTCCGATCGCCTGCGCCGCGGGAAATGTCACGTTTGGCATCATCGAACAGCTCCTCCCGG
GAATTGCAGCAAAAGGCGAACTTTTCAGAAAAGGTCTGGCCGCATTCAACCCGCGGGTACGGGGTCTGATGGTTGGGTTC
ACGCTCGGAGAAGCCGCTCCCAAACTTGCCGAACTCTGTATGGAAAAGGGCGTTCTCATCAATGTTGCCGGTGACGGCAA
CATCAGGATCGTCCCGCCTCTGACAATCTCGGCCGACGAAATCAACTATGCAGTCGGAGTGATCAATGAAGCCGCGGGTC
AGATCTGA

Upstream 100 bases:

>100_bases
TAGAAAAACCCTCGAATTTGCCGTATTTTTTCCAGGCCGACATGCAGTTTCAATACACAGAACGACAAATACTTATCTAA
ATATCCAGGGAGAAAAAATC

Downstream 100 bases:

>100_bases
GTTCGTCAAATCAGGCTACGTCTTTGCAAAATCCCCGGCCGATATCGCAAAGGAATACGGGTTCACCGAAGTTGCCATGC
TCGGCAGCAACGAAAACCCC

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MSTYKELDAKYYMPCFGRSMEIVKGEGCNVWDDNGKKYLDLVAGIAVCSTGHCHPQVVDAICRQAHELIHCSNLYYIPGQ
AELAEKLSKASGMGKVFFGNSGAEAIDAALKLAKVRSGRKNFVSFNHDFHGRTIGSLAVTHKPQIREPFEPLGIHCDFPD
YGDLEGLKAAVNKDTAAVVFEPIQGETGIIIPPEDFLPGIRDICDDARALMICDEVQSGMGRTGKWFAFQHSKVQPDIIS
IAKGIASGVPMGAIIAREGLEFTKGEHGSTFAGGPIACAAGNVTFGIIEQLLPGIAAKGELFRKGLAAFNPRVRGLMVGF
TLGEAAPKLAELCMEKGVLINVAGDGNIRIVPPLTISADEINYAVGVINEAAGQI

Sequences:

>Translated_375_residues
MSTYKELDAKYYMPCFGRSMEIVKGEGCNVWDDNGKKYLDLVAGIAVCSTGHCHPQVVDAICRQAHELIHCSNLYYIPGQ
AELAEKLSKASGMGKVFFGNSGAEAIDAALKLAKVRSGRKNFVSFNHDFHGRTIGSLAVTHKPQIREPFEPLGIHCDFPD
YGDLEGLKAAVNKDTAAVVFEPIQGETGIIIPPEDFLPGIRDICDDARALMICDEVQSGMGRTGKWFAFQHSKVQPDIIS
IAKGIASGVPMGAIIAREGLEFTKGEHGSTFAGGPIACAAGNVTFGIIEQLLPGIAAKGELFRKGLAAFNPRVRGLMVGF
TLGEAAPKLAELCMEKGVLINVAGDGNIRIVPPLTISADEINYAVGVINEAAGQI
>Mature_374_residues
STYKELDAKYYMPCFGRSMEIVKGEGCNVWDDNGKKYLDLVAGIAVCSTGHCHPQVVDAICRQAHELIHCSNLYYIPGQA
ELAEKLSKASGMGKVFFGNSGAEAIDAALKLAKVRSGRKNFVSFNHDFHGRTIGSLAVTHKPQIREPFEPLGIHCDFPDY
GDLEGLKAAVNKDTAAVVFEPIQGETGIIIPPEDFLPGIRDICDDARALMICDEVQSGMGRTGKWFAFQHSKVQPDIISI
AKGIASGVPMGAIIAREGLEFTKGEHGSTFAGGPIACAAGNVTFGIIEQLLPGIAAKGELFRKGLAAFNPRVRGLMVGFT
LGEAAPKLAELCMEKGVLINVAGDGNIRIVPPLTISADEINYAVGVINEAAGQI

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=372, Percent_Identity=30.1075268817204, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI13994255, Length=446, Percent_Identity=28.47533632287, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI284507298, Length=296, Percent_Identity=29.7297297297297, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI37574042, Length=414, Percent_Identity=28.0193236714976, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI24119277, Length=402, Percent_Identity=25.8706467661692, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI226442709, Length=383, Percent_Identity=27.9373368146214, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI226442705, Length=414, Percent_Identity=26.8115942028986, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI188536080, Length=420, Percent_Identity=23.5714285714286, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI38679950, Length=420, Percent_Identity=23.5714285714286, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI38679946, Length=420, Percent_Identity=23.5714285714286, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788044, Length=376, Percent_Identity=35.3723404255319, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1789759, Length=383, Percent_Identity=36.0313315926893, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI145693181, Length=388, Percent_Identity=37.6288659793814, Blast_Score=207, Evalue=8e-55,
Organism=Escherichia coli, GI1787560, Length=392, Percent_Identity=32.1428571428571, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1789016, Length=391, Percent_Identity=32.4808184143223, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1786991, Length=394, Percent_Identity=28.9340101522843, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1786349, Length=300, Percent_Identity=29.6666666666667, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=369, Percent_Identity=32.2493224932249, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=31.264367816092, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI25144274, Length=361, Percent_Identity=28.5318559556787, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI71992977, Length=408, Percent_Identity=27.6960784313726, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71981843, Length=139, Percent_Identity=33.0935251798561, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324432, Length=382, Percent_Identity=34.5549738219895, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323470, Length=387, Percent_Identity=32.5581395348837, Blast_Score=185, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6324386, Length=325, Percent_Identity=24.6153846153846, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321456, Length=298, Percent_Identity=25.503355704698, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357415, Length=373, Percent_Identity=29.7587131367292, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI161085790, Length=423, Percent_Identity=29.7872340425532, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28574759, Length=420, Percent_Identity=30.2380952380952, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI21356575, Length=312, Percent_Identity=29.4871794871795, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281366494, Length=347, Percent_Identity=23.342939481268, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24667139, Length=347, Percent_Identity=23.342939481268, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24667143, Length=347, Percent_Identity=23.342939481268, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 40021; Mature: 39889

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00028 ZINC_FINGER_C2H2_1 ; PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTYKELDAKYYMPCFGRSMEIVKGEGCNVWDDNGKKYLDLVAGIAVCSTGHCHPQVVDA
CCCHHHHCCCEECCCCCCCEEEEECCCCCEECCCCHHHHHHHHHHHHHCCCCCCHHHHHH
ICRQAHELIHCSNLYYIPGQAELAEKLSKASGMGKVFFGNSGAEAIDAALKLAKVRSGRK
HHHHHHHHEECCCEEEECCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCC
NFVSFNHDFHGRTIGSLAVTHKPQIREPFEPLGIHCDFPDYGDLEGLKAAVNKDTAAVVF
CEEEECCCCCCCEECCEEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHCCCCEEEEE
EPIQGETGIIIPPEDFLPGIRDICDDARALMICDEVQSGMGRTGKWFAFQHSKVQPDIIS
EECCCCCCEEECCHHHCCHHHHHHCCHHHEEEHHHHHHCCCCCCCEEEEECCCCCCHHHH
IAKGIASGVPMGAIIAREGLEFTKGEHGSTFAGGPIACAAGNVTFGIIEQLLPGIAAKGE
HHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCHH
LFRKGLAAFNPRVRGLMVGFTLGEAAPKLAELCMEKGVLINVAGDGNIRIVPPLTISADE
HHHHHHHHCCCCCCEEEEEEEHHHCCHHHHHHHHHCCEEEEEECCCCEEEECCCEEEHHH
INYAVGVINEAAGQI
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
STYKELDAKYYMPCFGRSMEIVKGEGCNVWDDNGKKYLDLVAGIAVCSTGHCHPQVVDA
CCHHHHCCCEECCCCCCCEEEEECCCCCEECCCCHHHHHHHHHHHHHCCCCCCHHHHHH
ICRQAHELIHCSNLYYIPGQAELAEKLSKASGMGKVFFGNSGAEAIDAALKLAKVRSGRK
HHHHHHHHEECCCEEEECCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCC
NFVSFNHDFHGRTIGSLAVTHKPQIREPFEPLGIHCDFPDYGDLEGLKAAVNKDTAAVVF
CEEEECCCCCCCEECCEEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHCCCCEEEEE
EPIQGETGIIIPPEDFLPGIRDICDDARALMICDEVQSGMGRTGKWFAFQHSKVQPDIIS
EECCCCCCEEECCHHHCCHHHHHHCCHHHEEEHHHHHHCCCCCCCEEEEECCCCCCHHHH
IAKGIASGVPMGAIIAREGLEFTKGEHGSTFAGGPIACAAGNVTFGIIEQLLPGIAAKGE
HHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCHH
LFRKGLAAFNPRVRGLMVGFTLGEAAPKLAELCMEKGVLINVAGDGNIRIVPPLTISADE
HHHHHHHHCCCCCCEEEEEEEHHHCCHHHHHHHHHCCEEEEEECCCCEEEECCCEEEHHH
INYAVGVINEAAGQI
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]