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The map label for this gene is hisC

Identifier: 124485948

GI number: 124485948

Start: 1141480

End: 1142535

Strand: Reverse

Name: hisC

Synonym: Mlab_1128

Alternate gene names: 124485948

Gene position: 1142535-1141480 (Counterclockwise)

Preceding gene: 124485949

Following gene: 124485947

Centisome position: 63.3

GC content: 55.11

Gene sequence:

>1056_bases
ATGAAGCCGCGGGTCAGATCTGAGTTCGTCAAATCAGGCTACGTCTTTGCAAAATCCCCGGCCGATATCGCAAAGGAATA
CGGGTTCACCGAAGTTGCCATGCTCGGCAGCAACGAAAACCCCTACCCTCCTTCGGACAAGGTCCTTCGGGCAGCAGAAG
CTGAGCTTTCAGGCGTAAACCGGTATCCGGATCCAAAAGCCGCCGCATTTCACGCCGCGCTCCGTACATACATCTGCGAT
TGCCCCGTCGTTACGTCTGGACTCGGTATGGACGGCGTTATCGAGACCGTGATTCGAACGATCGTCGAGCCGGGTGACAA
AGTTGTCATCTCCACGCCGACCTTCTCTATGTACGGCCTTGCAGCAAAGGCCGCATCTGCCCGTGTGGTCAATGTCTCGC
GAAGCGCCGACTTCTCGGTCGATCTCGACACATTCCTGAACGAAGCCAAAGATGCACGTCTTTCGTTCCTCTGCACGCCG
AACAATCCAACAGGGACCGTGACCCCGGTTGAGGACATTGAATATATTCTCGATAGGATCGAGGGAGTTTTATTCCTGGA
TTGTGCCTACGTAGAGTTTTCAGACATCAACTATCTGCCGCTTCTTTCCCGCGACAACCTGATCATCGGCCGGACCATGT
CCAAAGTGTATGGTCTTGCAGGTCTTCGGATCGGCTACGCATTCGTCCCGGAATGGCTGGAGGCTCCCTATAATATTGCC
GCCACGCCGTTCACGATGAATCGTCTTTCTGAAGCCGCGGCCTCCGTGGCCGTTTCAGATGCCGCCTACCGCGAATCATT
CATCGCCCATGTTCAAAAATGGCGGGATGTTTTCATGCAGGAGATCCCGTTCCCGGTTTACCCAAGCGGGTCGAACTTCA
TACTCATCAATGTCGCCCCGCAGAAAGGCGACGCTGCGGCCGAATCCCTGGCAAAACACGGCGTGCTGGTTCGTTCCTGT
ACCAGTTTCCCGGGTCTTGGAGATACGTTCATTCGCGTAAGCGTAGGTGCCGACTGGGAGAACGAGCGGTTCCTCGCTGC
GGTGAAAAAACTATGA

Upstream 100 bases:

>100_bases
AAGGGCGTTCTCATCAATGTTGCCGGTGACGGCAACATCAGGATCGTCCCGCCTCTGACAATCTCGGCCGACGAAATCAA
CTATGCAGTCGGAGTGATCA

Downstream 100 bases:

>100_bases
TGATCGGGATCACCGGAACCCCGGGATGTGGGAAGACGACCGTCGCAGACCTCCTTCGGGATATGGGGTATCCGGTTCTC
GATCTGAAAACCACCGTCGG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MKPRVRSEFVKSGYVFAKSPADIAKEYGFTEVAMLGSNENPYPPSDKVLRAAEAELSGVNRYPDPKAAAFHAALRTYICD
CPVVTSGLGMDGVIETVIRTIVEPGDKVVISTPTFSMYGLAAKAASARVVNVSRSADFSVDLDTFLNEAKDARLSFLCTP
NNPTGTVTPVEDIEYILDRIEGVLFLDCAYVEFSDINYLPLLSRDNLIIGRTMSKVYGLAGLRIGYAFVPEWLEAPYNIA
ATPFTMNRLSEAAASVAVSDAAYRESFIAHVQKWRDVFMQEIPFPVYPSGSNFILINVAPQKGDAAAESLAKHGVLVRSC
TSFPGLGDTFIRVSVGADWENERFLAAVKKL

Sequences:

>Translated_351_residues
MKPRVRSEFVKSGYVFAKSPADIAKEYGFTEVAMLGSNENPYPPSDKVLRAAEAELSGVNRYPDPKAAAFHAALRTYICD
CPVVTSGLGMDGVIETVIRTIVEPGDKVVISTPTFSMYGLAAKAASARVVNVSRSADFSVDLDTFLNEAKDARLSFLCTP
NNPTGTVTPVEDIEYILDRIEGVLFLDCAYVEFSDINYLPLLSRDNLIIGRTMSKVYGLAGLRIGYAFVPEWLEAPYNIA
ATPFTMNRLSEAAASVAVSDAAYRESFIAHVQKWRDVFMQEIPFPVYPSGSNFILINVAPQKGDAAAESLAKHGVLVRSC
TSFPGLGDTFIRVSVGADWENERFLAAVKKL
>Mature_351_residues
MKPRVRSEFVKSGYVFAKSPADIAKEYGFTEVAMLGSNENPYPPSDKVLRAAEAELSGVNRYPDPKAAAFHAALRTYICD
CPVVTSGLGMDGVIETVIRTIVEPGDKVVISTPTFSMYGLAAKAASARVVNVSRSADFSVDLDTFLNEAKDARLSFLCTP
NNPTGTVTPVEDIEYILDRIEGVLFLDCAYVEFSDINYLPLLSRDNLIIGRTMSKVYGLAGLRIGYAFVPEWLEAPYNIA
ATPFTMNRLSEAAASVAVSDAAYRESFIAHVQKWRDVFMQEIPFPVYPSGSNFILINVAPQKGDAAAESLAKHGVLVRSC
TSFPGLGDTFIRVSVGADWENERFLAAVKKL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=332, Percent_Identity=28.3132530120482, Blast_Score=103, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322075, Length=365, Percent_Identity=29.041095890411, Blast_Score=109, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_METLZ (A2SSJ1)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001030564.1
- ProteinModelPortal:   A2SSJ1
- SMR:   A2SSJ1
- STRING:   A2SSJ1
- GeneID:   4795647
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_1128
- eggNOG:   arNOG04897
- HOGENOM:   HBG646350
- OMA:   MSARYHH
- ProtClustDB:   PRK00950
- BioCyc:   MLAB410358:MLAB_1128-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 38283; Mature: 38283

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPRVRSEFVKSGYVFAKSPADIAKEYGFTEVAMLGSNENPYPPSDKVLRAAEAELSGVN
CCCCHHHHHHHCCEEEECCHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
RYPDPKAAAFHAALRTYICDCPVVTSGLGMDGVIETVIRTIVEPGDKVVISTPTFSMYGL
CCCCHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
AAKAASARVVNVSRSADFSVDLDTFLNEAKDARLSFLCTPNNPTGTVTPVEDIEYILDRI
HHHHCCEEEEEECCCCCCEEEHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHH
EGVLFLDCAYVEFSDINYLPLLSRDNLIIGRTMSKVYGLAGLRIGYAFVPEWLEAPYNIA
CCEEEEEEEEEEECCCCEEEEECCCCEEEECHHHHHHHHHHHHHHHHHCCHHHCCCCCEE
ATPFTMNRLSEAAASVAVSDAAYRESFIAHVQKWRDVFMQEIPFPVYPSGSNFILINVAP
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECC
QKGDAAAESLAKHGVLVRSCTSFPGLGDTFIRVSVGADWENERFLAAVKKL
CCCCHHHHHHHHCCCEEEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHCC
>Mature Secondary Structure
MKPRVRSEFVKSGYVFAKSPADIAKEYGFTEVAMLGSNENPYPPSDKVLRAAEAELSGVN
CCCCHHHHHHHCCEEEECCHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
RYPDPKAAAFHAALRTYICDCPVVTSGLGMDGVIETVIRTIVEPGDKVVISTPTFSMYGL
CCCCHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
AAKAASARVVNVSRSADFSVDLDTFLNEAKDARLSFLCTPNNPTGTVTPVEDIEYILDRI
HHHHCCEEEEEECCCCCCEEEHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHH
EGVLFLDCAYVEFSDINYLPLLSRDNLIIGRTMSKVYGLAGLRIGYAFVPEWLEAPYNIA
CCEEEEEEEEEEECCCCEEEEECCCCEEEECHHHHHHHHHHHHHHHHHCCHHHCCCCCEE
ATPFTMNRLSEAAASVAVSDAAYRESFIAHVQKWRDVFMQEIPFPVYPSGSNFILINVAP
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECC
QKGDAAAESLAKHGVLVRSCTSFPGLGDTFIRVSVGADWENERFLAAVKKL
CCCCHHHHHHHHCCCEEEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA