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The map label for this gene is 124485799

Identifier: 124485799

GI number: 124485799

Start: 975410

End: 976426

Strand: Reverse

Name: 124485799

Synonym: Mlab_0978

Alternate gene names: NA

Gene position: 976426-975410 (Counterclockwise)

Preceding gene: 124485800

Following gene: 124485798

Centisome position: 54.1

GC content: 59.39

Gene sequence:

>1017_bases
GTGACCGAGGACAAAACCATCTGGTGGAACGATGAAAACAGTTCCGTGATGCTCATCGACCAGACGCTGCTCCCAACCGA
GTATAAGGTCATCGAGATCACCGAGGTTTCCCGGCTCGCGGACGCGATCCGCCGGCTCGAAGTCAGAGGAGCTCCGGCCC
TCGGCGTTGCCGGCGCATTCGGGGTCGCTTTATCTGCGGCACGCTGCGTTTCGGACGTCGAGTTCGACGAGACGATCGCG
TCCGATGCGGCGCTTCTGAAAAGCACCCGCCCGACCGCCGTGAATCTCGCATGGGGCGTGGACAAAGTCCTCCGCAGCAT
GGAAAATCTCCCCCCGGAGATGGCACGGGTCATGGCGCTTTTCGCCGCGAAAACCATCGCCGAAAACGACACCAAAGCCT
GCATGCTTCTGGGTCACAACGGCGCCTCGCTTCTCCCGCAGATCGGGACCGTGCTTACCCACTGTAATGCAGGGGCACTC
GCCTGCTCTTCATGGGGGACGGCGCTCGGGGTCATCCGCTCGGCCAAAAAGATGGGCAAGAAGATCTCGGTCGTCTCCTG
CGAGACCCGCCCCCTTCTCCAGGGCTCCAGGCTCACCGCCTGGGAACTCGCCCGTGATGAGATCCCCGTGACAACGATCG
TTGACTCAGAAGCCGCATTTTTGATGCGTCAGGGAAAAATCGACGCCGTCATCGTCGGTGCCGACCGGATCACAAAAGAC
GCCGTCTTCAACAAGATCGGGACTTACATGCACGCCGTCTGTGCCAAATATCACGACATCCCGTTCTACGTCGCGGCTCC
CGTCTCGACTTTTGACGCAGCGGCGTCAGAGTCCGATATCACCATCGAACAGCGTGACCGGACCGAAGTTTCCGGCCTCT
TTGGGAGAACGACCGTTCCGGAAAACGTCCCGGTCATCAACTACGCCTTCGACGCGACGCCGCTGGATCTAGTTACCGCC
ATTATAACCGAAAAGGGTGTCCTGTATCCCCCGTATGATTTCCAGGACATGAAATAA

Upstream 100 bases:

>100_bases
TCGCCGGCGCCGCCCTTGCTCCAAAAGACATCCCTGACTCGGTCATGTCCGCCGGTGCCGCCGCCATGAAAGCCTCCATC
GACGTCGTCAGGAGCGAACA

Downstream 100 bases:

>100_bases
ATGGCTGCGACCCTCTCCCTCGCATTTTTCGACAGTCCGGTCTGGAACAACCTGGCCCTGATCCTCGGCCAGCTTCTTCT
GATCTTCATAGCCTTCTGGC

Product: translation initiation factor 2B subunit I

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; MTNA-like protein; aMTNA; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MTEDKTIWWNDENSSVMLIDQTLLPTEYKVIEITEVSRLADAIRRLEVRGAPALGVAGAFGVALSAARCVSDVEFDETIA
SDAALLKSTRPTAVNLAWGVDKVLRSMENLPPEMARVMALFAAKTIAENDTKACMLLGHNGASLLPQIGTVLTHCNAGAL
ACSSWGTALGVIRSAKKMGKKISVVSCETRPLLQGSRLTAWELARDEIPVTTIVDSEAAFLMRQGKIDAVIVGADRITKD
AVFNKIGTYMHAVCAKYHDIPFYVAAPVSTFDAAASESDITIEQRDRTEVSGLFGRTTVPENVPVINYAFDATPLDLVTA
IITEKGVLYPPYDFQDMK

Sequences:

>Translated_338_residues
MTEDKTIWWNDENSSVMLIDQTLLPTEYKVIEITEVSRLADAIRRLEVRGAPALGVAGAFGVALSAARCVSDVEFDETIA
SDAALLKSTRPTAVNLAWGVDKVLRSMENLPPEMARVMALFAAKTIAENDTKACMLLGHNGASLLPQIGTVLTHCNAGAL
ACSSWGTALGVIRSAKKMGKKISVVSCETRPLLQGSRLTAWELARDEIPVTTIVDSEAAFLMRQGKIDAVIVGADRITKD
AVFNKIGTYMHAVCAKYHDIPFYVAAPVSTFDAAASESDITIEQRDRTEVSGLFGRTTVPENVPVINYAFDATPLDLVTA
IITEKGVLYPPYDFQDMK
>Mature_337_residues
TEDKTIWWNDENSSVMLIDQTLLPTEYKVIEITEVSRLADAIRRLEVRGAPALGVAGAFGVALSAARCVSDVEFDETIAS
DAALLKSTRPTAVNLAWGVDKVLRSMENLPPEMARVMALFAAKTIAENDTKACMLLGHNGASLLPQIGTVLTHCNAGALA
CSSWGTALGVIRSAKKMGKKISVVSCETRPLLQGSRLTAWELARDEIPVTTIVDSEAAFLMRQGKIDAVIVGADRITKDA
VFNKIGTYMHAVCAKYHDIPFYVAAPVSTFDAAASESDITIEQRDRTEVSGLFGRTTVPENVPVINYAFDATPLDLVTAI
ITEKGVLYPPYDFQDMK

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=337, Percent_Identity=38.5756676557863, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI23943880, Length=325, Percent_Identity=32.9230769230769, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI4503503, Length=186, Percent_Identity=30.6451612903226, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17557462, Length=333, Percent_Identity=35.7357357357357, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6325375, Length=386, Percent_Identity=34.9740932642487, Blast_Score=162, Evalue=5e-41,
Organism=Drosophila melanogaster, GI21357667, Length=345, Percent_Identity=36.5217391304348, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24651647, Length=345, Percent_Identity=36.5217391304348, Blast_Score=197, Evalue=6e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 36586; Mature: 36455

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEDKTIWWNDENSSVMLIDQTLLPTEYKVIEITEVSRLADAIRRLEVRGAPALGVAGAF
CCCCCEEEECCCCCEEEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHH
GVALSAARCVSDVEFDETIASDAALLKSTRPTAVNLAWGVDKVLRSMENLPPEMARVMAL
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHH
FAAKTIAENDTKACMLLGHNGASLLPQIGTVLTHCNAGALACSSWGTALGVIRSAKKMGK
HHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCC
KISVVSCETRPLLQGSRLTAWELARDEIPVTTIVDSEAAFLMRQGKIDAVIVGADRITKD
EEEEEEECCCCCCCCCCCCHHHHHHCCCCEEEEECCHHHHHHHCCCCCEEEECCCHHHHH
AVFNKIGTYMHAVCAKYHDIPFYVAAPVSTFDAAASESDITIEQRDRTEVSGLFGRTTVP
HHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCEEECCCCHHHHHHCCCCCCC
ENVPVINYAFDATPLDLVTAIITEKGVLYPPYDFQDMK
CCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEDKTIWWNDENSSVMLIDQTLLPTEYKVIEITEVSRLADAIRRLEVRGAPALGVAGAF
CCCCEEEECCCCCEEEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHH
GVALSAARCVSDVEFDETIASDAALLKSTRPTAVNLAWGVDKVLRSMENLPPEMARVMAL
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHH
FAAKTIAENDTKACMLLGHNGASLLPQIGTVLTHCNAGALACSSWGTALGVIRSAKKMGK
HHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCC
KISVVSCETRPLLQGSRLTAWELARDEIPVTTIVDSEAAFLMRQGKIDAVIVGADRITKD
EEEEEEECCCCCCCCCCCCHHHHHHCCCCEEEEECCHHHHHHHCCCCCEEEECCCHHHHH
AVFNKIGTYMHAVCAKYHDIPFYVAAPVSTFDAAASESDITIEQRDRTEVSGLFGRTTVP
HHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCEEECCCCHHHHHHCCCCCCC
ENVPVINYAFDATPLDLVTAIITEKGVLYPPYDFQDMK
CCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]