Click here to switch to the map view.

The map label for this gene is uvrB [H]

Identifier: 124485733

GI number: 124485733

Start: 905606

End: 907540

Strand: Reverse

Name: uvrB [H]

Synonym: Mlab_0911

Alternate gene names: 124485733

Gene position: 907540-905606 (Counterclockwise)

Preceding gene: 124485734

Following gene: 124485725

Centisome position: 50.28

GC content: 56.18

Gene sequence:

>1935_bases
ATGCCTGATCAGTTCTCGCTTCAATCCACCTATTCGCCGAAAGGATCCCAGCCGGAAGCGATCGAAGAACTGACCGAAGG
CCTTCTCGATGGTGAGCAGTTTCAGACGCTTCTCGGGGTCACCGGTTCGGGGAAGACGTTTACGATCGCAAACGTCATCC
AGAACGTTCAGCGCCCGACTCTCGTTCTGGCCCATAACAAGACTCTCGCCGCCCAGCTCTACAACGAGTTCAAGGATTTT
TTTCCGAACAATCACGTCGAGTACTTCATCTCCTACTATGACTACTATCAGCCGGAGAGTTACATCGCGAAAAAGGATCA
GTATATAGAAAAGGACGCCTCCATCAATCCGAAAATTGAGATGATGCGTCTTGCCGCGACCGCGTCGATCCTCTCGCACC
GGGATACGATCGTGGTCGCGTCGGTTTCCTGTATTTACGGTCTCGGCAACCCGGAAAACTTCCAGAATCTCGGGTTCGAG
GTCCGCAGGGGACAAAAAATCACCCGCCGCGAACTTCTCGAACGGCTGCTCTCGATCCTTTTCGAGAGAAACGACATCGA
GTTGATGCCCGGTCGGTTCCGGGTCAAAGGCGACACGGTGGATCTGATCCCGGGTTATTTCAATAATATCATCAGGATCG
AACTGTTCGGCGACACGATCGACAGGATCAGTGAGATCGATAAAACCACGGGAAAGGAGAAGGAGCGGATGGAGTATTTC
TTCATCTATCCGGCCCGCCATTTCGTCACGCCCGAGTCGGAAAAGCAGGCAGCTATTGATTCGATCCGGGGAGAGCTGGA
AGAGGTGCTCGCCGAGAACCGTCTGGACGATCTTGCGGCGCACCGGCTGCGTCAGAGGACCCAGTATGATCTGGAGATGA
TCGAGGAGACCGGTTCCTGTAAAGGGATCGAGAATTATTCCCGGCACTTCGACCGGCGTGCCGCGGGAGAGAAGCCGTAC
TGTCTGCTGGATTATTTCCCGGATGATTTTCTGATGGTGATCGACGAGAGCCATCAGTCTCTCCCGCAGGTCCGGGGGAT
GTACAACGGCGATCATTCCCGCAAGCAGTCCCTTGTGGAATACGGGTTCCGTCTGCCGAGTGCGTTCGACAACCGGCCGC
TGAAGTTCGTTGAGTTCGAGAAGTATCTCAAACAGGTGATCTTCGTTTCGGCAACGCCGGGAGATTACGAGCGGAAGTAT
TCGTCACAGATCATCGAGCAGATCATCCGCCCGACTGGTCTCGTTGATCCGGTGGTTGAGGTCCGGCCGATCACGGGCCA
GACGGATGATCTGCTGAGAGAGATCAGCGCCGTCATCGGGCGGGGCGACCGTGCTCTTGTGACGACGCTCACAAAAAAAC
TCGCCGAAGAGCTGACCGAGTATCTTGCGGGGCAGGGGATCAAGACCCGGTATCTGCATTCGGAGATCCAGACACTGGAG
CGGACCGAGCTTATCCGTCAGCTCAGGCTTGGGATGTTCGATGTTCTGGTCGGCATCAATCTGTTAAGGGAGGGGCTGGA
TATCCCGGAGATCGGGTTCATCGGTATTCTGGATGCAGATAAGGAGGGGTTCCTGCGGGATGCCAGGAGTCTTATCCAGA
TCATCGGCCGGGCGGCCAGGAACTCGGACTCGCATGTCGTGCTGTATGCCGATAAGATGACGGATTCGATGCGTGAGGCT
CTTGCCGAGACGGCACGCCGCCGCGAGATGCAGATGGCGTTCAATACAGAGCACGGGATCACGCCGGTGACGATCAAGAA
ACCGGTGCGGGAGAAGGAGGTCGATATCAAGGATATCCGGCACCTGCCGAAGTCGGAGATCCCGAACCTGATCATCGAAC
TGGAGGCCGAGATGAATGCGGCGGCGGCGGCGCTGGATTTCGAGCGGGCGATCCAGCTGAGGGATCGGGTGAAGGAGTTG
AGAGGCGGGTCATGA

Upstream 100 bases:

>100_bases
TCCCGATCATGGTCTTTTTCATCAGATACCTCTCCGAGGTCTACGACACGGCATTCCGGGTCCCCGAAGAGGACGACGTA
GACTTCGATGATTTCTGAAA

Downstream 100 bases:

>100_bases
GGGGAGATTAGCGAAAAGTAATACCTTTCATGTATTTTGGGGTGCGGGGACGCGACTACGGGGTGGACGCTGGAAACGAA
CGCCCTCAGTTGAGCAAATC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 644; Mature: 643

Protein sequence:

>644_residues
MPDQFSLQSTYSPKGSQPEAIEELTEGLLDGEQFQTLLGVTGSGKTFTIANVIQNVQRPTLVLAHNKTLAAQLYNEFKDF
FPNNHVEYFISYYDYYQPESYIAKKDQYIEKDASINPKIEMMRLAATASILSHRDTIVVASVSCIYGLGNPENFQNLGFE
VRRGQKITRRELLERLLSILFERNDIELMPGRFRVKGDTVDLIPGYFNNIIRIELFGDTIDRISEIDKTTGKEKERMEYF
FIYPARHFVTPESEKQAAIDSIRGELEEVLAENRLDDLAAHRLRQRTQYDLEMIEETGSCKGIENYSRHFDRRAAGEKPY
CLLDYFPDDFLMVIDESHQSLPQVRGMYNGDHSRKQSLVEYGFRLPSAFDNRPLKFVEFEKYLKQVIFVSATPGDYERKY
SSQIIEQIIRPTGLVDPVVEVRPITGQTDDLLREISAVIGRGDRALVTTLTKKLAEELTEYLAGQGIKTRYLHSEIQTLE
RTELIRQLRLGMFDVLVGINLLREGLDIPEIGFIGILDADKEGFLRDARSLIQIIGRAARNSDSHVVLYADKMTDSMREA
LAETARRREMQMAFNTEHGITPVTIKKPVREKEVDIKDIRHLPKSEIPNLIIELEAEMNAAAAALDFERAIQLRDRVKEL
RGGS

Sequences:

>Translated_644_residues
MPDQFSLQSTYSPKGSQPEAIEELTEGLLDGEQFQTLLGVTGSGKTFTIANVIQNVQRPTLVLAHNKTLAAQLYNEFKDF
FPNNHVEYFISYYDYYQPESYIAKKDQYIEKDASINPKIEMMRLAATASILSHRDTIVVASVSCIYGLGNPENFQNLGFE
VRRGQKITRRELLERLLSILFERNDIELMPGRFRVKGDTVDLIPGYFNNIIRIELFGDTIDRISEIDKTTGKEKERMEYF
FIYPARHFVTPESEKQAAIDSIRGELEEVLAENRLDDLAAHRLRQRTQYDLEMIEETGSCKGIENYSRHFDRRAAGEKPY
CLLDYFPDDFLMVIDESHQSLPQVRGMYNGDHSRKQSLVEYGFRLPSAFDNRPLKFVEFEKYLKQVIFVSATPGDYERKY
SSQIIEQIIRPTGLVDPVVEVRPITGQTDDLLREISAVIGRGDRALVTTLTKKLAEELTEYLAGQGIKTRYLHSEIQTLE
RTELIRQLRLGMFDVLVGINLLREGLDIPEIGFIGILDADKEGFLRDARSLIQIIGRAARNSDSHVVLYADKMTDSMREA
LAETARRREMQMAFNTEHGITPVTIKKPVREKEVDIKDIRHLPKSEIPNLIIELEAEMNAAAAALDFERAIQLRDRVKEL
RGGS
>Mature_643_residues
PDQFSLQSTYSPKGSQPEAIEELTEGLLDGEQFQTLLGVTGSGKTFTIANVIQNVQRPTLVLAHNKTLAAQLYNEFKDFF
PNNHVEYFISYYDYYQPESYIAKKDQYIEKDASINPKIEMMRLAATASILSHRDTIVVASVSCIYGLGNPENFQNLGFEV
RRGQKITRRELLERLLSILFERNDIELMPGRFRVKGDTVDLIPGYFNNIIRIELFGDTIDRISEIDKTTGKEKERMEYFF
IYPARHFVTPESEKQAAIDSIRGELEEVLAENRLDDLAAHRLRQRTQYDLEMIEETGSCKGIENYSRHFDRRAAGEKPYC
LLDYFPDDFLMVIDESHQSLPQVRGMYNGDHSRKQSLVEYGFRLPSAFDNRPLKFVEFEKYLKQVIFVSATPGDYERKYS
SQIIEQIIRPTGLVDPVVEVRPITGQTDDLLREISAVIGRGDRALVTTLTKKLAEELTEYLAGQGIKTRYLHSEIQTLER
TELIRQLRLGMFDVLVGINLLREGLDIPEIGFIGILDADKEGFLRDARSLIQIIGRAARNSDSHVVLYADKMTDSMREAL
AETARRREMQMAFNTEHGITPVTIKKPVREKEVDIKDIRHLPKSEIPNLIIELEAEMNAAAAALDFERAIQLRDRVKELR
GGS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=667, Percent_Identity=53.3733133433283, Blast_Score=667, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 73761; Mature: 73630

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDQFSLQSTYSPKGSQPEAIEELTEGLLDGEQFQTLLGVTGSGKTFTIANVIQNVQRPT
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCEEEHHHHHHHCCCCE
LVLAHNKTLAAQLYNEFKDFFPNNHVEYFISYYDYYQPESYIAKKDQYIEKDASINPKIE
EEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHH
MMRLAATASILSHRDTIVVASVSCIYGLGNPENFQNLGFEVRRGQKITRRELLERLLSIL
HHHHHHHHHHHHCCCEEEEEEHHHHEECCCCCCHHHCCCHHHCCCHHHHHHHHHHHHHHH
FERNDIELMPGRFRVKGDTVDLIPGYFNNIIRIELFGDTIDRISEIDKTTGKEKERMEYF
HCCCCCEECCCEEEECCCCEEECCHHHCCEEEEEEECCHHHHHHHHHHHCCCCCCCCEEE
FIYPARHFVTPESEKQAAIDSIRGELEEVLAENRLDDLAAHRLRQRTQYDLEMIEETGSC
EEECHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCC
KGIENYSRHFDRRAAGEKPYCLLDYFPDDFLMVIDESHQSLPQVRGMYNGDHSRKQSLVE
CCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECHHHHHHHHHCCCCCCHHHHHHHHH
YGFRLPSAFDNRPLKFVEFEKYLKQVIFVSATPGDYERKYSSQIIEQIIRPTGLVDPVVE
HHCCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCHH
VRPITGQTDDLLREISAVIGRGDRALVTTLTKKLAEELTEYLAGQGIKTRYLHSEIQTLE
EECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RTELIRQLRLGMFDVLVGINLLREGLDIPEIGFIGILDADKEGFLRDARSLIQIIGRAAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHC
NSDSHVVLYADKMTDSMREALAETARRREMQMAFNTEHGITPVTIKKPVREKEVDIKDIR
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHCCCHHHHH
HLPKSEIPNLIIELEAEMNAAAAALDFERAIQLRDRVKELRGGS
CCCHHHCCCEEEEEECHHCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PDQFSLQSTYSPKGSQPEAIEELTEGLLDGEQFQTLLGVTGSGKTFTIANVIQNVQRPT
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCEEEHHHHHHHCCCCE
LVLAHNKTLAAQLYNEFKDFFPNNHVEYFISYYDYYQPESYIAKKDQYIEKDASINPKIE
EEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHH
MMRLAATASILSHRDTIVVASVSCIYGLGNPENFQNLGFEVRRGQKITRRELLERLLSIL
HHHHHHHHHHHHCCCEEEEEEHHHHEECCCCCCHHHCCCHHHCCCHHHHHHHHHHHHHHH
FERNDIELMPGRFRVKGDTVDLIPGYFNNIIRIELFGDTIDRISEIDKTTGKEKERMEYF
HCCCCCEECCCEEEECCCCEEECCHHHCCEEEEEEECCHHHHHHHHHHHCCCCCCCCEEE
FIYPARHFVTPESEKQAAIDSIRGELEEVLAENRLDDLAAHRLRQRTQYDLEMIEETGSC
EEECHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCC
KGIENYSRHFDRRAAGEKPYCLLDYFPDDFLMVIDESHQSLPQVRGMYNGDHSRKQSLVE
CCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECHHHHHHHHHCCCCCCHHHHHHHHH
YGFRLPSAFDNRPLKFVEFEKYLKQVIFVSATPGDYERKYSSQIIEQIIRPTGLVDPVVE
HHCCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCHH
VRPITGQTDDLLREISAVIGRGDRALVTTLTKKLAEELTEYLAGQGIKTRYLHSEIQTLE
EECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RTELIRQLRLGMFDVLVGINLLREGLDIPEIGFIGILDADKEGFLRDARSLIQIIGRAAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHC
NSDSHVVLYADKMTDSMREALAETARRREMQMAFNTEHGITPVTIKKPVREKEVDIKDIR
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHCCCHHHHH
HLPKSEIPNLIIELEAEMNAAAAALDFERAIQLRDRVKELRGGS
CCCHHHCCCEEEEEECHHCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]