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The map label for this gene is glxR [H]

Identifier: 124266168

GI number: 124266168

Start: 1038146

End: 1039045

Strand: Direct

Name: glxR [H]

Synonym: Mpe_A0975

Alternate gene names: 124266168

Gene position: 1038146-1039045 (Clockwise)

Preceding gene: 124266167

Following gene: 124266169

Centisome position: 25.67

GC content: 70.89

Gene sequence:

>900_bases
ATGAAGATCGGATTCATCGGCCTGGGCATCATGGGCACGCCGATGGCGCTGCACCTGGCGGCCGCGGGCCACGCGCTGTT
CGTCCACACCCGCGGCAAGTTGCCCGAGGCGATCGCCGCGTCTGGCGCGCAGGCCTGCGCCAACGCGGCCGAGGTGGCGC
GCAACGCGGAGGTGGTGTTCACCATGCTGCCCGACACGCCGGACGTCGAGACCGTGCTGTTCGGTGCGAACGGTATCGCC
GCCGGTCTGGAGAGCGGCGCCGGCAGCGTGCGCAAGGTCGTCGTCGACATGAGCTCGATCTCGCCGATGGCCACCAAGGC
CTACGCGCAGCGCATCAACGCGCTCGGCGCCGACTACCTGGACGCACCGGTGTCCGGCGGCGAGGTCGGTGCCAAGGCGG
CCTCGCTGACCATCATGTGCGGCGGCGACGAGGCGGTGTTCGCGCGCGTGCGCCCGCTGCTCGAGACGATGGGCAAGAAC
ATCACGCTGGTCGGTGGCAACGGCGACGGCCAGACGACCAAGGTGGCCAACCAGATCATCGTCGCGCTCAACATCGCGGC
GGTCGGCGAGGCCTTGCTGTTCGCCAGCAAGGCCGGCGCCGACCCGGCCAAGGTGCGCCAGGCGCTGATGGGCGGCTTCG
CGGCCAGCCGCATCCTGGAAGTGCATGGTGAACGCATGATCAAGCGCAGCTTCGCGCCGGGCTTCCGCATCAAGCTGCAC
CAGAAGGACCTGGGCCTCGCGTTGCAGGGCGCGCGCGAACTGGGCGTGTCGCTGCCGCAGACCGCCGGCGCGGCTCAGCT
GATGCAGGCCTGCGCCGCCAACGGCATGGCCGACCTCGACCACTCCGCGCTGGTGCGGGCGCTGGAGCTGATGGCGGGCC
ACGACGTGGCCGCGGCCTGA

Upstream 100 bases:

>100_bases
ATGGCCGCTGGCGCGCAGCAGGTGGTGGCGAAGATGCGCGACCGCCCGACGTCGGGCAGCGCACAGGGCTATTGATCCAC
GCACAGAGAAGGACCTCACC

Downstream 100 bases:

>100_bases
GCGACCGTGACCGCCGCCACCGCGATAGATCGCCGGCCGCTGCTGCGCGCGCTGTTCGACGCGGCCGTGGCTGCGGCGCA
GCCGGCGCTGTGCCTGCCGG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKIGFIGLGIMGTPMALHLAAAGHALFVHTRGKLPEAIAASGAQACANAAEVARNAEVVFTMLPDTPDVETVLFGANGIA
AGLESGAGSVRKVVVDMSSISPMATKAYAQRINALGADYLDAPVSGGEVGAKAASLTIMCGGDEAVFARVRPLLETMGKN
ITLVGGNGDGQTTKVANQIIVALNIAAVGEALLFASKAGADPAKVRQALMGGFAASRILEVHGERMIKRSFAPGFRIKLH
QKDLGLALQGARELGVSLPQTAGAAQLMQACAANGMADLDHSALVRALELMAGHDVAAA

Sequences:

>Translated_299_residues
MKIGFIGLGIMGTPMALHLAAAGHALFVHTRGKLPEAIAASGAQACANAAEVARNAEVVFTMLPDTPDVETVLFGANGIA
AGLESGAGSVRKVVVDMSSISPMATKAYAQRINALGADYLDAPVSGGEVGAKAASLTIMCGGDEAVFARVRPLLETMGKN
ITLVGGNGDGQTTKVANQIIVALNIAAVGEALLFASKAGADPAKVRQALMGGFAASRILEVHGERMIKRSFAPGFRIKLH
QKDLGLALQGARELGVSLPQTAGAAQLMQACAANGMADLDHSALVRALELMAGHDVAAA
>Mature_299_residues
MKIGFIGLGIMGTPMALHLAAAGHALFVHTRGKLPEAIAASGAQACANAAEVARNAEVVFTMLPDTPDVETVLFGANGIA
AGLESGAGSVRKVVVDMSSISPMATKAYAQRINALGADYLDAPVSGGEVGAKAASLTIMCGGDEAVFARVRPLLETMGKN
ITLVGGNGDGQTTKVANQIIVALNIAAVGEALLFASKAGADPAKVRQALMGGFAASRILEVHGERMIKRSFAPGFRIKLH
QKDLGLALQGARELGVSLPQTAGAAQLMQACAANGMADLDHSALVRALELMAGHDVAAA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=299, Percent_Identity=30.7692307692308, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI40556376, Length=288, Percent_Identity=27.4305555555556, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1786719, Length=297, Percent_Identity=65.3198653198653, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI145693186, Length=299, Percent_Identity=45.819397993311, Blast_Score=245, Evalue=2e-66,
Organism=Escherichia coli, GI1790315, Length=295, Percent_Identity=33.5593220338983, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789092, Length=293, Percent_Identity=27.9863481228669, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17557316, Length=279, Percent_Identity=32.258064516129, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24655230, Length=299, Percent_Identity=36.4548494983278, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI19922568, Length=299, Percent_Identity=36.4548494983278, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28574115, Length=283, Percent_Identity=26.1484098939929, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30389; Mature: 30389

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFIGLGIMGTPMALHLAAAGHALFVHTRGKLPEAIAASGAQACANAAEVARNAEVVF
CEEEEEECCCCCCCHHHHEECCCCEEEEEECCCCCHHHHHCCHHHHHHHHHHHCCCEEEE
TMLPDTPDVETVLFGANGIAAGLESGAGSVRKVVVDMSSISPMATKAYAQRINALGADYL
EECCCCCCCCEEEECCCCHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHH
DAPVSGGEVGAKAASLTIMCGGDEAVFARVRPLLETMGKNITLVGGNGDGQTTKVANQII
CCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHEE
VALNIAAVGEALLFASKAGADPAKVRQALMGGFAASRILEVHGERMIKRSFAPGFRIKLH
EEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
QKDLGLALQGARELGVSLPQTAGAAQLMQACAANGMADLDHSALVRALELMAGHDVAAA
CCCCCHHHHCHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKIGFIGLGIMGTPMALHLAAAGHALFVHTRGKLPEAIAASGAQACANAAEVARNAEVVF
CEEEEEECCCCCCCHHHHEECCCCEEEEEECCCCCHHHHHCCHHHHHHHHHHHCCCEEEE
TMLPDTPDVETVLFGANGIAAGLESGAGSVRKVVVDMSSISPMATKAYAQRINALGADYL
EECCCCCCCCEEEECCCCHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHH
DAPVSGGEVGAKAASLTIMCGGDEAVFARVRPLLETMGKNITLVGGNGDGQTTKVANQII
CCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHEE
VALNIAAVGEALLFASKAGADPAKVRQALMGGFAASRILEVHGERMIKRSFAPGFRIKLH
EEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
QKDLGLALQGARELGVSLPQTAGAAQLMQACAANGMADLDHSALVRALELMAGHDVAAA
CCCCCHHHHCHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]