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The map label for this gene is paaH [H]

Identifier: 124266073

GI number: 124266073

Start: 921366

End: 922910

Strand: Reverse

Name: paaH [H]

Synonym: Mpe_A0880

Alternate gene names: 124266073

Gene position: 922910-921366 (Counterclockwise)

Preceding gene: 124266074

Following gene: 124266072

Centisome position: 22.82

GC content: 75.28

Gene sequence:

>1545_bases
ATGAGGCACGCACTCGACACGCAATCGCCGGTGTGCGTGATCGGCGCCGGCATCATGGGCGCGGGCATCGCGCAGGTGGC
GGCGCAGGCCGGGCACCCGGTGCAGCTGCATGACGCCCGCGACGGCGCGGCGCTCGCCGCATTGCGCCGGCTCGCCACCG
GCCTGGACGCGCTCGTGGCGAAGGGTCGCCTGAGCGCGGAGGCGGCGCAGGCCACGCTGGCGCGCATCACCCCGGCCACG
TCGATCGACGCGGCAGCCGGCGCCCGGCTGGTGGTCGAGGCCATCGTCGAGCAGGCCGAGGCCAAGCGCACGCTGTTCGC
GCAACTCGAGGCGATCGTCGACGCCGACTGCGTGCTGGCGTCCAACACCTCGTCGATCTCGATCACCGCGCTGGCGCGCG
ACCTGCGGCACCCGGGGCGCTGCGTCGGTCTGCACTTCTTCAACCCGGTGCCCGTGATGAAGCTGGTGGAGGTGGTCTCC
GGCCTGCGCACCGAGCCGAGCGTGGCGCAGGCCGTGTTCGCGCTCAGCGAGCGCTGGCGCAAGACGCCGGTGCACGCCCG
CTCGACGCCGGGCTTCATCGTCAACCGCATCGCCCGGCCCTACTACGCCGAGACGCTGGCGCTGCTGCAGGAGCGTGCGG
CCGAGCCGGCTGTGCTCGACGCCTGCCTGCGCGGCGCAGGGTTCCGCATGGGGCCCTGCGAGCTGATGGACCTGATCGGT
CACGACACCAACTTCGCGGTGACCGCCTCGGTCCACGACGCCAACTTCGGCGACCGGCGCTACGGGCCTTCGCTGGTGCA
GCGCGAGCTGGTGGACGGCGGCCTGCTCGGCCGCAAGTCGGGGCGCGGCTTCTACGACCACGCAGAGCGCGCGGCGCCGG
ACCCGGCCGCGCACCCCGCCGCGCCGGCGCCCGCGCTGCCGCAGGCGGCGCGCTGTCGGGTGCACGGCCACGGTGCGCTG
GTCGAGCGATGGCTCGACGGCCTGGCGCGCGAGGGCCGGGCCTTCGAGCGGGTGGCCGAGAGCCCCTGGAACGGCCTCGA
ACTCGACGGCGCCCAGCTGCGCCAGACCGACGGCCGGCTGGCCGCGCAGGTGGCCGCCGAGCACGCGGTGCGCGACCTCG
CGCTGTTCGACCGCACGGTCGGCCCGCCGTCCGCCGGCGGCGACACCGCGCTGGCCTGGAGCGCCAGCGGCGGCGCGAGC
GAGGACTGGCAGGCGAGCGCTGCGCAGTGCCTGCAGGCTGCCGGCCGGCAGCCGCAGCGGCTGCGCGACGTGCCGGGCCT
GGTGGTCGCGCGCACGCTGGCGATGCTGATCAACGAGGCGTCCGACGCCGTGCTGCAGGGTGTGTGCAGCGCGGCGGACG
CCGACATGGCGATGAAGCTCGGCGTCAACTACCCGGCCGGCCCGTTCGAATGGCTGGCGGACTGGGAAGCGCGCCAGGTG
GTCGCGCTGCTCGACCGCCTGGACACCCACTACCGCGGCGAACGCTACCGCGCGAGCCCCGCGCTGCGGGAACGGGCCTG
GCTGCAGGCAGCGACCGCGCCCTGA

Upstream 100 bases:

>100_bases
CGGCGCAGACCATCAGCCGCGTGCGCCTGGGCGACGAGGCGCGCGAAGGCTTTGCCGCCTTCTTCGCGAAGCGCCCGCCG
CCGTGGGCGAAGGGGCCGGC

Downstream 100 bases:

>100_bases
GCGCCCGGCATCGACGAACCCTCCCCTGCCTCTCATCATGATCCGTGACGCCTACCTCTGCGATGCACTGCGCACTCCGT
TCGGCCGCTACGGCGGCGCC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MRHALDTQSPVCVIGAGIMGAGIAQVAAQAGHPVQLHDARDGAALAALRRLATGLDALVAKGRLSAEAAQATLARITPAT
SIDAAAGARLVVEAIVEQAEAKRTLFAQLEAIVDADCVLASNTSSISITALARDLRHPGRCVGLHFFNPVPVMKLVEVVS
GLRTEPSVAQAVFALSERWRKTPVHARSTPGFIVNRIARPYYAETLALLQERAAEPAVLDACLRGAGFRMGPCELMDLIG
HDTNFAVTASVHDANFGDRRYGPSLVQRELVDGGLLGRKSGRGFYDHAERAAPDPAAHPAAPAPALPQAARCRVHGHGAL
VERWLDGLAREGRAFERVAESPWNGLELDGAQLRQTDGRLAAQVAAEHAVRDLALFDRTVGPPSAGGDTALAWSASGGAS
EDWQASAAQCLQAAGRQPQRLRDVPGLVVARTLAMLINEASDAVLQGVCSAADADMAMKLGVNYPAGPFEWLADWEARQV
VALLDRLDTHYRGERYRASPALRERAWLQAATAP

Sequences:

>Translated_514_residues
MRHALDTQSPVCVIGAGIMGAGIAQVAAQAGHPVQLHDARDGAALAALRRLATGLDALVAKGRLSAEAAQATLARITPAT
SIDAAAGARLVVEAIVEQAEAKRTLFAQLEAIVDADCVLASNTSSISITALARDLRHPGRCVGLHFFNPVPVMKLVEVVS
GLRTEPSVAQAVFALSERWRKTPVHARSTPGFIVNRIARPYYAETLALLQERAAEPAVLDACLRGAGFRMGPCELMDLIG
HDTNFAVTASVHDANFGDRRYGPSLVQRELVDGGLLGRKSGRGFYDHAERAAPDPAAHPAAPAPALPQAARCRVHGHGAL
VERWLDGLAREGRAFERVAESPWNGLELDGAQLRQTDGRLAAQVAAEHAVRDLALFDRTVGPPSAGGDTALAWSASGGAS
EDWQASAAQCLQAAGRQPQRLRDVPGLVVARTLAMLINEASDAVLQGVCSAADADMAMKLGVNYPAGPFEWLADWEARQV
VALLDRLDTHYRGERYRASPALRERAWLQAATAP
>Mature_514_residues
MRHALDTQSPVCVIGAGIMGAGIAQVAAQAGHPVQLHDARDGAALAALRRLATGLDALVAKGRLSAEAAQATLARITPAT
SIDAAAGARLVVEAIVEQAEAKRTLFAQLEAIVDADCVLASNTSSISITALARDLRHPGRCVGLHFFNPVPVMKLVEVVS
GLRTEPSVAQAVFALSERWRKTPVHARSTPGFIVNRIARPYYAETLALLQERAAEPAVLDACLRGAGFRMGPCELMDLIG
HDTNFAVTASVHDANFGDRRYGPSLVQRELVDGGLLGRKSGRGFYDHAERAAPDPAAHPAAPAPALPQAARCRVHGHGAL
VERWLDGLAREGRAFERVAESPWNGLELDGAQLRQTDGRLAAQVAAEHAVRDLALFDRTVGPPSAGGDTALAWSASGGAS
EDWQASAAQCLQAAGRQPQRLRDVPGLVVARTLAMLINEASDAVLQGVCSAADADMAMKLGVNYPAGPFEWLADWEARQV
VALLDRLDTHYRGERYRASPALRERAWLQAATAP

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=39.7212543554007, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI296179427, Length=304, Percent_Identity=37.828947368421, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI20127408, Length=279, Percent_Identity=31.5412186379928, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI261878539, Length=302, Percent_Identity=30.794701986755, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI68989263, Length=302, Percent_Identity=30.794701986755, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI115430219, Length=235, Percent_Identity=29.3617021276596, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1787661, Length=505, Percent_Identity=43.960396039604, Blast_Score=367, Evalue=1e-102,
Organism=Escherichia coli, GI1788682, Length=280, Percent_Identity=33.5714285714286, Blast_Score=142, Evalue=7e-35,
Organism=Escherichia coli, GI1790281, Length=276, Percent_Identity=31.8840579710145, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=36.2369337979094, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17549919, Length=290, Percent_Identity=38.2758620689655, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17553560, Length=298, Percent_Identity=34.8993288590604, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71985923, Length=301, Percent_Identity=27.906976744186, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71985930, Length=292, Percent_Identity=28.0821917808219, Blast_Score=138, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17508953, Length=287, Percent_Identity=30.6620209059233, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17508951, Length=287, Percent_Identity=30.6620209059233, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25144276, Length=287, Percent_Identity=30.6620209059233, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17558304, Length=284, Percent_Identity=30.2816901408451, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24583077, Length=286, Percent_Identity=35.6643356643357, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24583079, Length=286, Percent_Identity=35.6643356643357, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI19921000, Length=284, Percent_Identity=35.9154929577465, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI45549573, Length=231, Percent_Identity=29.4372294372294, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 54487; Mature: 54487

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHALDTQSPVCVIGAGIMGAGIAQVAAQAGHPVQLHDARDGAALAALRRLATGLDALVA
CCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
KGRLSAEAAQATLARITPATSIDAAAGARLVVEAIVEQAEAKRTLFAQLEAIVDADCVLA
HCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
SNTSSISITALARDLRHPGRCVGLHFFNPVPVMKLVEVVSGLRTEPSVAQAVFALSERWR
CCCCCEEHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KTPVHARSTPGFIVNRIARPYYAETLALLQERAAEPAVLDACLRGAGFRMGPCELMDLIG
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHC
HDTNFAVTASVHDANFGDRRYGPSLVQRELVDGGLLGRKSGRGFYDHAERAAPDPAAHPA
CCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCC
APAPALPQAARCRVHGHGALVERWLDGLAREGRAFERVAESPWNGLELDGAQLRQTDGRL
CCCCCCCHHHCEEECCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHCHHH
AAQVAAEHAVRDLALFDRTVGPPSAGGDTALAWSASGGASEDWQASAAQCLQAAGRQPQR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHH
LRDVPGLVVARTLAMLINEASDAVLQGVCSAADADMAMKLGVNYPAGPFEWLADWEARQV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCHHHHHHCHHHHHH
VALLDRLDTHYRGERYRASPALRERAWLQAATAP
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRHALDTQSPVCVIGAGIMGAGIAQVAAQAGHPVQLHDARDGAALAALRRLATGLDALVA
CCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
KGRLSAEAAQATLARITPATSIDAAAGARLVVEAIVEQAEAKRTLFAQLEAIVDADCVLA
HCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
SNTSSISITALARDLRHPGRCVGLHFFNPVPVMKLVEVVSGLRTEPSVAQAVFALSERWR
CCCCCEEHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KTPVHARSTPGFIVNRIARPYYAETLALLQERAAEPAVLDACLRGAGFRMGPCELMDLIG
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHC
HDTNFAVTASVHDANFGDRRYGPSLVQRELVDGGLLGRKSGRGFYDHAERAAPDPAAHPA
CCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCC
APAPALPQAARCRVHGHGALVERWLDGLAREGRAFERVAESPWNGLELDGAQLRQTDGRL
CCCCCCCHHHCEEECCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHCHHH
AAQVAAEHAVRDLALFDRTVGPPSAGGDTALAWSASGGASEDWQASAAQCLQAAGRQPQR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHH
LRDVPGLVVARTLAMLINEASDAVLQGVCSAADADMAMKLGVNYPAGPFEWLADWEARQV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCHHHHHHCHHHHHH
VALLDRLDTHYRGERYRASPALRERAWLQAATAP
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]