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The map label for this gene is catF [H]

Identifier: 124266072

GI number: 124266072

Start: 920123

End: 921328

Strand: Reverse

Name: catF [H]

Synonym: Mpe_A0879

Alternate gene names: 124266072

Gene position: 921328-920123 (Counterclockwise)

Preceding gene: 124266073

Following gene: 124266070

Centisome position: 22.78

GC content: 73.96

Gene sequence:

>1206_bases
ATGATCCGTGACGCCTACCTCTGCGATGCACTGCGCACTCCGTTCGGCCGCTACGGCGGCGCCCTGTCCGGCGTGCGTGC
CGACGACCTGGCCGCAGTGCCGCTCGCGGCCCTGATGGCCCGCAACCCGCGCGTCGACTGGCAGGCCGTCGACGACGTGG
TGCTGGGCTGCGCCAACCAGGCCGGCGAGGACAACCGCAACGTGGCGCGCATGGCCGGGCTGCTGGCCGGGCTGCCGGTC
GAGGTGCCGGGCAGCACCGTCAACCGCCTGTGCGGCTCCGGCATGGACGCGGTGGGCACCGCCGCACGCGCCATCCGGAG
CGGCGAGGCGCGCCTGATGCTGGCCGGTGGCGTGGAGAGCATGAGCCGTGCGCCGTTCGTGATGCCCAAGGCCGACAACG
CCTGGTCGCGCAGCGCCGCGATCCACGACACCACGTTGGGCTGGCGGTTCGTCAATCCGTGCATGCAGGCGCTGCACGGC
ACCGACTCGATGCAGGAGACGGCCGAGAACGTGGCCGCCGAGTTCGGCATCGAGCGCGAGGCGCAGGACCGCATGGCGCT
GGCCTCGCAGCGCAAGGCGGTGGCGGCACAGCAGCGCGGCTTCTTCGACGCCGAGATCACGCCGGTGACGGTGCCGCAGC
GCAAGGGCGAGCCCCTTGTCGTCGCGAAGGACGAGCACCCGCGCGAGACCCGCCTCGAGGCGCTGGCCCGCCTGAAGGGC
GTGGTGCGTCCCGACGGCACGGTGACGGCGGGCAATGCCTCGGGCCTCAACGACGGCGCCTGCGCGCTGCTGCTGGCCGA
CGAGGAAGGCGCGGCCCGGCACGGCCTCACGCCGCGCGCACGCGTGGTGGGCATGGCCACCGCCGGCGTCGCGCCGCGCC
TCATGGGCATCGGCCCGGTGCCGGCCACGCGGCGCGTGCTGCAGCTCACCGGCCTGACGCTGGCGCAGATGGACGTGATC
GAGCTGAACGAGGCGTTCGCGGCTCAGGGCCTGGCGGTACTGCGCCAGCTCGGACTGGCCGACGACGACGCGCGCGTCAA
CCCGAACGGCGGCGCCATCGCGCTCGGCCATCCGCTGGGCGCCAGCGGCGCGCGGCTGATCGCCACCGCGATGCACCAAC
TGCACGCCGGCGGCGGACGCTATGCGCTGTGCACCATGTGCATCGGCGTCGGCCAGGGCATCGCGGTGGTGCTGGAGCGG
GTGTGA

Upstream 100 bases:

>100_bases
CGCTACCGCGCGAGCCCCGCGCTGCGGGAACGGGCCTGGCTGCAGGCAGCGACCGCGCCCTGAGCGCCCGGCATCGACGA
ACCCTCCCCTGCCTCTCATC

Downstream 100 bases:

>100_bases
GCCGGGCGTGAGCACCGGTCAGAGATCGAGCTCGAGGACCGATGAGCGTGCCCTCGATACGCAGACCATGATGGATCGCC
CGGACCGCCGCTGCGCCTCG

Product: Acetyl-CoA C-acyltransferase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MIRDAYLCDALRTPFGRYGGALSGVRADDLAAVPLAALMARNPRVDWQAVDDVVLGCANQAGEDNRNVARMAGLLAGLPV
EVPGSTVNRLCGSGMDAVGTAARAIRSGEARLMLAGGVESMSRAPFVMPKADNAWSRSAAIHDTTLGWRFVNPCMQALHG
TDSMQETAENVAAEFGIEREAQDRMALASQRKAVAAQQRGFFDAEITPVTVPQRKGEPLVVAKDEHPRETRLEALARLKG
VVRPDGTVTAGNASGLNDGACALLLADEEGAARHGLTPRARVVGMATAGVAPRLMGIGPVPATRRVLQLTGLTLAQMDVI
ELNEAFAAQGLAVLRQLGLADDDARVNPNGGAIALGHPLGASGARLIATAMHQLHAGGGRYALCTMCIGVGQGIAVVLER
V

Sequences:

>Translated_401_residues
MIRDAYLCDALRTPFGRYGGALSGVRADDLAAVPLAALMARNPRVDWQAVDDVVLGCANQAGEDNRNVARMAGLLAGLPV
EVPGSTVNRLCGSGMDAVGTAARAIRSGEARLMLAGGVESMSRAPFVMPKADNAWSRSAAIHDTTLGWRFVNPCMQALHG
TDSMQETAENVAAEFGIEREAQDRMALASQRKAVAAQQRGFFDAEITPVTVPQRKGEPLVVAKDEHPRETRLEALARLKG
VVRPDGTVTAGNASGLNDGACALLLADEEGAARHGLTPRARVVGMATAGVAPRLMGIGPVPATRRVLQLTGLTLAQMDVI
ELNEAFAAQGLAVLRQLGLADDDARVNPNGGAIALGHPLGASGARLIATAMHQLHAGGGRYALCTMCIGVGQGIAVVLER
V
>Mature_401_residues
MIRDAYLCDALRTPFGRYGGALSGVRADDLAAVPLAALMARNPRVDWQAVDDVVLGCANQAGEDNRNVARMAGLLAGLPV
EVPGSTVNRLCGSGMDAVGTAARAIRSGEARLMLAGGVESMSRAPFVMPKADNAWSRSAAIHDTTLGWRFVNPCMQALHG
TDSMQETAENVAAEFGIEREAQDRMALASQRKAVAAQQRGFFDAEITPVTVPQRKGEPLVVAKDEHPRETRLEALARLKG
VVRPDGTVTAGNASGLNDGACALLLADEEGAARHGLTPRARVVGMATAGVAPRLMGIGPVPATRRVLQLTGLTLAQMDVI
ELNEAFAAQGLAVLRQLGLADDDARVNPNGGAIALGHPLGASGARLIATAMHQLHAGGGRYALCTMCIGVGQGIAVVLER
V

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=400, Percent_Identity=43, Blast_Score=301, Evalue=7e-82,
Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=39.7984886649874, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4501853, Length=406, Percent_Identity=40.1477832512315, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI4557237, Length=402, Percent_Identity=35.5721393034826, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI4504327, Length=432, Percent_Identity=33.1018518518519, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI194353979, Length=402, Percent_Identity=31.0945273631841, Blast_Score=139, Evalue=3e-33,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=66.5835411471322, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI1788554, Length=403, Percent_Identity=48.1389578163772, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=44.8877805486284, Blast_Score=280, Evalue=8e-77,
Organism=Escherichia coli, GI48994986, Length=405, Percent_Identity=44.1975308641975, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=32.6241134751773, Blast_Score=161, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI133906874, Length=405, Percent_Identity=42.4691358024691, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI25147385, Length=401, Percent_Identity=33.4164588528678, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17535921, Length=401, Percent_Identity=33.9152119700748, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=431, Percent_Identity=31.0904872389791, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17535917, Length=405, Percent_Identity=28.3950617283951, Blast_Score=154, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6325229, Length=405, Percent_Identity=35.5555555555556, Blast_Score=219, Evalue=9e-58,
Organism=Saccharomyces cerevisiae, GI6322031, Length=415, Percent_Identity=34.4578313253012, Blast_Score=205, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24655093, Length=406, Percent_Identity=44.3349753694581, Blast_Score=317, Evalue=9e-87,
Organism=Drosophila melanogaster, GI17648125, Length=401, Percent_Identity=40.1496259351621, Blast_Score=274, Evalue=7e-74,
Organism=Drosophila melanogaster, GI24640423, Length=403, Percent_Identity=33.0024813895782, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI17137578, Length=429, Percent_Identity=32.4009324009324, Blast_Score=178, Evalue=7e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 41811; Mature: 41811

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRDAYLCDALRTPFGRYGGALSGVRADDLAAVPLAALMARNPRVDWQAVDDVVLGCANQ
CCCHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
AGEDNRNVARMAGLLAGLPVEVPGSTVNRLCGSGMDAVGTAARAIRSGEARLMLAGGVES
CCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCHHH
MSRAPFVMPKADNAWSRSAAIHDTTLGWRFVNPCMQALHGTDSMQETAENVAAEFGIERE
HCCCCEEECCCCCCCCCCCCEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHH
AQDRMALASQRKAVAAQQRGFFDAEITPVTVPQRKGEPLVVAKDEHPRETRLEALARLKG
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHC
VVRPDGTVTAGNASGLNDGACALLLADEEGAARHGLTPRARVVGMATAGVAPRLMGIGPV
CCCCCCCEECCCCCCCCCCEEEEEEECCCCCHHCCCCCCHHEEEEECCCCCHHHHCCCCC
PATRRVLQLTGLTLAQMDVIELNEAFAAQGLAVLRQLGLADDDARVNPNGGAIALGHPLG
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEECCCCC
ASGARLIATAMHQLHAGGGRYALCTMCIGVGQGIAVVLERV
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHCCC
>Mature Secondary Structure
MIRDAYLCDALRTPFGRYGGALSGVRADDLAAVPLAALMARNPRVDWQAVDDVVLGCANQ
CCCHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
AGEDNRNVARMAGLLAGLPVEVPGSTVNRLCGSGMDAVGTAARAIRSGEARLMLAGGVES
CCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCHHH
MSRAPFVMPKADNAWSRSAAIHDTTLGWRFVNPCMQALHGTDSMQETAENVAAEFGIERE
HCCCCEEECCCCCCCCCCCCEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHH
AQDRMALASQRKAVAAQQRGFFDAEITPVTVPQRKGEPLVVAKDEHPRETRLEALARLKG
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHC
VVRPDGTVTAGNASGLNDGACALLLADEEGAARHGLTPRARVVGMATAGVAPRLMGIGPV
CCCCCCCEECCCCCCCCCCEEEEEEECCCCCHHCCCCCCHHEEEEECCCCCHHHHCCCCC
PATRRVLQLTGLTLAQMDVIELNEAFAAQGLAVLRQLGLADDDARVNPNGGAIALGHPLG
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEECCCCC
ASGARLIATAMHQLHAGGGRYALCTMCIGVGQGIAVVLERV
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]