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The map label for this gene is menB [C]

Identifier: 124266074

GI number: 124266074

Start: 922907

End: 923698

Strand: Reverse

Name: menB [C]

Synonym: Mpe_A0881

Alternate gene names: 124266074

Gene position: 923698-922907 (Counterclockwise)

Preceding gene: 124266085

Following gene: 124266073

Centisome position: 22.84

GC content: 73.36

Gene sequence:

>792_bases
GTGAACACATTGAGCATCGACGTGACGTCCTCCGGGGTGGCGCGCGTGGAGATGGCCCGACCGCAGGTGTTCAACGCCTT
CGACGAGGCGATGATCGGCGAGCTGGACGCCGCCTATGCCCGGCTTGCGGCCGATCCGCAGGTGCGCGTGATCGTGCTGG
CCGGCCAGGGCAAGGCCTTCTCGGCCGGCGCCGACCTGGCCTGGATGCAGCGTGCCAGCGCCGCCACGCCGGAGTGGAAC
CTGGACGACGCGCGCCGCTTCGCGGCGATGCTCGACCGCGTTGCCGCCTGTCCGCAACCCACCATCGCACGCGTGCACGG
CGTGGCGCTGGGCGGCGGCGTCGGGCTGGTGTGCGCCTGTGACCTCGCGGTGGCCAGCGAGGACGCGAAGTTCGCCGTCA
GCGAGGCCCGCTTCGGCATCCTGCCGTCGGTGATCGGGCCCTACCTCACCAACGCGGTCGGCAAGCGCCAGGCGAAGCGG
CTGGCGCTGACGGCCACACGGATCGGCGCCGCCGAGGCCCGCGAGCTGGGCCTGGTGCAGCAGGTGGTGGCGCCCGACGC
GCTGGATGCGGCGGTCGACGCGCTCGCGGCCGAGCTGCTGCAGAACGGTCCGTGCGCGCAGGCGGAGATCAAGGCGCTGT
TCGGCCGCCTCGAGGTCGGCGCCATCACGGCCGAGGTCCGCGAGCTGACGGCGCAGACCATCAGCCGCGTGCGCCTGGGC
GACGAGGCGCGCGAAGGCTTTGCCGCCTTCTTCGCGAAGCGCCCGCCGCCGTGGGCGAAGGGGCCGGCATGA

Upstream 100 bases:

>100_bases
GGCACGGCCGGCCAACGCGGGAAGGCGATCGCGGCGACACTGCGCCGCGAAGGACGCCCGCACTTCGAGACCGACCGAGC
GACCCGAAAAGGAACCCGCC

Downstream 100 bases:

>100_bases
GGCACGCACTCGACACGCAATCGCCGGTGTGCGTGATCGGCGCCGGCATCATGGGCGCGGGCATCGCGCAGGTGGCGGCG
CAGGCCGGGCACCCGGTGCA

Product: putative enoyl-CoA hydratase protein

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MNTLSIDVTSSGVARVEMARPQVFNAFDEAMIGELDAAYARLAADPQVRVIVLAGQGKAFSAGADLAWMQRASAATPEWN
LDDARRFAAMLDRVAACPQPTIARVHGVALGGGVGLVCACDLAVASEDAKFAVSEARFGILPSVIGPYLTNAVGKRQAKR
LALTATRIGAAEARELGLVQQVVAPDALDAAVDALAAELLQNGPCAQAEIKALFGRLEVGAITAEVRELTAQTISRVRLG
DEAREGFAAFFAKRPPPWAKGPA

Sequences:

>Translated_263_residues
MNTLSIDVTSSGVARVEMARPQVFNAFDEAMIGELDAAYARLAADPQVRVIVLAGQGKAFSAGADLAWMQRASAATPEWN
LDDARRFAAMLDRVAACPQPTIARVHGVALGGGVGLVCACDLAVASEDAKFAVSEARFGILPSVIGPYLTNAVGKRQAKR
LALTATRIGAAEARELGLVQQVVAPDALDAAVDALAAELLQNGPCAQAEIKALFGRLEVGAITAEVRELTAQTISRVRLG
DEAREGFAAFFAKRPPPWAKGPA
>Mature_263_residues
MNTLSIDVTSSGVARVEMARPQVFNAFDEAMIGELDAAYARLAADPQVRVIVLAGQGKAFSAGADLAWMQRASAATPEWN
LDDARRFAAMLDRVAACPQPTIARVHGVALGGGVGLVCACDLAVASEDAKFAVSEARFGILPSVIGPYLTNAVGKRQAKR
LALTATRIGAAEARELGLVQQVVAPDALDAAVDALAAELLQNGPCAQAEIKALFGRLEVGAITAEVRELTAQTISRVRLG
DEAREGFAAFFAKRPPPWAKGPA

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=250, Percent_Identity=32, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI70995211, Length=201, Percent_Identity=34.3283582089552, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI31542718, Length=252, Percent_Identity=26.5873015873016, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI37594469, Length=174, Percent_Identity=29.3103448275862, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI37594471, Length=174, Percent_Identity=29.3103448275862, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI4502327, Length=265, Percent_Identity=32.8301886792453, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI213417737, Length=182, Percent_Identity=28.021978021978, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI157694516, Length=182, Percent_Identity=28.021978021978, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI68989263, Length=184, Percent_Identity=27.1739130434783, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788597, Length=262, Percent_Identity=29.7709923664122, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787659, Length=250, Percent_Identity=33.6, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI221142681, Length=268, Percent_Identity=30.5970149253731, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787660, Length=261, Percent_Identity=27.5862068965517, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082183, Length=261, Percent_Identity=25.6704980842912, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1790281, Length=189, Percent_Identity=30.1587301587302, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788682, Length=196, Percent_Identity=28.0612244897959, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25145438, Length=260, Percent_Identity=31.1538461538462, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17554946, Length=253, Percent_Identity=31.2252964426877, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17540714, Length=201, Percent_Identity=32.3383084577114, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17534483, Length=268, Percent_Identity=23.8805970149254, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17540306, Length=239, Percent_Identity=30.1255230125523, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17558304, Length=168, Percent_Identity=29.1666666666667, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17535521, Length=258, Percent_Identity=27.1317829457364, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17549921, Length=177, Percent_Identity=28.8135593220339, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI25141363, Length=179, Percent_Identity=26.8156424581006, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=160, Percent_Identity=31.25, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508951, Length=181, Percent_Identity=29.2817679558011, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25144276, Length=168, Percent_Identity=29.1666666666667, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508953, Length=168, Percent_Identity=29.1666666666667, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20129971, Length=254, Percent_Identity=33.0708661417323, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24653477, Length=254, Percent_Identity=33.0708661417323, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI19920382, Length=213, Percent_Identity=34.7417840375587, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24653139, Length=261, Percent_Identity=32.183908045977, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI19922422, Length=249, Percent_Identity=22.8915662650602, Blast_Score=88, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 27493; Mature: 27493

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLSIDVTSSGVARVEMARPQVFNAFDEAMIGELDAAYARLAADPQVRVIVLAGQGKAF
CCEEEEEECCCCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEE
SAGADLAWMQRASAATPEWNLDDARRFAAMLDRVAACPQPTIARVHGVALGGGVGLVCAC
CCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHEEECCCCHHHHHH
DLAVASEDAKFAVSEARFGILPSVIGPYLTNAVGKRQAKRLALTATRIGAAEARELGLVQ
HHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
QVVAPDALDAAVDALAAELLQNGPCAQAEIKALFGRLEVGAITAEVRELTAQTISRVRLG
HHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DEAREGFAAFFAKRPPPWAKGPA
HHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNTLSIDVTSSGVARVEMARPQVFNAFDEAMIGELDAAYARLAADPQVRVIVLAGQGKAF
CCEEEEEECCCCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEE
SAGADLAWMQRASAATPEWNLDDARRFAAMLDRVAACPQPTIARVHGVALGGGVGLVCAC
CCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHEEECCCCHHHHHH
DLAVASEDAKFAVSEARFGILPSVIGPYLTNAVGKRQAKRLALTATRIGAAEARELGLVQ
HHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
QVVAPDALDAAVDALAAELLQNGPCAQAEIKALFGRLEVGAITAEVRELTAQTISRVRLG
HHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DEAREGFAAFFAKRPPPWAKGPA
HHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA