Click here to switch to the map view.

The map label for this gene is gpsA

Identifier: 124265910

GI number: 124265910

Start: 743598

End: 744599

Strand: Direct

Name: gpsA

Synonym: Mpe_A0717

Alternate gene names: 124265910

Gene position: 743598-744599 (Clockwise)

Preceding gene: 124265909

Following gene: 124265911

Centisome position: 18.39

GC content: 75.55

Gene sequence:

>1002_bases
ATGCGCATCACGGTCCTCGGCGCCGGTGCCTGGGGCACGGCCCTCTCCGTCGGCATCGCGCCGCGGCACGACACCCTGTT
GTGGGCGCGCGATGCCGCCCAGGCCGCGCACATCGAGGCCAGCCGCGACAACCGGCGCTACCTCCCCGGCGTGGCGCTGC
CCGCCGCGCTGCGCCTCACGGCCGACCTGGACGCGGCGATCGCGCACGCCCAGGCGGACGGTGGCCTGATCGTCATCGCC
ACGCCCATGTCGGGCCTGCGCGAGATGCTGGCCCGCTGCGCCGCCAGCGGCGCCGGACTGTGGTGGCTGTGCAAGGGCTT
CGAGGCCGGCACCGGCGCACTGGGCCACGAGGTGGCGCGCGAGGTGGCGCCGGCAGCCCGCGTGGGCGTGCTGTCGGGAC
CGAGCTTCGCGCTCGAGGTCGCGCGCGGTCAGCCCACCGCGCTGGTGGCCGCCAGCACCGACGAGGCGCTGCGCAACCAG
GCCGTCGAGGCCTTCCACAGCGAATCGCTGCGCGTCTACACCTCCGCCGACCCGGTGGGCGTGGAGGTCGGCGGCGCGGT
CAAGAACGTCATCGCCATCGCCACCGGCATTGCCGATGGCATGGGCCTGGGCCTCAACGCGCGAGCAGCGCTCGTCACCC
GCGGCCTGGCCGAGATCACGCGCCTGGGCACGGCGCTGGGCGCGCGAGTGGACACCTTCATGGGCCTCAGCGGCCTGGGC
GACCTGGTGCTCACCGCCACCGGCGATCTGTCGCGCAACCGCCAGGTCGGCCTGCAACTGGCCCAAGGCCGCTCGCTGCC
CGAGGTGCTGGCCGCGCTGGGCCACGTGGCCGAGGGCGTGTACAGCGCCGCCACCGTGCTGGCGCGCGCGCAGGCGCTGG
GCGTCGACATGCCCATCACCGCCGCCGTGGTGGCGGTGCTCGACGGGCGGCTGACGCCGGCGCAGGCGCTGGAGCGGTTG
ATGCGGCGGCAGGCAAGGGCCGAAGGCCACGCGCCGGACTGA

Upstream 100 bases:

>100_bases
CAGGCCGCCGCGCAGCAGCAAGGCGCGGTGAGCAACGGCAACGGCGGCTCGCCGATCATCACCAACGCCTGATCCGCGCC
GCCAGCCCGGCCCGCCGCGC

Downstream 100 bases:

>100_bases
GCGCGTCCCGCTCTCGCATCGCATCGACGTGACAGGCTGTTCGCAGCCTCCTGTCAGGACGTCGCTCCTGGTTACGCCTC
TGCCCTGTTGTTGCAGGGAA

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MRITVLGAGAWGTALSVGIAPRHDTLLWARDAAQAAHIEASRDNRRYLPGVALPAALRLTADLDAAIAHAQADGGLIVIA
TPMSGLREMLARCAASGAGLWWLCKGFEAGTGALGHEVAREVAPAARVGVLSGPSFALEVARGQPTALVAASTDEALRNQ
AVEAFHSESLRVYTSADPVGVEVGGAVKNVIAIATGIADGMGLGLNARAALVTRGLAEITRLGTALGARVDTFMGLSGLG
DLVLTATGDLSRNRQVGLQLAQGRSLPEVLAALGHVAEGVYSAATVLARAQALGVDMPITAAVVAVLDGRLTPAQALERL
MRRQARAEGHAPD

Sequences:

>Translated_333_residues
MRITVLGAGAWGTALSVGIAPRHDTLLWARDAAQAAHIEASRDNRRYLPGVALPAALRLTADLDAAIAHAQADGGLIVIA
TPMSGLREMLARCAASGAGLWWLCKGFEAGTGALGHEVAREVAPAARVGVLSGPSFALEVARGQPTALVAASTDEALRNQ
AVEAFHSESLRVYTSADPVGVEVGGAVKNVIAIATGIADGMGLGLNARAALVTRGLAEITRLGTALGARVDTFMGLSGLG
DLVLTATGDLSRNRQVGLQLAQGRSLPEVLAALGHVAEGVYSAATVLARAQALGVDMPITAAVVAVLDGRLTPAQALERL
MRRQARAEGHAPD
>Mature_333_residues
MRITVLGAGAWGTALSVGIAPRHDTLLWARDAAQAAHIEASRDNRRYLPGVALPAALRLTADLDAAIAHAQADGGLIVIA
TPMSGLREMLARCAASGAGLWWLCKGFEAGTGALGHEVAREVAPAARVGVLSGPSFALEVARGQPTALVAASTDEALRNQ
AVEAFHSESLRVYTSADPVGVEVGGAVKNVIAIATGIADGMGLGLNARAALVTRGLAEITRLGTALGARVDTFMGLSGLG
DLVLTATGDLSRNRQVGLQLAQGRSLPEVLAALGHVAEGVYSAATVLARAQALGVDMPITAAVVAVLDGRLTPAQALERL
MRRQARAEGHAPD

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=334, Percent_Identity=26.3473053892216, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI24307999, Length=335, Percent_Identity=25.0746268656716, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1790037, Length=311, Percent_Identity=44.3729903536978, Blast_Score=236, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI32564399, Length=347, Percent_Identity=27.0893371757925, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI193210136, Length=355, Percent_Identity=26.1971830985915, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI32564403, Length=355, Percent_Identity=26.1971830985915, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI193210134, Length=341, Percent_Identity=25.2199413489736, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17507425, Length=345, Percent_Identity=24.0579710144928, Blast_Score=88, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6324513, Length=345, Percent_Identity=28.695652173913, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320181, Length=360, Percent_Identity=26.3888888888889, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17136204, Length=347, Percent_Identity=25.0720461095101, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136202, Length=347, Percent_Identity=25.0720461095101, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136200, Length=347, Percent_Identity=25.0720461095101, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI22026922, Length=358, Percent_Identity=22.9050279329609, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281362270, Length=294, Percent_Identity=24.4897959183673, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551945, Length=294, Percent_Identity=24.4897959183673, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648969, Length=251, Percent_Identity=25.8964143426295, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_METPP (A2SDP0)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001019914.1
- ProteinModelPortal:   A2SDP0
- SMR:   A2SDP0
- STRING:   A2SDP0
- GeneID:   4783902
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0717
- NMPDR:   fig|279263.3.peg.3276
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- PhylomeDB:   A2SDP0
- ProtClustDB:   PRK00094
- BioCyc:   MPET420662:MPE_A0717-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 34022; Mature: 34022

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 188-188 BINDING 105-105 BINDING 105-105 BINDING 137-137 BINDING 252-252 BINDING 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRITVLGAGAWGTALSVGIAPRHDTLLWARDAAQAAHIEASRDNRRYLPGVALPAALRLT
CEEEEEECCCCHHHEEECCCCCCCCEEEECCCHHHHHEECCCCCCCCCCCCCCCHHHEEH
ADLDAAIAHAQADGGLIVIATPMSGLREMLARCAASGAGLWWLCKGFEAGTGALGHEVAR
HHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHH
EVAPAARVGVLSGPSFALEVARGQPTALVAASTDEALRNQAVEAFHSESLRVYTSADPVG
HHCCHHHEEEECCCCEEEEECCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCC
VEVGGAVKNVIAIATGIADGMGLGLNARAALVTRGLAEITRLGTALGARVDTFMGLSGLG
EEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DLVLTATGDLSRNRQVGLQLAQGRSLPEVLAALGHVAEGVYSAATVLARAQALGVDMPIT
CEEEEECCCCCCCHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AAVVAVLDGRLTPAQALERLMRRQARAEGHAPD
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRITVLGAGAWGTALSVGIAPRHDTLLWARDAAQAAHIEASRDNRRYLPGVALPAALRLT
CEEEEEECCCCHHHEEECCCCCCCCEEEECCCHHHHHEECCCCCCCCCCCCCCCHHHEEH
ADLDAAIAHAQADGGLIVIATPMSGLREMLARCAASGAGLWWLCKGFEAGTGALGHEVAR
HHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHH
EVAPAARVGVLSGPSFALEVARGQPTALVAASTDEALRNQAVEAFHSESLRVYTSADPVG
HHCCHHHEEEECCCCEEEEECCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCC
VEVGGAVKNVIAIATGIADGMGLGLNARAALVTRGLAEITRLGTALGARVDTFMGLSGLG
EEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DLVLTATGDLSRNRQVGLQLAQGRSLPEVLAALGHVAEGVYSAATVLARAQALGVDMPIT
CEEEEECCCCCCCHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AAVVAVLDGRLTPAQALERLMRRQARAEGHAPD
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA