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The map label for this gene is uppS [H]

Identifier: 124027955

GI number: 124027955

Start: 1100359

End: 1101093

Strand: Direct

Name: uppS [H]

Synonym: Hbut_1087

Alternate gene names: 124027955

Gene position: 1100359-1101093 (Clockwise)

Preceding gene: 124027954

Following gene: 124027967

Centisome position: 66.0

GC content: 56.46

Gene sequence:

>735_bases
ATGCTTAGGAGTCTAGCTGCAAGGTTTCTAAGAGGCAAAGTTTCCAGGGGGAGACTCCCCCGCCACATAGCCATCATACC
TGACGGCAATCGTAGGTGGGCGCGCAAGCAAGGCCTTCCAGTTTATGCCGGCCACGCTGCCGGGTATCGTGTGGCACGGC
GTACCCTCGACCTCCTCTGGGAGCTAGGCGTGGACTACGTGACGTTCTATGCGCTCTCCCGTGAGAACTGCCTACGGAGG
CCCCTTGAGGAGCGCGAGCACCTCTACAAGCTCCTGCTAAGGGCTATAGATGACCTTCTCACGGATCCCCGTGTAGTCAA
CGGTAGTGTCCGCGTATACTTTGTTGGCGACTTTACACTACTGCCGGGTCAGCTCGCTGAAAGGCTAGAGGAGGTTAATG
CTGCCACAGCCACTAATGGACCCAATGTACTGACTATAGCGACTTGTTATGGTGGCCGTTGGGAGGTTCTCGAGACACTA
CGCAGCCTAGCCACAAAGGGATTTGTGCCCAACGATGAGGAGGAGCTGCGGAAGCTTATGCCTCTCGGCTTGCTCCCAGA
GCCGGATCTGCTCATAAGGACTGGTGGAGAGTTACGGCTTAGCGGCTTCCTGCTATACCACGTAGCCTATACGGAGCTAT
ACTTCACTCGGCGCTTGTGGCCCGAGTTTGACGAGTTTGAGCTTCTTCGTGCTCTCCGCTCTTACCAGATGAGGGAGCGT
AGGTTCGGGCGATAG

Upstream 100 bases:

>100_bases
AGGGGTAAGGCCTGGGTACTCATCTGCGAAGCTTGTGGCGCAGAGCAGCCCGTACCACCACTATAGCCCGAGCCGCCCAG
GCCTACGGGATGGAGTAGTC

Downstream 100 bases:

>100_bases
CCTTCTCCAGGCTCTTGGCTAGCCTCCACGTCACCGCCACCGCTACCACTGAGCCTATCGCATACATATGGAAGTTAACC
CTCACGAGAGAGGCTATGAA

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MLRSLAARFLRGKVSRGRLPRHIAIIPDGNRRWARKQGLPVYAGHAAGYRVARRTLDLLWELGVDYVTFYALSRENCLRR
PLEEREHLYKLLLRAIDDLLTDPRVVNGSVRVYFVGDFTLLPGQLAERLEEVNAATATNGPNVLTIATCYGGRWEVLETL
RSLATKGFVPNDEEELRKLMPLGLLPEPDLLIRTGGELRLSGFLLYHVAYTELYFTRRLWPEFDEFELLRALRSYQMRER
RFGR

Sequences:

>Translated_244_residues
MLRSLAARFLRGKVSRGRLPRHIAIIPDGNRRWARKQGLPVYAGHAAGYRVARRTLDLLWELGVDYVTFYALSRENCLRR
PLEEREHLYKLLLRAIDDLLTDPRVVNGSVRVYFVGDFTLLPGQLAERLEEVNAATATNGPNVLTIATCYGGRWEVLETL
RSLATKGFVPNDEEELRKLMPLGLLPEPDLLIRTGGELRLSGFLLYHVAYTELYFTRRLWPEFDEFELLRALRSYQMRER
RFGR
>Mature_244_residues
MLRSLAARFLRGKVSRGRLPRHIAIIPDGNRRWARKQGLPVYAGHAAGYRVARRTLDLLWELGVDYVTFYALSRENCLRR
PLEEREHLYKLLLRAIDDLLTDPRVVNGSVRVYFVGDFTLLPGQLAERLEEVNAATATNGPNVLTIATCYGGRWEVLETL
RSLATKGFVPNDEEELRKLMPLGLLPEPDLLIRTGGELRLSGFLLYHVAYTELYFTRRLWPEFDEFELLRALRSYQMRER
RFGR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=241, Percent_Identity=34.4398340248963, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI45580742, Length=241, Percent_Identity=34.4398340248963, Blast_Score=126, Evalue=2e-29,
Organism=Escherichia coli, GI1786371, Length=229, Percent_Identity=42.7947598253275, Blast_Score=169, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71993029, Length=238, Percent_Identity=33.6134453781513, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319474, Length=210, Percent_Identity=35.2380952380952, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323748, Length=225, Percent_Identity=32.8888888888889, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI18857969, Length=238, Percent_Identity=31.9327731092437, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28261; Mature: 28261

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRSLAARFLRGKVSRGRLPRHIAIIPDGNRRWARKQGLPVYAGHAAGYRVARRTLDLLW
CHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHCCCCEEECCHHHHHHHHHHHHHHH
ELGVDYVTFYALSRENCLRRPLEEREHLYKLLLRAIDDLLTDPRVVNGSVRVYFVGDFTL
HHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEEECCEE
LPGQLAERLEEVNAATATNGPNVLTIATCYGGRWEVLETLRSLATKGFVPNDEEELRKLM
CCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHC
PLGLLPEPDLLIRTGGELRLSGFLLYHVAYTELYFTRRLWPEFDEFELLRALRSYQMRER
CCCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RFGR
HCCC
>Mature Secondary Structure
MLRSLAARFLRGKVSRGRLPRHIAIIPDGNRRWARKQGLPVYAGHAAGYRVARRTLDLLW
CHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHCCCCEEECCHHHHHHHHHHHHHHH
ELGVDYVTFYALSRENCLRRPLEEREHLYKLLLRAIDDLLTDPRVVNGSVRVYFVGDFTL
HHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEEECCEE
LPGQLAERLEEVNAATATNGPNVLTIATCYGGRWEVLETLRSLATKGFVPNDEEELRKLM
CCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHC
PLGLLPEPDLLIRTGGELRLSGFLLYHVAYTELYFTRRLWPEFDEFELLRALRSYQMRER
CCCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RFGR
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]