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The map label for this gene is eif2b [H]

Identifier: 124027954

GI number: 124027954

Start: 1099887

End: 1100324

Strand: Direct

Name: eif2b [H]

Synonym: Hbut_1086

Alternate gene names: 124027954

Gene position: 1099887-1100324 (Clockwise)

Preceding gene: 124027952

Following gene: 124027955

Centisome position: 65.97

GC content: 52.51

Gene sequence:

>438_bases
GTGGTTGACCCGGAGGCTAAGCTGCTCTACGACTACGACCACCTGCTTAGCAGACTGTATAGTAGACTGCCAACTAGGAC
GGGTAAGGCTTCGAGATTCGAGCTTCCGAGACTGCAGGTAGAGCGCATAGGTTCGAAGACCATTATCAGGAACTTCAAAC
AGCTAGCAGATGTTATGAGGCGTGAGCCACGGATACTCATGCGCTACCTGCTAAAGGAGCTTGGCGCTAGTGGCAACTAC
GACGAGGAGAACGGTATGCTAGTGATAAACGTCAAAGTCTCAATCACGACACTCAATAACCTCATGCAAAGGTTCGTTAA
GACCTACGTTATATGCCCAACCTGTGGCGCCCCTGACACCAGGCTTGAGAGGAGGGGTAAGGCCTGGGTACTCATCTGCG
AAGCTTGTGGCGCAGAGCAGCCCGTACCACCACTATAG

Upstream 100 bases:

>100_bases
CAGACAGGGGGTGGATGGGGTCTCCTAATATTAGGGACGGGTGTCACACCCATTTTTAGGGATTGTAGCCAGTAGAGGAG
GATCCTGGAGGGAGATAGGT

Downstream 100 bases:

>100_bases
CCCGAGCCGCCCAGGCCTACGGGATGGAGTAGTCATGCTTAGGAGTCTAGCTGCAAGGTTTCTAAGAGGCAAAGTTTCCA
GGGGGAGACTCCCCCGCCAC

Product: translation initiation factor IF-2 subunit beta

Products: NA

Alternate protein names: aIF2-beta; eIF-2-beta [H]

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MVDPEAKLLYDYDHLLSRLYSRLPTRTGKASRFELPRLQVERIGSKTIIRNFKQLADVMRREPRILMRYLLKELGASGNY
DEENGMLVINVKVSITTLNNLMQRFVKTYVICPTCGAPDTRLERRGKAWVLICEACGAEQPVPPL

Sequences:

>Translated_145_residues
MVDPEAKLLYDYDHLLSRLYSRLPTRTGKASRFELPRLQVERIGSKTIIRNFKQLADVMRREPRILMRYLLKELGASGNY
DEENGMLVINVKVSITTLNNLMQRFVKTYVICPTCGAPDTRLERRGKAWVLICEACGAEQPVPPL
>Mature_145_residues
MVDPEAKLLYDYDHLLSRLYSRLPTRTGKASRFELPRLQVERIGSKTIIRNFKQLADVMRREPRILMRYLLKELGASGNY
DEENGMLVINVKVSITTLNNLMQRFVKTYVICPTCGAPDTRLERRGKAWVLICEACGAEQPVPPL

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA [H]

COG id: COG1601

COG function: function code J; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2-beta/eIF-5 family [H]

Homologues:

Organism=Homo sapiens, GI29826335, Length=135, Percent_Identity=34.0740740740741, Blast_Score=87, Evalue=7e-18,
Organism=Homo sapiens, GI37537716, Length=112, Percent_Identity=33.0357142857143, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI21361337, Length=112, Percent_Identity=33.0357142857143, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508049, Length=141, Percent_Identity=28.3687943262411, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25146154, Length=110, Percent_Identity=32.7272727272727, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32566626, Length=110, Percent_Identity=32.7272727272727, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25146151, Length=110, Percent_Identity=32.7272727272727, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6325018, Length=142, Percent_Identity=33.0985915492958, Blast_Score=80, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17647377, Length=135, Percent_Identity=34.8148148148148, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI45555633, Length=112, Percent_Identity=31.25, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45555623, Length=112, Percent_Identity=31.25, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI18860089, Length=112, Percent_Identity=31.25, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45555642, Length=112, Percent_Identity=31.25, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24642373, Length=112, Percent_Identity=31.25, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45555665, Length=112, Percent_Identity=31.25, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45555652, Length=112, Percent_Identity=31.25, Blast_Score=66, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004458
- InterPro:   IPR002735
- InterPro:   IPR016189
- InterPro:   IPR016190 [H]

Pfam domain/function: PF01873 eIF-5_eIF-2B [H]

EC number: NA

Molecular weight: Translated: 16655; Mature: 16655

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS50114 GATA_ZN_FINGER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDPEAKLLYDYDHLLSRLYSRLPTRTGKASRFELPRLQVERIGSKTIIRNFKQLADVMR
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHH
REPRILMRYLLKELGASGNYDEENGMLVINVKVSITTLNNLMQRFVKTYVICPTCGAPDT
CCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHEEECCCCCCCCH
RLERRGKAWVLICEACGAEQPVPPL
HHHHCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MVDPEAKLLYDYDHLLSRLYSRLPTRTGKASRFELPRLQVERIGSKTIIRNFKQLADVMR
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHH
REPRILMRYLLKELGASGNYDEENGMLVINVKVSITTLNNLMQRFVKTYVICPTCGAPDT
CCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHEEECCCCCCCCH
RLERRGKAWVLICEACGAEQPVPPL
HHHHCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]