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The map label for this gene is aIF-2BII [H]

Identifier: 124027386

GI number: 124027386

Start: 480364

End: 481338

Strand: Reverse

Name: aIF-2BII [H]

Synonym: Hbut_0499

Alternate gene names: 124027386

Gene position: 481338-480364 (Counterclockwise)

Preceding gene: 124027387

Following gene: 124027385

Centisome position: 28.87

GC content: 52.82

Gene sequence:

>975_bases
TTGTCTAAACCGGAAAGCCCCTCCCTAGGCATCAACATGCTTGGAGCCACTGAGGCTACTGAGGAAGTCCTAAAGAAGTT
CCGCCAGCTCATATCAAGCGCTAAAGATGTGTGGGGGCTACTAGAGGCACTAGACTATCTCGAGGCTAGCCTCGCTGCGA
GGCCCTTCTCAGCACCCCTCATCAATGCTTCTCGCGAGCTACTGACTGTTATCGCCCATGGAGAATATGATAACATACCA
AGGCTTAAAGAGCTTGTCGAGGAAAATGTTGAGAAGCTGCTGAGGAGAATGATAGAAGAGACCGAGGCTGCAGCAGAGAT
CGCCGCCCGGAGGCTAGAAAACGGAGATACTGTATTGACGCACAGCTATAGCAGGAGCGTGCTGAGGACCATAGAGAAGG
CTGTGGCAATGGGCAAGACTATACGCGTCATAGTAGCAGAGTCGCGGCCCGTGTTAGACGGCATCGAGATGGCCAAGGCG
CTCACAAAACTGGAGATAGACGTAACACTCATCGTGGACTCTGCAATGAGGTTTATGGCGCGTGAGGCAACAAAGGCATT
GATAGGCGCTGACGCAGTAACAGCCGATGGAAGCATCATAGCGAGGACCGGTGCAGGGCTACTGGCACTTGCAGCCAACG
AGTCAAGGGTTAGAGTGATTGTCGTAGCGGGAACATACAAGTTCTACCCCGAAACCGTCTATGGGCTAATGGTGGAGTCG
CCAGCATTGCAAGAGGAGATAGTACCGGAGAGCCACAAGAAGCTAGGCATTAAAGGCTACGCGCCACTCTTCGAGTTCGT
ACCTCCACACCTCATAGATGCACTTGCCACTGAGAAGGGGCTCATAGCGCCGGAGGCTGTACCCCTGCTAGTCAAGGAGG
AATTTGGAGAGTGGCCGCCAAGGCTTGAGAGCCTCGAAAAACTATTCACCAAGGCTAGGGAGGAGCTAAAGAAGATAGGT
GCAAAACCATCCTAA

Upstream 100 bases:

>100_bases
AACCTGTCTACACGATCATTGCCGGGAGAATAGTCCACGCCGAGGAGGATAGTTTTTGAAGGGGGTATTGTAAGGTGTAT
AGCCTAGGTGTTATAGGGCC

Downstream 100 bases:

>100_bases
GAGGAGGTGACCTACGTGGAGTTTCCGGAGGAGGTCACAAGCATAGCCGAGGACATTAAGACTATGAAGATACGTGGGGC
GGGCAGGATAGCGAAGGCTG

Product: putative translation initiation factor eIF-2B subunit 2

Products: NA

Alternate protein names: eIF-2B GDP-GTP exchange factor [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MSKPESPSLGINMLGATEATEEVLKKFRQLISSAKDVWGLLEALDYLEASLAARPFSAPLINASRELLTVIAHGEYDNIP
RLKELVEENVEKLLRRMIEETEAAAEIAARRLENGDTVLTHSYSRSVLRTIEKAVAMGKTIRVIVAESRPVLDGIEMAKA
LTKLEIDVTLIVDSAMRFMAREATKALIGADAVTADGSIIARTGAGLLALAANESRVRVIVVAGTYKFYPETVYGLMVES
PALQEEIVPESHKKLGIKGYAPLFEFVPPHLIDALATEKGLIAPEAVPLLVKEEFGEWPPRLESLEKLFTKAREELKKIG
AKPS

Sequences:

>Translated_324_residues
MSKPESPSLGINMLGATEATEEVLKKFRQLISSAKDVWGLLEALDYLEASLAARPFSAPLINASRELLTVIAHGEYDNIP
RLKELVEENVEKLLRRMIEETEAAAEIAARRLENGDTVLTHSYSRSVLRTIEKAVAMGKTIRVIVAESRPVLDGIEMAKA
LTKLEIDVTLIVDSAMRFMAREATKALIGADAVTADGSIIARTGAGLLALAANESRVRVIVVAGTYKFYPETVYGLMVES
PALQEEIVPESHKKLGIKGYAPLFEFVPPHLIDALATEKGLIAPEAVPLLVKEEFGEWPPRLESLEKLFTKAREELKKIG
AKPS
>Mature_323_residues
SKPESPSLGINMLGATEATEEVLKKFRQLISSAKDVWGLLEALDYLEASLAARPFSAPLINASRELLTVIAHGEYDNIPR
LKELVEENVEKLLRRMIEETEAAAEIAARRLENGDTVLTHSYSRSVLRTIEKAVAMGKTIRVIVAESRPVLDGIEMAKAL
TKLEIDVTLIVDSAMRFMAREATKALIGADAVTADGSIIARTGAGLLALAANESRVRVIVVAGTYKFYPETVYGLMVESP
ALQEEIVPESHKKLGIKGYAPLFEFVPPHLIDALATEKGLIAPEAVPLLVKEEFGEWPPRLESLEKLFTKAREELKKIGA
KPS

Specific function: Catalyzes the exchange of initiation factor 2-bound GDP for GTP [H]

COG id: COG1184

COG function: function code J; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family [H]

Homologues:

Organism=Homo sapiens, GI4503503, Length=228, Percent_Identity=32.8947368421053, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI78000156, Length=267, Percent_Identity=26.5917602996255, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI187607323, Length=267, Percent_Identity=26.5917602996255, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI78000158, Length=267, Percent_Identity=26.5917602996255, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI7657058, Length=219, Percent_Identity=30.5936073059361, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17557123, Length=287, Percent_Identity=25.0871080139373, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322878, Length=218, Percent_Identity=28.4403669724771, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358605, Length=298, Percent_Identity=26.8456375838926, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281364091, Length=266, Percent_Identity=27.0676691729323, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24659399, Length=266, Percent_Identity=27.0676691729323, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24659407, Length=266, Percent_Identity=27.0676691729323, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19922816, Length=266, Percent_Identity=27.0676691729323, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI18543295, Length=221, Percent_Identity=28.5067873303167, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005250
- InterPro:   IPR000649
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: NA

Molecular weight: Translated: 35455; Mature: 35323

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPESPSLGINMLGATEATEEVLKKFRQLISSAKDVWGLLEALDYLEASLAARPFSAPL
CCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
INASRELLTVIAHGEYDNIPRLKELVEENVEKLLRRMIEETEAAAEIAARRLENGDTVLT
HHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
HSYSRSVLRTIEKAVAMGKTIRVIVAESRPVLDGIEMAKALTKLEIDVTLIVDSAMRFMA
EHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REATKALIGADAVTADGSIIARTGAGLLALAANESRVRVIVVAGTYKFYPETVYGLMVES
HHHHHHHHCCCCEECCCCEEEECCCCEEEEECCCCCEEEEEEECCCHHCHHHHHHHHHCC
PALQEEIVPESHKKLGIKGYAPLFEFVPPHLIDALATEKGLIAPEAVPLLVKEEFGEWPP
CHHHHHHCCCHHHHCCCCCCCHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCH
RLESLEKLFTKAREELKKIGAKPS
HHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SKPESPSLGINMLGATEATEEVLKKFRQLISSAKDVWGLLEALDYLEASLAARPFSAPL
CCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
INASRELLTVIAHGEYDNIPRLKELVEENVEKLLRRMIEETEAAAEIAARRLENGDTVLT
HHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
HSYSRSVLRTIEKAVAMGKTIRVIVAESRPVLDGIEMAKALTKLEIDVTLIVDSAMRFMA
EHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REATKALIGADAVTADGSIIARTGAGLLALAANESRVRVIVVAGTYKFYPETVYGLMVES
HHHHHHHHCCCCEECCCCEEEECCCCEEEEECCCCCEEEEEEECCCHHCHHHHHHHHHCC
PALQEEIVPESHKKLGIKGYAPLFEFVPPHLIDALATEKGLIAPEAVPLLVKEEFGEWPP
CHHHHHHCCCHHHHCCCCCCCHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCH
RLESLEKLFTKAREELKKIGAKPS
HHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]