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The map label for this gene is 124027385

Identifier: 124027385

GI number: 124027385

Start: 479380

End: 480348

Strand: Reverse

Name: 124027385

Synonym: Hbut_0498

Alternate gene names: NA

Gene position: 480348-479380 (Counterclockwise)

Preceding gene: 124027386

Following gene: 124027383

Centisome position: 28.81

GC content: 50.15

Gene sequence:

>969_bases
GTGGAGTTTCCGGAGGAGGTCACAAGCATAGCCGAGGACATTAAGACTATGAAGATACGTGGGGCGGGCAGGATAGCGAA
GGCTGCAGCTCGGGCATTAATGATTGCTGCCGAGAGGTTTCAGGGAGGCAGTGTGGACGAGTTTGTAAACTATATGCGTG
CTACCGGCGAGCTACTCATATCCACTAGGCCCACAGCTGTGAGCCTACCTAATGCTGTTAATTATGTCCTAAGAGTCCTT
GAAGAAAGACGTTATACAAGCGTTGAGGAGGTAAGGAAGGCTGTTATAGAAGCTGCTAGAAGCTTCATAGAATACTCGGA
GCAAGCCCTTAAGAAGATAGGAGAGATAGGGGCAAGACTCATAAAGACTGGCGACAGAATACTGACACACTGCAATAGCA
AGGCCGTAGAGTCGATACTCATAACCGCGTGGAGGCAGGGTAAGCGCTTCGAGGTCTATGCAACCGAGACTAGGCCAAGA
TACCAGGGCCACATAACCTCCATGGATTTAGCCATGGAGGGCATACCTGTCACTCTTATACCAGATGCTGCTGTTCTACA
AGTGATGGAGTCTAAACGAATAACCAAGGTGATCGTTGGCGCAGACACAGTTACCGCCAACGGAGCCGTGATAAATAAGA
TTGGTACAAGCCAGATAGCCCTCGCAGCAAGACTATTCAGAATACCCTTCATCGTTGCAACAGAGACCTACAAGTTTAGC
CCCTATACAGTCGTCGGCCAGCCGGTAGAGATTGAGGAAAGACCTGCTGAGGAGGTACTGCCAGCACACATTCCCGGTGT
TAAGGTTAGAAATCCAGCATTTGACGCTACACCGCCAGACTATATAGACATGATTGTTACCGAAAGAGGCATCATCCCGC
CAAAGTCGGCTGCGCTAATGCTCTGGGAGCTATTCCATAGAAAACCCTCAGAGTCCCGACTACCGGGCGTGGAGGAGGAT
TCAGGCTAG

Upstream 100 bases:

>100_bases
GTGGCCGCCAAGGCTTGAGAGCCTCGAAAAACTATTCACCAAGGCTAGGGAGGAGCTAAAGAAGATAGGTGCAAAACCAT
CCTAAGAGGAGGTGACCTAC

Downstream 100 bases:

>100_bases
CCCTCAACCTCGAAAGCTTCGCCACTAGATCCCCCTTCAACACCGTATTTTTCGAGGGCATCGATGAGCTTGTCGGCTAG
CTTATTTGGATCCTTGTATT

Product: translation initiation factor IF-2B subunit delta

Products: NA

Alternate protein names: eIF-2B GDP-GTP exchange factor [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MEFPEEVTSIAEDIKTMKIRGAGRIAKAAARALMIAAERFQGGSVDEFVNYMRATGELLISTRPTAVSLPNAVNYVLRVL
EERRYTSVEEVRKAVIEAARSFIEYSEQALKKIGEIGARLIKTGDRILTHCNSKAVESILITAWRQGKRFEVYATETRPR
YQGHITSMDLAMEGIPVTLIPDAAVLQVMESKRITKVIVGADTVTANGAVINKIGTSQIALAARLFRIPFIVATETYKFS
PYTVVGQPVEIEERPAEEVLPAHIPGVKVRNPAFDATPPDYIDMIVTERGIIPPKSAALMLWELFHRKPSESRLPGVEED
SG

Sequences:

>Translated_322_residues
MEFPEEVTSIAEDIKTMKIRGAGRIAKAAARALMIAAERFQGGSVDEFVNYMRATGELLISTRPTAVSLPNAVNYVLRVL
EERRYTSVEEVRKAVIEAARSFIEYSEQALKKIGEIGARLIKTGDRILTHCNSKAVESILITAWRQGKRFEVYATETRPR
YQGHITSMDLAMEGIPVTLIPDAAVLQVMESKRITKVIVGADTVTANGAVINKIGTSQIALAARLFRIPFIVATETYKFS
PYTVVGQPVEIEERPAEEVLPAHIPGVKVRNPAFDATPPDYIDMIVTERGIIPPKSAALMLWELFHRKPSESRLPGVEED
SG
>Mature_322_residues
MEFPEEVTSIAEDIKTMKIRGAGRIAKAAARALMIAAERFQGGSVDEFVNYMRATGELLISTRPTAVSLPNAVNYVLRVL
EERRYTSVEEVRKAVIEAARSFIEYSEQALKKIGEIGARLIKTGDRILTHCNSKAVESILITAWRQGKRFEVYATETRPR
YQGHITSMDLAMEGIPVTLIPDAAVLQVMESKRITKVIVGADTVTANGAVINKIGTSQIALAARLFRIPFIVATETYKFS
PYTVVGQPVEIEERPAEEVLPAHIPGVKVRNPAFDATPPDYIDMIVTERGIIPPKSAALMLWELFHRKPSESRLPGVEED
SG

Specific function: Catalyzes the exchange of initiation factor 2-bound GDP for GTP [H]

COG id: COG1184

COG function: function code J; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=310, Percent_Identity=34.1935483870968, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI78000156, Length=270, Percent_Identity=30.3703703703704, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI78000158, Length=270, Percent_Identity=30.3703703703704, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI187607323, Length=270, Percent_Identity=30.3703703703704, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI4503503, Length=285, Percent_Identity=30.8771929824561, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI23943880, Length=297, Percent_Identity=31.6498316498317, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI7657058, Length=345, Percent_Identity=27.2463768115942, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17557462, Length=317, Percent_Identity=31.2302839116719, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17557123, Length=289, Percent_Identity=27.681660899654, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322878, Length=272, Percent_Identity=32.3529411764706, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6325375, Length=369, Percent_Identity=25.4742547425474, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323322, Length=345, Percent_Identity=25.5072463768116, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21357667, Length=325, Percent_Identity=33.2307692307692, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24651647, Length=325, Percent_Identity=33.2307692307692, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21358605, Length=286, Percent_Identity=31.8181818181818, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI18543295, Length=190, Percent_Identity=33.1578947368421, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281364091, Length=279, Percent_Identity=29.3906810035842, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24659399, Length=279, Percent_Identity=29.3906810035842, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24659407, Length=279, Percent_Identity=29.3906810035842, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922816, Length=279, Percent_Identity=29.3906810035842, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005250
- InterPro:   IPR000649
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: NA

Molecular weight: Translated: 35595; Mature: 35595

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFPEEVTSIAEDIKTMKIRGAGRIAKAAARALMIAAERFQGGSVDEFVNYMRATGELLI
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEE
STRPTAVSLPNAVNYVLRVLEERRYTSVEEVRKAVIEAARSFIEYSEQALKKIGEIGARL
ECCCCEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKTGDRILTHCNSKAVESILITAWRQGKRFEVYATETRPRYQGHITSMDLAMEGIPVTLI
HHCCHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEHHHHHCCCCEEEC
PDAAVLQVMESKRITKVIVGADTVTANGAVINKIGTSQIALAARLFRIPFIVATETYKFS
CCHHHHHHHHHCCCEEEEEECCEEECCCEEEECCCCHHHHHHHHHHHCCEEEEECEEECC
PYTVVGQPVEIEERPAEEVLPAHIPGVKVRNPAFDATPPDYIDMIVTERGIIPPKSAALM
CEEEECCCCCCCCCCHHHCCCCCCCCCEECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHH
LWELFHRKPSESRLPGVEEDSG
HHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEFPEEVTSIAEDIKTMKIRGAGRIAKAAARALMIAAERFQGGSVDEFVNYMRATGELLI
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEE
STRPTAVSLPNAVNYVLRVLEERRYTSVEEVRKAVIEAARSFIEYSEQALKKIGEIGARL
ECCCCEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKTGDRILTHCNSKAVESILITAWRQGKRFEVYATETRPRYQGHITSMDLAMEGIPVTLI
HHCCHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEHHHHHCCCCEEEC
PDAAVLQVMESKRITKVIVGADTVTANGAVINKIGTSQIALAARLFRIPFIVATETYKFS
CCHHHHHHHHHCCCEEEEEECCEEECCCEEEECCCCHHHHHHHHHHHCCEEEEECEEECC
PYTVVGQPVEIEERPAEEVLPAHIPGVKVRNPAFDATPPDYIDMIVTERGIIPPKSAALM
CEEEECCCCCCCCCCHHHCCCCCCCCCEECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHH
LWELFHRKPSESRLPGVEEDSG
HHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]