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The map label for this gene is 124027336

Identifier: 124027336

GI number: 124027336

Start: 430528

End: 431394

Strand: Reverse

Name: 124027336

Synonym: Hbut_0445

Alternate gene names: NA

Gene position: 431394-430528 (Counterclockwise)

Preceding gene: 124027340

Following gene: 124027333

Centisome position: 25.88

GC content: 50.63

Gene sequence:

>867_bases
GTGTACAGCATTAACGGTCTAAGGGTTAGACGGGTGGGCGAGGCACTAGCAGTTGTTAGCCCACACGCCCTCGATGTTAT
TGAGAGGCGTGATCCCCAGTACAAGGCTATCAGCATGTTAGCTGAAAAATATGGTGTGGAGGCTCTAGCAGTTATTGTAG
CTAATGCCCTCATAAGCTATCGGCTCACGTTGAAGGGGGAGGAGTACTGGCTAGAATTTGCAAGCTACTTCTCTAAAGCC
GGGCTCCCTCGAACGGCACAGGAAATAGTCTCCGCCTTCAGAGGATTCCTCTCAGAGAGCCGTGGCAATCGTAGGCTTGT
AGAGCAGAAGCTCTTGAGGATACGTCGTGCAGCTCCTCTCCTTGAGGATGTTGCAAGTGATCCGCTACGCTACAGCGATG
TAGGCTTGTTGGTTGAAATGCTAGCTAGACAGCTTAGGGCGAGAAGGCATGAGAAGACGATAGTGTTTGCAGGCAAGATG
GCCTACTATCTCTTCAAAGCCTTGAACGTGGAGGTTAGGGGGCTAGAGAGAATACCGTTACCTGTTGATAGGCGTGTAGC
ATTAATAACAGTAACATCCGGTATAGCTGATGCAGACATATCAACCATAGTGTCACGGCCAGATGCAGCTATAGAGGCTT
GGAGCGAAATAGCGAAGATTTCTAGCATACCAGCAATGAGGCTTGATGCCGTGATATGGTTGCCGGCTGCAGAGATGGAG
AAGAACTTGCGTAGAGGACTCGAGTATGCTCGCGACGAGTATGCAAGGAGACTTGTATCCTACAGTGGGGGCTCCATAAG
CTGGCCCTCTGCCCGCAAGATAGCATCTGAGATTGTCTACAGGTTTCCGCCCAACACAGCCCTGTAA

Upstream 100 bases:

>100_bases
CGGCCCATACATAGTTGGAGAGCGGAGGGTAGGGGTATTAGCGCTGGTTCCCCCTTATACCTGCTAGCATCCCGCTGTCC
CAGGATGGGGTTACAGGGCA

Downstream 100 bases:

>100_bases
AACCGCTCAGCTAACATGGCGTCGCGATGCTCGAGGAGCCTTACACTAGCTTGGAAAGCTTGAATAAGCTGTCCAGAGTC
AACATCAATCGCCCAGCCGG

Product: N-glycosylase/DNA lyase

Products: NA

Alternate protein names: 8-oxoguanine DNA glycosylase; AGOG; DNA-(apurinic or apyrimidinic site) lyase; AP lyase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MYSINGLRVRRVGEALAVVSPHALDVIERRDPQYKAISMLAEKYGVEALAVIVANALISYRLTLKGEEYWLEFASYFSKA
GLPRTAQEIVSAFRGFLSESRGNRRLVEQKLLRIRRAAPLLEDVASDPLRYSDVGLLVEMLARQLRARRHEKTIVFAGKM
AYYLFKALNVEVRGLERIPLPVDRRVALITVTSGIADADISTIVSRPDAAIEAWSEIAKISSIPAMRLDAVIWLPAAEME
KNLRRGLEYARDEYARRLVSYSGGSISWPSARKIASEIVYRFPPNTAL

Sequences:

>Translated_288_residues
MYSINGLRVRRVGEALAVVSPHALDVIERRDPQYKAISMLAEKYGVEALAVIVANALISYRLTLKGEEYWLEFASYFSKA
GLPRTAQEIVSAFRGFLSESRGNRRLVEQKLLRIRRAAPLLEDVASDPLRYSDVGLLVEMLARQLRARRHEKTIVFAGKM
AYYLFKALNVEVRGLERIPLPVDRRVALITVTSGIADADISTIVSRPDAAIEAWSEIAKISSIPAMRLDAVIWLPAAEME
KNLRRGLEYARDEYARRLVSYSGGSISWPSARKIASEIVYRFPPNTAL
>Mature_288_residues
MYSINGLRVRRVGEALAVVSPHALDVIERRDPQYKAISMLAEKYGVEALAVIVANALISYRLTLKGEEYWLEFASYFSKA
GLPRTAQEIVSAFRGFLSESRGNRRLVEQKLLRIRRAAPLLEDVASDPLRYSDVGLLVEMLARQLRARRHEKTIVFAGKM
AYYLFKALNVEVRGLERIPLPVDRRVALITVTSGIADADISTIVSRPDAAIEAWSEIAKISSIPAMRLDAVIWLPAAEME
KNLRRGLEYARDEYARRLVSYSGGSISWPSARKIASEIVYRFPPNTAL

Specific function: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates [H]

COG id: COG4047

COG function: function code S; Uncharacterized protein conserved in archaea

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR023170
- InterPro:   IPR015254
- InterPro:   IPR016544 [H]

Pfam domain/function: PF09171 DUF1886 [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 32367; Mature: 32367

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSINGLRVRRVGEALAVVSPHALDVIERRDPQYKAISMLAEKYGVEALAVIVANALISY
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHH
RLTLKGEEYWLEFASYFSKAGLPRTAQEIVSAFRGFLSESRGNRRLVEQKLLRIRRAAPL
HEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LEDVASDPLRYSDVGLLVEMLARQLRARRHEKTIVFAGKMAYYLFKALNVEVRGLERIPL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHCCCCCCCCC
PVDRRVALITVTSGIADADISTIVSRPDAAIEAWSEIAKISSIPAMRLDAVIWLPAAEME
CCCCCEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHEEECCHHHHH
KNLRRGLEYARDEYARRLVSYSGGSISWPSARKIASEIVYRFPPNTAL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MYSINGLRVRRVGEALAVVSPHALDVIERRDPQYKAISMLAEKYGVEALAVIVANALISY
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHH
RLTLKGEEYWLEFASYFSKAGLPRTAQEIVSAFRGFLSESRGNRRLVEQKLLRIRRAAPL
HEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LEDVASDPLRYSDVGLLVEMLARQLRARRHEKTIVFAGKMAYYLFKALNVEVRGLERIPL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHCCCCCCCCC
PVDRRVALITVTSGIADADISTIVSRPDAAIEAWSEIAKISSIPAMRLDAVIWLPAAEME
CCCCCEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHEEECCHHHHH
KNLRRGLEYARDEYARRLVSYSGGSISWPSARKIASEIVYRFPPNTAL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]